CN104547717A - Traditional Chinese medicine preparation for treating silicosis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating silicosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating silicosis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following eighteen traditional Chinese medicinal raw materials: selaginella doederleinii hieron, mongolian dandelion herb, platycodon root, unibract fritillary bulb, root of whiteflower hogfennel, cicada slough, barbed skullcap herb, green tangerine peel, chicken gizzard-membrane, loquat leaf, beartiful sweetgum fruit, ginkgo seed, codonopsis pilosula, milkvetch root, white radish, eucommia bark, lalang grass rhizome, corm of waternut and liquorice root. Compared with the prior art, the traditional Chinese medicine preparation disclosed by the invention has the advantages of quick action, good effect, functions of treating both symptoms and root causes, conditioning and treatment combination and the like, and also has the technical advantages of simple, convenient and feasible process, small individual curative effect difference, stable medicine effects of the preparation, easiness in popularization and application and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of anthraco-silicosis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Anthraco-silicosis is the one of pneumoconiosis, is serious occupation disease.Free silica dust is piled up on the alveolar of people by respiratory tract, affects gas exchange, and the alveolar of most descendant is ineffective, the whole fibrosis of lung tissue.
General in early days can be asymptomatic or symptom is not obvious, along with pathological development, symptom increases.Stimulate respiratory tract to cause reflex cough because silicious dust sucks, but the degree of cough and amount of expectoration number closely related with respiratory tract infection, and inconsistent with pneumosilicosis lesion degree.Small number of patients can have expectorant blood.If there is massive hemoptysis repeatedly, should consider to merge pulmonary tuberculosis or bronchiectasis.Early stage normal sense middle and upper part, shirtfront with breathe position and the acupuncture sample pain had nothing to do of work, be everlasting climate variability time occur.Degree uncomfortable in chest with out of breath is relevant with extent of disease and character.Pathological changes is extensive and progress is fast, then obviously out of breath, and Progressive symmetric erythrokeratodermia increases the weight of.Patient Shang Ke has the symptoms such as giddy, weak, insomnia, cardiopalmus, anorexia.
Domestic foreign minister is continuous for many years have developed a collection of medicine, as: tetrandrine, phosphoric acid croak quinoline (anti-silicon 14), oxypovidinum, phosphoric acid hydroxyl croak quinoline, aluminium citrate etc., through a large amount of observation on Clinical Application, alleviating patients symptomatic, stablize the state of an illness, control development etc. in have certain effect, but treat unsatisfactory, because it is unstable that what administration time long (for many years medication 1-4), x-ray rabat took a favorable turn only have 13.32%, the improvement of x-ray rabat absorbs performance, after drug withdrawal " knock-on " phenomenon many, have the conditions of patients of 10 to continue to develop.Simultaneously almost so medicine has serious impact to the heart, liver, slow and premature beat is crossed in heart beating, liver transaminase raises.Present treatment is except lavation lung, and the drug research of pneumoconiosis seizes up state substantially.Therefore, the Chinese medicine formula new drug that research good effect consumption has no side effect less just becomes important research topic both domestic and external.
Summary of the invention
The technical problem to be solved in the present invention is the new Chinese prescription of invention one, and is made into by modern pharmaceutical technique and facilitates easy-to-use finished product preparation.
For solving this technical problem, the technical scheme of inventor is, from the dialectical of the traditional Chinese medical science to anthraco-silicosis, in conjunction with self tcm clinical practice experience for many years and the feature of modern pharmaceutical technique, the category of adjustment medical material and deal, and being put to the checking of clinical trial, a final invention Chinese prescription and preparation technology supporting with it, the final finished product Chinese medicine preparation obtained has significant therapeutic effect to anthraco-silicosis.This Chinese prescription is (with parts by weight):
Herba Selaginellae Doederleinii 16-28 part, Herba Taraxaci 18-32 part, Radix Platycodonis 10-22 part, Bulbus Fritillariae Cirrhosae 7-17 part, Radix Peucedani 8-18 part, Periostracum Cicadae 7-15 part, Herba Scutellariae Barbatae 18-30 part, Pericarpium Citri Reticulatae Viride 8-18 part, Endothelium Corneum Gigeriae Galli 10-20 part, Folium Eriobotryae 9-19 part, Fructus Liquidambaris 7-13 part, Semen Ginkgo 6-12 part, Radix Codonopsis 12-22 part, Radix Astragali 10-22 part, white turnip 20-32 part, Cortex Eucommiae 7-15 part, fresh cogongrass 16-28 part, Corm Eleocharitis 10-22 part, Radix Glycyrrhizae 9-15 part.
