CN106233818B - 一种直流加热器 - Google Patents
一种直流加热器 Download PDFInfo
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Abstract
一种DC加热器,包括:分立的加热区,所述分立的加热区由热传导材料制成,并设置在不导电表面上;和至少一条导电线路,所述导电线路配置为用于连接DC电压源,并在连接至DC电压源时将所述分立的加热区加热至均匀的温度,所述至少一条导电线路以起伏状构造设置在所述表面上,并且至少部分地围绕所述分立的加热区。
Description
技术领域
本发明涉及一种DC(直流)加热器及其应用。
背景技术
电加热器通常被用于许多应用中。然而,目前还没有使用9伏或小于9伏电压能被加热到高达或超过100℃的DC加热器,其中,DC加热器为一平方英寸或小于一平方英寸。这种由低电压源提供电力的小型加热器将为许多应用开辟有关节省空间和节能方面的多种可能性,尤其是对于便携式乃至一次性使用。
例如,对于诸如用于测序、诊断疾病、识别DNA样品中的个体以及进行基因的功能分析的DNA克隆的各种应用而言,聚合酶链式反应(PCR)是一种常用的获得DNA序列的多个拷贝的方法。在PCR中,在多个热循环中发生DNA序列的复制,其中每个循环一般包括三个主要步骤:变性、退火和延伸。在变性步骤中,双链DNA模板被加热到约94℃-98℃下持续20-30秒,以得到单链DNA。在退火步骤中,通过将温度降低到约50℃-65℃下持续20-40秒将引物退火至单链DNA。在延伸步骤中,使用DNA聚合酶(如Taq),通过在DNA聚合酶的最佳活性温度(Taq酶为75℃-80℃)下扩展已被退火至单链DNA的引物来合成新的双链DNA。明显地,DNA的复制随着在下一循环中经历变性、退火和延伸的循环所形成的新的双链DNA呈指数增长,这样,每个循环均有效地使获得的DNA序列数量翻倍。除了上面提到的三个主要步骤之外,如果所用的DNA聚合酶是热活化的,可能还需要初始化步骤,并且最后一个循环的最后的延伸步骤也需保持较长的时间周期(例如,5-15分钟)以确保没有剩余的单链DNA片段。
因此,用于执行PCR的任何装置均需要能够执行重复的热循环,以便进行变性、退火和延伸步骤。这涉及加热和冷却反应至所需的温度,并在必要长度的时间内保持该所需的温度。鉴于温度上升至接近和/或超过100℃,现有的微流体或芯片实验室通常需要外部热循环仪以提供必要的热量,因此限制了这些PCR装置在使用过程中的真正的便携性和尺寸。
在其它应用中,例如预热输血用的血袋或更为简单地加热储存在俗称蒸煮袋的袋中的食物,目前通常使用的是需要明显高于9伏的电压源的大体积的加热装置,因此对它们的用户而言,限制了便携性和便利性。
发明内容
根据第一方面,提供了一种DC加热器,该DC加热器包括:分立(discrete)的加热区,所述分立的加热区由热传导材料制成,并设置在不导电表面上的;和至少一条导电线路,该导电线路配置为用于连接DC电压源,并在连接至DC电压源时将分立的加热区加热至均匀的温度,该至少一条导电线路以起伏状构造设置在所述表面上,并且至少部分地围绕分立的加热区。
DC电压源可以供给达到最多只有9伏。
DC电压源可以供给达到最多只有5伏。
该至少一条导电线路可以包括接线端子,该接线端子配置有USB接口,所述USB接口用于连接提供所述DC电压源的主机装置的USB端口。
起伏状构造可以选自下组中的至少一种,该组包括:圆齿状、锯齿状、波纹状、方波状、燕尾状、邮票边缘状,以及每个前述起伏状构造的改进形式。
该表面可以是柔性片材材料上的表面。
DC加热器还可以包括保护层,该保护层提供在表面、分立的加热区和至少一条导电线路之上。
只有分立的加热区可以被配置为与待被加热的物品相邻放置。
