CN106266563A - 安神促眠含片制备方法 - Google Patents
安神促眠含片制备方法 Download PDFInfo
- Publication number
- CN106266563A CN106266563A CN201610788551.8A CN201610788551A CN106266563A CN 106266563 A CN106266563 A CN 106266563A CN 201610788551 A CN201610788551 A CN 201610788551A CN 106266563 A CN106266563 A CN 106266563A
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- Prior art keywords
- group
- fructus
- semen
- radix
- nerves
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Abstract
本发明公开了一种安神促眠含片制备方法,以刺五加、蚕蛾、桑椹、黄芪、陈皮、黄精、柏子仁等多味传统中药配合,加以核桃仁、黑芝麻、蜂蜜、香蕉、奶粉等常用健脑益智食品,采用中医药药食同源理念,创造出传统中药与食品的配伍,其特性互补,效力增加,稳定情绪、缓解焦虑、改善睡眠的作用,最终成品几无毒副作用,尤其适合青少年使用,成品制备成为含片,口味略有药香,具有浓郁香甜奶味,适合含化。
Description
技术领域
本发明涉及医药领域,具体地说,是涉及一种安神促眠含片制备方法。
背景技术
青少年学习焦虑症,是青少年成长过程中最常遇到的心理问题,是一种以焦虑情绪为主的神经症。青少年学习焦虑症具体表现不尽相同,主要表现症状包括紧张不安和焦虑的心境,难以入睡;伴发的心理症状,如注意困难、记忆不良、对声敏感和易激惹;以及过分看重成绩和分数,考试过分紧张不安等。
青少年的心理不成熟,压力承受能力差,来自社会、学校、家长和学生自身的压力,达到学生心理难以负荷的程度,就会衍生出焦虑。学生在学习过程中,在某种程度以内适当地感觉焦虑,是正常的,但是焦虑情绪一旦达到影响学习和生活的程度,就应该注意调节和治疗了。学习焦虑达到一定程度,可能引起严重自责心理,甚至更严重后果。无论哪一种程度的学习焦虑,如果不及时调节和控制,都会对学生的性格和人格产生影响。轻则悲观、优柔寡断,造成忧郁型人格,或者易发脾气与人起冲突,成为冲动型人格;重则可能终身患有强迫症,乃至产生精神疾病甚至心理崩溃。青少年焦虑症的治疗多偏重于心理治疗,但是心理治疗周期漫长,耗费时间多,效果差,药物治疗相对少,主要原因是治疗焦虑症的药物毒副作用大,对青少年成长发育不利。
发明内容
本发明的目的在于克服上述传统技术的不足之处,提供一种缓解青少年紧张不安和焦虑的心境,改善睡眠,易于服用,副作用小,不影响青少年成长发育的安神促眠含片制备方法
本发明的目的是通过以下技术措施来达到的:
安神促眠含片制备方法,其特征在于:包括以下步骤:
步骤一,准备第一组原料药,第一组原料药由以下组分构成:刺五加、蚕蛾、桑椹、黄芪、枸杞子、山楂、熟地黄、淫羊藿、陈皮、茯苓、法半夏、泽泻、山药、莲子、大枣、桂圆;各组分按重量份比例为:刺五加3~10、蚕蛾1~3、桑椹5~12、黄芪3~8、枸杞子2~6、山楂5~15、熟地黄2~6、淫羊藿1~3、陈皮1~3、茯苓5~12、法半夏2~6、泽泻1~3、山药5~15、莲子5~15、大枣5~15、桂圆5~15;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,得第一组预混药;
步骤二,将第一组预混药加水微沸动态回流提取两次,第一次加5~12倍量水提取1~2小时,第二次加5~12倍量水提取0.5~1.5小时,合并药液,滤过,得滤液;
