CA2947239A1 - Multi-trace quantitation - Google Patents

Multi-trace quantitation Download PDF

Info

Publication number
CA2947239A1
CA2947239A1 CA2947239A CA2947239A CA2947239A1 CA 2947239 A1 CA2947239 A1 CA 2947239A1 CA 2947239 A CA2947239 A CA 2947239A CA 2947239 A CA2947239 A CA 2947239A CA 2947239 A1 CA2947239 A1 CA 2947239A1
Authority
CA
Canada
Prior art keywords
peak
correlated
profiles
peak profile
profile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2947239A
Other languages
English (en)
French (fr)
Inventor
Gordana Ivosev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CA2947239A1 publication Critical patent/CA2947239A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G01N30/8634—Peak quality criteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G01N30/8637—Peak shape
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Landscapes

  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Quality & Reliability (AREA)
  • Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CA2947239A 2014-04-28 2015-04-14 Multi-trace quantitation Abandoned CA2947239A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461985335P 2014-04-28 2014-04-28
US61/985,335 2014-04-28
PCT/IB2015/000477 WO2015166322A1 (en) 2014-04-28 2015-04-14 Multi-trace quantitation

Publications (1)

Publication Number Publication Date
CA2947239A1 true CA2947239A1 (en) 2015-11-05

Family

ID=54358228

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2947239A Abandoned CA2947239A1 (en) 2014-04-28 2015-04-14 Multi-trace quantitation

Country Status (6)

Country Link
US (1) US10732156B2 (enExample)
EP (1) EP3137891B1 (enExample)
JP (1) JP6929645B2 (enExample)
CN (1) CN106233138B (enExample)
CA (1) CA2947239A1 (enExample)
WO (1) WO2015166322A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7624400B2 (ja) * 2019-06-12 2025-01-30 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド パラメータ調節を伴わないピーク積分補正
CN115699247A (zh) * 2020-05-22 2023-02-03 Dh科技发展私人贸易有限公司 用于增加通量的方法
EP4226152B1 (en) * 2020-10-06 2025-12-03 DH Technologies Development Pte. Ltd. Automated modeling of lc peak shape
JP7605073B2 (ja) * 2021-09-27 2024-12-24 株式会社島津製作所 データ処理方法及びデータ処理システム
WO2026058168A1 (en) 2024-09-11 2026-03-19 Dh Technologies Development Pte. Ltd. Ms2-driven deconvolution of ms1 peaks that are co-eluting and isobaric, for improved accuracy and quantitation of compounds

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353242A (en) * 1980-12-16 1982-10-12 University Of Utah Research Foundation Multichannel detection and resolution of chromatographic peaks
JPS6285850A (ja) * 1985-10-11 1987-04-20 Shimadzu Corp エネルギ−スペクトルの成分ピ−ク分離方法
US5938932A (en) * 1997-11-14 1999-08-17 Pharmacopeia, Inc. High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
JP3807306B2 (ja) * 1999-09-27 2006-08-09 株式会社日立製作所 クロマトデータ処理装置、クロマトデータ処理方法、及びクロマトグラフ分析装置
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
GB2412487A (en) * 2004-03-26 2005-09-28 Thermo Finnigan Llc A method of improving a mass spectrum
US7117103B2 (en) 2004-06-03 2006-10-03 Agilent Technologies, Inc. Rapid automatic target compound confirmation using deconvolution and spectral matching
CN1712955A (zh) * 2004-06-25 2005-12-28 中国科学院大连化学物理研究所 一种精确测定色谱峰形参数和重叠峰面积的方法
JP4783743B2 (ja) 2004-07-29 2011-09-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 質量分析法による指数関数的に変換されたタンパク質発現量指標に基づくタンパク質含有量の絶対定量
US20060255258A1 (en) * 2005-04-11 2006-11-16 Yongdong Wang Chromatographic and mass spectral date analysis
JP4577266B2 (ja) * 2006-05-16 2010-11-10 株式会社島津製作所 クロマトグラフ質量分析装置
US7983852B2 (en) * 2008-10-21 2011-07-19 Thermo Finnigan Llc Methods of automated spectral peak detection and quantification without user input
GB0915474D0 (en) 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
CN102667789A (zh) * 2009-10-02 2012-09-12 梅塔博隆有限公司 用于分析复杂混合物中小分子成分的设备和相关方法
GB201002447D0 (en) 2010-02-12 2010-03-31 Micromass Ltd Mass spectrometer
GB201002445D0 (en) 2010-02-12 2010-03-31 Micromass Ltd Improved differentiation and determination of ionic conformations by combining ion mobility and hydrogen deuterium exchange reactions
CN103079697B (zh) * 2010-06-25 2015-07-01 吉坤日矿日石能源株式会社 烃油用加氢脱硫催化剂、其生产方法及烃油用加氢精制方法
JP5370312B2 (ja) 2010-08-23 2013-12-18 株式会社島津製作所 質量分析装置
EP2614517B1 (en) * 2010-09-08 2020-08-05 DH Technologies Development Pte. Ltd. Systems and methods for using variable mass selection window widths in tandem mass spectrometry
US8935101B2 (en) * 2010-12-16 2015-01-13 Thermo Finnigan Llc Method and apparatus for correlating precursor and product ions in all-ions fragmentation experiments
JP5454462B2 (ja) * 2010-12-22 2014-03-26 株式会社島津製作所 クロマトグラフ質量分析装置
JP5454484B2 (ja) 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
JP5736235B2 (ja) 2011-05-23 2015-06-17 株式会社日立製作所 質量分析システム及びコンピュータプログラム
EP2807669A2 (en) * 2012-01-24 2014-12-03 Thermo Finnigan LLC Multinotch isolation for ms3 mass analysis
WO2013134771A1 (en) * 2012-03-09 2013-09-12 Torion Technologies, Inc. Deconvolution and identification algorithms for use on spectroscopic data
US9702807B2 (en) * 2012-06-16 2017-07-11 Ningbo Alabama, Llc Measurement of serum lipoproteins
WO2014049823A1 (ja) * 2012-09-28 2014-04-03 株式会社島津製作所 クロマトグラフ質量分析装置
US10488376B2 (en) * 2014-03-03 2019-11-26 Shimadzu Corporation Data processing system and program for chromatograph mass spectrometer

Also Published As

Publication number Publication date
WO2015166322A1 (en) 2015-11-05
EP3137891B1 (en) 2024-01-17
JP6929645B2 (ja) 2021-09-01
EP3137891A1 (en) 2017-03-08
JP2017514140A (ja) 2017-06-01
CN106233138B (zh) 2019-03-01
US20170038351A1 (en) 2017-02-09
CN106233138A (zh) 2016-12-14
EP3137891A4 (en) 2017-10-25
US10732156B2 (en) 2020-08-04

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123