CN103705769B - 一种治疗流行性乙型脑炎的药物及其制备方法 - Google Patents
一种治疗流行性乙型脑炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗流行性乙型脑炎的药物及其制备方法,它主要是由淡豆豉、橄榄、刘寄奴、丝瓜络、龟版、荸荠、白花蛇舌草、荆芥、芦根、磁石等药物按一定重量配比制备而成,本发明药物具有祛风理气,清热解毒的功能,用于治疗流行性乙型脑炎见效快,疗效好,无毒副作用,治愈后不复发。
Description
技术领域
[0001] 本发明涉及一种治疗流行性乙型脑炎的药物及其制备方法,属中药领域。 技术背景
[0002] 流行性乙型脑炎简称乙脑,是由嗜神经的乙脑病毒所致的中枢神经系统性传染 病。本病主要分布在亚洲远东和东南亚地区,经蚊传播,多见于夏秋季,临床上急起发病,有 高热、意识障碍、惊厥、强直性痉挛和脑膜刺激症等,重型患者病后往往留有后遗症。由于西 药无法有效治疗流行性乙型脑炎,且服用西药有较多副作用,费用高,因此人们对快速有效 治疗流行性乙型脑炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有 关报道。
发明内容
[0003] 本发明人依据中医理论的研宄和临床试验的反复验证,终于找到了有效治疗流行 性乙型脑炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种更有效的治疗流行性乙型脑炎的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择淡豆豉、橄榄、刘寄奴、丝瓜络、龟版、荸荠、白花蛇舌草、荆芥、 芦根、磁石、羚羊角、梨皮、佩兰、大蒜、牡丹皮、浮萍、紫背天葵草、栀子、寒水石、桑叶、胆星、 远志、杏仁、牛筋草、阿胶、虎耳草、牛蒡子、冬瓜子、竹沥、陈皮、地肤子、桔梗、木瓜、山楂药 物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗流 行性乙型脑炎的复发。选用淡淡豆豉是因为其性味苦,寒,入肺、胃经,有解表,除烦,宣郁, 解毒的功能,治伤寒热病,寒热,头痛,烦燥,胸闷。选用橄榄是因为其性味甘涩酸,平,入 肺、胃经,有清肺,利咽,生津,解毒的功能,治咽喉肿痛,烦渴,咳嗽吐血,菌痢,癫癎,解河豚 毒及酒毒。选用刘寄奴是因为其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治 经闭癥瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒掀肿。选用丝瓜络是因为其性味 甘,平,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经 闭,乳汁不通,痈肿,痔漏。选用龟版是因为其性味咸甘,平,入肝、肾经,有滋阴,潜阳,补肾, 健骨的功能,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨瘘,阴虚风 动,久痢,久疟,痔疮,小儿囟门不合。选用荸荠是因为其性味甘平,有清热止渴,利湿化痰, 降血压的功能,治热病伤津烦渴,咽喉肿痛,口腔炎,湿热黄疸,高血压病,小便不利,麻瘆, 肺热咳嗽,硅肺,痔疮出血。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清 热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎, 痈肿疔疮,毒蛇咬伤。选用荆芥是因为其性味辛,温,入肺、肝经,有发表,祛风,理血的功能, 炒炭止血,治感冒发热,头痛,咽喉肿痛,中风口噤,吐血,衄血,便血,崩漏,产后血晕,痈肿, 疮疥,瘰疬。选用芦根是因为其性味甘,寒,入肺,胃经,有清热,生津,除烦,止呕的功能,治 热病烦渴,胃热呕吐,噎膈,反胃,肺瘘,肺痈,并解河豚鱼毒。选用磁石是因为其性味辛咸, 平,入肾、肝、肺经,有潜阳纳气,镇惊安神的功能,治头目眩晕,耳鸣耳聋,虚喘,惊癎,怔忡。 选用羚羊角是因为其性味咸,寒,入肝、心经,有平肝熄风,清热镇惊,解毒的功能,治热病神 昏痉厥,谵语发狂,头痛眩晕,惊癎搐搦,目赤翳膜。选用梨皮是因为其性味凉,味甘涩,无 毒,有清心润肺,降火生津的功能,治暑热烦渴,咳嗽,吐血,发背,疔疮。