CN106133024B - 用于疏水性药物递送的新颖的基于聚合物的助水溶物 - Google Patents

用于疏水性药物递送的新颖的基于聚合物的助水溶物 Download PDF

Info

Publication number
CN106133024B
CN106133024B CN201480077633.0A CN201480077633A CN106133024B CN 106133024 B CN106133024 B CN 106133024B CN 201480077633 A CN201480077633 A CN 201480077633A CN 106133024 B CN106133024 B CN 106133024B
Authority
CN
China
Prior art keywords
polymer
hydrophobic
polymer conjugate
drug
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480077633.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN106133024A (zh
Inventor
应文彬
曾国贤
白浩
尹海清
刘继华
王丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Publication of CN106133024A publication Critical patent/CN106133024A/zh
Application granted granted Critical
Publication of CN106133024B publication Critical patent/CN106133024B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nanotechnology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyamides (AREA)
CN201480077633.0A 2014-04-07 2014-09-01 用于疏水性药物递送的新颖的基于聚合物的助水溶物 Expired - Fee Related CN106133024B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461976354P 2014-04-07 2014-04-07
US61/976,354 2014-04-07
PCT/JP2014/004480 WO2015155810A1 (en) 2014-04-07 2014-09-01 Novel polymer-based hydrotropes for hydrophobic drug delivery

Publications (2)

Publication Number Publication Date
CN106133024A CN106133024A (zh) 2016-11-16
CN106133024B true CN106133024B (zh) 2019-07-05

Family

ID=51535486

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480077633.0A Expired - Fee Related CN106133024B (zh) 2014-04-07 2014-09-01 用于疏水性药物递送的新颖的基于聚合物的助水溶物

Country Status (10)

Country Link
US (1) US10080737B2 (enExample)
EP (1) EP3129425B1 (enExample)
JP (1) JP6480467B2 (enExample)
KR (1) KR102256453B1 (enExample)
CN (1) CN106133024B (enExample)
AU (1) AU2014390729B2 (enExample)
CA (1) CA2943733C (enExample)
RU (1) RU2676680C2 (enExample)
TW (1) TWI694838B (enExample)
WO (1) WO2015155810A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801847A (zh) * 2016-03-16 2016-07-27 华东师范大学 一种用于抗肿瘤药物递送的助溶高分子载体及制备方法
CN112402617B (zh) * 2020-11-20 2023-06-09 汕头大学 血影紫杉醇及其制备方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101321806A (zh) * 2005-12-05 2008-12-10 日东电工株式会社 聚谷氨酸盐-氨基酸轭合物及方法
CN101678123A (zh) * 2007-05-09 2010-03-24 日东电工株式会社 包含疏水性化合物和聚氨基酸结合物的组合物
CN102159247A (zh) * 2008-07-30 2011-08-17 日东电工株式会社 药物载体
WO2013154707A1 (en) * 2012-04-12 2013-10-17 Nitto Denko Corporation Co-polymer conjugates

