CN105250755A - Medicine for treating bronchitis based on traditional Chinese and western medicine therapy and preparation method of medicine - Google Patents
Medicine for treating bronchitis based on traditional Chinese and western medicine therapy and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses medicine for treating bronchitis based on the traditional Chinese and western medicine therapy. The medicine comprises the following components in parts by weight: 25-30 parts of ephedra, 10-15 parts of raw astragalus membranaceus, 20-25 parts of rhizoma discoreae, 20-25 parts of folium eriobotryae, 5-10 parts of milkwort, 8-10 parts of almond powder, 25-30 parts of dried orange peel, 20-30 parts of radix codonopsitis, 3-5 parts of raw rhizoma atractylodis macrocephalae, 5-10 parts of Szechuan-fritillary bulb, 8-12 parts of liquorice, 5-8 parts of common coltsfoot flower, 5-10 parts of white poria cocos, 8-10 parts of natural fresh bamboo juice, 3-5 parts of epimedium, 0.8-1.2 parts of promethazine hydrochloride, 0.2-0.5 part of a mixed solution of a nucleotide and casein injection as well as a BCG polysaccharide and nucleic acid injection, 1-1.5 parts of dextromethorphan hydrobromide and 2.5-3.5 parts of compound sulfamethoxazole. The medicine can effectively treat bronchitis and other respiration medicine diseases, and is convenient to take, short in treating course, effective, and free of toxic and side effects and medicine dependence. A preparation method of the medicine is simple and low in cost.
Description
Technical Field
The invention belongs to the field of Chinese and western synthetic medicines, and particularly relates to a medicine for treating bronchitis by using Chinese and western medicines and a preparation method thereof.
Background
Bronchitis is a disease of respiratory medicine and is a chronic nonspecific inflammation of the trachea, the mucosa of the bronchi and the surrounding tissues. Bronchitis is mainly caused by the chronic nonspecific inflammation of the bronchi resulting from repeated infections with viruses and bacteria. When the temperature is reduced, the respiratory tract small vessel spasm ischemia, defense function is reduced, and the like, the disease is favorably caused; chronic irritation such as smog and dust, and air pollution can also cause diseases; smoking causes bronchospasm, mucosal variation, ciliary movement reduction, mucus secretion increase and infection is benefited; allergic factors are also related.
Bronchitis is a clinical frequently-occurring disease, especially is common in northern China, and has the characteristics of repeated attack and difficulty in radical treatment, and part of patients can develop chronic obstructive emphysema and pulmonary heart disease and seriously harm health and life. Although some traditional Chinese medicines and western medicines for preventing and treating bronchitis are clinically used at present, some medicines are high in cost and difficult to burden for patients after long-term application, and some medicines are required to be injected persistently for a long time, so that the operation is troublesome, the persistence is difficult, and a few patients are satisfied in curative effect.
Disclosure of Invention
The medicament is safe to use, has definite curative effect, aims at improving the cure rate and reducing the medicament cost, treats both principal and secondary aspects of diseases, has the functions of relieving cough, eliminating phlegm and relieving asthma besides strengthening healthy energy and enhancing resistance, and can effectively treat respiratory internal diseases such as bronchitis. The medicine has the advantages of convenient administration, short treatment course, quick action, no toxic or side effect, no drug dependence, simple preparation method, and low cost.
The invention adopts a technical scheme for solving the technical problems that the medicine for treating bronchitis by traditional Chinese and western medicine comprises the following components in parts by weight: 25-30 parts of ephedra, 10-15 parts of raw astragalus membranaceus, 20-25 parts of common yam rhizome, 20-25 parts of loquat leaf, 5-10 parts of polygala tenuifolia, 8-10 parts of almond powder, 25-30 parts of dried orange peel, 20-30 parts of codonopsis pilosula, 3-5 parts of raw bighead atractylodes rhizome, 5-10 parts of bulbus fritillariae cirrhosae, 8-12 parts of liquorice, 5-8 parts of coltsfoot flower, 5-10 parts of white poria cocos, 8-10 parts of natural fresh bamboo juice, 3-5 parts of epimedium herb, 0.8-1.2 parts of promethazine hydrochloride, 0.2-0.5 part of a mixed solution of walnut shell and sculellaria sinensis, 1-1.5 parts of dextromethorphan hydrobromide and 2.5-3.5 parts of compound sulfamethoxazole.
Preferably, the medicine consists of the following components in parts by weight: 28 parts of ephedra, 12 parts of raw astragalus, 23 parts of common yam rhizome, 22 parts of loquat leaf, 8 parts of polygala root, 9 parts of almond powder, 28 parts of dried orange peel, 25 parts of codonopsis pilosula, 4 parts of raw bighead atractylodes rhizome, 7 parts of bulbus fritillariae cirrhosae, 10 parts of liquorice, 6 parts of tussilago farfarfara, 7 parts of white poria, 9 parts of natural fresh bamboo juice, 4 parts of epimedium herb, 1 part of promethazine hydrochloride, 0.4 part of mixed liquid of walnut shell and Szechwan-style drug, 1.2 parts of dextromethorphan hydrobromide and 3 parts of compound sulfamethoxazole.
