CN106039056A - Medicine composition for treating infantile cough and asthma - Google Patents

Medicine composition for treating infantile cough and asthma Download PDF

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Publication number
CN106039056A
CN106039056A CN201610478241.6A CN201610478241A CN106039056A CN 106039056 A CN106039056 A CN 106039056A CN 201610478241 A CN201610478241 A CN 201610478241A CN 106039056 A CN106039056 A CN 106039056A
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parts
pharmaceutical composition
raw material
asthma
medicine composition
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王立丽
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention provides a medicine composition for treating infantile cough and asthma. The medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of ephedra, 2-5 parts of flos magnoliae, 3-5 parts of cinnamon, 4-8 parts of cassia twigs, 1-5 parts of apricot kernels, 1-5 parts of loquat leaves, 1-5 parts of peppermint, 1-5 parts of periostracum cicada, 1.5-3 parts of kudzu vine roots, 1-3 parts of rhizoma phragmitis and 1-3 parts of licorice roots. The medicine composition is strict in prescription and reasonable in medication, and has the effects of dispelling wind to relieve exogenous syndrome, facilitating lung and relieving cough to achieve the aims of removing wind-evil, inducing lung-qi and relieving cough.

Description

A kind of pharmaceutical composition treating infantile asthma
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating infantile asthma.
Background technology
Cough with asthma is the common disease of pulmonary system, is one of the common disease of children's, clinically with heating, cough, tachypnea and The wet sound of pulmonary is main performance.Include the acute tracheobronchitis in modern medicine, chronic bronchitis, pneumonia, prop up Many diseases such as san bronchial asthma.The category of diseases such as " flu " " cough " " bronchial wheezing " " asthma " is belonged in Chinese Internal Medicine.Cough Breathe heavily and can involve caused by internal organs because having a delicate constitution, relevant with six evil again, the most especially with wind and cold as elder generation.Cough with asthma is many in clinic Seeing, the most often pulmonary's sound absorbs slow, and most infant refusal medicine administered by injection, it is impossible to partner treatment, causes the state of an illness to be moved Prolong and do not heal, thus have a strong impact on the growth promoter of infant.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition treating infantile asthma, this pharmaceutical composition Good effect.
The technical scheme that the present invention provides is a kind of pharmaceutical composition treating infantile asthma, former including following weight portion Material: Herba Ephedrae 5～15 parts, Flos Magnoliae 2～5 parts, Cortex Cinnamomi 3～5 parts, Ramulus Cinnamomi 4～8 parts, Semen Armeniacae Amarum 1～5 parts, Folium Eriobotryae 1～5 parts, Herba Menthae 1 ～5 parts, Periostracum Cicadae 1～5 parts, Radix Puerariae 1.5～3 parts, Rhizoma Phragmitis 1～3 parts, Radix Glycyrrhizae 1～3 parts.
As preferably, also include Cortex Mori 1～3 parts.
It is further preferred that also include Fructus Hordei Germinatus 1～2 parts.
Its preparation method is: by each raw material pulverizing of formula ratio, boiling, filters, concentrates the filtrate to extractum, dry Dry, to obtain final product.
Further preferably, its preparation method is: by each raw material pulverizing of formula ratio, adds raw material gross weight 8～the water of 10 times Decocting 2～3 times, merge decoction liquor, filter, concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.1～1.3, is dried, i.e. ?.
We's epheday intermedia, Flos Magnoliae are monarch, and Xin Wen delivers, relieving exterior syndrome and dispelling cold；Cortex Cinnamomi, Ramulus Cinnamomi dispersing cold for relieving pain, Folium Eriobotryae, Semen Armeniacae Amarum drop Lung qi, cough-relieving are breathed heavily, and above four is minister altogether；Periostracum Cicadae, Radix Puerariae expelling pathogenic factors from muscles for clearing heat, Herba Menthae, Rhizoma Phragmitis sore-throat relieving promote the production of body fluid, and are adjuvant drug altogether；Radix Glycyrrhizae Almond cough-relieving is coordinated to reduce phlegm, moreover it is possible to coordinating the actions of various ingredients in a prescription.Prescription is rigorous, medication is reasonable, and full side plays expelling pathogenic wind from the body surface altogether, lung qi dispersing cough-relieving it Merit, makes ailment said due to cold or exposure dispel, and lung qi is declared, then cough with asthma is only.On the basis of we, add Cortex Mori and contribute to sending down the abnormal ascending QI cough-relieving, add Fructus Hordei Germinatus and contribute to Dyspepsia and intestinal stasis relieving.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Formula: 5 parts of Herba Ephedrae, Flos Magnoliae 2 parts, Cortex Cinnamomi 3 parts, Ramulus Cinnamomi 4 parts, 1 part of Semen Armeniacae Amarum, Folium Eriobotryae 1 part, Herba Menthae 1 part, Periostracum Cicadae 1 Part, Radix Puerariae 1.5 parts, Rhizoma Phragmitis 1 part, 1 part of Radix Glycyrrhizae.
