CN106266192A - One treats polypous medicine and preparation method thereof - Google Patents
One treats polypous medicine and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses one and treat polypous medicine and preparation method thereof, it is mainly prepared from according to a certain weight ratio by Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Rehmanniae, Flos Magnoliae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, medicine of the present invention has activating QI to alleviate the depression, expelling pathogenic wind and restoring the functions of orifices in face, promoting blood circulation to restore menstrual flow, spleen reinforcing stomach reinforcing, dampness and in function, for treating nasal polyp instant effect, good effect, do not recur.
Description
Technical field
The present invention relates to one and treat polypous medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Nasal polyp is for nose commonly encountered diseases, is apt to occur in adult, is more common in maxillary sinus, sieve hole, middle nasal meatus, middle nasal concha etc.
Place.The traditional Chinese medical science then thinks that nasal polyp and lung meridian excess-heat, phlegm-damp are tied stagnant, and asthenia of pulmonosplenic qi is relevant.Owing to western medicine side effect is big, therefore
There is great demand to the effectively polypous Chinese medicine for the treatment of in people, up to now, does not the most find about the present invention's
Relevant report.
Summary of the invention
The research of the present inventor's foundation theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found and effectively treat breath
The medicine of meat, thus complete the present invention.
It is an object of the invention to provide the polypous Chinese medicine composition of a kind of effectively treatment.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Rehmanniae, Flos Magnoliae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Spica Prunellae, male
Oyster, Radix Glycyrrhizae are combined preparation, these drug regimens make each efficacy of drugs produce synergism such that it is able to effectively control
Treat nasal polyp.Semen Persicae is wherein selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize sliding warp
Function, controls amenorrhea, abdominal mass, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selection Flos Carthami is because
Its nature and flavor are pungent, temperature, enter the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea, abdominal mass, difficult labour, stillborn fetus, dislike puerperal
Revealing not all right, blood stasis is had a pain, carbuncle, injury from falling down.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, enrich blood
And blood, menstruction regulating and pain relieving, to moisturize the function of laxation, control menoxenia, amenorrhea is suffered from abdominal pain, and abdominal mass knot is poly-, metrorrhagia, headache due to deficiency of blood, dizziness,
Flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting the Radix Angelicae Dahuricae, to be because its nature and flavor pungent, temperature, enter lung,
Spleen, stomach warp, dispel the wind, dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage hemorrhoid
Leakage, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Radix Rehmanniae is selected to be because its nature and flavor sweet, cold, GUIXIN, liver, kidney channel,
There are clearing away heat and cooling blood, yin nourishing, the function promoted the production of body fluid, control calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out
Speckle dermexanthesis.Flos Magnoliae is selected to be because its nature and flavor pungent, temperature, enter lung, stomach warp, dispel the wind, sensible function, control headache, nasal sinusitis, nasal obstruction
Obstructed, toothache.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enter spleen, stomach warp, have a spleen reinforcing, stomach reinforcing, dampness, and in function,
Control deficient QI of the spleen and stomach, anorexia, the few gas of asthenia, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, from
Antiperspirant, nausea is uneasy.Rhizoma Chuanxiong is selected to be because its nature and flavor pungent, temperature, enter liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain
Function, control air-cooled headache rotation dizzy, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select
Spica Prunellae is because its nature and flavor toil, cold, enters liver, gallbladder meridian, has liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma,
Mesh pearl nyctalgia, photophobia sheds tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, blood
Collapse, leukorrhagia.Concha Ostreae is selected to be because its nature and flavor salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, the function of arresting seminal emission, control
Frightened, dizziness, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Radix Glycyrrhizae to be because its nature and flavor sweet flat, enter
Spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, and the function of coordinating the actions of various ingredients in a prescription is processed with controlling weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain,
Overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, and ulcer sores solves in poison of drug and food
Poison.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component is following heavy
All there is in weight range preferable curative effect:
7-12 gram of Semen Persicae, 7-12 gram of Flos Carthami, Radix Angelicae Sinensis 7-12 gram, Radix Angelicae Dahuricae 7-12 gram, Radix Rehmanniae 7-12 gram, Flos Magnoliae 7-12 gram, the Rhizoma Atractylodis Macrocephalae
7-12 gram, Rhizoma Chuanxiong 15-20 gram, Spica Prunellae 10-20 gram, Concha Ostreae 25-35 gram, 3-7 gram of Radix Glycyrrhizae.