3 preferred prescriptions with optimum curative effect are:
1, Herba Selaginellae Doederleinii 22 parts, Herba Taraxaci 25 parts, Radix Platycodonis 16 parts, Bulbus Fritillariae Cirrhosae 12 parts, Radix Peucedani 13 parts, Periostracum Cicadae 11 parts, Herba Scutellariae Barbatae 24 parts, 13 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 15 parts, Folium Eriobotryae 14 parts, Fructus Liquidambaris 10 parts, Semen Ginkgo 9 parts, Radix Codonopsis 17 parts, the Radix Astragali 16 parts, white turnip 26 parts, the Cortex Eucommiae 11 parts, fresh cogongrass 22 parts, Corm Eleocharitis 16 parts, 12 parts, Radix Glycyrrhizae.
2, Herba Selaginellae Doederleinii 24 parts, Herba Taraxaci 26 parts, Radix Platycodonis 17 parts, Bulbus Fritillariae Cirrhosae 13 parts, Radix Peucedani 12 parts, Periostracum Cicadae 12 parts, Herba Scutellariae Barbatae 23 parts, 15 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 17 parts, Folium Eriobotryae 13 parts, Fructus Liquidambaris 11 parts, Semen Ginkgo 8 parts, Radix Codonopsis 16 parts, the Radix Astragali 15 parts, white turnip 28 parts, the Cortex Eucommiae 12 parts, fresh cogongrass 24 parts, Corm Eleocharitis 18 parts, 13 parts, Radix Glycyrrhizae.
3, Herba Selaginellae Doederleinii 21 parts, Herba Taraxaci 24 parts, Radix Platycodonis 15 parts, Bulbus Fritillariae Cirrhosae 14 parts, Radix Peucedani 12 parts, Periostracum Cicadae 10 parts, Herba Scutellariae Barbatae 26 parts, 12 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 16 parts, Folium Eriobotryae 15 parts, Fructus Liquidambaris 11 parts, Semen Ginkgo 9 parts, Radix Codonopsis 16 parts, the Radix Astragali 17 parts, white turnip 25 parts, the Cortex Eucommiae 12 parts, fresh cogongrass 21 parts, Corm Eleocharitis 15 parts, 11 parts, Radix Glycyrrhizae.
The technique above-mentioned Chinese prescription being made finished product preparation is:
(1) ingredientss such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, white turnip, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, fresh cogongrass, Corm Eleocharitis, Radix Glycyrrhizae are taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 6-12 times weight is added after mixing, soak 10-20 hour, backflow decocts 2-4 hour, filter, add the purified water of initial weight 4-9 times weight again, backflow decocts 1-3 hour, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 65-75% of 5-9 times of weight, reflux, extract, 2 times, each 2-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs, as dosage forms such as granule, pill, syrup, capsule, tablet, powder, oral liquids.
Source, the nature and flavor of the present invention's Chinese crude drug used, return through and effect:
Herba Selaginellae Doederleinii: be Selaginaceae Rock lily plant selaginella doederleinii, with all herbal medicine.Sweet in the mouth, micro-hardship, puckery, cool in nature, light, temperature; Heat-clearing and toxic substances removing; Expelling wind and removing dampness.
Herba Taraxaci: this product is feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together.Bitter in the mouth, sweet, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis.Bitter in the mouth, pungent, property is put down; Return lung meridian; Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.
Bulbus Fritillariae Cirrhosae: this product is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae, Fritillaria unibracteata, Gansu Bulbus Fritillariae Uninbracteatae or Bulbus Fritillariae cirrhosae.Bitter in the mouth, sweet, cold nature; Return lung, heart channel; Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.