步骤三,将滤液减压浓缩至50℃时相对密度1.15~1.25的浸膏,加入醇沉罐中,在搅拌条件下缓慢加入浸膏5~10倍量浓度90~95%乙醇,继续搅拌20~30分钟,静置24~48小时,提取第一组上清液;
步骤四,准备第二组原料药,第二组原料药由以下组分构成:黄精、灵芝、百合、核桃仁、黑芝麻、柏子仁;各组分按重量份比例为:黄精3~10、灵芝2~6、百合1~3、核桃仁3~10、黑芝麻3~10、柏子仁3~10;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,以5~10倍量乙醇为溶剂渗漉法提取,过滤,得第二组提取液;
步骤五,将第一组上清液与第二组提取液混合,注入乙醇回收塔内回收乙醇,并浓缩至无醇味,得到无醇味浓缩液,备用;
步骤六,准备第三组原料药,第二组原料药中各组分按重量份比例为:蜂蜜20~50、香蕉20~50、奶粉10~30,将香蕉碾成泥状,与蜂蜜和奶粉混合,得预混膏;
步骤七,准备调味组分,调味组分按重量份比例为:罗汉果甜苷3~5、麦芽糖浆10~20、水3~5,将罗汉果甜苷、麦芽糖浆、水混合,得调味预混料;
步骤八,将步骤五获得的无醇味浓缩液、步骤六获得的预混膏与步骤七获得的调味预混料混合后,搅拌均匀,静置3~4h,得药膏;
步骤九,将步骤八获得的药膏切成小块,置入真空干燥机,真空干燥至含水率4~6%后,加入粉碎机粉碎至40~60目,再加入2~6重量份的92~95°的食用酒精,混合均匀后,得到细粉,备用;
步骤十,将所述细粉通过压片机压制成形后,即得安神促眠含片。
作为一种优选方案,步骤八中还添加3~5重量份的罗通定。罗通定常用于镇痛和催眠,如胃溃疡及十二指肠溃疡的疼痛、月经痛、分娩后宫缩痛、紧张性失眠、痉挛性咳嗽等,在本发明中,罗通定用以与刺五加配合,以缓解紧张不安和焦虑情绪。刺五加具有补中益精、坚筋骨、强志意的作用,与罗通定配伍有明显改善情绪、增强记忆的作用,尤其是对于失眠症状明显的青少年添加罗通定后效果尤其明显,还可以改善睡眠。
作为一种优选方案,步骤九中真空干燥机的设置为温度40~60℃、真空度为-0.07~-0.09MPa下真空干燥。在负压下水份更易挥发,能够在不提高温度、充分保留药物有效成分的情况下加快干燥速度,节约制备时间。
本发明以刺五加、蚕蛾、桑椹、黄芪、枸杞子、山楂、熟地黄、淫羊藿、陈皮、茯苓、法半夏、泽泻、山药、莲子、大枣、桂圆、黄精、灵芝、百合、柏子仁等多味传统中药配合,加以核桃仁、黑芝麻、蜂蜜、香蕉、奶粉等常用健脑益智食品,采用中医药药食同源理念,创造出传统中药与食品的配伍,其特性互补,效力增加,最终成品几无毒副作用,尤其适合青少年使用,成品制备成为含片,口味略有药香,具有浓郁香甜奶味,适合含化。蜂蜜在本发明中不仅仅是调节口味,蜂蜜对神经系统疾病等都有良好的辅助医疗作用,睡前使用蜂蜜有助于治疗神经衰弱。香蕉含有多种微量元素和维生素,能帮助肌肉松弛,使人身心愉悦,并具有一定的减肥功效。奶粉中的L-色氨酸可用于制造诱发睡眠的荷尔蒙5-羟色胺与褪黑激素,虽然少量奶粉不足以产生充足的“催眠激素”,但是奶粉与蜂蜜、香蕉配伍作用,可起到较好的稳定情绪、缓解焦虑、改善睡眠的作用。
由于采用了上述技术方案,与现有技术相比,本发明的优点是:
本发明以刺五加、蚕蛾、桑椹、黄芪、陈皮、黄精、柏子仁等多味传统中药配合,加以核桃仁、黑芝麻、蜂蜜、香蕉、奶粉等常用健脑益智食品,采用中医药药食同源理念,创造出传统中药与食品的配伍,其特性互补,效力增加,稳定情绪、缓解焦虑、改善睡眠的作用,最终成品几无毒副作用,尤其适合青少年使用,成品制备成为含片,口味略有药香,具有浓郁香甜奶味,适合含化。
下面结合具体实施方式对本发明作进一步说明。
具体实施方式
实施例1:安神促眠含片制备方法,包括以下步骤:
步骤一,准备第一组原料药,第一组原料药由以下组分构成:刺五加、蚕蛾、桑椹、黄芪、枸杞子、山楂、熟地黄、淫羊藿、陈皮、茯苓、法半夏、泽泻、山药、莲子、大枣、桂圆;各组分按重量份比例为:刺五加3~10、蚕蛾1~3、桑椹5~12、黄芪3~8、枸杞子2~6、山楂5~15、熟地黄2~6、淫羊藿1~3、陈皮1~3、茯苓5~12、法半夏2~6、泽泻1~3、山药5~15、莲子5~15、大枣5~15、桂圆5~15;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,得第一组预混药;
步骤二,将第一组预混药加水微沸动态回流提取两次,第一次加5~12倍量水提取1~2小时,第二次加5~12倍量水提取0.5~1.5小时,合并药液,滤过,得滤液;
步骤三,将滤液减压浓缩至50℃时相对密度1.15~1.25的浸膏,加入醇沉罐中,在搅拌条件下缓慢加入浸膏5~10倍量浓度90~95%乙醇,继续搅拌20~30分钟,静置24~48小时,提取第一组上清液;
步骤四,准备第二组原料药,第二组原料药由以下组分构成:黄精、灵芝、百合、核桃仁、黑芝麻、柏子仁;各组分按重量份比例为:黄精3~10、灵芝2~6、百合1~3、核桃仁3~10、黑芝麻3~10、柏子仁3~10;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,以5~10倍量乙醇为溶剂渗漉法提取,过滤,得第二组提取液;
步骤五,将第一组上清液与第二组提取液混合,注入乙醇回收塔内回收乙醇,并浓缩至无醇味,得到无醇味浓缩液,备用;
步骤六,准备第三组原料药,第二组原料药中各组分按重量份比例为:蜂蜜20~50、香蕉20~50、奶粉10~30,将香蕉碾成泥状,与蜂蜜和奶粉混合,得预混膏;
步骤七,准备调味组分,调味组分按重量份比例为:罗汉果甜苷3~5、麦芽糖浆10~20、水3~5,将罗汉果甜苷、麦芽糖浆、水混合,得调味预混料;
步骤八,将步骤五获得的无醇味浓缩液、步骤六获得的预混膏与步骤七获得的调味预混料混合后,搅拌均匀,静置3~4h,得药膏;
步骤九,将步骤八获得的药膏切成小块,置入真空干燥机,真空干燥机的设置为温度40~60℃、真空度为-0.07~-0.09MPa下真空干燥,真空干燥至含水率4~6%后,加入粉碎机粉碎至40~60目,再加入2~6重量份的92~95°的食用酒精,混合均匀后,得到细粉,备用;
步骤十,将所述细粉通过压片机压制成形后,即得安神促眠含片。
实施例2:安神促眠含片制备方法,包括以下步骤:
步骤一,准备第一组原料药,第一组原料药由以下组分构成:刺五加、蚕蛾、桑椹、黄芪、枸杞子、山楂、熟地黄、淫羊藿、陈皮、茯苓、法半夏、泽泻、山药、莲子、大枣、桂圆;各组分按重量份比例为:刺五加3~10、蚕蛾1~3、桑椹5~12、黄芪3~8、枸杞子2~6、山楂5~15、熟地黄2~6、淫羊藿1~3、陈皮1~3、茯苓5~12、法半夏2~6、泽泻1~3、山药5~15、莲子5~15、大枣5~15、桂圆5~15;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,得第一组预混药;
步骤二,将第一组预混药加水微沸动态回流提取两次,第一次加5~12倍量水提取1~2小时,第二次加5~12倍量水提取0.5~1.5小时,合并药液,滤过,得滤液;
步骤三,将滤液减压浓缩至50℃时相对密度1.15~1.25的浸膏,加入醇沉罐中,在搅拌条件下缓慢加入浸膏5~10倍量浓度90~95%乙醇,继续搅拌20~30分钟,静置24~48小时,提取第一组上清液;
步骤四,准备第二组原料药,第二组原料药由以下组分构成:黄精、灵芝、百合、核桃仁、黑芝麻、柏子仁;各组分按重量份比例为:黄精3~10、灵芝2~6、百合1~3、核桃仁3~10、黑芝麻3~10、柏子仁3~10;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,以5~10倍量乙醇为溶剂渗漉法提取,过滤,得第二组提取液;
步骤五,将第一组上清液与第二组提取液混合,注入乙醇回收塔内回收乙醇,并浓缩至无醇味,得到无醇味浓缩液,备用;
步骤六,准备第三组原料药,第二组原料药中各组分按重量份比例为:蜂蜜20~50、香蕉20~50、奶粉10~30,将香蕉碾成泥状,与蜂蜜和奶粉混合,得预混膏;
