CN106214674B - 7-羟基-丁苯酞的医药用途 - Google Patents

7-羟基-丁苯酞的医药用途 Download PDF

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Publication number
CN106214674B
CN106214674B CN201610538809.9A CN201610538809A CN106214674B CN 106214674 B CN106214674 B CN 106214674B CN 201610538809 A CN201610538809 A CN 201610538809A CN 106214674 B CN106214674 B CN 106214674B
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China
Prior art keywords
butylphenyl phthaleine
hydroxyls
disease
cerebral
phthaleine
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CN201610538809.9A
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English (en)
Chinese (zh)
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CN106214674A (zh
Inventor
郑智慧
路新华
马瑛
朱京童
李业英
任晓
林洁
沈文斌
张雪莲
石英
崔晓兰
栗若兰
赵峰
张雪霞
段宝玲
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NCPC New Drug Research and Development Co Ltd
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NCPC New Drug Research and Development Co Ltd
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Priority to CN201610538809.9A priority Critical patent/CN106214674B/zh
Priority to PCT/CN2016/103066 priority patent/WO2018010332A1/fr
Publication of CN106214674A publication Critical patent/CN106214674A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610538809.9A 2016-07-11 2016-07-11 7-羟基-丁苯酞的医药用途 Active CN106214674B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610538809.9A CN106214674B (zh) 2016-07-11 2016-07-11 7-羟基-丁苯酞的医药用途
PCT/CN2016/103066 WO2018010332A1 (fr) 2016-07-11 2016-10-24 Applications de 7-hydroxyphthalide dans un médicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610538809.9A CN106214674B (zh) 2016-07-11 2016-07-11 7-羟基-丁苯酞的医药用途

Publications (2)

Publication Number Publication Date
CN106214674A CN106214674A (zh) 2016-12-14
CN106214674B true CN106214674B (zh) 2018-10-26

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ID=57520536

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CN201610538809.9A Active CN106214674B (zh) 2016-07-11 2016-07-11 7-羟基-丁苯酞的医药用途

Country Status (2)

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CN (1) CN106214674B (fr)
WO (1) WO2018010332A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112625016B (zh) * 2019-09-24 2024-06-07 华北制药集团新药研究开发有限责任公司 7-羟基丁苯酞晶型b及其制备方法
KR20220156597A (ko) 2020-03-20 2022-11-25 씨에스피씨 엔비피 파머슈티컬 캄파니 리미티드 부틸프탈라이드 및 이의 유도체의 용도
CN113666895B (zh) * 2020-05-15 2023-12-08 华北制药集团新药研究开发有限责任公司 卤代2-苯并[c]呋喃酮类化合物及其应用
CN114762700B (zh) * 2021-01-13 2023-03-21 浙江泛亚生物医药股份有限公司 一种狐粪青霉培养物的应用
CN113024422B (zh) * 2021-03-12 2022-12-20 上海科州药物研发有限公司 丁苯酞开环化合物、药物化合物以及它们的制备方法、组合物和应用
CN115141861A (zh) * 2022-08-03 2022-10-04 华北制药集团新药研究开发有限责任公司 一种利用狐粪青霉菌发酵生产7-羟基丁苯酞的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482027B2 (en) * 2005-04-30 2009-01-27 Angiolab, Inc. Composition for the prevention or treatment of diseases associated with angiogenesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482027B2 (en) * 2005-04-30 2009-01-27 Angiolab, Inc. Composition for the prevention or treatment of diseases associated with angiogenesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
丁苯酞脑缺血治疗作用的相关药理学研究进展;端木寅等;《中药药理与临床》;20121231;第28卷(第3期);126-129 *

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Publication number Publication date
WO2018010332A1 (fr) 2018-01-18
CN106214674A (zh) 2016-12-14

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