In addition, the invention provides a preparation method of the traditional Chinese and western medicine for treating bronchitis, which comprises the following steps:
1) firstly, weighing the ephedra, the loquat leaves and the codonopsis pilosula in parts by weight, uniformly mixing, drying at 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 75-80 meshes; adding the weight of ephedra, loquat leaves and codonopsis pilosula and 1.5-2 times of ethanol with the mass concentration of 68-72%, heating at 55-65 ℃, carrying out reflux extraction for 2 times, and 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 60-62 ℃ until the concentration of the liquid medicine is 0.5g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use; the dregs of ephedra, loquat leaf and radix codonopsitis after the ethanol extraction are reserved;
2) uniformly mixing the polygala tenuifolia, the almond powder and the epimedium herb in parts by weight, drying for 10-15 minutes at 65-70 ℃, uniformly stirring while drying, then putting the mixture into a crusher to be crushed, sieving with a 120-140-mesh sieve, then adding water to soak for 0.5-1.5 hours, heating and distilling at 85-95 ℃ for 1-1.5 hours, freezing the distillate at low temperature for 15-20 hours, and extracting volatile oil from the distillate for later use; extracting volatile oil from cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii residue;
3) mixing and uniformly crushing the dregs after ethanol extraction in the step 1) and the dregs after volatile oil extraction in the step 2) with the bulbus fritillariae cirrhosae, the liquorice and the flos farfarae in parts by weight, adding water with the amount 9-10 times of the sum of the combined raw materials, decocting for 2 times, decocting for 1.5-2 hours each time, combining decoction liquids, filtering by using a macroporous adsorption resin column with the volume of 10L, concentrating to the relative density of 1.05-1.07 when the temperature is measured at 75 ℃, standing for 1.5-2 hours, and spray-drying to obtain spray-dried powder for later use;
4) mixing the white poria cocos, the raw astragalus membranaceus, the common yam rhizome, the raw bighead atractylodes rhizome and the dried orange peel in parts by weight, completely immersing the mixture in the ginger juice, sealing and soaking for 12-20 hours, taking out the mixture, filtering out the juice, completely immersing the filtered mixture in rice swill obtained by washing millet for 10-12 hours, fishing out the soaked mixture, drying the soaked mixture, frying the dried mixture to be yellow in a pot, crushing the fried mixture, and sieving the dried mixture by a 120-140-mesh sieve;
5) adding water with the volume being 8-10 times of that of the volatile oil extracted in the step 2), the natural fresh bamboo juice and the mixed liquid of the walnut shell milk and the Skyunoki, grinding, clathrating and filtering to obtain a clathrate compound, drying at 55-60 ℃, crushing, uniformly mixing with the alcohol extraction drying powder, the spray drying powder and the product obtained in the step 4), adding the dextromethorphan hydrobromide and the compound sulfamethoxazole in parts by weight, uniformly mixing, placing on a steel plate for cooling, crushing into granules, adding the promethazine hydrochloride in parts by weight, granulating and tabletting.
Preferably, the natural fresh bamboo juice is extracted by the following steps: firstly, cleaning fresh bamboos and bamboo roots, then cutting the bamboos and the bamboo roots into shreds according to the weight ratio of 10: 1, or mechanically tearing the shreds into thin strips, putting the thin strips into a container, adding 12-15 kg of clean water into each kg of the shreds, and boiling for 5-8 hours; or firstly cleaning fresh bamboos and bamboo roots, then cutting the cleaned bamboos and bamboo roots into shreds according to the weight ratio of 8: 1, placing the shreds or shreds into a container by using a machine, adding 3-5 kg of clean water into each kg of the shreds, and continuously spraying high-pressure steam for 3-5 hours to obtain the natural fresh bamboo juice.
In any of the above schemes, preferably, supercritical fluid extraction can be adopted to extract the volatile oil in step 2).
In any of the above schemes, the drying temperature in the step 4) is preferably 65-75 ℃.
In any of the above embodiments, the volume ratio of the core cheese to the strobilurin in the mixture of the core cheese and the strobilurin is preferably 1: 1.
Wherein,
herba ephedrae: inducing sweat to relieve exterior syndrome, ventilating and smoothing lung to relieve dyspnea, inducing diuresis to alleviate edema, it is often used for relieving exterior syndrome, asthma and cough.
Natural fresh bamboo juice: contains various amino acids, polysaccharides and more than ten kinds of microelements beneficial to human body, has the functions of activating human body cells, relieving cough, eliminating phlegm, clearing heat and detoxicating, etc., and has adjuvant therapeutic effect on hypertension, bronchitis, constipation, hemorrhoid, etc.
Raw astragalus root: sweet in taste and slightly warm in nature, has the effects of tonifying qi, consolidating superficial resistance, supporting sores, promoting granulation and inducing diuresis, and is mainly used for treating symptoms such as qi and blood weakness, spontaneous perspiration and the like.