Preferable amount is:
9 grams of Semen Persicae, 9 grams of Flos Carthami, Radix Angelicae Sinensis 9 grams, the Radix Angelicae Dahuricae 9 grams, Radix Rehmanniae 9 grams, Flos Magnoliae 9 grams, the Rhizoma Atractylodis Macrocephalae 9 grams, Rhizoma Chuanxiong 18 grams, Spica Prunellae
15 grams, Concha Ostreae 30 grams, 5 grams of Radix Glycyrrhizae.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to crust microcreping, pull out, immerses in cold water, rubs with the hands and remove seed coat, dry,
Winnow with a dustpan clean；
2, Flos Carthami: pick clean impurity, removes stem and leaf, base of a fruit head, dries；
3, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, slightly dries in the air, and section is dried；
4, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, section
It is dried；
5, Radix Rehmanniae: take crude drug, removes impurity, cleans, slightly moistens, cut sheet, is dried, and sieve removes chip；
6, Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces；
7, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dry；
8, Rhizoma Chuanxiong: pick decontamination, is soaked in water by the most large and small, and solarization is dried in the air, and cuts into slices after moistening, is dried；
9, Spica Prunellae: take crude drug, except discarding stalk, blade and impurity, sieve dedusting bits；
10, Concha Ostreae: clean, dry, pulverize use；
11, Radix Glycyrrhizae: pick decontamination, cleans, be soaked in water to eighty per cant thoroughly time, pull out, run through, section, dry.
Two, preparation
1, the Semen Persicae after concocting, Flos Carthami, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Rehmanniae, Flos Magnoliae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Spica Prunellae, Concha Ostreae, Radix Glycyrrhizae are put
Entering in decocting container, add water for the first time 6 times amount, and after soaking 100 minutes, intense fire decocts and seethes with excitement, then by slow fire boiling 20 minutes, mistake
Filter to obtain first time decoction liquor, first time decoction liquor is poured in container；
2, the medicinal residues of filtration being added 4 times amount, intense fire boils, then with slow fire boiling 20 minutes, filters to obtain second time decoction liquor；
3, by twice decoction liquor mixing and stirring, it is divided into 2 doses to take.
In prescription, Rhizoma Chuanxiong has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is monarch drug；Flos Magnoliae dispels the wind, sensible
Function；Flos Carthami has promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, and the two is ministerial drug, and three taste medicines play activating QI to alleviate the depression jointly, dispel the wind dry
Wet, promoting blood circulation and stopping pain, expelling pathogenic wind and restoring the functions of orifices in face, promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing, treatment nasal polyp effect is comprehensive, and with activating QI to alleviate the depression,
Expelling pathogenic wind and restoring the functions of orifices in face, promoting blood circulation to restore menstrual flow is that master can be effected a permanent cure, and the Rhizoma Atractylodis Macrocephalae has a spleen reinforcing, stomach reinforcing, dampness, and in function be adjuvant drug, Radix Glycyrrhizae have and in
Emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription is for making medicine, and medicine all with remainder is to take stopgap measures.
Medicine of the present invention has an activating QI to alleviate the depression, expelling pathogenic wind and restoring the functions of orifices in face, promoting blood circulation to restore menstrual flow, spleen reinforcing stomach reinforcing, dampness and in function, be used for
Treatment nasal polyp, short treating period, instant effect, non-relapse after healing.
The beneficial effect of of the present invention medicine is expanded on further below by way of test example, these test examples include this
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention:
Taking rabbit 30, male and female dual-purpose, body weight 2.0 2.5kg, divide two groups, often group 15, one of which is overdose test
Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is that administration by gavage is given
Medicine, twice daily, serve on 7 days, observes every day and is administered reaction, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad
Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept nasal polyp out-patient totally 25 example for medical treatment.
2, diagnostic criteria
Classical symptom is that persistence nasal obstruction is grown up with polyp volume and increased the weight of, and bilateral is multiple, and unilateral less, nasal secretion increases
Many, sneeze, olfactory disorder, nasal obstruction, dyspnea.
3, Therapeutic Method
Selecting above-mentioned medicament, take to patient, each take 1 dose, every 2 times, 8 days be a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: nasal polyp transference cure, recover normal, recovery from illness；
Take a turn for the better: patient's nasal secretion increases, sneeze, olfactory disorder, dyspnea, and the phenomenon of nasal obstruction alleviates, nasal polyp symptom
It is clearly better, progressively recovers；
Invalid: not reach improvement standard person.
