CN106237169A - 一种治疗白带异常的药物及其制备方法 - Google Patents

一种治疗白带异常的药物及其制备方法 Download PDF

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CN106237169A
CN106237169A CN201610707535.1A CN201610707535A CN106237169A CN 106237169 A CN106237169 A CN 106237169A CN 201610707535 A CN201610707535 A CN 201610707535A CN 106237169 A CN106237169 A CN 106237169A
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兰恒才
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Abstract

本发明公开了一种治疗白带异常的药物及其制备方法，其主要是由当归、白芍、川芎、白术、茯苓、泽漆、枳壳、牛膝、木香、没药、苍术、黄柏按一定重量配比制备而成，本发明药物具有清热利湿，养血柔肝，益脾和胃，补肝肾的功能，用于治疗白带异常见效快，疗效好，不复发。

Description

一种治疗白带异常的药物及其制备方法
技术领域
本发明涉及一种治疗白带异常的药物及其制备方法，属中药领域。
技术背景
白带异常是妇科疾病中最常见的症状，指女性阴道分泌物的异常。中医则认为是由于湿邪伤体，肝郁伤脾，脾肾虚弱所致。由于西药治疗白带异常副作用大，因此人们对有效治疗白带异常的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗白带异常的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗白带异常的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择当归、白芍、川芎、白术、茯苓、泽漆、枳壳、牛膝、木香、没药、苍术、黄柏、薏苡仁、香附进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗白带异常。其中选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用川芎是因为其性味辛，温，入肝、胆经，有行气开郁，祛风燥湿，活血止痛的功能，治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。选用白术是因为其性味苦甘，温，入脾、胃经，有补脾，益胃，燥湿，和中的功能，治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。选用泽漆是因为其性味辛苦，凉，有毒，入大、小肠，脾，有行水、消痰，杀虫，解毒的功能，治水气肿满，痰饮喘咳，疟疾，瘰疬，癣疮，结核性痿管，骨髓炎。选用枳壳是因为其性味苦辛、凉。入肺、脾、大肠经。破气，行痰，消积。治胸膈痰滞，胸痞，胁胀，食积，噫气，呕逆，下痢后重，脱肛，子宫脱垂。选用牛膝是因为其性味甘苦酸，平，入肝、肾经，生用散瘀血，消痈肿，治淋病，尿血，经闭，癥瘕，难产，胞衣不下，产后瘀血腹痛，喉痹，痈肿，跌打损伤，熟用补肝肾，强筋骨，治腰膝骨痛，四肥拘挛，痿痹。选用木香是因为其性味辛苦，温，入肺、肝、脾经，有行气止痛，温中和胃的功能，治中寒气滞，胸腹胀痛，呕吐，泄泻，下痢里急后重，寒疝。选用没药是因为其性味苦，平，入肝经，有散血去瘀，消肿定痛的功能，治跌损，金疮，筋骨，心腹诸痛，癥瘕，经闭，痈疽肿痛，痔漏，目障。选用苍术是因为其性味辛苦，温，入脾、胃经，有健脾，燥湿，解郁，辟秽的功能，治湿盛困脾，倦怠嗜卧，脘痞腹胀，食欲不振，呕吐，泄泻，痢疾，疟疾，痰饮，水肿，时气感冒，风寒湿痹，足痿，夜盲。选用黄柏是因为其性味苦，寒，入肺、胃、肾经，有滋阴降火，润燥滑肠的功能，治烦热消渴，骨蒸劳热，肺热咳嗽，大便燥结，小便不利。选用薏苡仁是因为其性味甘淡，凉，入脾、肺、肾经，有健脾，补肺，清热，利湿的功能，治泄泻，湿痹，筋脉拘挛，屈伸不利，水肿，脚气，肺痿，肺痈，肠痈，淋浊，白带。选用香附是因为其性味辛微苦干，平，入肝、三焦经，有理气解郁，止痛调经的功能，治肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效
当归5-15克，白芍10-20克，川芎10-20克，白术20-30克，茯苓45-55克，泽漆100-200克，枳壳10-20克，牛膝10-20克，木香10-20克，没药10-20克，苍术10-20克，黄柏10-20克，薏苡仁80-120克，香附10-20克。
优选用量为
当归10克，白芍15克，川芎15克，白术25克，茯苓50克，泽漆150克，枳壳15克，牛膝15克，木香15克，没药15克，苍术15克，黄柏15克，薏苡仁100克，香附15克。
本发明药物的制备方法如下
一、备料
1、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
2、白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
3、川芎：拣去杂质，分开大、小个，用水浸泡，晒晾，闷润后切片，干燥；
4、白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
5、茯苓：用水浸泡，洗净，捞出，闷透后，切片，晒干；
6、泽漆：取原药材，除去残根，杂质，洗净，稍润，切段，干燥；
7、枳壳：除去瓤、核，洗净，稍浸，捞出，润软，以手能捏对折为止，切片，晾干；
8、牛膝：拣去杂质，洗净，润软，去芦，切段，晒干；
9、木香：将原生药放清水内洗净，捞出，闷润12—24小时使软，切片，晒干；
10、没药：拣去杂质，打成碎块；
11、苍术：拣去杂质，用水泡至七、八成透，捞出，润透后切片，晒干；
12、黄柏：拣去杂质，用水洗净，捞出，润透，切片或切丝，晒干；
13、薏苡仁：取原药材，除去残留皮壳、杂质；
14、香附：拣去杂质，碾成碎粒，簸去细毛及细末。
二、制备
1、将炮制好的当归，白芍，川芎，白术，茯苓，泽漆，枳壳，牛膝，木香，没药，苍术，黄柏，薏苡仁，香附放入煎药容器内加水煎煮二次，第一次加水6倍量，煎煮1.5小时，第二次加水4倍量煎煮1小时，合并两次煎煮液，过滤得滤液；
2、将滤液浓缩成比重为1.35的浸膏，加90%-95%乙醇进行醇沉，回收乙醇并浓缩，在45-50℃下干燥，制得干浸膏；
3、将干浸膏研为细粉装瓶待用。
组方中薏苡仁健脾，补肺，清热利湿为君药；白芍养血柔肝，缓中止痛，敛阴收汗；茯苓有渗湿利水，益脾和胃的功能，二者为臣药，三味药共同发挥健脾，补肺，清热利湿，养血柔肝，敛阴收汗，益脾和胃的作用，治疗白带异常效力全面，且以清热利湿，养血柔肝，益脾和胃为主可治本，牛膝散瘀血，消痈肿，补肝肾，强筋骨的功能为佐药，泽漆行水、消痰，杀虫，解毒为使药，与下余诸药是治标。
本发明药物具有清热利湿，养血柔肝，益脾和胃，补肝肾的功能，用于治疗白带异常，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组口服粉剂为0.2g/kg，正常量为0.1g/kg，给药方式为稀释灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治白带异常门诊患者共19例。
2、诊断标准
白带异常的症状为白带色黄或黄绿，黏液或呈泡沫状，有臭味，混有血，排尿障碍，并伴有外阴瘙痒或灼热感等。
3、治疗方法
选用上述药粉，给患者服用，每次服用一汤匙，每天2次，温水送服，7天为一个疗程，连续服用2个疗程。
4、疗效评定标准
显效：白带异常症状消失，恢复正常，痊愈；
好转：患者白带泡沫状，有臭味，混有血，排尿障碍和外阴瘙痒或灼热感的现象减轻，白带异常症状明显好转，体质逐步恢复；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗白带异常患者19人，结果显效15人，显效率为78.95%，好转3人，好转率为15.79%，无效1例，总有效率为94.74%。