Rhizoma dioscoreae: tonify spleen and stomach, promote the production of body fluid and benefit lung, clear heat and remove toxicity, and is mainly used for treating spleen deficiency, anorexia, lung deficiency and cough and asthma.
Loquat leaf: clear lung heat and stop cough, check adverse rise of qi and arrest vomiting.
Polygala root: has effects in tranquilizing mind, improving intelligence, eliminating phlegm, and relieving swelling, and can be used for treating expectoration.
Almond powder: relieving cough, eliminating phlegm, strengthening throat and trachea function, regulating lung, moistening lung, consolidating lung, and dispelling pathogenic wind and cold.
Dried orange peel: regulating qi-flowing, strengthening spleen, drying dampness and resolving phlegm, it is indicated for abdominal distention, poor appetite, vomiting and diarrhea, cough with excessive phlegm.
Codonopsis pilosula: has the effects of invigorating spleen and replenishing qi, and invigorating spleen and lung.
Raw rhizoma atractylodis macrocephalae: invigorate spleen, replenish qi, dry dampness, induce diuresis, and check sweating.
Bulbus Fritillariae Cirrhosae: relieving cough and eliminating phlegm.
Licorice root: can be used for treating asthma and cough.
And (3) common coltsfoot flower: moisten lung and descend qi, resolve phlegm and stop cough. It can be used for treating cough, asthma, and pharyngitis.
White poria: eliminating dampness and promoting diuresis; strengthening the spleen and stomach; to calm heart and induce tranquilization. Is used for; cough with phlegm and fluid retention; vomiting.
Herba epimedii: improving immunity, relieving inflammation, and resisting virus.
Dextromethorphan hydrobromide: can be used for relieving cough.
Compound sulfamethoxazole: used for department of gastroenterology, cardiovascular medicine, respiratory medicine, sexually transmitted diseases, neurology, pediatrics and infectious diseases.
Sibikan and walnut: can improve the immunity of the organism and prevent cold, and the combination of the two is also the combination of the principal and the secondary aspects.
Promethazine hydrochloride: (pharmacokinetics) absorption is good, oral metabolism, liver (mostly). Is suitable for various allergies and has tranquilizing effect.
The invention has the beneficial effects that:
1. the medicine for treating bronchitis by traditional Chinese and western medicine has the advantages of convenient administration, short treatment course, quick effect, no toxic and side effects, and no drug dependence.
2. The medicine combines traditional Chinese medicine and western medicine for treatment, has the effects of consolidating the specimens and strengthening the body, exerts the synergistic effect and promotes early rehabilitation.
3. The medicine of the invention effectively aims at the disease mechanism, treats both principal and secondary aspects of diseases from inside to outside, and can achieve the purpose of good cure.
4. The preparation method of the medicine is simple, the cost is low, the efficiency is high, and the economic benefit and the social benefit are obvious.
The medicinal components are verified, recorded and tested for many years, although the efficacies of the medicinal components are different, the selection of each component is not random, the proportion of the components obtained by the test for many years is not simple superposition of the efficacies of the raw materials of the components, and various action relationships such as growing, reinforcing, mutual incompatibility, killing and the like can exist among the components, and the raw materials are correspondingly selected according to the principle and the optimal proportion among the raw materials is determined, so the medicinal components have remarkable significance.
Clinical practice
Case 1: sunzhi, women, 43 years old, suffered from chronic bronchitis for 6 years, was treated in a certain hospital, and did not get better, took the medicine of the invention to treat and fully recover after one month, followed up half a year and did not relapse.
Case 2: in Qinzhi, male, age 65, continuously for 20 years, cough and expectoration for 4 months in winter and spring every year, and the warmth in the sky is relieved, and the chest radiograph is diagnosed as bronchitis (clinical remission stage). After the medicine is taken for 10-15 g each time, the medicine is taken twice a day for two months, the attack is greatly reduced, and after the medicine is taken for four months, the cough never occurs, and the physical strength is obviously enhanced.
In addition, the medicine is used for special clinical research.
100 cases were randomly selected, and all cases met the diagnostic criteria for bronchitis. The age is 50-75 years old, and the course of disease is 5-35 years, which are all in clinical remission.
The treatment method comprises the following steps: the medicine (tablet) is taken 10-15 g each time twice a day, one month is a treatment course, and two treatment courses can be taken continuously.
As a result: the therapeutic effect judgment standard is judged according to the therapeutic effect judgment standard of bronchitis. 56 cases are cured, 32 cases are obviously effective, 10 cases are improved, 2 cases are ineffective, and the total effective rate is 98%. The diagnosis of the disease condition is informed of the diagnosis of the doctor issued by the regular hospital.
Detailed Description
The present invention will be further described with reference to the following embodiments.