根据第二方面,提供了一种一次性的PCR装置,包括:基片;顶片,该顶片具有至少一个样品采集开口和配置为结果窗口的透明部分;微流体通道,该微流体通道包括提供在基片和顶片之间的PCR室,微流体通道配置为与至少一个样品采集开口流体连接,PCR室下游的微流体通道的一部分通过结果窗口可被观察到;和提供在基片和顶片之间的第一方面的DC加热器,以使DC加热器的分立的加热区与PCR室相邻。
基片、顶片和微流体通道由至少一种柔性片材材料形成。
根据第三方面,提供了一种电加热袋,该电加热袋配置为用于储存该电加热袋中的产品,该电加热袋包括:柔性材料的第一片材,该柔性材料的第一片材密封至聚合物材料的第二片材,以限定柔性材料的第一片材与聚合物材料的第二片材之间的空腔并形成边界,该边界包括围绕在空腔周围的柔性材料的第一片材和柔性材料的第二片材;和第一方面的DC加热器,其中,分立的加热区被设置在形成该空腔的第一壁的柔性材料的第一片材的一部分上,并且其中至少一条导电线路以起伏状构造设置在柔性材料的第一片材的边界上。
电加热袋还可以包括可闭合开口,该可闭合开口与空腔流体连通,并配置为用于分配通过所述可闭合开口的产品。
该可闭合开口可以被配置为可连接至管子,电加热袋配置为血袋,该血袋配置为用于下述的至少一种:收集和储存患者血液,和提供血液或血液产品给患者。
附图说明
为了使本发明可被完全理解并容易地付诸实际效果,现将通过非限制性实施例的方式仅描述本发明的示例性实施例,该描述将参考所附的说明性附图进行说明。
图1是本发明的DC加热器的第一示例性实施例的示意图。
图2是本发明的DC加热器的导电线路的起伏状构造的不同实施例的示意图。
图3是包括图1的DC加热器的示例性的一次性PCR装置的示意图。
图4是包括本发明的DC加热器的示例性的电加热袋的示意图。
图5(a)和图5(b)是本发明的DC加热器的可替代的示例性配置的示意图。
具体实施方式
DC加热器10的示例性实施例及其各种应用将在下面参照图1至图5进行描述,其中,相同的附图标记用于表示相同或相似的部件。
如图1所示,在DC加热器10的第一实施例中,DC加热器10包括分立的加热区20,该分立的加热区20由热传导材料制成,并设置在不导电表面30上。表面30例如可以由聚合物材料制成,且该表面30可以是相对刚性的(例如,诸如用于印刷电路板的那些层压板)或柔性的(例如,柔性的聚丙烯片材、聚合物薄膜、卡片纸等)。
DC加热器10还包括导电线路40,导电线路40被配置为用于连接DC电压源50(表示为图中的(+)和(-)),并在连接至DC电压源50时,用于将分立的加热区20加热至均匀的温度。分立的加热区20不与导电线路40导电接触。导电线路40和分立的加热区20优选由相同的导电材料制成,该导电材料例如为导电墨水或适合的金属。
导电线路40至少部分地围绕分立的加热区20以起伏状构造60设置在表面30上。在图1中,起伏状构造60具有如图2所示的圆齿状41形式,该圆齿状包括一系列朝向相同方向的圆弧弯曲,以一定角度汇合,形成向外的点,并具有朝向分立的加热区20的弧凸。在本实施例中,分立的加热区是矩形形状,并且起伏状构造60仅提供在分立的加热区20的两个相对侧。
在替代实施例中,起伏状构造60可以是锯齿状42、波纹状43、方波状44、燕尾状45、邮票边缘状46,或上述各起伏状构造60的改进形式,如图2所示。起伏状构造60可以被认为是包括导电线路40的弯曲或弯折的重复单元,导电线路40可能穿插有或可能不穿插有直线部分。已发现,无论导电线路40是弯曲还是弯折,较高的温度点均出现在导电线路40的外部或凸边或拐角61处。因此,在表面30上提供导电线路40的适合的起伏状构造60会产生邻近分立的加热区20定位的多个较高温度点。这样,例如使用由笔记本电脑的USB端口提供的仅有5伏的DC电压,能够通过导电线路40的起伏状构造60产生足够的热量,以使例如具有仅3mm乘10mm尺寸的分立的加热区20加热至期望高的温度,例如100℃或更高。
