CN105902912A - 一种治疗小儿肺炎的药物组合物 - Google Patents

一种治疗小儿肺炎的药物组合物 Download PDF

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CN105902912A
CN105902912A CN201610482514.4A CN201610482514A CN105902912A CN 105902912 A CN105902912 A CN 105902912A CN 201610482514 A CN201610482514 A CN 201610482514A CN 105902912 A CN105902912 A CN 105902912A
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王立丽
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Abstract

本发明提供了一种治疗小儿肺炎的药物组合物，包括以下重量份的原料：麻黄5～15份、枇杷叶2～5份、半夏3～5份、苍术4～8份、厚朴1～5份、细辛1～5份、川贝1～5份、橘红1～5份、桑叶1.5～3份、百部1～3份、甘草1～3份。本发明组方严谨、用药合理，全方共奏宣肺解表，化痰止咳平喘，对风寒闭肺证小儿肺炎十分有效。

Description

一种治疗小儿肺炎的药物组合物
技术领域
本发明属于中药技术领域，具体涉及一种治疗小儿肺炎的药物组合物。
背景技术
小儿肺炎是儿科常见疾病之一，四季均易发生，任何年龄的小儿皆可发病，如治疗不彻底，易反复发作，甚至引起多种并发症，甚至影响发育。小儿肺炎临床表现为发热、咳嗽、喉中痰鸣、喘息、呼吸困难等和肺部干湿啰音，也有无发热表现而咳喘重者，年龄小于6个月患儿更有口吐白沫而无咳嗽表现者。肺为娇脏，加之小儿肤薄神怯，卫外不固，易为外邪所侵，若外感咳嗽迁延日久，损伤肺气则病就难愈。又由于小儿行气未充，肺气不足，常易感寒，加上小儿常喜食生冷，易致寒邪客肺，肺气不宣，导致风寒闭肺肺炎。
发明内容
本发明要解决的技术问题是提供一种治疗小儿肺炎的药物组合物，该药物组合物疗效好。
本发明提供的技术方案是一种治疗小儿肺炎的药物组合物，包括以下重量份的原料：麻黄5～15份、枇杷叶2～5份、半夏3～5份、苍术4～8份、厚朴1～5份、细辛1～5份、川贝1～5份、橘红1～5份、桑叶1.5～3份、百部1～3份、甘草1～3份。
作为优选，还包括桑白皮1～3份。
进一步优选地，还包括麦芽1～2份。
其制备方法为：将配方量的各原料粉碎，加水煎煮，过滤，将滤液浓缩至浸膏，干燥，即得。
进一步优选，其制备方法为：将配方量的各原料粉碎，加入原料总重8～10倍的水煎煮2～3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1～1.3的浸膏，干燥，即得。
方中麻黄具有发汗解表，宣肺平喘之功，枇杷叶降利肺气，与麻黄相配，善宣肺气而平喘止咳，共为君药；半夏、苍术、厚朴、细辛燥湿化痰，利气，共为臣药；川贝、橘红、桑叶、百部归辅助臣药止咳化痰；甘草，调和诸药，为使药。全方共奏宣肺解表，化痰止咳平喘，对小儿肺炎(风寒闭肺证)十分有效。在本方基础上，加桑白皮有助于降气止咳，加麦芽有助于消食导滞。
具体实施方式
以下具体实施例对本发明作进一步阐述，但不作为对本发明的限定。
配方：麻黄5份、枇杷叶2份、半夏3份、苍术4份、厚朴1份、细辛1份、川贝1份、橘红1份、桑叶1.5份、百部1份、甘草1份。
制备方法为：将配方量的各原料粉碎，加入原料总重8倍的水煎煮2次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1的浸膏，干燥，即得。
实施例2
配方：麻黄15份、枇杷叶5份、半夏5份、苍术8份、厚朴5份、细辛5份、川贝5份、橘红5份、桑叶3份、百部3份、甘草3份、桑白皮3份。
制备方法为：将配方量的各原料粉碎，加入原料总重10倍的水煎煮3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.3的浸膏，干燥，即得。
实施例3
配方：麻黄10份、枇杷叶4份、半夏4份、苍术6份、厚朴2份、细辛3份、川贝2份、橘红2份、桑叶2.5份、百部2份、甘草2份、桑白皮2份、麦芽1份。
制备方法为：将配方量的各原料粉碎，加入原料总重8倍的水煎煮3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1的浸膏，干燥，即得。
实施例4
配方：麻黄5份、枇杷叶5份、半夏3份、苍术8份、厚朴1份、细辛5份、川贝1份、橘红5份、桑叶1.5份、百部3份、甘草1份、桑白皮1份、麦芽2份。
制备方法为：将配方量的各原料粉碎，加入原料总重9倍的水煎煮2次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.2的浸膏，干燥，即得。
通过以下临床试验验证本发明的有益效果：
1、门诊病例
选取小儿肺炎(风寒闭肺证)住院治疗病例250例，年龄在2～12岁之间，女孩150例，男孩100例，随机分为5组，分别为实验组1～4和对照组，每组50人。
2、诊断标准
2.1中医诊断标准
参照2008年中华中医药协会儿科分会《小儿肺炎喘嗽中医诊疗指南》以及2007十一五规划教材《中医儿科学》进行诊断。
恶寒发热、头身痛、无汗、鼻塞流清涕、喷嚏、咳嗽、气喘鼻煽、痰稀白，可见泡沫样痰，或闻喉间痰鸣，咽部红，口不渴，面色淡白，纳呆，小便清长，舌淡红，脉浮紧，指纹浮红。其中，咳嗽、发热、气喘、痰鸣为主症；头身痛、鼻塞流清涕，喷嚏，口不渴，咽不红，纳呆，小便清长，脉浮紧或指纹浮红为次症。
3、纳入标准
1)符合中医诊断以及辨证标准；
2)年龄在2～12岁；
3)病程小于5天；
4、排除标准：
1)重症肺炎患儿；
2)中医小儿肺炎其他证型患儿
3)合并呼吸系统结核、肿瘤及心脑血管、肺、肝、肾和造血系统严重原发性疾病。
5、用药方法
实验组1～4服用实施例1～4的药物组合物，每次服用相当于生药0.1g，每日3次。七天为一个疗程。
对照组给予头孢硫脒(广州白云山制药总厂，0.5g/瓶，产品批号：3141279)，每日50-100mg/kg，静滴，分2～4次执行。七天一个疗程。
6、症状体征量化标准
7、综合疗效判定标准：
痊愈：体温正常，症候总积分减少大于95％；
显效：体温正常，症候总积分减少70～95％；
有效：体温正常或降低1℃以上，症候总积分减少30～70％(不包括70％)；
无效：体温没有降低，症候总积分减少＜30％。
8、实验结果
组别 治愈 显效 有效 无效 总有效率
实验组1 28 9 9 4 92*
实验组2 30 10 7 3 94*
实验组3 32 11 5 2 96**
实验组4 29 13 7 1 98*
对照组 5 18 7 20 60
注：与对照组相比，*P＜0.05，**P＜0.01。
对治疗前后患者血常规、肝功能、肾功能及尿常规的检测，未见异常。