Radix Peucedani: this product is the dry root of samphire Peucedanum praeruptorum DUNN or RADIX PEUCEDANI.Bitter in the mouth, pungent, cold nature; Return lung meridian; Loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr..Sweet in the mouth, cold in nature; Return lung, Liver Channel; Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Herba Scutellariae Barbatae: this product is the dry herb of labiate Herba Scutellariae Barbatae.Acrid in the mouth, hardship, cold in nature; Return lung, liver, kidney channel; Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.
Pericarpium Citri Reticulatae Viride: this product is the dry young fruit of rutaceae orange and variety thereof or the peel of immature fruit.Bitter in the mouth, pungent, warm in nature; Return liver, gallbladder, stomach warp; Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
Endothelium Corneum Gigeriae Galli: this product is the dry inner wall of sandbag of Phasianidae animal man chicken.Sweet in the mouth, property is put down; Return spleen, stomach, small intestinal, urinary bladder channel; Invigorating the stomach and promoting digestion, arresting seminal emission.
Folium Eriobotryae: this product is the dried leaves of rosaceous plant Folium Eriobotryae.Bitter in the mouth, cold nature; Attach to the lung and stomach meridians; Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Fructus Liquidambaris: this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum.Bitter in the mouth, property is put down; Return liver, kidney channel; Dispelling, collateral-activating, diuretic stimulates the menstrual flow.
Semen Ginkgo: this product is the dry mature seed of Ginkgoaceae plant Ginkgo biloba (maidenhair tree, Gong Sunshu).Sweet in the mouth, hardship, puckery, property is put down; Return lung meridian; Astringing lung QI for relieving asthma, leukorrhagia stopping is turbid, urine reducing.
Radix Codonopsis: the dry root that this product is Campanulaceae Radix Codonopsis, element spends Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen.Sweet in the mouth, property is put down; Return spleen, lung meridian; Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, warm in nature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
White turnip: white turnip, rhizome vegetable, Cruciferae Rhaphanus plant.Sweet in the mouth, pungent, cool in nature, enter liver, stomach, lung, large intestine channel; There is clearing away heat and promoting production of body fluid, cooling blood for hemostasis, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, relieving dyspepsia, appetite promoting and the spleen strengthening, pleasant effect of reducing phlegm.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae.Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Fresh cogongrass: this product is the dry rhizome of grass Herba Imperatae.Sweet in the mouth, cold in nature; Return lung, stomach, urinary bladder channel; Cooling blood for hemostasis, clearing away heat and promoting diuresis.
Corm Eleocharitis: Cyperaceae Eleocharis plant Corm Eleocharitis, is used as medicine with bulb and aerial parts.Sweet in the mouth, cold in nature; Enter lung, stomach warp; Heat clearing away, reduces phlegm, removing food stagnancy.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
The prescription of Chinese medicine preparation of the present invention is with Herba Selaginellae Doederleinii, Herba Taraxaci, Herba Scutellariae Barbatae, white turnip, fresh cogongrass for monarch drug, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, blood stasis dispelling diuresis, pleasantly to reduce phlegm, inducing diuresis for treating stranguria syndrome; With Radix Platycodonis, Radix Codonopsis, the Radix Astragali, Folium Eriobotryae, Corm Eleocharitis for ministerial drug; Lung qi dispersing eliminates the phlegm, invigorating the spleen and replenishing QI, invigorating QI to consolidate the body surface resistance, clearing away lung-heat to relieve cough, transforming phlegm and dispersing accumulations; With Fructus Liquidambaris, Bulbus Fritillariae Cirrhosae, Periostracum Cicadae, Radix Peucedani for adjuvant drug, diuretic stimulate the menstrual flow, clearing heat and moistening lung, loose wind heat extraction, lowering the adverse-rising QI to resolve phlegm; With Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Semen Ginkgo, the Cortex Eucommiae for making medicine, soothing the liver dispelling the stagnated QI, invigorating the stomach and promoting digestion, astringing lung QI for relieving asthma, the kidney invigorating bone strengthening; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines are complemented each other, YIN and YANG balancing, jointly reach heat-clearing and toxic substances removing, pleasantly to reduce phlegm, the effect such as inducing diuresis for treating stranguria syndrome, lung qi dispersing eliminate the phlegm, astringing lung QI for relieving asthma, treatment anthraco-silicosis Be very effective.
