CN106068269B - 氨基噻嗪化合物 - Google Patents

氨基噻嗪化合物 Download PDF

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Publication number
CN106068269B
CN106068269B CN201580012436.5A CN201580012436A CN106068269B CN 106068269 B CN106068269 B CN 106068269B CN 201580012436 A CN201580012436 A CN 201580012436A CN 106068269 B CN106068269 B CN 106068269B
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CN
China
Prior art keywords
solution
compound
bases
amino
pyridine radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580012436.5A
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English (en)
Chinese (zh)
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CN106068269A (zh
Inventor
F·M·马丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
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Eli Lilly and Co
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Publication of CN106068269A publication Critical patent/CN106068269A/zh
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Publication of CN106068269B publication Critical patent/CN106068269B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580012436.5A 2014-03-14 2015-03-05 氨基噻嗪化合物 Expired - Fee Related CN106068269B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953206P 2014-03-14 2014-03-14
US61/953,206 2014-03-14
PCT/US2015/018909 WO2015138208A1 (en) 2014-03-14 2015-03-05 Aminothiazine compounds

Publications (2)

Publication Number Publication Date
CN106068269A CN106068269A (zh) 2016-11-02
CN106068269B true CN106068269B (zh) 2017-12-19

Family

ID=52815268

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580012436.5A Expired - Fee Related CN106068269B (zh) 2014-03-14 2015-03-05 氨基噻嗪化合物

Country Status (9)

Country Link
US (1) US9708345B1 (es)
EP (1) EP3116881B1 (es)
JP (1) JP6185192B2 (es)
CN (1) CN106068269B (es)
CA (1) CA2938616C (es)
ES (1) ES2681285T3 (es)
TR (1) TR201809609T4 (es)
TW (1) TWI684452B (es)
WO (1) WO2015138208A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR107774A1 (es) * 2016-03-16 2018-05-30 Lilly Co Eli Terapia de combinación, método para el tratamiento de la enfermedad de alzheimer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101910143A (zh) * 2008-01-18 2010-12-08 卫材R&D管理有限公司 稠合的氨基二氢噻嗪衍生物
WO2014013076A1 (en) * 2012-07-20 2014-01-23 Eisai R&D Management Co., Ltd. Hexahydropyrrolothiazine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI537263B (zh) * 2010-06-09 2016-06-11 健生藥品公司 使用作為β－分泌酶抑制劑之５，６－二氫－２Ｈ－［１，４］－３－基－胺衍生物
US8883779B2 (en) * 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
CN103649082A (zh) * 2011-04-26 2014-03-19 盐野义制药株式会社 吡啶衍生物和含有该吡啶衍生物的bace1抑制剂
JO3143B1 (ar) * 2012-04-03 2017-09-20 Lilly Co Eli مركبات تتراهيدرو بيرولو ثيازين
PT2912041T (pt) * 2012-10-26 2017-02-13 Lilly Co Eli Inibidores de bace
TWI593692B (zh) 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101910143A (zh) * 2008-01-18 2010-12-08 卫材R&D管理有限公司 稠合的氨基二氢噻嗪衍生物
WO2014013076A1 (en) * 2012-07-20 2014-01-23 Eisai R&D Management Co., Ltd. Hexahydropyrrolothiazine compounds

Also Published As

Publication number Publication date
CA2938616C (en) 2018-10-02
US9708345B1 (en) 2017-07-18
JP6185192B2 (ja) 2017-08-23
EP3116881A1 (en) 2017-01-18
TW201622729A (zh) 2016-07-01
WO2015138208A1 (en) 2015-09-17
CN106068269A (zh) 2016-11-02
TR201809609T4 (tr) 2018-07-23
TWI684452B (zh) 2020-02-11
JP2017506658A (ja) 2017-03-09
EP3116881B1 (en) 2018-06-13
ES2681285T3 (es) 2018-09-12
CA2938616A1 (en) 2015-09-17

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Granted publication date: 20171219

Termination date: 20210305