选用佩兰是因为其 性味辛,平,入脾、胃经,有清暑,辟秽,化湿,调经的功能,治感受暑湿,寒热头痛,湿邪内蕴, 脘痞不饥,口甘苔腻,月经不调。选用大蒜是因为其性味辛,温,入脾、胃、肺经,有行滞气,暖 脾胃,消癥积,解毒,杀虫的功能,治饮食积滞,脘腹冷痛,水肿胀满,泄泻,痢疾,疟疾,百日 咳,痈痈肿毒,白秃癣疮,蛇虫咬伤。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清 热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈 疡,扑损。选用浮萍是因为其性味辛,寒,入肺经,有发汗,祛风,行水,清热,解毒的功能,治 时行热病,斑瘆不透,风热瘾瘆,皮肤瘙痒,水肿,癃闭,疮癣,丹毒,烫伤。选用紫背天葵草是 因为其性味辛微酸涩,平,有祛瘀,活血,调经的功能,治月经不调,白带过多,风湿,跌打内 外伤。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病 虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用 寒水石是因为其性味辛咸,寒,入心、胃、肾经,有清热降火,利窍,消肿的功能,治时行热病, 积热烦渴,吐泻,水肿,尿闭,齿衄,丹毒,烫伤。选用桑叶是因为其性味苦甘,寒,入肺、肝经, 有祛风清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾瘆,下肢象 皮肿。选用胆星是因为其性味苦,性凉,入心、肝、肺三经,有清火化痰,镇惊定癎,痰火喘嗽, 头风眩晕。选用远志是因为其性味苦辛,温,入心、肾经,有安神益智,祛痰,解郁的功能,治 惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿。选用杏仁是因为其性味苦,温,有毒,入肺、大 肠经,有祛痰止咳,平喘,润肠的功能,治外感咳嗽,喘满,喉痹,肠燥便秘。选用牛筋草是因 为其性味甘、淡,平,有清热解毒,祛风利湿,散瘀止血的功能,用于防治流行性乙型脑炎、流 行性脑脊髓膜炎,风湿性关节炎,黄疸型肝炎,小儿消化不良,肠炎,痢疾,尿道炎;外用治跌 打损伤,外伤出血,狗咬伤。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎 的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,治漏。选用虎耳草是因为 其性味微苦、辛,寒,有小毒,有祛风清热,凉血解毒的功能,治风瘆;湿瘆,中耳炎,丹毒,咳 嗽吐血,肺痈,崩漏,痔疾。选用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺 透瘆,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑瘆不透,风瘆作痒,痈肿疮毒。选用冬瓜 子是因为其性味甘,凉,入足厥阴经,有润肺,化痰,消痈,利水的功能,治痰热咳嗽,肺痈,肠 痈,淋病,水肿,脚气,痔疮,鼻面酒皴。选用竹沥是因为其性味甘苦,寒,入心、胃经,有清热 滑痰,镇惊利窍的功能,治中风痰迷,肺热痰壅,惊风,癫癎,壮热烦渴,子烦,破伤风。选用陈 皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐 泻,咳嗽痰多。选用地肤子是因为其性味甘苦,寒,入肾、膀胱经,有利小便,清湿热的功能, 治小便不利,淋病,带下,疝气,风瘆,疮毒,疥癣,阴部湿痒。选用桔梗是因为其性味苦辛, 平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛, 痢疾腹痛。选用木瓜是因为其性味酸,温,入肝、脾经,有平肝和胃,去湿舒筋的功能,治吐 泻转筋,湿痹,脚气,水肿,痢疾。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食 积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿 枕痛,恶露不尽,小儿乳食停滞。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效
[0008] 淡豆豉 8-16克橄榄 15-25克刘寄奴 10-20克
[0009] 丝瓜络 6-15克 龟版 10-15克荸荠 10-20克