Compared with prior art, Chinese medicine preparation of the present invention has the treatment advantages such as instant effect, effective, treating both the principal and secondary aspects of a disease, medical treatment combination, and it also has that simple process is easy, curative effect individual variation is little, preparation efficacy stability, be easy to technical advantages such as applying.
The toxicity test of Chinese medicine preparation of the present invention
1, basic document
(1) test drug: the Chinese medicine preparation produced by Chinese prescription of the present invention and preparation technology, adds purified water and be modulated into magma.
(2) test animal used: regular grade NIH mice, body weight 21g ± 4g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 217 ± 13g, male and female half and half, female rats is all without pregnant.
2, acute toxicity test
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine preparation of the present invention, under 722.4g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 2 hours recover normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine preparation of the present invention is 722.4g crude drug/kg/d(LD
50> 722.4g crude drug/kg).Chinese medicine preparation clinical application every day amount of the present invention is 0.23g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3140.9 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
3, long term toxicity test
Select SD rat, give the Chinese medicine preparation of the present invention of Three doses: 41.4g crude drug/kg, 13.8g crude drug/kg, 4.6g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (41.4g crude drug/kg, 13.8g crude drug/kg, 4.6g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
Detailed description of the invention
Embodiment 1: produce pill by Chinese prescription optimum ratio 1 of the present invention
(1) ingredients such as Herba Selaginellae Doederleinii 22kg, Herba Taraxaci 25kg, Radix Platycodonis 16kg, Bulbus Fritillariae Cirrhosae 12kg, Radix Peucedani 13kg, Periostracum Cicadae 11kg, Herba Scutellariae Barbatae 24kg, Pericarpium Citri Reticulatae Viride 13kg, Endothelium Corneum Gigeriae Galli 15kg, Folium Eriobotryae 14kg, Fructus Liquidambaris 10kg, Semen Ginkgo 9kg, Radix Codonopsis 17kg, Radix Astragali 16kg, white turnip 26kg, Cortex Eucommiae 11kg, fresh cogongrass 22kg, Corm Eleocharitis 16kg, Radix Glycyrrhizae 12kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 2: produce pill by Chinese prescription optimum ratio 2 of the present invention
(1) ingredients such as Herba Selaginellae Doederleinii 24kg, Herba Taraxaci 26kg, Radix Platycodonis 17kg, Bulbus Fritillariae Cirrhosae 13kg, Radix Peucedani 12kg, Periostracum Cicadae 12kg, Herba Scutellariae Barbatae 23kg, Pericarpium Citri Reticulatae Viride 15kg, Endothelium Corneum Gigeriae Galli 17kg, Folium Eriobotryae 13kg, Fructus Liquidambaris 11kg, Semen Ginkgo 8kg, Radix Codonopsis 16kg, Radix Astragali 15kg, white turnip 28kg, Cortex Eucommiae 12kg, fresh cogongrass 24kg, Corm Eleocharitis 18kg, Radix Glycyrrhizae 13kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 3: produce pill by Chinese prescription optimum ratio 3 of the present invention
(1) ingredients such as Herba Selaginellae Doederleinii 21kg, Herba Taraxaci 24kg, Radix Platycodonis 15kg, Bulbus Fritillariae Cirrhosae 14kg, Radix Peucedani 12kg, Periostracum Cicadae 10kg, Herba Scutellariae Barbatae 26kg, Pericarpium Citri Reticulatae Viride 12kg, Endothelium Corneum Gigeriae Galli 16kg, Folium Eriobotryae 15kg, Fructus Liquidambaris 11kg, Semen Ginkgo 9kg, Radix Codonopsis 16kg, Radix Astragali 17kg, white turnip 25kg, Cortex Eucommiae 12kg, fresh cogongrass 21kg, Corm Eleocharitis 15kg, Radix Glycyrrhizae 11kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 4: produce pill by the minimum proportioning of Chinese prescription scope of the present invention