Preparation method is: by each raw material pulverizing of formula ratio, the soak by water of addition raw material gross weight 8 times 2 times, merges and decocts Liquid, filters, and concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.1, is dried, to obtain final product.
Embodiment 2
Formula: 15 parts of Herba Ephedrae, Flos Magnoliae 5 parts, Cortex Cinnamomi 5 parts, Ramulus Cinnamomi 8 parts, 5 parts of Semen Armeniacae Amarum, Folium Eriobotryae 5 parts, Herba Menthae 5 parts, Periostracum Cicadae 5 Part, Radix Puerariae 3 parts, Rhizoma Phragmitis 3 parts, 3 parts of Radix Glycyrrhizae, Cortex Mori 3 parts.
Preparation method is: by each raw material pulverizing of formula ratio, the soak by water of addition raw material gross weight 10 times 3 times, merges and decocts Liquid, filters, and concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.3, is dried, to obtain final product.
Embodiment 3
Formula: 10 parts of Herba Ephedrae, Flos Magnoliae 4 parts, Cortex Cinnamomi 4 parts, Ramulus Cinnamomi 6 parts, 2 parts of Semen Armeniacae Amarum, Folium Eriobotryae 3 parts, Herba Menthae 3 parts, Periostracum Cicadae 3 Part, Radix Puerariae 2 parts, Rhizoma Phragmitis 2 parts, 2 parts of Radix Glycyrrhizae, Cortex Mori 2 parts, 1 part of Fructus Hordei Germinatus.
Preparation method is: by each raw material pulverizing of formula ratio, the soak by water of addition raw material gross weight 8 times 3 times, merges and decocts Liquid, filters, and concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.1, is dried, to obtain final product.
Embodiment 4
Formula: 5 parts of Herba Ephedrae, Flos Magnoliae 5 parts, Cortex Cinnamomi 3 parts, Ramulus Cinnamomi 8 parts, 1 part of Semen Armeniacae Amarum, Folium Eriobotryae 5 parts, Herba Menthae 1 part, Periostracum Cicadae 5 Part, Radix Puerariae 1.5 parts, Rhizoma Phragmitis 3 parts, 1 part of Radix Glycyrrhizae, Cortex Mori 3 parts, 2 parts of Fructus Hordei Germinatus.
Preparation method is: by each raw material pulverizing of formula ratio, the soak by water of addition raw material gross weight 9 times 2 times, merges and decocts Liquid, filters, and concentrating the filtrate to relative density when 60 DEG C is the extractum of 1.2, is dried, to obtain final product.
By following clinical trial checking beneficial effects of the present invention:
1, clinic case
Choose infantile asthma (cold closed lung card) clinic case 250 example, the age between 2～12 years old, girl 150 example, man Child 100 example, is randomly divided into 5 groups, and respectively experimental group 1～4 and matched group, often organizes 50 people.
2, diagnostic criteria
2.1 tcm diagnosis standards
Compiled " Pediatrics of Chinese Medicine " with reference to Wang by the hero of biography, " traditional Chinese medical science Clinical Researches of New Drugs guideline " is formulated.
Primary symptom: cough, asthma；
Secondary disease: abundant expectoration color is the dilutest such as foam, or spit as Ovum Gallus domesticus album shape, the most then to pant and can not put down, auscultation has dry, moist Sound nasal obstruction watery nasal discharge, sneeze, itching throat or pain；
Tongue pulse condition: the common neatly of tongue fur, body of the tongue typically changes not quite, if yang-energy is impaired, it is seen that corpulent tongue is big, pale tongue Tender, floating pulse string or see floating tight.
There is primary symptom and any two 2 items time disease, diagnosis can be made in conjunction with tongue, pulse condition.
3, inclusive criteria
1) tcm diagnosis and CM syndrome differentiation criterion are met；
2) age is 2～12 years old.
4, exclusion standard:
Merge respiratory tuberculosis, tumor and cardiovascular and cerebrovascular vessel, lung, liver, kidney and hemopoietic system severe primary disease.
5, administrated method
Experimental group 1～4 takes the pharmaceutical composition of embodiment 1～4, each takes and is equivalent to crude drug 0.1g, three times a day. It within seven days, it is a course for the treatment of.
Matched group takes Xuanfei Zhike mixture (as long as Jin An, Gansu company limited, quasi-word of traditional Chinese medicines: 20050288).Each serving With 20ml, one day 3 times.It within seven days, it is a course for the treatment of.
6, symptom and sign quantitative criteria
7, comprehensive therapeutic effect criterion:
Recovery from illness: body temperature is normal, disease total mark reduces more than 95%；
Effective: body temperature is normal, disease total mark reduces 70～95%；
Effective: body temperature is normal or reduces by more than 1 DEG C, disease total mark minimizing 30～70% (not including 70%)；
Invalid: body temperature does not reduce, disease total mark reduces ＜ 30%.
8, experimental result
Group Cure Effective Effectively Invalid Total effective rate
Experimental group 1 28 9 9 4 92*
Experimental group 2 30 10 7 3 94*
Experimental group 3 32 11 5 2 96**
Experimental group 4 29 13 7 1 98*
Matched group 5 18 7 20 60
Note: compared with matched group, * P ＜ 0.05, * * P ＜ 0.01.
To treatment Patients Before And After routine blood test, liver function, renal function and the detection of routine urinalysis, no abnormality seen.

