CN106233138B - 多痕迹量化 - Google Patents

多痕迹量化 Download PDF

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Publication number
CN106233138B
CN106233138B CN201580020937.8A CN201580020937A CN106233138B CN 106233138 B CN106233138 B CN 106233138B CN 201580020937 A CN201580020937 A CN 201580020937A CN 106233138 B CN106233138 B CN 106233138B
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peak
profile
relevant peaks
peak profile
profiles
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CN106233138A (zh
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G·伊沃什夫
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DH Technologies Development Pte Ltd
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DH Technologies Development Pte Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G01N30/8634—Peak quality criteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G01N30/8637—Peak shape
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

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  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Quality & Reliability (AREA)
  • Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201580020937.8A 2014-04-28 2015-04-14 多痕迹量化 Active CN106233138B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461985335P 2014-04-28 2014-04-28
US61/985,335 2014-04-28
PCT/IB2015/000477 WO2015166322A1 (en) 2014-04-28 2015-04-14 Multi-trace quantitation

Publications (2)

Publication Number Publication Date
CN106233138A CN106233138A (zh) 2016-12-14
CN106233138B true CN106233138B (zh) 2019-03-01

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CN201580020937.8A Active CN106233138B (zh) 2014-04-28 2015-04-14 多痕迹量化

Country Status (6)

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US (1) US10732156B2 (enExample)
EP (1) EP3137891B1 (enExample)
JP (1) JP6929645B2 (enExample)
CN (1) CN106233138B (enExample)
CA (1) CA2947239A1 (enExample)
WO (1) WO2015166322A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113677989B (zh) * 2019-06-12 2024-05-28 Dh科技发展私人贸易有限公司 无需参数调整的峰积分校正
WO2022074583A1 (en) * 2020-10-06 2022-04-14 Dh Technologies Development Pte. Ltd. Automated modeling of lc peak shape
JP7605073B2 (ja) * 2021-09-27 2024-12-24 株式会社島津製作所 データ処理方法及びデータ処理システム

Citations (6)

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JPS6285850A (ja) * 1985-10-11 1987-04-20 Shimadzu Corp エネルギ−スペクトルの成分ピ−ク分離方法
US5938932A (en) * 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
US20050273276A1 (en) * 2004-06-03 2005-12-08 Michael Joseph Szelewski Rapid automatic target compound confirmation using deconvolution and spectral matching
CN1712955A (zh) * 2004-06-25 2005-12-28 中国科学院大连化学物理研究所 一种精确测定色谱峰形参数和重叠峰面积的方法
US20080319676A1 (en) * 2004-07-29 2008-12-25 Yasushi Ishihama Absolute Quantitation of Protein Contents Based on Exponentially Modified Protein Abundance Index by Mass Spectrometry
US20130238253A1 (en) * 2012-03-09 2013-09-12 Torion Technologies, Inc. Deconvolution and identification algorithms for use on spectroscopic data

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US4353242A (en) * 1980-12-16 1982-10-12 University Of Utah Research Foundation Multichannel detection and resolution of chromatographic peaks
JP3807306B2 (ja) * 1999-09-27 2006-08-09 株式会社日立製作所 クロマトデータ処理装置、クロマトデータ処理方法、及びクロマトグラフ分析装置
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
GB2412487A (en) * 2004-03-26 2005-09-28 Thermo Finnigan Llc A method of improving a mass spectrum
US20060255258A1 (en) * 2005-04-11 2006-11-16 Yongdong Wang Chromatographic and mass spectral date analysis
JP4577266B2 (ja) * 2006-05-16 2010-11-10 株式会社島津製作所 クロマトグラフ質量分析装置
US7983852B2 (en) * 2008-10-21 2011-07-19 Thermo Finnigan Llc Methods of automated spectral peak detection and quantification without user input
GB0915474D0 (en) * 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
JP5866287B2 (ja) * 2009-10-02 2016-02-17 メタボロン，インコーポレイテッド 複雑な混合物における小分子成分分析のための装置及び関連する方法
GB201002445D0 (en) 2010-02-12 2010-03-31 Micromass Ltd Improved differentiation and determination of ionic conformations by combining ion mobility and hydrogen deuterium exchange reactions
GB201002447D0 (en) * 2010-02-12 2010-03-31 Micromass Ltd Mass spectrometer
RU2562607C2 (ru) * 2010-06-25 2015-09-10 ДжейЭкс НИППОН ОЙЛ ЭНД ЭНЕРДЖИ КОРПОРЕЙШН Катализатор гидродесульфуризации для жидкого нефтепродукта, способ его получения и способ гидроочистки
JP5370312B2 (ja) * 2010-08-23 2013-12-18 株式会社島津製作所 質量分析装置
CA2810143C (en) 2010-09-08 2019-03-26 Dh Technologies Development Pte. Ltd. Systems and methods for using variable mass selection window widths in tandem mass spectrometry
US8935101B2 (en) * 2010-12-16 2015-01-13 Thermo Finnigan Llc Method and apparatus for correlating precursor and product ions in all-ions fragmentation experiments
JP5454462B2 (ja) * 2010-12-22 2014-03-26 株式会社島津製作所 クロマトグラフ質量分析装置
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
JP5736235B2 (ja) * 2011-05-23 2015-06-17 株式会社日立製作所 質量分析システム及びコンピュータプログラム
EP2807669A2 (en) * 2012-01-24 2014-12-03 Thermo Finnigan LLC Multinotch isolation for ms3 mass analysis
US9702807B2 (en) * 2012-06-16 2017-07-11 Ningbo Alabama, Llc Measurement of serum lipoproteins
JP5858166B2 (ja) * 2012-09-28 2016-02-10 株式会社島津製作所 クロマトグラフ質量分析装置
JP6132067B2 (ja) * 2014-03-03 2017-05-24 株式会社島津製作所 クロマトグラフ質量分析装置用データ処理装置及びプログラム

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6285850A (ja) * 1985-10-11 1987-04-20 Shimadzu Corp エネルギ−スペクトルの成分ピ−ク分離方法
US5938932A (en) * 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
US20050273276A1 (en) * 2004-06-03 2005-12-08 Michael Joseph Szelewski Rapid automatic target compound confirmation using deconvolution and spectral matching
CN1712955A (zh) * 2004-06-25 2005-12-28 中国科学院大连化学物理研究所 一种精确测定色谱峰形参数和重叠峰面积的方法
US20080319676A1 (en) * 2004-07-29 2008-12-25 Yasushi Ishihama Absolute Quantitation of Protein Contents Based on Exponentially Modified Protein Abundance Index by Mass Spectrometry
US20130238253A1 (en) * 2012-03-09 2013-09-12 Torion Technologies, Inc. Deconvolution and identification algorithms for use on spectroscopic data

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A Blind-Deconvolution Approach for Chromatographic and Spectroscopic Peak Restoration;S.Sarkar等;《IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT》;19980831;第47卷(第4期);第941～947页 *
Overlapping spectra resolution using non-negative matrix factorization;Hong-Tao Gao等;《Talanta》;20051231;第66卷;摘要 *

Also Published As

Publication number Publication date
EP3137891A1 (en) 2017-03-08
EP3137891B1 (en) 2024-01-17
WO2015166322A1 (en) 2015-11-05
EP3137891A4 (en) 2017-10-25
US20170038351A1 (en) 2017-02-09
JP6929645B2 (ja) 2021-09-01
CA2947239A1 (en) 2015-11-05
JP2017514140A (ja) 2017-06-01
US10732156B2 (en) 2020-08-04
CN106233138A (zh) 2016-12-14

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