(1) Herba Selaginellae Doederleinii 16kg, Herba Taraxaci 18kg, Radix Platycodonis 10kg, Bulbus Fritillariae Cirrhosae 7kg, Radix Peucedani 8kg, Periostracum Cicadae 7kg, Herba Scutellariae Barbatae 18kg, Pericarpium Citri Reticulatae Viride 8kg, Endothelium Corneum Gigeriae Galli 10kg, Folium Eriobotryae 9kg, Fructus Liquidambaris 7kg, Semen Ginkgo 6kg, Radix Codonopsis 12kg, Radix Astragali 10kg, white turnip 20kg, Cortex Eucommiae 7kg, fresh cogongrass 16kg, Corm Eleocharitis 10kg, Radix Glycyrrhizae 9kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 5: produce pill by the maximum proportioning 1 of Chinese prescription scope of the present invention
(1) Herba Selaginellae Doederleinii 28kg, Herba Taraxaci 32kg, Radix Platycodonis 22kg, Bulbus Fritillariae Cirrhosae 17kg, Radix Peucedani 18kg, Periostracum Cicadae 15kg, Herba Scutellariae Barbatae 30kg, Pericarpium Citri Reticulatae Viride 18kg, Endothelium Corneum Gigeriae Galli 20kg, Folium Eriobotryae 19kg, Fructus Liquidambaris 13kg, Semen Ginkgo 12kg, Radix Codonopsis 22kg, Radix Astragali 22kg, white turnip 32kg, Cortex Eucommiae 15kg, fresh cogongrass 28kg, Corm Eleocharitis 22kg, Radix Glycyrrhizae 15kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 6: produce pill by any proportioning within the scope of Chinese prescription of the present invention
(1) Herba Selaginellae Doederleinii 16kg, Herba Taraxaci 32kg, Radix Platycodonis 10kg, Bulbus Fritillariae Cirrhosae 17kg, Radix Peucedani 8kg, Periostracum Cicadae 15kg, Herba Scutellariae Barbatae 18kg, Pericarpium Citri Reticulatae Viride 18kg, Endothelium Corneum Gigeriae Galli 10kg, Folium Eriobotryae 19kg, Fructus Liquidambaris 7kg, Semen Ginkgo 12kg, Radix Codonopsis 12kg, Radix Astragali 22kg, white turnip 20kg, Cortex Eucommiae 15kg, fresh cogongrass 16kg, Corm Eleocharitis 22kg, Radix Glycyrrhizae 9kg is taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 10 times of weight is added after mixing, soak 15 hours, backflow decoction 3 hours, filter, add the purified water of initial weight 7 times of weight again, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 70% of 7 times of weight, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make pill, specification: to amount to crude drug content 0.92g crude drug/g pill.
Embodiment 7: the clinical trial of Chinese medicine preparation of the present invention
1, basic document
The experimenter of this clinical trial provides by certain First People's Hospital of city Pneumology Department.The diagnostic criteria of anthraco-silicosis is:
(1) I phase pneumosilicosis: hilar shadow can increase, increased bronchovascular shadows, torsional deformation, can have netted shade, in two lungs, the sparse nodular shadow, particularly right side of visible distribution of marching off into political wilderness, emphysema and pachynsis pleurae not obvious.
(2) II phase pneumosilicosis: hilar shadow obviously increases, density, pulmonary module shape shade increases, density, lower four regions during distribution exceedes in lung field, and district can see the nodular shadow of affirmative in addition on side or bilateral lung field, because Complicated with Pulmonary edema due to disorder of QI lung marking can reduce, and visible pachynsis pleurae or adhesion image.
(3) III phase pneumosilicosis: pulmonary module shape shade produces and merges, occur the lumps shade of lamellar and densification, shade diameter is greater than 2 centimetres, merges shade many in two lung u'enos, often form symmetrical splayed, have obvious emphysema sign and pachynsis pleurae image more.
(4) Silicosis Complicated with Tuberculosis: pneumosilicosis is still clearly demarcated as stated above, and pulmonary tuberculosis is still by domestic current classification method, and the cavernous pathological changes of focal type, infiltrative type and chronic fibro is comparatively common on rabat.
