CN1720918A - Compound capsule with dextromethorphan and promethazine and method for preparing the same - Google Patents
Compound capsule with dextromethorphan and promethazine and method for preparing the same Download PDFInfo
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- CN1720918A CN1720918A CN 200410068920 CN200410068920A CN1720918A CN 1720918 A CN1720918 A CN 1720918A CN 200410068920 CN200410068920 CN 200410068920 CN 200410068920 A CN200410068920 A CN 200410068920A CN 1720918 A CN1720918 A CN 1720918A
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- promethazine
- adhesive
- dextromethorphan
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- granule
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Abstract
The invention relates to a compound capsule with dextromethorphan and promethazine and method for preparation, wherein each bag of the granule contains Dextromethorphan Hydrobromide 7.5-30mg, preferably 14-16mg, promethazine hydrochloride 3.1-12.5 mg, preferably 5-7mg, anti-oxidizing agent 3-24%, preferably 14-16%, bonding agent 90-97%, preferably 94-95%. The invention has the advantages of increased medicament stability, and guaranteed quality and curative effect.
Description
Technical field the present invention relates to compound granular agent of pharmaceutical dextromethorphan and promethazine and preparation method thereof.
The background technology dextromethorphan is an effective antitussive medicine, uses combined therapies such as many and other antipyretic analgesic, antihistaminic, expectorant, vasoconstrictor except that folk prescription and catches a cold.Promethazine tool antihistaminic and sedation, can improve the antitussive effect of dextromethorphan with dextromethorphan combination, be applicable to treatment and alleviate by flu, acute or cough that chronic bronchitis, bronchial asthma, pharyngolaryngitis, pulmonary tuberculosis and other upper respiratory tract infection cause.
The cough-relieving medicine that has gone on the market at present is a lot, but many medicines is arranged because of some reason and not ideal enough.When being tablet or capsule as dosage form, the patient who often is not suitable for child and dysphagia takes; When dosage form is syrup or solution, have the problem of storing, carrying inconvenience again, and owing to be syrup or solution, many medicine stabilities are relatively poor, reduce quality as the easy oxidation of promethazine, these all directly influence the curative effect of medicine.
Summary of the invention the present invention is intended to overcome existing antitussive poor stability, is not easy to the problem of patient's application of child and dysphagia, the characteristics separately that kept solid dosage formss such as liquid dosage form such as syrup, solution and tablet, capsule, granule, the compound granular agent that has prepared dextromethorphan and promethazine.By adopting special prescription and production technology, improved the stability of product, thereby guaranteed quality and curative effect.Be characterized in:
(1) stability is better.Because granule is in dry anhydrous state all the time, and packing is tight, avoids contacting with air, thereby more stable than liquid preparations such as syrup, solutions.
(2) though granule is a solid preparation, it adds mixing in water for oral taking that is has formed solution when taking, thus than tablet and capsule good absorbing, rapid-action, bioavailability is high.
(3) suitable crowd is wider.When granule adds mixing in water for oral taking, form the such as clear as crystal solution of similar solution, patient be willing to accept, and the patient who is suitable for child more than 2 years old and swallows inconvenience takes.
(4) granule is a unit dose package, and each taking dose is accurate than tablet, capsule, and can repeatedly not take easily as syrup, solution and pollute, and the back residue medicine of recovering is easy to keeping, also can use in the future.
(5) produce, transport, preserve, carry and use more convenient.
The compound granular agent of dextromethorphan of the present invention and promethazine contains active component dextromethorphan and promethazine, antioxidative stabilizer, adhesive and fragrant correctives, and adopts the specific process preparation, to guarantee the stability of product.Every bag contains dextromethorphan 7.5～30mg, is preferably 14～16mg in the prescription; Contain promethazine 3.1～12.5mg, be preferably 5～7mg, dextromethorphan and promethazine are hydrobromate and hydrochlorate commonly used.Antioxidative stabilizer can be used sodium sulfite, sodium sulfite, thiourea, cysteine hydrochloride, calcium disodium edetate, disodium edetate, ascorbic acid, the acid of Fructus Citri tangerinae rafter, sodium benzoate, Fructus Citri tangerinae rafter acid sodium etc., these stabilizing agents can use separately, also can multiple use in conjunction, consumption be recipe quantity 3～24%, be preferably 14～16%.Adhesive can adopt the mixture of starch slurry and cellulose family such as carmethose, ethyl cellulose, hyprolose, hypromellose etc.; these adhesive both can make medicine bind into granule; can form a skim at medical surfaces again, medicine is played a protective role.These adhesive can be used separately, can also mix application by different proportion.Preparation adhesive available water, ethanol and ethanol water.Can adopt traditional method whole materials to be granulated simultaneously during granulation, also can granulate respectively promptly earlier medicine and antioxidative stabilizer and part Icing Sugar are granulated with the cellulose family adhesive, and then get final product with the granule mixing of other Icing Sugar with the cellulose family adhesive.Fragrance correctives can be sucrose, glycyrrhizic acid, steviosin, saccharin sodium, the acid of Fructus Citri tangerinae rafter, tartaric acid, synthetic and natural perfume material, consumption be recipe quantity 90～97%, be preferably 94～95% so that the granule that makes is fragrant and sweet good to eat, patient takes like a shot.
Specific embodiment the present invention can be illustrated with the following examples.