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5811119A (en) 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
DK0494264T3 (da) 1989-09-29 1998-01-26 Jolla Cancer Res Found Inhibering af transformede vækstfaktor til hindring af akkumulation af ekstracellulær matrix
US20040028682A1 (en) 1989-09-29 2004-02-12 Border Wayne A. Inhibiting transforming growth factor beta to prevent accumulation of extracellular matrix
US5234604A (en) 1991-02-26 1993-08-10 Betz Laboratories, Inc. Water soluble block copolymers and methods of use therof
AU670777B2 (en) 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
JPH08268906A (ja) 1995-03-31 1996-10-15 Sumitomo Pharmaceut Co Ltd 肺線維症予防剤
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
US5851538A (en) 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US6183774B1 (en) 1996-01-31 2001-02-06 Collaborative Laboratories, Inc. Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts
WO1999009045A1 (en) 1997-08-20 1999-02-25 Somagenics, Inc. Antisense and antigene therapeutics with improved binding properties and methods for their use
JPH11269076A (ja) 1998-01-22 1999-10-05 Seikagaku Kogyo Co Ltd 抗線維化剤
DE60045890D1 (de) 1999-04-27 2011-06-09 Mitsubishi Tanabe Pharma Corp Arzneimittel zur präventiven oder therapeutische Behandlung von Lebererkrankungen
US20020041898A1 (en) 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
EP1267834A4 (en) 2000-03-29 2003-08-27 Aradigm Corp CATIONIC LIPOSOMES
JP2002047211A (ja) 2000-08-04 2002-02-12 Japan Science & Technology Corp 脂溶性物質と生理活性高分子物質結合体および細胞核内への導入方法
EP1392366A4 (en) 2001-04-13 2005-01-19 Population Council Inc CORE RECEPTOR-MEDIATED INTRODUCTION OF A PNA PROTEIN IN CELL CHERRIES
JP4547696B2 (ja) 2001-06-07 2010-09-22 第一三共株式会社 肝硬変予防・治療剤
JP2002371006A (ja) 2001-06-11 2002-12-26 Mochida Pharmaceut Co Ltd 肺線維症予防および／または進行防止剤
JP2003119138A (ja) 2001-10-09 2003-04-23 Tohoku Techno Arch Co Ltd 間質性肺炎および／または肺線維症の予防治療剤
CA2464346A1 (en) 2001-10-30 2003-05-08 Nektar Therapeutics Al, Corporation Water-soluble polymer conjugates of retinoic acid
CN1612930A (zh) 2001-11-21 2005-05-04 三菱化学株式会社 抑制基因表达的方法
JP3803318B2 (ja) 2001-11-21 2006-08-02 株式会社ＲＮＡｉ 遺伝子発現阻害方法
AU2002343094A1 (en) 2001-11-26 2003-06-10 Arachnova Therapeutics Ltd. Use of ppar activators for the treatment of pulmonary fibrosis
ES2324708T3 (es) 2002-05-15 2009-08-13 Endocyte, Inc. Conjugados de vitamina-mitomicina.
US7527969B2 (en) 2002-06-19 2009-05-05 Raven Biotechnologies, Inc. RAAG10 cell surface target and a family of antibodies recognizing that target
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
JP2006502153A (ja) 2002-08-27 2006-01-19 インターミューン インコーポレイティッド 特発性肺線維症の治療方法
AU2003259381A1 (en) 2002-08-29 2004-03-19 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
EP1592457B1 (en) 2003-01-27 2012-07-25 Endocyte, Inc. Folate-vinblastine conjugate as medicament
AU2004227414A1 (en) 2003-04-03 2004-10-21 Alnylam Pharmaceuticals iRNA conjugates
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
WO2005084702A1 (ja) 2004-03-02 2005-09-15 Hokkaido Technology Licensing Office Co., Ltd. 臓器線維症予防・治療剤
US20130171240A1 (en) 2004-12-22 2013-07-04 Nitto Denko Corporation Drug carrier and drug carrier kit for inhibiting fibrosis
SI2730277T1 (sl) 2004-12-22 2020-07-31 Nitto Denko Corporation Nosilec zdravila in komplet za nosilec zdravila za zaviranje fibroze
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
JP5342834B2 (ja) 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
US20130210744A1 (en) 2007-03-30 2013-08-15 Nitto Denko Corporation Targeting agent for cancer cell or cancer-associated fibroblast
TWI407971B (zh) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
WO2009036368A2 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
AR073582A1 (es) 2008-09-12 2010-11-17 Nitto Denko Corp Agentes de produccion de imagenes de enfermedades fibroticas.conjugado. metodo
TWI611021B (zh) 2009-12-09 2018-01-11 日東電工股份有限公司 Ｈｓｐ４７表現之調節
RU2711531C2 (ru) 2010-06-17 2020-01-17 Нитто Денко Корпорейшн Средство для лечения фиброза почек
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
US20160015656A2 (en) 2010-08-05 2016-01-21 Nitto Denko Corporation Composition for regenerating normal tissue from fibrotic tissue
JP6023709B2 (ja) 2011-06-21 2016-11-09 日東電工株式会社 アポトーシス誘導剤
TWI627965B (zh) 2011-11-18 2018-07-01 日東電工股份有限公司 腸道纖維化處置劑