The experimenter of this clinical trial has made a definite diagnosis all suffers from anthraco-silicosis, wherein, and I phase pneumosilicosis 48 example, II phase pneumosilicosis 64 example, III phase pneumosilicosis 36 example, Silicosis Complicated with Tuberculosis 20 example; Age 25-52 year.All experimenters commented by the anthraco-silicosis order of severity and be divided into a group, the comparability between each group in coincidence statistics meaning, is numbered respectively: matched group, test 1, test 2, test 3.
2, medication is tested
(1) medicine is contrasted: Xifeining Tablet, specification: plate core weight 0.35g, authentication code: the accurate word Z10920005 of traditional Chinese medicines, manufacturing enterprise: Huqingyutang Pharmaceutical Co., Ltd., Hangzhou City.
(2) 3 kinds of pills producing by optimum ratio of embodiment of the present invention 1-3, specification: amount to crude drug content 0.92g crude drug/g pill.
3, test method
The oral Xifeining Tablet of matched group, each 4, every day 3 times, warm water delivery service after meal 1 year is a course for the treatment of.Test 1-3 group is the pill produced of oral embodiment of the present invention 1-3 respectively, each 20g, every day 2 minor tick more than 8 hours, one after each meal 1 year is a course for the treatment of.All experimenters, after a course for the treatment of of treatment, carry out statistical analysis to test data.
4, test effect evaluation
Cure: all symptoms of anthraco-silicosis disappear completely, and make a definite diagnosis through doctor and return to one's perfect health;
Effective: the symptom of anthraco-silicosis obviously alleviates, or by stages by high-grade step-down grade;
Effective: the symptom of anthraco-silicosis is slightly improved or takes a turn for the better;
Invalid: the symptom of anthraco-silicosis is without any improvement or improve, even more serious.
5, result of the test statistical analysis
After test all terminates, by as shown in table 1 for test data statistical analysis:
Table 1 test data statistical analysis table
| Group | Number of cases | Cure (rate) | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 42 | 4（9.5%） | 13 | 16 | 9 | 78.6% |
| Test 1 | 42 | 17（40.5%） | 18 | 6 | 1 | 97.6% |
| Test 2 | 42 | 16（38.1%） | 21 | 5 | 0 | 100% |
| Test 3 | 42 | 19（45.2%） | 16 | 5 | 2 | 95.2% |
6, conclusion (of pressure testing)
As can be seen from result of the test statistics, compared with matched group, the average cure rate of test group is 41.3%, is 4.3 times of matched group; The average total effective rate of test group is 97.6%, higher than matched group 19 percentage points; Therefore, Chinese medicine preparation of the present invention has relative to prior art treats advantage very significantly, and obtain technical breakthrough progress, achievement is unexpected.
Claims (6)
1. treat a Chinese medicine preparation for anthraco-silicosis, it is characterized in that being made up of the raw material of following weight portion: Herba Selaginellae Doederleinii 16-28 part, Herba Taraxaci 18-32 part, Radix Platycodonis 10-22 part, Bulbus Fritillariae Cirrhosae 7-17 part, Radix Peucedani 8-18 part, Periostracum Cicadae 7-15 part, Herba Scutellariae Barbatae 18-30 part, Pericarpium Citri Reticulatae Viride 8-18 part, Endothelium Corneum Gigeriae Galli 10-20 part, Folium Eriobotryae 9-19 part, Fructus Liquidambaris 7-13 part, Semen Ginkgo 6-12 part, Radix Codonopsis 12-22 part, Radix Astragali 10-22 part, white turnip 20-32 part, Cortex Eucommiae 7-15 part, fresh cogongrass 16-28 part, Corm Eleocharitis 10-22 part, Radix Glycyrrhizae 9-15 part.
