CN106267128A - 用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 - Google Patents
用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 Download PDFInfo
- Publication number
- CN106267128A CN106267128A CN201610892025.6A CN201610892025A CN106267128A CN 106267128 A CN106267128 A CN 106267128A CN 201610892025 A CN201610892025 A CN 201610892025A CN 106267128 A CN106267128 A CN 106267128A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- cold
- medicine composition
- insufficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 210000000952 spleen Anatomy 0.000 title claims abstract description 29
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 210000000582 semen Anatomy 0.000 claims abstract description 42
- 229940079593 drug Drugs 0.000 claims abstract description 16
- 241000756943 Codonopsis Species 0.000 claims abstract description 14
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 14
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 14
- 239000004615 ingredient Substances 0.000 claims abstract description 9
- 244000268590 Euryale ferox Species 0.000 claims description 13
- 244000295724 Allium chinense Species 0.000 claims 1
- 235000016790 Allium chinense Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 2
- 241000600871 Euryale <brittle star> Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 6
- 201000000117 functional diarrhea Diseases 0.000 description 4
- 231100001274 therapeutic index Toxicity 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000010832 independent-sample T-test Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000010831 paired-sample T-test Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 208000011726 slow pulse Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种用于改善脾虚寒湿证腹泻的中药组合物及其制备方法和应用,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓10‑15份、苍术3‑9份、厚朴3‑9份、白术6‑10份、党参10‑20份、陈皮3‑9份、葛根10‑15份、薏苡仁10‑20份、大枣6‑15份、莲子6‑15份、芡实9‑15份、乌梅6‑12份、木香3‑6份、薤白5‑10份、艾叶3‑9份、干姜3‑9份。本发明所述的中药组合物配伍合理,诸药合用,共奏改善脾虚寒湿证腹泻之效。
Description
技术领域
