CN106083932B - 新型的预活化的氧氮杂膦衍生物、应用和制备方法 - Google Patents
新型的预活化的氧氮杂膦衍生物、应用和制备方法 Download PDFInfo
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- CN106083932B CN106083932B CN201610463620.8A CN201610463620A CN106083932B CN 106083932 B CN106083932 B CN 106083932B CN 201610463620 A CN201610463620 A CN 201610463620A CN 106083932 B CN106083932 B CN 106083932B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract
Description
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR1060350 | 2010-12-10 | ||
FR1060350A FR2968662B1 (fr) | 2010-12-10 | 2010-12-10 | Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation |
CN201180059905.0A CN103328494B (zh) | 2010-12-10 | 2011-12-09 | 新型的预活化的氧氮杂膦衍生物、应用和制备方法 |
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CN201180059905.0A Division CN103328494B (zh) | 2010-12-10 | 2011-12-09 | 新型的预活化的氧氮杂膦衍生物、应用和制备方法 |
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CN106083932A CN106083932A (zh) | 2016-11-09 |
CN106083932B true CN106083932B (zh) | 2019-08-06 |
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CN201180059905.0A Active CN103328494B (zh) | 2010-12-10 | 2011-12-09 | 新型的预活化的氧氮杂膦衍生物、应用和制备方法 |
CN201610463620.8A Active CN106083932B (zh) | 2010-12-10 | 2011-12-09 | 新型的预活化的氧氮杂膦衍生物、应用和制备方法 |
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CN201180059905.0A Active CN103328494B (zh) | 2010-12-10 | 2011-12-09 | 新型的预活化的氧氮杂膦衍生物、应用和制备方法 |
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EP (1) | EP2649084B1 (zh) |
CN (2) | CN103328494B (zh) |
ES (1) | ES2625476T3 (zh) |
FR (1) | FR2968662B1 (zh) |
WO (1) | WO2012076824A1 (zh) |
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PL3143032T3 (pl) | 2014-05-14 | 2019-02-28 | Institut Gustave Roussy | Nowe pochodne oksazafosforyn i ich zastosowania terapeutyczne |
WO2017056494A1 (en) * | 2015-09-29 | 2017-04-06 | Sumitomo Dainippon Pharma Co., Ltd. | Adenine conjugate compounds and their use as vaccine adjuvants |
JP2022553649A (ja) * | 2019-10-11 | 2022-12-26 | アンスティテュ・ギュスターヴ・ルシー | がんの治療用のオキシアザホスホリンの誘導体を含む新規の治療の組合せ |
FR3110427B1 (fr) | 2020-05-20 | 2023-07-14 | Laboratoires Eriger | Conjugué terpenique de couplage |
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JPS55154984A (en) * | 1979-05-24 | 1980-12-02 | Shionogi & Co Ltd | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
US4623742A (en) * | 1981-03-24 | 1986-11-18 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Oxazaphosphorin-4-thio-alkanesulphonic acids, and neutral salts thereof |
US4770870A (en) * | 1981-12-31 | 1988-09-13 | Asta Pharma Aktiengesellschaft | Method for reducing pain associated with the administration of 4-sulfido-oxazaphosphorines and 4-sulfoalkylthio-oxazaphorphorines |
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DE3132221A1 (de) * | 1981-08-14 | 1983-05-19 | Behringwerke Ag, 3550 Marburg | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
WO1998010795A2 (en) | 1996-09-10 | 1998-03-19 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
FR2775435B1 (fr) | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
FR2786398B1 (fr) | 1998-11-30 | 2002-12-27 | Synt Em | Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide |
FR2786397B1 (fr) | 1998-11-30 | 2003-01-10 | Synt Em | Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc |
FR2805821B1 (fr) | 2000-03-01 | 2004-01-16 | Diatos | Sequences d'acides amines facilitant la penetration d'une substance d'interet a l'interieur des cellules et/ou des noyaux cellulaires |
NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
FR2821272B1 (fr) | 2001-02-23 | 2004-12-17 | Synt Em | Composes constitues d'une molecule analgesique liee a un vecteur capable de vectoriser ladite molecule a travers la barriere hematoencephalique et compositions pharmaceutiques les contenant |
FR2829940A1 (fr) | 2001-09-27 | 2003-03-28 | Synt Em | Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central |