Example 1
A medicine for treating bronchitis by traditional Chinese and western medicine comprises the following components in parts by weight: 28g of ephedra, 12g of raw astragalus, 23g of common yam rhizome, 22g of loquat leaf, 8g of polygala root, 9g of almond powder, 28g of dried orange peel, 25g of codonopsis pilosula, 4g of raw bighead atractylodes rhizome, 7g of bulbus fritillariae cirrhosae, 10g of liquorice, 6g of tussilago farfarfara, 7g of white poria, 9g of natural fresh bamboo juice, 4g of epimedium herb, 1g of promethazine hydrochloride, 0.4g of mixed liquid of walnut shell and Szechwan-style, 1.2g of dextromethorphan hydrobromide and 3g of compound sulfamethoxazole.
The preparation method of the medicine for treating bronchitis by the traditional Chinese and western medicine comprises the following steps:
1) firstly, weighing the ephedra, the loquat leaves and the codonopsis pilosula in parts by weight, uniformly mixing, drying at 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 75-80 meshes; adding the weight of ephedra, loquat leaves and codonopsis pilosula and 1.5-2 times of ethanol with the mass concentration of 68-72%, heating at 55-65 ℃, carrying out reflux extraction for 2 times, and 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 60-62 ℃ until the concentration of the liquid medicine is 0.5g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use; the dregs of ephedra, loquat leaf and radix codonopsitis after the ethanol extraction are reserved;
2) uniformly mixing the polygala tenuifolia, the almond powder and the epimedium herb in parts by weight, drying for 10-15 minutes at 65-70 ℃, uniformly stirring while drying, then putting the mixture into a crusher to be crushed, sieving with a 120-140-mesh sieve, then adding water to soak for 0.5-1.5 hours, heating and distilling at 85-95 ℃ for 1-1.5 hours, freezing the distillate at low temperature for 15-20 hours, and extracting volatile oil from the distillate for later use; extracting volatile oil from cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii residue;
3) mixing and uniformly crushing the dregs after ethanol extraction in the step 1) and the dregs after volatile oil extraction in the step 2) with the bulbus fritillariae cirrhosae, the liquorice and the flos farfarae in parts by weight, adding water with the amount 9-10 times of the sum of the combined raw materials, decocting for 2 times, decocting for 1.5-2 hours each time, combining decoction liquids, filtering by using a macroporous adsorption resin column with the volume of 10L, concentrating to the relative density of 1.05-1.07 when the temperature is measured at 75 ℃, standing for 1.5-2 hours, and spray-drying to obtain spray-dried powder for later use;
4) mixing the white poria cocos, the raw astragalus membranaceus, the common yam rhizome, the raw bighead atractylodes rhizome and the dried orange peel in parts by weight, completely immersing the mixture in the ginger juice, sealing and soaking for 12-20 hours, taking out the mixture, filtering out the juice, completely immersing the filtered mixture in rice swill obtained by washing millet for 10-12 hours, fishing out the soaked mixture, drying the soaked mixture, frying the dried mixture to be yellow in a pot, crushing the fried mixture, and sieving the dried mixture by a 120-140-mesh sieve;
5) adding water with the volume being 8-10 times of that of the volatile oil extracted in the step 2), the natural fresh bamboo juice and the mixed liquid of the walnut shell milk and the Skyunoki, grinding, clathrating and filtering to obtain a clathrate compound, drying at 55-60 ℃, crushing, uniformly mixing with the alcohol extraction drying powder, the spray drying powder and the product obtained in the step 4), adding the dextromethorphan hydrobromide and the compound sulfamethoxazole in parts by weight, uniformly mixing, placing on a steel plate for cooling, crushing into granules, adding the promethazine hydrochloride in parts by weight, granulating and tabletting.
The natural fresh bamboo juice is extracted by the following steps: firstly, cleaning fresh bamboos and bamboo roots, then cutting the bamboos and the bamboo roots into shreds according to the weight ratio of 10: 1, or mechanically tearing the shreds into thin strips, putting the thin strips into a container, adding 12-15 kg of clean water into each kg of the shreds, and boiling for 5-8 hours; or firstly cleaning fresh bamboos and bamboo roots, then cutting or mechanically tearing the bamboo and the bamboo roots into fine strips of broken filaments according to the weight ratio of 8: 1, putting the strips into a container, adding 3-5 kg of clean water into each kg of the broken bamboos, and continuously spraying high-pressure steam for 3-5 hours to obtain the natural fresh bamboo juice.
Wherein, the supercritical fluid extraction method can be adopted to extract the volatile oil in the step 2), the drying temperature in the step 4) is 65-75 ℃, and the volume ratio of the nuclear cheese to the Skyang in the mixed liquid of the nuclear cheese and the Skyang is 1: 1.
Example 2
A medicine for treating bronchitis by traditional Chinese and western medicine comprises the following components in parts by weight: 25g of ephedra, 15g of raw astragalus, 20g of common yam rhizome, 25g of loquat leaf, 5g of polygala root, 10g of almond powder, 25g of dried orange peel, 30g of codonopsis pilosula, 3g of raw bighead atractylodes rhizome, 10g of bulbus fritillariae cirrhosae, 8g of liquorice, 8g of tussilago farfarfara, 5g of white poria, 10g of natural fresh bamboo juice, 3g of epimedium herb, 1.2g of promethazine hydrochloride, 0.2g of mixed liquid of walnut shell and Szechwan-style, 1.5g of dextromethorphan hydrobromide and 2.5g of compound sulfamethoxazole.