本发明涉及中药领域,特别是涉及一种用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用。
背景技术
功能性腹泻是临床上常见的一种消化性疾病,以腹泻为主要临床表现,是一种不伴有腹痛或腹部不适,持续性或反复发作排松散便或水样便的功能性肠病,是下消化道最为主要的功能性胃肠病之一。主要表现为胃肠蠕动过快,小肠吸收功能下降。实验室检查及特殊检查皆无器质性病变,此种疾病的发生常与精神因素、温度、食物等相关。随着生活节奏的加快,精神压力的增高,生活习惯及饮食结构的改变,功能性腹泻的发生率达9.7%,其发病率还有逐年增长趋势。
功能性腹泻在中医属“泄泻”范畴。影响因素有外感六淫之邪、饮食所伤、情志失调、形体劳倦,涉及脏腑有脾胃、肝、肾及大、小肠,但关系最为密切为脾胃。该病多由脾虚湿生,脾胃运化功能失调,肠道分清泌浊、传导功能失司所致。
发明内容
基于此,本发明目的之一在于提供一种用于改善脾虚寒湿证腹泻的中药组合物。
解决上述技术问题的具体技术方案如下:
一种用于改善脾虚寒湿证腹泻的中药组合物,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓10-15份、苍术3-9份、厚朴3-9份、白术6-10份、党参10-20份、陈皮3-9份、葛根10-15份、薏苡仁10-20份、大枣6-15份、莲子6-15份、芡实9-15份、乌梅6-12份、木香3-6份、薤白5-10份、艾叶3-9份、干姜3-9份。
优选的,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓11-14份、苍术4-7份、厚朴4-7份、白术7-9份、党参12-18份、陈皮4-7份、葛根11-14份、薏苡仁12-18份、大枣8-12份、莲子8-12份、芡实10-14份、乌梅7-10份、木香4-5份、薤白6-9份、艾叶4-8份、干姜4-8份。
优选的,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓12-13份、苍术5-6份、厚朴5-6份、白术8-9份、党参15-16份、陈皮5-6份、葛根12-13份、薏苡仁15-16份、大枣9-10份、莲子9-10份、芡实12-13份、乌梅8-9份、木香4-5份、薤白7-8份、艾叶6-7份、干姜6-7份。
本发明的另一目的在于提供一种上述用于改善脾虚寒湿证腹泻的中药组合物的制备方法,包括如下步骤:
取茯苓、苍术、厚朴、白术、党参、陈皮、葛根、薏苡仁、大枣、莲子、芡实、乌梅、木香、薤白、艾叶和干姜煎煮,过滤,即可。
优选的,所述煎煮的时间为10-20min。
优选的,所述煎煮的时间为10-15min。
本发明的另一目的在于提供一种上述中药组合物在制备用于改善脾虚寒湿证腹泻的药品或保健品中的应用。
本发明所述的一种用于改善脾虚寒湿证腹泻的中药组合物及其准备方法和应用具有以下优点和有益效果:
1)本发明所述的中药组合物配伍合理,诸药合用,共奏用于改善脾虚寒湿证腹泻之效,该中药组合物以运脾为主,化湿为辅,收涩加之,寒热并用,相互协同,显著改善脾阳虚寒湿盛所致功能性腹泻。
2)本发明所述制备方法,简单、方便。
具体实施方式
以下将结合具体实施例对本发明做进一步说明,以便本领域技术人员更清楚的了解本发明,但并不因此限制本发明。
实施例1
本实施例涉及一种用于改善脾虚寒湿证腹泻的中药组合物,其有效成分由下述重量的原料药制备而成:茯苓12g、苍术6g、厚朴6g、白术9g、党参16g、陈皮6g、葛根12g、薏苡仁16g、大枣9g、莲子9g、芡实12g、乌梅9g、木香4g、薤白8g、艾叶6g、干姜6g。
上述用于改善脾虚寒湿证腹泻的中药组合物的制备方法,步骤如下:
取茯苓、苍术、厚朴、白术、党参、陈皮、葛根、薏苡仁、大枣、莲子、芡实、乌梅、木香、薤白、艾叶和干姜煎煮10-15min,过滤,取滤渣继续煎煮10-15min,过滤,合并两次滤液,即可。
实施例2
本实施例涉及一种用于改善脾虚寒湿证腹泻的中药组合物,其有效成分由下述重量的原料药制备而成:茯苓10g、苍术3g、厚朴3g、白术6g、党参10g、陈皮3g、葛根10g、薏苡仁10g、大枣6g、莲子6g、芡实9g、乌梅6g、木香3g、薤白5g、艾叶3g、干姜3g。
上述用于改善脾虚寒湿证腹泻的中药组合物的制备方法参照实施例1。
实施例3
本实施例涉及一种用于改善脾虚寒湿证腹泻的中药组合物,其有效成分由下述重量的原料药制备而成:茯苓14g、苍术7g、厚朴7g、白术9g、党参18g、陈皮4-7g、葛根14g、薏苡仁18g、大枣12g、莲子12g、芡实14g、乌梅10g、木香5g、薤白9g、艾叶8g、干姜8g。
上述用于改善脾虚寒湿证腹泻的中药组合物的制备方法参照实施例1。
以下结合实践中典型病例对本发明的有益效果做进一步说明。