Claims (5)

1. the pharmaceutical composition treating infantile asthma, it is characterised in that: include the raw material of following weight portion: Herba Ephedrae 5～15 Part, Flos Magnoliae 2～5 parts, Cortex Cinnamomi 3～5 parts, Ramulus Cinnamomi 4～8 parts, Semen Armeniacae Amarum 1～5 parts, Folium Eriobotryae 1～5 parts, Herba Menthae 1～5 parts, Periostracum Cicadae 1 ～5 parts, Radix Puerariae 1.5～3 parts, Rhizoma Phragmitis 1～3 parts, Radix Glycyrrhizae 1～3 parts.
The pharmaceutical composition for the treatment of infantile asthma the most according to claim 1, it is characterised in that: also include Cortex Mori 1～3 Part.
The pharmaceutical composition for the treatment of infantile asthma the most according to claim 1, it is characterised in that: also include Fructus Hordei Germinatus 1～2 Part.
The pharmaceutical composition for the treatment of infantile asthma the most according to claim 1, it is characterised in that: its preparation method is: will Each raw material pulverizing of formula ratio, boiling, filter, concentrate the filtrate to extractum, be dried, to obtain final product.
The pharmaceutical composition for the treatment of infantile asthma the most according to claim 4, it is characterised in that: its preparation method is: By each raw material pulverizing of formula ratio, addition raw material gross weight 8～the soak by water 2 of 10 times～3 times, merge decoction liquor, filter, by filtrate When being concentrated into 60 DEG C, relative density is the extractum of 1.1～1.3, is dried, to obtain final product.
CN201610478241.6A 2016-06-24 2016-06-24 Medicine composition for treating infantile cough and asthma Pending CN106039056A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720936A (en) * 2005-06-03 2006-01-18 林定增 Medicine for treating breadth gasp, cough, asthma and phelgm
CN1927379A (en) * 2006-08-25 2007-03-14 陈朝东 Traditional medicine preparation for treating children's pulmonary disease
CN103721229A (en) * 2013-12-27 2014-04-16 施泽晶 Traditional Chinese medicinal composition for treating infantile cough and asthma and preparation method thereof
CN104721766A (en) * 2013-12-19 2015-06-24 上海市嘉定区中医医院 Chinese medicinal composition for treatment of cough and asthma, preparation method and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720936A (en) * 2005-06-03 2006-01-18 林定增 Medicine for treating breadth gasp, cough, asthma and phelgm
CN1927379A (en) * 2006-08-25 2007-03-14 陈朝东 Traditional medicine preparation for treating children's pulmonary disease
CN104721766A (en) * 2013-12-19 2015-06-24 上海市嘉定区中医医院 Chinese medicinal composition for treatment of cough and asthma, preparation method and application thereof
CN103721229A (en) * 2013-12-27 2014-04-16 施泽晶 Traditional Chinese medicinal composition for treating infantile cough and asthma and preparation method thereof

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Application publication date: 20161026