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101321806A (zh) * 2005-12-05 2008-12-10 日东电工株式会社 聚谷氨酸盐-氨基酸轭合物及方法
CN101678123A (zh) * 2007-05-09 2010-03-24 日东电工株式会社 包含疏水性化合物和聚氨基酸结合物的组合物
CN102159247A (zh) * 2008-07-30 2011-08-17 日东电工株式会社 药物载体
WO2013154707A1 (en) * 2012-04-12 2013-10-17 Nitto Denko Corporation Co-polymer conjugates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs;Ji Young Kim等;《Journal of Controlled Release》;20110223;第152卷;13-20页 *
Synthesis, characterization, and biological evaluation of poly(L-γ-glutamyl-glutamine)-paclitaxel nanoconjugate;Sang Van等;《International Journal of Nanomedicine》;20101012;第5卷;825-837页 *

Also Published As

Publication number Publication date
KR102256453B1 (ko) 2021-05-25
WO2015155810A1 (en) 2015-10-15
TWI694838B (zh) 2020-06-01
EP3129425A1 (en) 2017-02-15
US10080737B2 (en) 2018-09-25
JP6480467B2 (ja) 2019-03-13
KR20170016822A (ko) 2017-02-14
TW201540312A (zh) 2015-11-01
RU2016143395A (ru) 2018-05-07
JP2017516883A (ja) 2017-06-22
US20150283253A1 (en) 2015-10-08
AU2014390729B2 (en) 2018-11-29
CN106133024A (zh) 2016-11-16
EP3129425B1 (en) 2019-04-10
CA2943733C (en) 2022-03-01
AU2014390729A1 (en) 2016-11-17
RU2016143395A3 (enExample) 2018-05-07
CA2943733A1 (en) 2015-10-15
RU2676680C2 (ru) 2019-01-10

Similar Documents

Publication Publication Date Title
US10792328B2 (en) Nanocomplexes for delivery of saporin
US20240131170A1 (en) Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids
US8420692B1 (en) Heterocyclic and carbonate derivatives of NDGA and their use as new anti-HIV and anti-cancer agents
JP5037684B2 (ja) ドセタキセル高分子誘導体、並びにその製造方法及びその用途
US20120039983A1 (en) Amphiphilic macromolecule-lipid complexes
WO2016206626A1 (zh) 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用
TW200418906A (en) High-molecular weight derivatives of camptothecins
Liang et al. pH triggered re-assembly of nanosphere to nanofiber: The role of peptide conformational change for enhanced cancer therapy
CN110433292B (zh) 一种双靶向材料及其在药物传递中的应用
AU2022412640A1 (en) Cabazitaxel prodrug anti-tumor preparation
CN106133024B (zh) 用于疏水性药物递送的新颖的基于聚合物的助水溶物
KR20240082390A (ko) 생분해성 에스터 결합을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자
KR20250111222A (ko) 신규 이온화 가능한 지질 및 이를 포함하는 지질나노입자
KR20240082389A (ko) 생분해성 이황화 결합을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자
CN112105390A (zh) 用于提高物理稳定性和增强抗肿瘤功效的胶束中低聚乳酸缀合物的立体复合物
WO2024064661A2 (en) Amino acid-modified lipids for rna delivery
WO2025194120A1 (en) Zwitterionic polymer functionalized lipid nanoparticles for delivery of nucleic acids
KR20240159310A (ko) 신규한 이온화지질을 이용한 지질나노입자 조성물
EP3071238A1 (en) Conjugate comprising folic acid and indole-3-carbinol for medical use
CN118164866A (zh) 阳离子脂质化合物及其组合物和应用
Zhang TARGETED THERAPY FOR LIVER FIBROSIS AND CANCER

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190705