The preparation method of the medicine for treating bronchitis by the traditional Chinese and western medicine comprises the following steps:
1) firstly weighing the ephedra, the loquat leaf and the radix codonopsitis in parts by weight, uniformly mixing, drying for 30 minutes at 65 ℃, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 80-mesh sieve; adding herba Ephedrae, folium Eriobotryae and radix Codonopsis with weight of 1.5 times of 72% ethanol, heating at 55 deg.C, reflux extracting for 2 times, each for 2.5 hr, heating the obtained ethanol extractive solution at 60 deg.C, concentrating to obtain medicinal liquid with concentration of 0.5g crude drug/ml, and drying to obtain dry powder; the dregs of ephedra, loquat leaf and radix codonopsitis after the ethanol extraction are reserved;
2) mixing cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii at above weight parts, drying at 70 deg.C for 10 min while stirring, pulverizing in a pulverizer, sieving with 140 mesh sieve, soaking in water for 0.5 hr, heating and distilling at 95 deg.C for 1 hr, freezing distillate at low temperature for 20 hr, and extracting volatile oil from the distillate; extracting volatile oil from cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii residue;
3) mixing the dregs obtained after the ethanol extraction in the step 1) and the dregs obtained after the volatile oil extraction in the step 2) with the bulbus fritillariae cirrhosae, the liquorice and the flos farfarae in parts by weight, uniformly crushing, adding water with the amount 9 times of the sum of the combined raw materials, decocting for 2 times, decocting for 2 hours each time, combining the decoction, filtering by using a macroporous adsorption resin column with the volume of 10L, concentrating until the relative density is 1.05 when the temperature is measured at 75 ℃, standing for 2 hours and spray drying to obtain spray-dried powder for later use;
4) mixing the white poria, the raw astragalus, the common yam rhizome, the raw bighead atractylodes rhizome and the dried orange peel in parts by weight, completely immersing the mixture in ginger juice, sealing and soaking for 12 hours, taking out the mixture, filtering out the juice, completely immersing the filtered mixture in rice swill washing millet for 12 hours, fishing out the mixture, drying the mixture, frying the mixture to be yellow in a pot, crushing the mixture, and sieving the crushed mixture by a 120-mesh sieve;
5) adding 10 times of water, the natural fresh bamboo juice and the mixed liquid of the walnut shell milk and the Skyunogen in parts by weight into the volatile oil extracted in the step 2), grinding, clathrating and filtering to obtain a clathrate compound, drying at 55 ℃, crushing, uniformly mixing with alcohol extraction drying powder, spray drying powder and the product obtained in the step 4), adding the dextromethorphan hydrobromide and the compound sulfamethoxazole in parts by weight, uniformly mixing, placing on a steel plate for cooling, crushing into granules, adding the promethazine hydrochloride in parts by weight, granulating and tabletting.
The natural fresh bamboo juice is extracted by the following steps: firstly, cleaning fresh bamboos and bamboo roots, then cutting the bamboos and the bamboo roots into shreds according to the weight ratio of 10: 1, or mechanically tearing the shreds into thin strips, putting the thin strips into a container, adding 15 kilograms of clear water into each kilogram of the shreds, and boiling the shreds for 5 hours;
wherein, the supercritical fluid extraction method can be adopted to extract the volatile oil in the step 2), the drying temperature in the step 4) is 65 ℃, and the volume ratio of the nuclear cheese to the Skyran in the mixed liquid of the nuclear cheese and the Skyran is 1: 1.
Example 3
A medicine for treating bronchitis by traditional Chinese and western medicine comprises the following components in parts by weight: 30g of ephedra, 10g of raw astragalus, 25g of common yam rhizome, 20g of loquat leaf, 10g of polygala root, 8g of almond powder, 30g of dried orange peel, 20g of codonopsis pilosula, 5g of raw bighead atractylodes rhizome, 5g of bulbus fritillariae cirrhosae, 12g of liquorice, 5g of tussilago farfarfara, 10g of white poria, 8g of natural fresh bamboo juice, 5g of epimedium herb, 0.8g of promethazine hydrochloride, 0.5g of mixed liquid of walnut shell and Szechwan-style, 1g of dextromethorphan hydrobromide and 3.5g of compound sulfamethoxazole.
