CN106232583A - 用于抑制肌成束蛋白的化合物和方法 - Google Patents
用于抑制肌成束蛋白的化合物和方法 Download PDFInfo
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- CN106232583A CN106232583A CN201580009687.8A CN201580009687A CN106232583A CN 106232583 A CN106232583 A CN 106232583A CN 201580009687 A CN201580009687 A CN 201580009687A CN 106232583 A CN106232583 A CN 106232583A
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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Abstract
Description
4T1乳腺肿瘤细胞 |
MDA-MB-231乳腺肿瘤细胞 |
DU145前列腺肿瘤细胞 |
PC-3前列腺肿瘤细胞 |
LLC肺肿瘤细胞 |
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CN111655259A (zh) * | 2017-11-22 | 2020-09-11 | 康奈尔大学 | 包括转移抑制剂的共疗法 |
CN112912141A (zh) * | 2018-08-27 | 2021-06-04 | 斯皮诺吉尼克斯公司 | 用于树突棘生成的肌成束蛋白结合化合物 |
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CN108697690B (zh) * | 2016-01-05 | 2022-01-14 | 加利福尼亚大学董事会 | 苯并噻唑两亲物 |
CA3056501A1 (en) | 2017-04-11 | 2018-10-18 | Sunshine Lake Pharma Co., Ltd. | Fluorine-substituted indazole compounds and uses thereof |
CN111163773A (zh) | 2017-08-02 | 2020-05-15 | 斯皮诺吉尼克斯公司 | 苯并噻唑及相关化合物 |
EP3628330A1 (en) | 2018-09-28 | 2020-04-01 | Fundacion Universitaria San Antonio | Imipramine for use as inhibitor of fascin1 overexpression |
TW202043198A (zh) * | 2019-01-17 | 2020-12-01 | 美商Ifm Due有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111655259A (zh) * | 2017-11-22 | 2020-09-11 | 康奈尔大学 | 包括转移抑制剂的共疗法 |
CN112912141A (zh) * | 2018-08-27 | 2021-06-04 | 斯皮诺吉尼克斯公司 | 用于树突棘生成的肌成束蛋白结合化合物 |
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