[0010] 白花蛇舌草10-15克荆芥 10-20克芦根 10-20克
[0011] 磁石 10-20克羚羊角 6-10克梨皮 8-20克
[0012] 佩兰 8-16克大蒜 10-18克牡丹皮 6-15克
[0013] 浮萍 8-18克紫背天葵草8-16克栀子 12-20克
[0014] 寒水石 8-18克 桑叶 12-20克胆星 4_8克
[0015] 远志 10-20克杏仁 8-15克牛筋草 10-18克
[0016] 阿胶 5-10克虎耳草 10-20克牛蒡子 10-18克
[0017] 冬瓜子 12-20克竹沥 8-16克陈皮 10-18克
[0018] 地肤子 10-20克桔梗 12-18克木瓜 10-20克
[0019] 山楂 8-16 克
[0020] 优选为
[0021] 淡豆豉 10克 橄榄 20克 刘寄奴 15克
[0022] 丝瓜络 8克 龟版 12克 荸荠 15克
[0023] 白花蛇舌草12克 荆芥 12克 芦根 15克
[0024] 磁石 12克 羚羊角 8克 梨皮 10克
[0025] 佩兰 10克 大蒜 15克 牡丹皮 8克
[0026] 浮萍 10克 紫背天葵草1〇克 栀子 16克
[0027] 寒水石 10克 桑叶 15克 胆星 5克
[0028] 远志 15克 杏仁 10克 牛筋草 12克
[0029] 阿胶 8克 虎耳草 15克 牛蒡子 12克
[0030] 冬瓜子 15克 竹沥 10克 陈皮 12克
[0031] 地肤子 12克 桔梗 15克 木瓜 12克
[0032] 山楂 10克
[0033] 本发明药物的制备方法如下
[0034] -、备料
[0035] 1、淡豆豉:原品入药;
[0036] 2、橄榄:果实成熟后采摘,晒干或阴干,或用盐水浸渍后晒干;
[0037] 3、刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
[0038] 4、丝瓜络:洗净晒干,切段;
[0039] 5、龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
[0040] 6、荸# :洗净,削去外皮;
[0041] 7、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍瞭,切段,干燥,筛去灰肩;
[0042] 8、荆芥:拣净杂质,用水略泡,捞出切段,晒干;
[0043] 9、芦根:拣去杂质及根,切段,晒干;
[0044] 10、磁石:拣去杂质,砸碎,过筛;
[0045] 11、羚羊角:除去骨塞,锉碎;
[0046] 12、梨皮:拣去杂质,晒干;
[0047] 13、佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干;
[0048] 14、大蒜:洗净,切片;
[0049] 15、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
[0050] 16、浮萍:6_9月间捞取,晒士;
[0051] 17、紫背天葵草:取原药材,洗净,晒干;
[0052] 18、栀子:筛去灰肩,拣去杂质,碾碎过筛或剪去两端;
[0053] 19、寒水石:取原药材,除去杂质,洗净,干燥,打成碎块;
[0054] 20、桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩;
[0055] 21、胆星:将天南星磨粉、加入适量的牛胆汁在瓦盆中,混成糊状,每200斤南星, 用1000只牛胆的汁分3次加入,日晒夜露至干,再磨成粉,加入胆汁拌匀成糊,如此反复直 至胆汁全部吸干,色发黑,无麻辣味为止;
[0056] 22、远志:拣去杂质,切段,筛去灰肩;
[0057] 23、杏仁:拣净杂质,置沸水中略煮,俟皮微皱起捞出,浸凉水中,脱去种皮,晒干, 簸净;
[0058] 24、牛筋草:洗净,晒干,切断;
[0059] 25、阿胶:捣碎用;
[0060] 26、虎耳草:全年可采,洗净,晒干;
[0061] 27、牛蒡子:拣去杂质,筛去泥肩;
[0062] 28、冬瓜子:拣净杂质,用时捣碎,或用文火炒至黄白色,置干燥处;
[0063] 29、竹沥:取鲜竹杆,截成30-50厘米长,两端去节,劈开,架起,中部用火烤之,两 端即有液汁流出,以器盛之;