The preparation method of the medicine for treating bronchitis by the traditional Chinese and western medicine comprises the following steps:
1) firstly weighing the ephedra, the loquat leaf and the radix codonopsitis in parts by weight, uniformly mixing, drying at 55 ℃ for 40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a 75-mesh sieve; adding herba Ephedrae, folium Eriobotryae and radix Codonopsis in weight and 2 times of ethanol with mass concentration of 68% at 65 deg.C, heating and reflux-extracting for 2 times, each for 1.5 hr, heating and concentrating the obtained ethanol extract at 62 deg.C to obtain medicinal liquid with concentration of 0.5g crude drug/ml, and drying to obtain dry powder; the dregs of ephedra, loquat leaf and radix codonopsitis after the ethanol extraction are reserved;
2) mixing cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii at the above weight parts, drying at 65 deg.C for 15 min while stirring, pulverizing in a pulverizer, sieving with 120 mesh sieve, soaking in water for 1.5 hr, heating and distilling at 85 deg.C for 1.5 hr, freezing distillate at low temperature for 15 hr, and extracting volatile oil from the distillate; extracting volatile oil from cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii residue;
3) mixing the dregs after ethanol extraction in the step 1) and the dregs after volatile oil extraction in the step 2) with the bulbus fritillariae cirrhosae, the liquorice and the flos farfarae in parts by weight, uniformly crushing, adding water with the amount being 10 times of the sum of the combined raw materials, decocting for 2 times, decocting for 1.5 hours each time, combining decoction liquids, filtering by using a macroporous adsorption resin column with the volume of 10L, concentrating until the relative density is 1.07 when the temperature is measured at 75 ℃, standing for 1.5 hours and spray drying to obtain spray-dried powder for later use;
4) mixing the white poria, the raw astragalus, the common yam rhizome, the raw bighead atractylodes rhizome and the tangerine peel in parts by weight, completely immersing the mixture in ginger juice, sealing and soaking for 20 hours, taking out the mixture, filtering out the juice, completely immersing the filtered mixture in rice swill obtained by washing millet for 10 hours, fishing out the soaked mixture, drying the soaked mixture, frying the soaked mixture to be yellow in a pot, crushing the fried mixture, and sieving the crushed mixture by a 140-mesh sieve;
5) adding 10 times of water, the natural fresh bamboo juice and the mixed liquid of the walnut shell milk and the Skyunogen in parts by weight into the volatile oil extracted in the step 2), grinding, clathrating and filtering to obtain a clathrate compound, drying at 55 ℃, crushing, uniformly mixing with alcohol extraction drying powder, spray drying powder and the product obtained in the step 4), adding the dextromethorphan hydrobromide and the compound sulfamethoxazole in parts by weight, uniformly mixing, placing on a steel plate for cooling, crushing into granules, adding the promethazine hydrochloride in parts by weight, granulating and tabletting.
The natural fresh bamboo juice is extracted by the following steps: firstly, cleaning fresh bamboos and bamboo roots, then cutting the bamboos and the bamboo roots into shreds according to the weight ratio of 8: 1, or mechanically tearing the shreds into thin strips, putting the thin strips into a container, adding 5 kilograms of clear water into each kilogram of the shreds, and continuously spraying high-pressure steam for 3 hours to obtain natural fresh bamboo juice.
Wherein, the supercritical fluid extraction method can be adopted to extract the volatile oil in the step 2), the drying temperature in the step 4) is 75 ℃, and the volume ratio of the nuclear cheese to the Skyran in the mixed liquid of the nuclear cheese and the Skyran is 1: 1.
Experimental study
The safety toxicology test shows that the medicine of the invention: LD50 is 10000mg/kg, safety toxicology evaluation is actual nontoxic grade, and no toxic and side effect.
Acute toxicity test
The experimental samples are prepared into suspension, and the suspension is administrated to mice by intragastric administration at a dose which is 360 times of the daily clinical dose, and no toxic reaction of animals is found during the observation period. No animal died after 15 days of dosing; after the animal is sacrificed and dissected, the visceral organs of the animal are observed without obvious abnormality. Experiments show that half of lethal dose of the invention can not be detected by gastric lavage administration, and the tolerance of animal experiments is 260 times of the maximum dose of clinical adults every day.
Long term toxicity test in animals
The samples are provided for rats for long-term administration for 5-6 months at 5-fold, 20-fold and 60-fold clinical daily dosage, and common activities, mental states, hairs, excrement and the like of two dosage groups of rat drugs have no obvious abnormality; the peripheral hemogram including erythrocyte, leucocyte and classification, hemoglobin and hematocrit fluctuate within normal range before and after administration; no obvious influence on liver and kidney function indexes is seen; at the end of the test, the contents of total protein, albumin and alkaline phosphatase in the animal serum are not obviously different from those of a control group; no abnormality is found in electrocardiographic examination; the gross inspection of each main organ does not show obvious pathological morphological changes such as swelling, congestion, necrosis and the like; the weight coefficients of organs such as heart, liver, spleen, lung, kidney, thymus, adrenal gland and the like have no significant difference compared with the control group; no abnormality is found in the pathological histological examination. The results show that the invention is safer and has no obvious toxic and side effects within the dosage range.
Main pharmacodynamic experiments:
the method comprises the following steps: 50 ICR mice with the weight of 20-22g are taken, the male and female parts are divided into 5 groups randomly, each group comprises 10 mice, the groups respectively comprise 1.3 and 2.7g/kg of the medicine, 1.2g/kg of the cough and asthma relieving group and a model group, the 4 groups of animals are stimulated by 1.5% SO2 every day for 30 days, then the stimulation by SO2 is stopped, and the observation is carried out for 10 days. The group administration was started at the same time as the modeling. Another group was used as a normal control group, and the normal control group was perfused with normal saline every day. During the administration period, the animals of each group were observed to live diet, the mice were sacrificed 2.5 hours after the last administration, the bronchi and lungs of the mice were dissected and taken out and fixed with 10% formalin solution, and the sections were paraffin-embedded and examined by H-E staining microscopy. The results were examined by Ridit.