步骤七,准备调味组分,调味组分按重量份比例为:罗汉果甜苷3~5、麦芽糖浆10~20、水3~5,将罗汉果甜苷、麦芽糖浆、水混合,得调味预混料;
步骤八,将步骤五获得的无醇味浓缩液、步骤六获得的预混膏与步骤七获得的调味预混料以及3~5重量份的罗通定混合后,搅拌均匀,静置3~4h,得药膏;
步骤九,将步骤八获得的药膏切成小块,置入真空干燥机,真空干燥机的设置为温度40~60℃、真空度为-0.07~-0.09MPa下真空干燥,真空干燥至含水率4~6%后,加入粉碎机粉碎至40~60目,再加入2~6重量份的92~95°的食用酒精,混合均匀后,得到细粉,备用;
步骤十,将所述细粉通过压片机压制成形后,即得安神促眠含片。
本实施例与实施例1不同之处在于添加有罗通定,更适合紧张不安和焦虑情绪症状明显的患者,罗通定用以与刺五加配合,能够更好的缓解紧张不安和焦虑情绪。刺五加具有补中益精、坚筋骨、强志意的作用,与罗通定配伍有明显改善情绪、增强记忆的作用,尤其是对于失眠症状明显的青少年添加罗通定后效果尤其明显,还可以改善睡眠。
Claims (3)
1.安神促眠含片制备方法,其特征在于:包括以下步骤:
步骤一,准备第一组原料药,第一组原料药由以下组分构成:刺五加、蚕蛾、桑椹、黄芪、枸杞子、山楂、熟地黄、淫羊藿、陈皮、茯苓、法半夏、泽泻、山药、莲子、大枣、桂圆;各组分按重量份比例为:刺五加3~10、蚕蛾1~3、桑椹5~12、黄芪3~8、枸杞子2~6、山楂5~15、熟地黄2~6、淫羊藿1~3、陈皮1~3、茯苓5~12、法半夏2~6、泽泻1~3、山药5~15、莲子5~15、大枣5~15、桂圆5~15;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,得第一组预混药;
步骤二,将第一组预混药加水微沸动态回流提取两次,第一次加5~12倍量水提取1~2小时,第二次加5~12倍量水提取0.5~1.5小时,合并药液,滤过,得滤液;
步骤三,将滤液减压浓缩至50℃时相对密度1.15~1.25的浸膏,加入醇沉罐中,在搅拌条件下缓慢加入浸膏5~10倍量浓度90~95%乙醇,继续搅拌20~30分钟,静置24~48小时,提取第一组上清液;
步骤四,准备第二组原料药,第二组原料药由以下组分构成:黄精、灵芝、百合、核桃仁、黑芝麻、柏子仁;各组分按重量份比例为:黄精3~10、灵芝2~6、百合1~3、核桃仁3~10、黑芝麻3~10、柏子仁3~10;按重量份比例称取上述各组分,粉碎至粒径1~2毫米,混合,以5~10倍量乙醇为溶剂渗漉法提取,过滤,得第二组提取液;
步骤五,将第一组上清液与第二组提取液混合,注入乙醇回收塔内回收乙醇,并浓缩至无醇味,得到无醇味浓缩液,备用;
步骤六,准备第三组原料药,第二组原料药中各组分按重量份比例为:蜂蜜20~50、香蕉20~50、奶粉10~30,将香蕉碾成泥状,与蜂蜜和奶粉混合,得预混膏;
步骤七,准备调味组分,调味组分按重量份比例为:罗汉果甜苷3~5、麦芽糖浆10~20、水3~5,将罗汉果甜苷、麦芽糖浆、水混合,得调味预混料;
步骤八,将步骤五获得的无醇味浓缩液、步骤六获得的预混膏与步骤七获得的调味预混料混合后,搅拌均匀,静置3~4h,得药膏;
步骤九,将步骤八获得的药膏切成小块,置入真空干燥机,真空干燥至含水率4~6%后,加入粉碎机粉碎至40~60目,再加入2~6重量份的92~95°的食用酒精,混合均匀后,得到细粉,备用;
步骤十,将所述细粉通过压片机压制成形后,即得安神促眠含片。
2.根据权利要求1所述的安神促眠含片制备方法,其特征在于:步骤八中还添加3~5重量份的罗通定。
3.根据权利要求1所述的安神促眠含片制备方法,其特征在于:步骤九中真空干燥机的设置为温度40~60℃、真空度为~0.07~~0.09MPa下真空干燥。
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