5, therapeutic outcome (see table)
In above-mentioned treatment, by Drug therapy Nasal Polyps Patients 25 example of the present invention, effective 20 examples of result, obvious effective rate is 80%, takes a turn for the better
3 examples, improvement rate is 12%, invalid 2 examples, and total effective rate is 92%.
Claims (3)
1. treat polypous medicine for one kind, it is characterised in that: it is made up of the crude drug in following weight range:
7-12 gram of Semen Persicae, 7-12 gram of Flos Carthami, Radix Angelicae Sinensis 7-12 gram, Radix Angelicae Dahuricae 7-12 gram, Radix Rehmanniae 7-12 gram, Flos Magnoliae 7-12 gram, the Rhizoma Atractylodis Macrocephalae
7-12 gram, Rhizoma Chuanxiong 15-20 gram, Spica Prunellae 10-20 gram, Concha Ostreae 25-35 gram, 3-7 gram of Radix Glycyrrhizae.
Medicine the most according to claim 1, the consumption of the most each crude drug is:
9 grams of Semen Persicae, 9 grams of Flos Carthami, Radix Angelicae Sinensis 9 grams, the Radix Angelicae Dahuricae 9 grams, Radix Rehmanniae 9 grams, Flos Magnoliae 9 grams, the Rhizoma Atractylodis Macrocephalae 9 grams, Rhizoma Chuanxiong 18 grams, Spica Prunellae
15 grams, Concha Ostreae 30 grams, 5 grams of Radix Glycyrrhizae.
The preparation method of medicine the most according to claim 1 or claim 2, it comprises the following steps:
(1) get the raw materials ready
(1) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to crust microcreping, pull out, immerses in cold water, rubs with the hands and remove seed coat, shine
Dry, winnow with a dustpan clean；
(2) Flos Carthami: pick clean impurity, removes stem and leaf, base of a fruit head, dries；
(3) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, slightly dries in the air, and section is dried；
(4) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, cut
Sheet is dried；
(5) Radix Rehmanniae: take crude drug, removes impurity, cleans, slightly moistens, cut sheet, is dried, and sieve removes chip；
(6) Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces；
(7) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dry；
(8) Rhizoma Chuanxiong: pick decontamination, is soaked in water by the most large and small, and solarization is dried in the air, and cuts into slices after moistening, is dried；
(9) Spica Prunellae: take crude drug, except discarding stalk, blade and impurity, sieve dedusting bits；
(10) Concha Ostreae: clean, dry, pulverize use；
(11) Radix Glycyrrhizae: pick decontamination, cleans, be soaked in water to eighty per cant thoroughly time, pull out, run through, section, dry；
(2) prepare
(1) Semen Persicae after concocting, Flos Carthami, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Rehmanniae, Flos Magnoliae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Spica Prunellae, Concha Ostreae, Radix Glycyrrhizae are put
Entering in decocting container, add water 6 times amount, and after soaking 100 minutes, intense fire decocts boiling, then with slow fire boiling 20 minutes, filter the
Decoction liquor, pours into first time decoction liquor in container；
(2) add water 4 times amount by the medicinal residues of filtration, and intense fire boils, then with slow fire boiling 20 minutes, filters to obtain second time decoction liquor；
(3) by twice decoction liquor mixing and stirring, it is divided into 2 doses to take.
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| CN201610733891.0A CN106266192A (en) | 2016-08-28 | 2016-08-28 | One treats polypous medicine and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112507A (en) * | 2007-08-20 | 2008-01-30 | 山西医科大学第二医院 | Medicine for treating rhinitis and method for preparing the same |
| CN103961412A (en) * | 2014-01-22 | 2014-08-06 | 深圳市瑞莱贵生生物医药科技有限公司 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN105853701A (en) * | 2016-04-29 | 2016-08-17 | 刘涛 | Traditional Chinese medicine composition for treating nasosinusitis |
-
2016
- 2016-08-28 CN CN201610733891.0A patent/CN106266192A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112507A (en) * | 2007-08-20 | 2008-01-30 | 山西医科大学第二医院 | Medicine for treating rhinitis and method for preparing the same |
| CN103961412A (en) * | 2014-01-22 | 2014-08-06 | 深圳市瑞莱贵生生物医药科技有限公司 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN105853701A (en) * | 2016-04-29 | 2016-08-17 | 刘涛 | Traditional Chinese medicine composition for treating nasosinusitis |
Non-Patent Citations (1)
| Title |
|---|
| 田道法主编: "《耳鼻咽喉科中西医诊疗套餐》", 30 September 2013 * |
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Application publication date: 20170104 |