General conditions are as follows: the normal group of mice has good spirit, agile and powerful actions, normal food intake and dense and lustrous hair; the mice in the model group have poor spirit, tiredness, little lying food, no wheezing and lusterless hair; the mice in the cough and asthma relieving group are modeled as a model group. The medicine of the invention is 2.7g/kg group, the recovery starts after 5 days, and the recovery is normal after 7 days. The animals of the group 1.3g/kg of the drug begin to recover after 10 days, and the animals recover to normal after half a month.
Pathological changes are as follows: the drug 1.3 and 2.7g/kg groups of the invention can remarkably and very remarkably reduce the degree of the chronic bronchitis mouse bronchial pathology change caused by SO2, and compared with a model group, the difference has remarkable and very remarkable meanings (P < 0.05 and P < 0.01). The 2.7g/kg group of the medicine can also obviously reduce the pathological change degree of the lung of the mouse with chronic bronchitis caused by SO2, and compared with a model group, the difference has obvious significance (P is less than 0.05). See table below.
P < 0.05, P < 0.01 compared to NS group.
Note 1: +++: the trachea epithelium is severely degenerated, cilia are seriously detached and thinned, goblet cells are abundant, and the degeneration is severe. ++: the trachea epithelium is heavily degenerated, cilia are weakened and become thin, goblet cells are abundant, and degeneration is heavy. +: the trachea epithelium is less degenerated, cilia are less detached and thinned, goblet cells are more and the degeneration is less. 0: it is substantially normal.
Note 2: +++: inflammatory cell infiltration is severe and alveolar degeneration is severe. ++: heavy inflammatory cell infiltration; the pulmonary alveoli are heavily denatured. +: inflammatory cell infiltration is less and alveolar degeneration is less. 0: it is substantially normal.
The medicine has the functions of relieving cough, eliminating phlegm, resisting anoxia, resisting fatigue, resisting cold, resisting inflammation and raising immunity of body, and can reduce the pathological change of bronchus and lung of mouse in chronic bronchitis model and prolong the latent period of asthma reaction in guinea pig obviously.
In order to enhance the effect of the medicine, 11-15 parts of radix stemonae, 15-20 parts of sappan wood and 1-2 parts of radix asteris can be added into the components in parts by weight. Drying radix Stemonae, lignum sappan and radix Asteris at 65 deg.C for 50 min while stirring, pulverizing into fine powder with a pulverizer, sieving with 160 mesh sieve, and mixing the fine powder with Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix and flos Farfarae in step 3).
The traditional Chinese medicine and western medicine for treating bronchitis is convenient to take, short in treatment course, quick in effect, free of toxic and side effects and free of drug dependence. The traditional Chinese medicine and the western medicine are combined for treatment, so that the symptoms and the root causes are consolidated, the synergistic effect is exerted, and the early rehabilitation is promoted. The medicine of the invention effectively aims at the disease mechanism, treats both principal and secondary aspects of diseases from inside to outside, and can achieve the purpose of good cure. The preparation method of the medicine is simple, the cost is low, the efficiency is high, and the economic benefit and the social benefit are obvious.
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.
Claims (7)
1. A medicine for treating bronchitis by traditional Chinese and western medicine is characterized by comprising the following components in parts by weight: 25-30 parts of ephedra, 10-15 parts of raw astragalus membranaceus, 20-25 parts of common yam rhizome, 20-25 parts of loquat leaf, 5-10 parts of polygala tenuifolia, 8-10 parts of almond powder, 25-30 parts of dried orange peel, 20-30 parts of codonopsis pilosula, 3-5 parts of raw bighead atractylodes rhizome, 5-10 parts of bulbus fritillariae cirrhosae, 8-12 parts of liquorice, 5-8 parts of coltsfoot flower, 5-10 parts of white poria cocos, 8-10 parts of natural fresh bamboo juice, 3-5 parts of epimedium herb, 0.8-1.2 parts of promethazine hydrochloride, 0.2-0.5 part of a mixed solution of walnut shell and sculellaria sinensis, 1-1.5 parts of dextromethorphan hydrobromide and 2.5-3.5 parts of compound sulfamethoxazole.
2. The medicine for treating bronchitis in traditional Chinese and western medicine according to claim 1 is characterized in that the medicine comprises the following components in parts by weight: 28 parts of ephedra, 12 parts of raw astragalus, 23 parts of common yam rhizome, 22 parts of loquat leaf, 8 parts of polygala root, 9 parts of almond powder, 28 parts of dried orange peel, 25 parts of codonopsis pilosula, 4 parts of raw bighead atractylodes rhizome, 7 parts of bulbus fritillariae cirrhosae, 10 parts of liquorice, 6 parts of tussilago farfarfara, 7 parts of white poria, 9 parts of natural fresh bamboo juice, 4 parts of epimedium herb, 1 part of promethazine hydrochloride, 0.4 part of mixed liquid of walnut shell and Szechwan-style drug, 1.2 parts of dextromethorphan hydrobromide and 3 parts of compound sulfamethoxazole.