Claims (3)

1.一种治疗白带异常的药物，其特征在于：它是由下列重量范围内的原料药制成：
当归5-15克，白芍10-20克，川芎10-20克，白术20-30克，茯苓45-55克，泽漆100-200克，枳壳10-20克，牛膝10-20克，木香10-20克，没药10-20克，苍术10-20克，黄柏10-20克，薏苡仁80-120克，香附10-20克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
当归10克，白芍15克，川芎15克，白术25克，茯苓50克，泽漆150克，枳壳15克，牛膝15克，木香15克，没药15克，苍术15克，黄柏15克，薏苡仁100克，香附15克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
（2）白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
（3）川芎：拣去杂质，分开大、小个，用水浸泡，晒晾，闷润后切片，干燥；
（4）白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
（5）茯苓：用水浸泡，洗净，捞出，闷透后，切片，晒干；
（6）泽漆：取原药材，除去残根，杂质，洗净，稍润，切段，干燥；
（7）枳壳：除去瓤、核，洗净，稍浸，捞出，润软，以手能捏对折为止，切片，晾干；
（8）牛膝：拣去杂质，洗净，润软，去芦，切段，晒干；
（9）木香：将原生药放清水内洗净，捞出，闷润12—24小时使软，切片，晒干；
（10）没药：拣去杂质，打成碎块；
（11）苍术：拣去杂质，用水泡至七、八成透，捞出，润透后切片，晒干；
（12）黄柏：拣去杂质，用水洗净，捞出，润透，切片或切丝，晒干；
（13）薏苡仁：取原药材，除去残留皮壳、杂质；
（14）香附：拣去杂质，碾成碎粒，簸去细毛及细末；
（二）制备
（1）将炮制好的当归、白芍、川芎、白术、茯苓、泽漆、枳壳、牛膝、木香、没药、苍术、黄柏、薏苡仁、香附放入煎药容器内加水煎煮二次，第一次加水6倍量，煎煮1.5小时，第二次加水4倍量煎煮1小时，合并两次煎煮液，过滤得滤液；
（2）将滤液浓缩成比重为1.35的浸膏，加90%-95%乙醇进行醇沉，回收乙醇并浓缩，在45-50℃下干燥，制得干浸膏；
（3）将干浸膏研为细粉装瓶即得。
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101856492A (zh) * 2010-06-09 2010-10-13 杨青 妇科用中药组合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101856492A (zh) * 2010-06-09 2010-10-13 杨青 妇科用中药组合物

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