1、病人概况:选择200例,均符合《肠易激综合征中西医结合诊疗方案》中诊断标准。中医诊断为脾阳虚寒湿证:泄泻清稀,完谷不化,肢体浮肿,按之不起,畏寒,不思饮食,腹胀,舌色淡白湿润多津,舌体胖嫩,舌边有齿痕,脉沉迟或沉细。随机将病人平均分为治疗组1(50例,男性22例,女性28例,年龄45-56岁,病程1~3年)、治疗组2(50例,男性26例,女性24例,年龄40-60岁,病程1~4年)、治疗组3(50例,男性20例,女性30例,年龄55-67岁,病程1~3年)和对照组(50例,男性18例,女性32例,年龄49-61岁,病程1~3年)。四组性别、年龄、病程等比较无显著性差异(P>0.05),具有可比性。
2、治疗方法
治疗组1-3分别服用实施例1-3所制得的中药组合物,2次/日。对照组服用:茯苓12g、苍术6g、厚朴6g、白术9g、党参16g、陈皮6g、葛根12g、薏苡仁16g、大枣9g、莲子9g、芡实12g、乌梅9g、木香4g、干姜6g,制备方法参照实施例1,2次/日。四组疗程为4周,治疗期间停用其他药物,避免辛辣寒凉食物。
3、观测内容
将症状大便泄泻、腹胀、食欲不振、畏寒肢冷症状,根据《中药新药治疗泄泻临床研究指导原则》症状分级量化表,症状程度分为轻度、中度、重度3级,分别积分为1、2、3分。疗程结束后复查血常规、尿常规和生化指标。
采用spss进行数据分析,采用x±s表示,治疗前后采用配对样本t检验,各组间比较采用两组独立样本t检验,计数资料采用X2检验。
4、疗效标准
根据《中药新药治疗泄泻临床研究指导原则》证候疗效判定标准,疗效指数=[(治疗前症状积分-治疗后症状积分)/治疗前症状积分]×100%。
痊愈:≥95%;显效:70%≤疗效指数<95%;有效:30%≤疗效指数<70%;无效:疗效指数<30%。
5、治疗结果
四组疗效比较结果见表1。从表1可以看出,总有效率治疗组1>治疗组3>治疗组2>对照组。说明实施例1-3所制得的中药组合物可显著改善因脾阳虚寒湿所导致的腹泻。四组治疗前后未见明显不良反应,血、尿常规及生化指标未见异常变化。
表1
组别 | 例 | 痊愈 | 显效 | 有效 | 无效 | 总有效率 |
对照组 | 50 | 20 | 13 | 10 | 7 | 86% |
治疗组1 | 50 | 30 | 16 | 2 | 2 | 96% |
治疗组2 | 50 | 24 | 14 | 7 | 5 | 90% |
治疗组3 | 50 | 27 | 15 | 4 | 4 | 92% |
Claims (7)
1.一种用于改善脾虚寒湿证腹泻的中药组合物,其特征在于,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓10-15份、苍术3-9份、厚朴3-9份、白术6-10份、党参10-20份、陈皮3-9份、葛根10-15份、薏苡仁10-20份、大枣6-15份、莲子6-15份、芡实9-15份、乌梅6-12份、木香3-6份、薤白5-10份、艾叶3-9份、干姜3-9份。
2.根据权利要求1所述的用于改善脾虚寒湿证腹泻的中药组合物,其特征在于,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓11-14份、苍术4-7份、厚朴4-7份、白术7-9份、党参12-18份、陈皮4-7份、葛根11-14份、薏苡仁12-18份、大枣8-12份、莲子8-12份、芡实10-14份、乌梅7-10份、木香4-5份、薤白6-9份、艾叶4-8份、干姜4-8份。
3.根据权利要求2所述的用于改善脾虚寒湿证腹泻的中药组合物,其特征在于,所述中药组合物的有效成分由下述重量份的原料药制备而成:茯苓12-13份、苍术5-6份、厚朴5-6份、白术8-9份、党参15-16份、陈皮5-6份、葛根12-13份、薏苡仁15-16份、大枣9-10份、莲子9-10份、芡实12-13份、乌梅8-9份、木香4-5份、薤白7-8份、艾叶6-7份、干姜6-7份。
4.一种如上述权利要求1-3任一项所述的用于改善脾虚寒湿证腹泻的中药组合物的制备方法,其特征在于,包括如下步骤:
取茯苓、苍术、厚朴、白术、党参、陈皮、葛根、薏苡仁、大枣、莲子、芡实、乌梅、木香、薤白、艾叶和干姜煎煮,过滤,即可。
5.根据权利要求4所述的用于改善脾虚寒湿证腹泻的中药组合物的制备方法,其特征在于,所述煎煮的时间为10-20min。
6.根据权利要求5所述的用于改善脾虚寒湿证腹泻的中药组合物的制备方法,其特征在于,所述煎煮的时间为10-15min。