[0064] 30、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干 燥,筛去灰肩;
[0065] 32、地肤子:取原药材,除去杂质,筛去碎肩;
[0066] 33、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
[0067] 34、木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由 红转紫黑色为止;
[0068] 34、山植:栋净杂质,筛去核。
[0069] 二、制备
[0070] 1、将所述重量的淡豆豉、橄榄、刘寄奴、丝瓜络、龟版、荸荠、白花蛇舌草、荆芥、芦 根、磁石、羚羊角、梨皮、佩兰、大蒜、牡丹皮、浮萍、紫背天葵草、栀子、寒水石、桑叶、胆星、远 志、杏仁、牛筋草、阿胶、虎耳草、牛蒡子、冬瓜子、竹沥、陈皮、地肤子、桔梗、木瓜、山楂加水 煎煮两次,第一次加水8倍量,武火煎煮沸腾10分钟,再用文火煎煮25分钟,过滤得第一次 煎煮液。
[0071] 2、将第一次过滤后的药渣加水6倍量,武火煎煮沸腾,再用文火煎煮20分钟,过滤 得第二次煎煮液。
[0072] 3、合并两次煎煮液,武火煮沸,再用文火煎煮10分钟,分为4剂服用。
[0073] 本发明药物具有清热解毒、祛风理血的功能,用于治疗流行性乙型脑炎见效快、疗 效好、不复发。
[0074] 以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物 的动物毒性试验和临床疗效观察试验。
[0075] [试验例1]本发明药物的动物毒性试验
[0076] 取西德兔30只,雌雄兼用,体重2. 0-2. 5kg,分两组,每组15只,其中一组为超剂量 试验组,另一组为正常量试验组。超剂量试验组为25ml/kg,正常量为10ml/kg,给药方式为 灌胃法给药,每天二次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常, 药物无不良毒副作用。
[0077] [试验例2]本发明药物的临床疗效观察
[0078] 1、一般资料
[0079] 收治门诊患者共100例。
[0080] 2、诊断标准
[0081] 流行性乙型脑炎潜伏其为10~15天。大多数患者症状较轻或呈无症状的隐性 感染,仅少数出现中枢神经系统症状,表现为高热、意识障碍、惊厥等。在发病初期起病急, 体温急剧上升至39~40°C,伴头痛、恶心和呕吐,部分病人有嗜睡或精神倦怠,并有颈项轻 度强直,病程1~3天。在发病极期,患者体温持续上升,可达40°C以上。初期症状逐渐加 重,意识明显障碍,由嗜睡、昏睡乃至昏迷,昏迷越深,持续时间越长,病情越严重。神志不清 最早可发生在病程第1~2日,但多见于3~8日。重症患者可出现全身抽搐、强直性痉挛 或强直性瘫痪,少数也可软瘫。严重患者可因脑实质类(尤其是脑干病变)、缺氧、脑水肿、脑 疝、颅内高压、低血钠性脑病等病变而出现中枢性呼吸衰竭,表现为呼吸节律不规则、双吸 气、叹息样呼吸、呼吸暂停、潮式呼吸和下颁呼吸等,最后呼吸停止。
[0082] 3、治疗方法
[0083] 选用上述药剂,给患者服用,每日2次,每次1剂,15天为一个疗程,连续服用三个 疗程。
[0084] 4、疗效评定标准
[0085] 显效:流行性乙型脑炎症状痊愈,恢复正常;
[0086] 好转:流行性乙型脑炎症状减轻,病情逐步好转;
[0087] 无效:达不到好转标准者。
[0088] 5、治疗结果(见下表)
[0089]
[0090] 在上述治疗中,用本发明药物治疗流行性乙型脑炎患者100例,结果显效91例,显 效率为91%,好转4例,好转率为4%,无效5例,总有效率为95%。
Claims (3)
1. 一种治疗流行性乙型脑炎的药物,其特征在于:它是由下列重量范围内的原料药制 成: 淡豆豉8-16克橄榄15-25克刘寄奴10-20克 丝瓜络6-15克龟版10-15克荸荠10-20克 白花蛇舌草10-15克荆芥10-20克芦根10-20克 磁石10-20克羚羊角6-10克梨皮8-20克 佩兰8-16克大蒜10-18克牡丹皮6-15克 浮萍 8-18克紫背天葵草8-16克栀子U-20克 寒水石8-18克桑叶12-20克胆星4-8克 远志10-20克杏仁8-15克牛筋草10-18克 阿胶5-10克虎耳草10-20克牛蒡子10-18克 冬瓜子12-20克竹沥8-16克陈皮10-18克 地肤子10-20克桔梗12-18克木瓜10-20克 山楂8-16克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 淡豆豉10克橄榄20克刘寄奴15克 丝瓜络8克 龟版12克荸荠15克 白花蛇舌草12克荆芥12克芦根15克 磁石12克羚羊角8克 梨皮10克 佩兰10克大蒜15克牡丹皮8克 浮萍10克紫背天葵草10克栀子16克 寒水石10克桑叶15克胆星5克 远志15克杏仁10克牛筋草12克 阿胶8克 虎耳草15克牛蒡子12克 冬瓜子15克竹沥10克陈皮12克 地肤子12克桔梗15克木瓜12克 山楂10克。