DC电压源50可以是具有9伏或小于9伏电压的任何合适的电源,这取决于DC加热器10所配置使用的应用。例如,DC电压源50可以是电池的形式,或者,如上所述,是具有自身配置电源和5伏或小于5伏电压的笔记本电脑或计算机或其它主机装置的USB端口。这样,DC加热器10很容易携带,因为它可以用电池或其它便携式装置提供电力,该电池或其它便携式装置可提供供DC加热器10使用的低DC电压。
通过配置不与导电线路40的任何部分导电接触的分立的加热区20,发现当DC加热器10达到稳态加热时全部的分立加热区20具有均匀的温度。因此,通过配置加热器使得只有分立的加热区20被设置为与待被加热的物品相邻,因此期望该物品将经受分立的加热区20的相对均匀的加热。术语“相邻”在这里用于表示该物品被设置在分立的加热区20上或设置在分立的加热区20上方,或分立的加热区20被设置在物品上方,这取决于用于其应用的DC加热器的配置。均匀加热的特点对于生物应用是特别重要的,在该生物应用中,物品可以是对热敏感的生物样品或产品,并且更为重要的是物品的任何部分均不会暴露于可能造成损坏的过高的温度或温度尖峰下。
优选地,DC加热器10还具有保护层(未示出),该保护层提供在表面30、分立的加热区20和导电线路40之上,以保护它们免受由于暴露于环境而受到的损害。该保护层优选还提供了保护用户安全的电绝缘功能。
上述DC加热器10的实际应用是一种如图3所示的一次性PCR装置100。PCR装置100包括基片(未示出)、顶片101、微流体通道110以及DC加热器(未示出),其中,微流体通道110包括提供在基片和顶片101之间的PCR室120,DC加热器也提供在基片和顶片101之间。因此,基片和顶片101在小于3mm厚的包装件中容纳PCR室和DC加热器。
顶片101应具有至少一个样品采集开口102,样品采集开口102用于将DNA样品放置到其中,并且可以具有一个或多个其它开口103,其它开口103用于将各试剂添加到PCR室中。顶片101还具有被配置为结果窗口104的透明部分,用于观察PCR所得到的结果。
微流体通道被配置为与样品采集开口102流体连接,以使DNA样品可以流入到装置100的PCR室120中。PCR室120下游的微流体通道110的一部分130被配置为通过结果窗口104可被观察到。
在一次性PCR装置100中,分立的加热区和导电线路优选设置在由诸如聚合物薄膜的薄的柔性材料制成的表面上,以使DC加热器在一次性PCR装置100中仅占据非常小的空间。DC加热器被配置为:在装置100中,仅使DC加热器的分立的加热区与PCR室120相邻,而使包括起伏状部分的导电线路与PCR室120相间隔。这样,当分立的加热区通过起伏状部分被加热时,该分立的加热区为PCR室120提供均匀的热量,从而在装置100中提供执行PCR所需的热循环。
如果一次性PCR装置100使用由USB主机装置提供的DC电压源,PCR装置100可以额外地提供有翼片(tab)140,其中导电线路40配置有用于与USB主机装置连接的USB接口,如图3所示。
在DC加热器10的另一应用中,DC加热器10可以设置在电加热袋200上,电加热袋200配置为用于储存其中的产品,如图4所示。在本申请中,电加热袋200可具有柔性材料的第一片材201,该柔性材料的第一片材201密封至柔性材料的第二片材(未示出),以在它们之间限定空腔202。