Claims (5)

1.一种治疗小儿肺炎的药物组合物，其特征在于：包括以下重量份的原料：麻黄5～15份、枇杷叶2～5份、半夏3～5份、苍术4～8份、厚朴1～5份、细辛1～5份、川贝1～5份、橘红1～5份、桑叶1.5～3份、百部1～3份、甘草1～3份。
2.根据权利要求1所述的治疗小儿肺炎的药物组合物，其特征在于：还包括桑白皮1～3份。
3.根据权利要求1所述的治疗小儿肺炎的药物组合物，其特征在于：还包括麦芽1～2份。
4.根据权利要求1所述的治疗小儿肺炎的药物组合物，其特征在于：其制备方法为：将配方量的各原料粉碎，加水煎煮，过滤，将滤液浓缩至浸膏，干燥，即得。
5.根据权利要求4所述的治疗小儿肺炎的药物组合物，其特征在于：其制备方法为：将配方量的各原料粉碎，加入原料总重8～10倍的水煎煮2～3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1～1.3的浸膏，干燥，即得。
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111084862A (zh) * 2020-02-20 2020-05-01 石家庄江山动物药业有限公司 用于防治家禽肺热咳喘症的中药口服液及其制备方法
CN114224970A (zh) * 2021-12-24 2022-03-25 河南天纳图实业有限公司 一种抗家畜呼吸道疾病的中药试剂及其生产方法

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Publication number Priority date Publication date Assignee Title
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