FR2830016B1 (fr) | 2001-09-27 | 2004-06-25 | Synt Em | Compositions pour la vectorisation de derives taxoides a travers la barriere hematoencephalique et leur utilisation pour le traitement des cancers, plus particulierement des cancers du cerveau |
FR2834465A1 (fr) | 2002-01-10 | 2003-07-11 | Synt Em | Compositions pour la vectorisation d'oligonucleotides a travers la barriere hematoencephalique et leur utilisation pour le traitement des maladies du systeme nerveux central |
FR2836474B1 (fr) | 2002-02-22 | 2004-12-24 | Synt Em | Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique |
FR2840810B1 (fr) | 2002-06-18 | 2005-02-11 | Synt Em | Composition pour le transfert de molecules therapeutiques dans les poumons et leur utilisation pour le traitement des cancers du poumon et des maladies pulmonaires |
US8293700B2 (en) | 2003-08-14 | 2012-10-23 | Cellectis | Anti-bacterial composition especially for controlling gram-negative bacteria, comprising a peptide and an advantageously hydrophobic anti-bacterial agent |
US8361443B2 (en) | 2004-06-16 | 2013-01-29 | Ge Healthcare As | Peptide-based compounds |
FR2874016B1 (fr) | 2004-06-30 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Nanoparticules de derives de la gemcitabine |
ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
WO2008045252A2 (en) | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
EP1977765A1 (en) | 2007-04-03 | 2008-10-08 | Diatos | Peptide prodrugs |
CN100526322C (zh) * | 2007-05-30 | 2009-08-12 | 深圳万乐药业有限公司 | 异环磷酰胺的合成方法 |
-
2010
- 2010-12-10 FR FR1060350A patent/FR2968662B1/fr active Active
-
2011
- 2011-12-09 CN CN201180059905.0A patent/CN103328494B/zh active Active
- 2011-12-09 US US13/992,404 patent/US9073957B2/en active Active
- 2011-12-09 ES ES11811061.8T patent/ES2625476T3/es active Active
- 2011-12-09 WO PCT/FR2011/052914 patent/WO2012076824A1/fr active Application Filing
- 2011-12-09 CN CN201610463620.8A patent/CN106083932B/zh active Active
- 2011-12-09 EP EP11811061.8A patent/EP2649084B1/fr active Active
-
2015
- 2015-07-02 US US14/790,634 patent/US9428530B2/en active Active
-
2016
- 2016-07-28 US US15/222,316 patent/US10125157B2/en active Active
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JPS55154984A (en) * | 1979-05-24 | 1980-12-02 | Shionogi & Co Ltd | Novel 4-substituted-2h-1,3,2-oxaazaphospholine-2-oxide derivative |
US4623742A (en) * | 1981-03-24 | 1986-11-18 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Oxazaphosphorin-4-thio-alkanesulphonic acids, and neutral salts thereof |
US4770870A (en) * | 1981-12-31 | 1988-09-13 | Asta Pharma Aktiengesellschaft | Method for reducing pain associated with the administration of 4-sulfido-oxazaphosphorines and 4-sulfoalkylthio-oxazaphorphorines |
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Antitumor activity of monomeric and polymeric cyclophosphamide derivatives compared with in vitro hydrolysis;Hirano, Takashi et al.;《Cancer Research》;19801231;第2263-7页 |
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Mass spectrometric characterization of activated N-(2-chloroethyl)amidooxazaphosphorine derivatives;Przybylski, M et al.;《 Biomedical Mass Spectrometry》;19771231;第209-15页 |
NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- andtrans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide;Zon, Gerald et al.;《Journal of Medicinal Chemistry》;19841231;第466-85页 |
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Also Published As
Publication number | Publication date |
---|---|
US9428530B2 (en) | 2016-08-30 |
EP2649084B1 (fr) | 2017-02-22 |
FR2968662A1 (fr) | 2012-06-15 |
FR2968662B1 (fr) | 2013-11-22 |
US9073957B2 (en) | 2015-07-07 |
US20160333038A1 (en) | 2016-11-17 |
US10125157B2 (en) | 2018-11-13 |
CN103328494A (zh) | 2013-09-25 |
CN106083932A (zh) | 2016-11-09 |
EP2649084A1 (fr) | 2013-10-16 |
CN103328494B (zh) | 2016-08-10 |
US20130261088A1 (en) | 2013-10-03 |
US20150315220A1 (en) | 2015-11-05 |
WO2012076824A1 (fr) | 2012-06-14 |
ES2625476T3 (es) | 2017-07-19 |
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