7.如权利要求1-3任一项所述的用于改善脾虚寒湿证腹泻的中药组合物在制备用于改善脾虚寒湿证腹泻的药品或保健品中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610892025.6A CN106267128A (zh) | 2016-10-12 | 2016-10-12 | 用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610892025.6A CN106267128A (zh) | 2016-10-12 | 2016-10-12 | 用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106267128A true CN106267128A (zh) | 2017-01-04 |
Family
ID=57718413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610892025.6A Pending CN106267128A (zh) | 2016-10-12 | 2016-10-12 | 用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106267128A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110548127A (zh) * | 2019-10-22 | 2019-12-10 | 赵其民 | 一种祛湿中药组合丸剂及其使用方法 |
-
2016
- 2016-10-12 CN CN201610892025.6A patent/CN106267128A/zh active Pending
Non-Patent Citations (1)
Title |
---|
吴皓萌 等: "21位国医大师治疗慢性泄泻的经验撷菁", 《中华中医药杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110548127A (zh) * | 2019-10-22 | 2019-12-10 | 赵其民 | 一种祛湿中药组合丸剂及其使用方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101244193A (zh) | 一种治疗呼吸道疾病的中药及其制备方法 | |
CN103585514A (zh) | 一种用于治疗胃癌的中药组合物、应用及制剂 | |
CN104338078A (zh) | 一种治疗妊娠期肝内胆汁淤积症的药物组合物 | |
CN103405742A (zh) | 一种治疗小儿腹泻的药物组合物及其制备方法 | |
CN106267128A (zh) | 用于改善脾虚寒湿证腹泻的中药组合物和制备方法及其应用 | |
CN103285173B (zh) | 一种治疗血小板减少性紫癜的中药 | |
CN106267129A (zh) | 用于改善脾肾阳虚证腹泻的中药组合物和制备方法及其应用 | |
CN103301368B (zh) | 一种治疗多动症的药剂 | |
CN105902912A (zh) | 一种治疗小儿肺炎的药物组合物 | |
CN106267126A (zh) | 用于改善脾胃阳虚证腹泻的中药组合物和制备方法及其应用 | |
CN105056077A (zh) | 一种治疗功能性消化不良的中药组合物 | |
CN105056173A (zh) | 一种治疗寒热错杂型胃食管反流病的中药 | |
CN106310197A (zh) | 用于改善腹泻的中药组合物和制备方法及其应用 | |
CN104721745A (zh) | 一种治疗慢性胰腺炎的中药组合物 | |
CN106237177A (zh) | 用于改善湿热蕴脾证腹泻的中药组合物和制备方法及其应用 | |
CN104547768B (zh) | 一种用于慢性咳嗽的保健茶 | |
CN108355124A (zh) | 一种治疗气道粘液高分泌的中药组合物及其应用 | |
CN106389843A (zh) | 用于改善口干咽干的中药组合物和制备方法及其应用 | |
CN105641057A (zh) | 一种治疗脾不统血型原发性肾小球性血尿的药物组合物 | |
CN105999003A (zh) | 一种防治痛经的艾叶保健酒及其制备方法 | |
CN104721411B (zh) | 一种治疗贫血的药物组合物及其制备方法和用途 | |
CN105581231A (zh) | 一种长寿养生早餐粉 | |
CN106266765B (zh) | 一种适用于痰湿质的抗肺癌药物及其制备方法 | |
CN106377707A (zh) | 用于改善肝郁脾虚证腹泻的中药组合物和制备方法及其应用 | |
CN104189459A (zh) | 一种治疗便秘的中药制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170104 |