3.根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤: (一)备料 (1) 淡妓:原品入药; (2) 橄榄:果实成熟后采摘,晒干或阴干,或用盐水浸渍后晒干; (3)刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干; (4)丝瓜络:洗净晒干,切段; (5)龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块; (6) 荸# :洗净,削去外皮; ⑴白花蛇舌草:取原药材,除去杂质,抢水洗净,稍瞭,切段,干燥,筛去灰肩; (8) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (9)芦根:拣去杂质及根,切段,晒干; (10) 磁石:拣去杂质,砸碎,过筛; (11) 羚羊角:除去骨塞,锉碎; (12) 梨皮:拣去杂质,晒干; (13) 佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干; (14) 大蒜:洗净,切片; (15) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; (16) 浮萍:6-9月间捞取,晒士; (17) 紫背天葵草:取原药材,洗净,晒干; (18) 栀子:筛去灰肩,拣去杂质,碾碎过筛或剪去两端; (19) 寒水石:取原药材,除去杂质,洗净,干燥,打成碎块; (20) 桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩; (21) 胆星:将天南星磨粉、加入适量的牛胆汁在瓦盆中,混成糊状,每200斤南星,用 1000只牛胆的汁分3次加入,日晒夜露至干,再磨成粉,加入胆汁拌匀成糊,如此反复直至 胆汁全部吸干,色发黑,无麻辣味为止; (22) 远志:拣去杂质,切段,筛去灰肩; (23) 杏仁:拣净杂质,置沸水中略煮,俟皮微皱起捞出,浸凉水中,脱去种皮,晒干,簸 净; (24) 牛筋草:洗净,晒干,切断; (25) 阿胶:捣碎用; (26) 虎耳草:全年可采,洗净,晒干; (27) 牛蒡子:拣去杂质,筛去泥肩; (28) 冬瓜子:拣净杂质,用时捣碎,或用文火炒至黄白色,置干燥处; (29) 竹沥:取鲜竹杆,截成30-50厘米长,两端去节,劈开,架起,中部用火烤之,两端即 有液汁流出,以器盛之; (30) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (31) 地肤子:取原药材,除去杂质,筛去碎肩; (32) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (33) 木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由红转 紫黑色为止; (34) 山楂:拣净杂质,筛去核; (二)制备 (1) 将所述重量的淡豆豉、橄榄、刘寄奴、丝瓜络、龟版、荸荠、白花蛇舌草、荆芥、芦根、 磁石、羚羊角、梨皮、佩兰、大蒜、牡丹皮、浮萍、紫背天葵草、栀子、寒水石、桑叶、胆星、远志、 杏仁、牛筋草、阿胶、虎耳草、牛蒡子、冬瓜子、竹沥、陈皮、地肤子、桔梗、木瓜、山楂加水煎煮 两次,第一次加水8倍量,武火煎煮沸腾10分钟,再用文火煎煮25分钟,过滤得第一次煎煮 液; (2) 将第一次过滤后的药渣加水6倍量,武火煎煮沸腾,再用文火煎煮20分钟,过滤得 第二次煎煮液; (3) 合并两次煎煮液,武火煮沸,再用文火煎煮10分钟,分为4剂服用。
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