2. the Chinese medicine preparation for the treatment of anthraco-silicosis according to claim 1, is characterized in that being made up of the raw material of following weight portion: Herba Selaginellae Doederleinii 22 parts, Herba Taraxaci 25 parts, Radix Platycodonis 16 parts, Bulbus Fritillariae Cirrhosae 12 parts, Radix Peucedani 13 parts, Periostracum Cicadae 11 parts, Herba Scutellariae Barbatae 24 parts, 13 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 15 parts, Folium Eriobotryae 14 parts, Fructus Liquidambaris 10 parts, Semen Ginkgo 9 parts, Radix Codonopsis 17 parts, the Radix Astragali 16 parts, white turnip 26 parts, the Cortex Eucommiae 11 parts, fresh cogongrass 22 parts, Corm Eleocharitis 16 parts, 12 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of anthraco-silicosis according to claim 1, is characterized in that being made up of the raw material of following weight portion: Herba Selaginellae Doederleinii 24 parts, Herba Taraxaci 26 parts, Radix Platycodonis 17 parts, Bulbus Fritillariae Cirrhosae 13 parts, Radix Peucedani 12 parts, Periostracum Cicadae 12 parts, Herba Scutellariae Barbatae 23 parts, 15 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 17 parts, Folium Eriobotryae 13 parts, Fructus Liquidambaris 11 parts, Semen Ginkgo 8 parts, Radix Codonopsis 16 parts, the Radix Astragali 15 parts, white turnip 28 parts, the Cortex Eucommiae 12 parts, fresh cogongrass 24 parts, Corm Eleocharitis 18 parts, 13 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation for the treatment of anthraco-silicosis according to claim 1, is characterized in that being made up of the raw material of following weight portion: Herba Selaginellae Doederleinii 21 parts, Herba Taraxaci 24 parts, Radix Platycodonis 15 parts, Bulbus Fritillariae Cirrhosae 14 parts, Radix Peucedani 12 parts, Periostracum Cicadae 10 parts, Herba Scutellariae Barbatae 26 parts, 12 parts, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli 16 parts, Folium Eriobotryae 15 parts, Fructus Liquidambaris 11 parts, Semen Ginkgo 9 parts, Radix Codonopsis 16 parts, the Radix Astragali 17 parts, white turnip 25 parts, the Cortex Eucommiae 12 parts, fresh cogongrass 21 parts, Corm Eleocharitis 15 parts, 11 parts, Radix Glycyrrhizae.
5. prepare as arbitrary in claim 1-4 as described in the method for Chinese medicine preparation for the treatment of anthraco-silicosis, it is characterized in that comprising following processing step:
(1) ingredientss such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, white turnip, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, fresh cogongrass, Corm Eleocharitis, Radix Glycyrrhizae are taken by Chinese prescription;
(2) medical materials such as Herba Selaginellae Doederleinii, Herba Taraxaci, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Peucedani, Periostracum Cicadae, Herba Scutellariae Barbatae, Pericarpium Citri Reticulatae Viride, Endothelium Corneum Gigeriae Galli, Folium Eriobotryae, Fructus Liquidambaris, Semen Ginkgo, Radix Codonopsis, the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Radix Glycyrrhizae are pulverized respectively, the purified water of initial medical material 6-12 times weight is added after mixing, soak 10-20 hour, backflow decocts 2-4 hour, filter, add the purified water of initial weight 4-9 times weight again, backflow decocts 1-3 hour, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities is that the concentrated solution of 1.20-1.25 is for subsequent use;
(3) filtering residue of step (2) is added the ethanol of the concentration 65-75% of 5-9 times of weight, reflux, extract, 2 times, each 2-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.20-1.25 is for subsequent use;
(4) white turnip, fresh cogongrass, Corm Eleocharitis are cleaned and drained, co-grinding is squeezed the juice, and filters, and obtains filtrate, for subsequent use;
(5) concentrated solution of step (2), (3) gained and step (4) gained filtrate are merged, concentrate under reduced pressure at low temperature to a 45 DEG C relative density is the Chinese medical concrete of 1.30-1.35, for subsequent use;
(6) Chinese medical concrete of step (5) is added adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs.
6., according to the Chinese medicine preparation of the arbitrary described treatment anthraco-silicosis of claim 1-4, it is characterized in that: described Chinese medicine preparation dosage form is granule, pill, syrup, capsule, tablet, powder or oral liquid.
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