应当这样密封,使包括柔性材料的第一片材201和柔性材料的第二片材的边界203也形成在空腔202的周围。DC加热器10的分立的加热区20被设置在形成空腔202的第一壁的柔性材料的第一片材201的一部分204上。DC加热器10的导电线路40以起伏状60构造设置在柔性材料201的第一片材201的边界203上。这样,当导电线路40连接至DC电压源时,分立的加热区20被加热,通过来自该分立的加热区20的热量使包含在空腔202中的产品被加热到所需的温度。
如果电加热袋200的应用是为了储存待从该袋200中分配的产品,例如,该产品可以是用于消费的食品或用于输血的血液产品,那么袋200也将具有与空腔202流体连通的可闭合开口205,并且该可闭合开口205配置为用于分配通过该可闭合开口的产品。在具体情况下,袋200将是配置为用于收集和储存患者血液、和/或将血液或血液产品提供给患者的血袋,可闭合开口205优选进一步配置为可连接至管子(未示出),该管子具有配置为与患者建立静脉连接的端部。
虽然在前述描述中已描述了本发明的示例性实施例,但本领域技术人员将应理解,在不脱离本发明的情况下可以做出许多在设计、构造和/或操作方面更为具体的变型。例如,在不限制这些特征的可能的形状和尺寸的情况下,根据可能需要的DC加热器10的实际应用,可以设想提供分立的加热区20和起伏状构造60的可替代配置。一些示例如图5中所示。在图5(b)中可以看到,DC加热器10具有两条导电线路40,而不是一条导电线路40,以提供围绕分立的加热区20的起伏状构造60。因此,DC加热器10中导电线路40的数量可以是一条或多条。
Claims (5)
1.一次性PCR装置,包括:
基片;
顶片,所述顶片具有至少一个样品采集开口和配置为结果窗口的透明部分;
微流体通道,所述微流体通道包括提供在所述基片和所述顶片之间的PCR室,所述微流体通道配置为与所述至少一个样品采集开口流体连接,所述PCR室下游的微流体通道的一部分通过所述结果窗口可被观察到;和
提供在所述基片和所述顶片之间的DC加热器,以使所述DC加热器的分立的加热区与所述PCR室相邻,
其中,所述DC加热器包括:
所述分立的加热区,所述分立的加热区由热传导材料制成,并设置在不导电表面上;和
至少一条导电线路,所述导电线路配置为用于连接DC电压源,并在连接至所述DC电压源时将所述分立的加热区加热至均匀的温度,所述至少一条导电线路以起伏状构造设置在所述表面上,并且至少部分地围绕所述分立的加热区。
2.根据权利要求1所述的一次性PCR装置,其中,所述基片、顶片和微流体通道由至少一种柔性片材材料形成。
3.一种电加热袋,配置为用于储存所述电加热袋内的产品,所述电加热袋包括:
柔性材料的第一片材,所述柔性材料的第一片材密封至聚合物材料的第二片材,以限定所述柔性材料的第一片材与所述聚合物材料的第二片材之间的空腔并形成边界,所述边界包括围绕在所述空腔周围的所述柔性材料的第一片材和柔性材料的第二片材,和
DC加热器,其中,所述DC加热器包括:
分立的加热区,所述分立的加热区由热传导材料制成,并设置在不导电表面上;和
至少一条导电线路,所述导电线路配置为用于连接DC电压源,并在连接至所述DC电压源时将所述分立的加热区加热至均匀的温度,所述至少一条导电线路以起伏状构造设置在所述表面上,并且至少部分地围绕所述分立的加热区;
其中,所述分立的加热区被设置在形成所述空腔的第一壁的所述柔性材料的第一片材的一部分上,并且其中,所述至少一条导电线路以起伏状构造设置在所述柔性材料的第一片材的所述边界上。
4.根据权利要求3所述的电加热袋,还包括可闭合开口,所述可闭合开口与所述空腔流体连通,并配置为用于分配通过所述可闭合开口的产品。
5.根据权利要求4所述的电加热袋,其中,所述可闭合开口被配置为可连接至管子,所述电加热袋配置为血袋,所述血袋配置为用于下述的至少一种:收集和储存患者血液,和提供血液或血液产品给患者。
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