Embodiment 1 prescription:
Dextromethorphan hydrobromide 15g
Promethazine hydrochloride 6.25g
Vitamin C 10g
Disodium edetate 2g
Fructus Citri tangerinae rafter acid sodium 3g
Spice 15g
Cane sugar powder 936g
EC/HPMC ethanol liquid is an amount of
Make 1000 bags
Preparation method: with dextromethorphan hydrobromide, promethazine hydrochloride, vitamin C, disodium edetate, Fructus Citri tangerinae rafter acid sodium, sucrose fine mixing, make suitable soft material, granulate with 14 order nylon wires with the ethanol liquid of 6%EC/HPMC, in dry below 50 ℃, add spice, granulate is packed behind the mix homogeneously.
Embodiment 2 prescriptions:
Dextromethorphan hydrobromide 30g
Promethazine hydrochloride 12.5g
Vitamin C 15g
Disodium edetate 5g
Fructus Citri tangerinae rafter acid 8g
Spice 20g
Cane sugar powder 1400g
EC/HPMC ethanol liquid is an amount of
Make 1000 bags
Preparation method: with dextromethorphan hydrobromide, promethazine hydrochloride, vitamin C, disodium edetate, the acid of Fructus Citri tangerinae rafter and a little sugar fine powder mixing, ethanol liquid with EC/HPMC is made suitable soft material, granulate with 14 order nylon wires, make drug particles in drying below 50 ℃.Adopt traditional method granulation drying to make adjuvant Icing Sugar granule remaining cane sugar powder in addition.Drug particles is mixed with adjuvant Icing Sugar granule, add spice, granulate is packed behind the mix homogeneously.
Claims (6)
1, compound granular agent of dextromethorphan and promethazine and preparation method thereof.This granule contains active medicine, antioxidative stabilizer, adhesive and fragrant correctives.Characteristics are by adopting special prescription and preparation method, improved stability of drug, thereby have guaranteed quality and curative effect.
2, compound granular agent dosage form of described dextromethorphan of claim 1 and promethazine and preparation method thereof.Dextromethorphan and promethazine are hydrobromate and hydrochlorate commonly used.
3, every bag of the described granule of claim 1 contains dextromethorphan hydrobromide 7.5～30mg, is preferably 14～16mg; Hydrochloric promethazine 3.1～12.5mg, be preferably 5～7mg.
4, the described antioxidative stabilizer of claim 1 is sodium sulfite, sodium sulfite, thiourea, cysteine hydrochloride, calcium disodium edetate, disodium edetate, ascorbic acid, the acid of Fructus Citri tangerinae rafter, sodium benzoate, Fructus Citri tangerinae rafter acid sodium etc.These stabilizing agents can use separately, also can multiple use in conjunction, consumption be recipe quantity 3～24%, be preferably 14～16%.
5, the described adhesive of claim 1 can adopt the mixture of starch slurry and cellulose family such as carmethose, ethyl cellulose, hyprolose, hypromellose etc.; these adhesive both can make medicine bind into granule; can form a skim at medical surfaces again, medicine is played a protective role.These adhesive can be used separately, can also mix application by different proportion, preparation adhesive available water, ethanol and ethanol water.
6, the described special preparation method of claim 1 is granulated whole materials with the cellulose family adhesive simultaneously for adopting traditional method; also can granulate respectively promptly earlier medicine and antioxidative stabilizer and part Icing Sugar are granulated with the cellulose family adhesive, and then with the granule mixing of other Icing Sugar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410068920 CN1720918A (en) | 2004-07-14 | 2004-07-14 | Compound capsule with dextromethorphan and promethazine and method for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410068920 CN1720918A (en) | 2004-07-14 | 2004-07-14 | Compound capsule with dextromethorphan and promethazine and method for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1720918A true CN1720918A (en) | 2006-01-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410068920 Pending CN1720918A (en) | 2004-07-14 | 2004-07-14 | Compound capsule with dextromethorphan and promethazine and method for preparing the same |
Country Status (1)
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| CN (1) | CN1720918A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922510A (en) * | 2015-06-01 | 2015-09-23 | 袁志贤 | Phlegm-expelling and asthma-relieving medicine and preparation method thereof |
| CN105250755A (en) * | 2015-10-19 | 2016-01-20 | 王迁 | Medicine for treating bronchitis based on traditional Chinese and western medicine therapy and preparation method of medicine |
| CN108096203A (en) * | 2018-02-09 | 2018-06-01 | 常州康普药业有限公司 | A kind of promethazine hydrochloride piece and preparation method thereof |
-
2004
- 2004-07-14 CN CN 200410068920 patent/CN1720918A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922510A (en) * | 2015-06-01 | 2015-09-23 | 袁志贤 | Phlegm-expelling and asthma-relieving medicine and preparation method thereof |
| CN105250755A (en) * | 2015-10-19 | 2016-01-20 | 王迁 | Medicine for treating bronchitis based on traditional Chinese and western medicine therapy and preparation method of medicine |
| CN108096203A (en) * | 2018-02-09 | 2018-06-01 | 常州康普药业有限公司 | A kind of promethazine hydrochloride piece and preparation method thereof |
| CN108096203B (en) * | 2018-02-09 | 2019-11-12 | 常州康普药业有限公司 | A kind of promethazine hydrochloride piece and preparation method thereof |
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