3. A method for preparing a medicament for treating bronchitis according to claim 1 or 2, comprising the steps of:
1) firstly, weighing the ephedra, the loquat leaves and the codonopsis pilosula in parts by weight, uniformly mixing, drying at 55-65 ℃ for 30-40 minutes, and uniformly stirring while drying; then, the raw materials are put into a crusher to be crushed into coarse materials, and the coarse materials are sieved by a sieve of 75-80 meshes; adding the weight of ephedra, loquat leaves and codonopsis pilosula and 1.5-2 times of ethanol with the mass concentration of 68-72%, heating at 55-65 ℃, carrying out reflux extraction for 2 times, and 1.5-2.5 hours each time, heating and concentrating the prepared ethanol extract at 60-62 ℃ until the concentration of the liquid medicine is 0.5g crude drug/ml, and drying into powder to obtain ethanol extraction dry powder for later use; the dregs of ephedra, loquat leaf and radix codonopsitis after the ethanol extraction are reserved;
2) uniformly mixing the polygala tenuifolia, the almond powder and the epimedium herb in parts by weight, drying for 10-15 minutes at 65-70 ℃, uniformly stirring while drying, then putting the mixture into a crusher to be crushed, sieving with a 120-140-mesh sieve, then adding water to soak for 0.5-1.5 hours, heating and distilling at 85-95 ℃ for 1-1.5 hours, freezing the distillate at low temperature for 15-20 hours, and extracting volatile oil from the distillate for later use; extracting volatile oil from cortex et radix Polygalae, semen Armeniacae amarum powder and herba Epimedii residue;
3) mixing and uniformly crushing the dregs after ethanol extraction in the step 1) and the dregs after volatile oil extraction in the step 2) with the bulbus fritillariae cirrhosae, the liquorice and the flos farfarae in parts by weight, adding water with the amount 9-10 times of the sum of the combined raw materials, decocting for 2 times, decocting for 1.5-2 hours each time, combining decoction liquids, filtering by using a macroporous adsorption resin column with the volume of 10L, concentrating to the relative density of 1.05-1.07 when the temperature is measured at 75 ℃, standing for 1.5-2 hours, and spray-drying to obtain spray-dried powder for later use;
4) mixing the white poria cocos, the raw astragalus membranaceus, the common yam rhizome, the raw bighead atractylodes rhizome and the dried orange peel in parts by weight, completely immersing the mixture in the ginger juice, sealing and soaking for 12-20 hours, taking out the mixture, filtering out the juice, completely immersing the filtered mixture in rice swill obtained by washing millet for 10-12 hours, fishing out the soaked mixture, drying the soaked mixture, frying the dried mixture to be yellow in a pot, crushing the fried mixture, and sieving the dried mixture by a 120-140-mesh sieve;
5) adding water with the volume being 8-10 times of that of the volatile oil extracted in the step 2), the natural fresh bamboo juice and the mixed liquid of the walnut shell milk and the Skyunoki, grinding, clathrating and filtering to obtain a clathrate compound, drying at 55-60 ℃, crushing, uniformly mixing with the alcohol extraction drying powder, the spray drying powder and the product obtained in the step 4), adding the dextromethorphan hydrobromide and the compound sulfamethoxazole in parts by weight, uniformly mixing, placing on a steel plate for cooling, crushing into granules, adding the promethazine hydrochloride in parts by weight, granulating and tabletting.
4. The method for preparing a medicine for treating bronchitis according to claim 3, wherein said natural fresh bamboo juice is extracted by the following steps: firstly, cleaning fresh bamboos and bamboo roots, then cutting the bamboos and the bamboo roots into shreds according to the weight ratio of 10: 1, or mechanically tearing the shreds into thin strips, putting the thin strips into a container, adding 12-15 kg of clean water into each kg of the shreds, and boiling for 5-8 hours; or firstly cleaning fresh bamboos and bamboo roots, then cutting the cleaned bamboos and bamboo roots into shreds according to the weight ratio of 8: 1, placing the shreds or shreds into a container by using a machine, adding 3-5 kg of clean water into each kg of the shreds, and continuously spraying high-pressure steam for 3-5 hours to obtain the natural fresh bamboo juice.
5. The method for preparing a medicine for treating bronchitis according to claim 3 or 4, wherein the supercritical fluid extraction method is adopted in step 2) to extract volatile oil.
6. The preparation method of the medicine for treating bronchitis in traditional Chinese and western medicine according to claim 5, wherein the drying temperature in the step 4) is 65-75 ℃.
7. The method for preparing a medicine for treating bronchitis according to claim 6, wherein the volume ratio of the core cheese to the Siqikang in the mixed solution of the core cheese and the Siqikang is 1: 1.
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Application publication date: 20160120 |