CN1628667A - Compound dried suspension of dextromethorphan and gualfenesin and preparation method thereof - Google Patents
Compound dried suspension of dextromethorphan and gualfenesin and preparation method thereof Download PDFInfo
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- CN1628667A CN1628667A CN 200410075022 CN200410075022A CN1628667A CN 1628667 A CN1628667 A CN 1628667A CN 200410075022 CN200410075022 CN 200410075022 CN 200410075022 A CN200410075022 A CN 200410075022A CN 1628667 A CN1628667 A CN 1628667A
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- dextromethorphan
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- guaifenesin
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Abstract
The invention relates to a compound dried suspension of dextromethorphan and gualfenesin and preparation method, wherein each bag of suspension comprises dextromethorphan 2.5-32.5mg, preferably 5-30mg, guaifenesin 20-400mg, preferably 50-300mg, thickening agent and suspending agent whose total amount is 0.5-7% of prescription amount, preferably 1-5%, 0.5-2%, preferably 1-1.5% of stabilizing agent, 0.1-2%, preferably 0.5-1.5% of surface-active agent, 75-97%, preferably 80-95% of fragrant taste correction agent, the preparation has the advantages of good taste, high medicament dissolving degree, and fitting for children.
Description
Technical field the present invention relates to the compound dried suspension and the method for making thereof of pharmaceutical dextromethorphan and guaifenesin.
The background technology dextromethorphan is an effective antitussive medicine, uses combined therapies such as many and other antipyretic analgesic, expectorant, antihistaminic, vasoconstrictor except that folk prescription and catches a cold.Guaifenesin tool phlegm-dispelling functions with the antitussive effect of dextromethorphan combination can raising dextromethorphan, is applicable to the cough that treatment upper respiratory tract infection, acute bronchitis etc. cause.
The dextromethorphan that has gone on the market at present and the compound preparation dosage form of guaifenesin have syrup, tablet and capsule.Take though syrup is fit to the patient of child and dysphagia, exist and store transportation inconvenience, carry trouble, repeatedly use easy pollution problems, and, influence stability of drug because syrup is a liquid preparation.And often being not suitable for the patient of child and dysphagia, tablet or capsule take.
Summary of the invention the present invention is intended to overcome existing dextromethorphan and Genatuss Syrup agent poor stability, tablet or capsule and is not suitable for the problem that child and dysphagia patien use, kept syrup, tablet and capsule characteristics separately, prepared and be fit to the dextromethorphan of child's application and the compound dried suspension of guaifenesin more.Be characterized in:
(1) stability is better.Because dry suspension is in dry anhydrous state all the time, and packing is tight, avoids contacting with air, thereby more stable than syrup.
(2) though dry suspension is a solid preparation, it adds mixing in water for oral taking that is has formed solution when taking, thus with syrup the same than tablet and capsule good absorbing, rapid-action, bioavailability is high.
(3) suitable crowd is wider.When dry suspension adds mixing in water for oral taking, formed the such as clear as crystal solution of similar syrup, mouthfeel is good, and patient be willing to accept, and is more suitable for taking in infant, child and the patient that swallows inconvenience.
(4) dry suspension is a unit dose package, easy administered in divided doses, and taking dose is accurate, and can repeatedly not take easily as syrup and pollute, and the back residue medicine of recovering is easy to keeping, also can use in the future.
(5) produce, transport, preserve, carry and use more convenient.
The compound dried suspension of dextromethorphan of the present invention and guaifenesin contains active component dextromethorphan hydrobromide and guaifenesin, also contains thickening agent, suspending agent, stabilizing agent, surfactant and fragrant correctives.Characteristics are to adopt special prescription and preparation technology, make that the medicine mouthfeel that makes is good, drug dissolution is high, be more suitable for the child uses.Every bag contains hydrobromic acid dextromethorphan 2.5～32.5mg, is preferably 5～30mg in the prescription; Contain guaifenesin 20～400mg, be preferably 50～300mg.Thickening agent, suspending agent are hyprolose, hypromellose, carmethose, Polyethylene Glycol, polyvinyl alcohol, alginate, pectin, arabic gum, silica sol, xanthan gum, 30 POVIDONE K 30 BP/USP 30 etc., can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～7%, be preferably 1%～5%, can the homodisperse suspendible after being added in the water to guarantee dry suspension.Stabilizing agent can be disodium edetate, ascorbic acid, citric acid etc., can separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～2%, be preferably 1%～1.5%.Surfactant is tween 80, sodium lauryl sulphate, sucrose fatty acid ester, soybean phospholipid, can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.1～2%, be preferably 0.5%～1.5%.The fragrance correctives can be sucrose, glycyrrhetate, steviosin, saccharin sodium, synthetic and natural perfume material, can be separately, also can mix use in varing proportions, total consumption be recipe quantity 75～97%, be preferably 80～95% so that the dry suspension that makes is fragrant and sweet good to eat, patient takes like a shot.
Specific embodiment the present invention can be illustrated with the following examples.
Embodiment 1 prescription:
Dextromethorphan hydrobromide 15g
Guaifenesin 100g
Xanthan gum 14g
Hyprolose 20g
Soybean phospholipid 10g
Ascorbic acid 10g
Fructus Citri tangerinae rafter acid 6g
Glycyrrhetate 10g
Spice 15g
Cane sugar powder 1800g
Make 1000 bags
Preparation method: all supplementary materials are dried to moisture below 1%, are ground into fine powder.Take by weighing each supplementary material fine powder in the prescription, mix homogeneously, packing is promptly.
Embodiment 2 prescriptions:
Dextromethorphan hydrobromide 7.5g
Guaifenesin 50g
Polyethylene Glycol 10g
Alginic acid 8g
Soybean phospholipid 20g
Fructus Citri tangerinae rafter acid 6g
Folium Stevlae Rebaudianae 10g
Spice 15g
Cane sugar powder 1874g
Make 1000 bags
Preparation method: with embodiment 1.
The product that makes by above-mentioned prescription and preparation method meets the prescription of Chinese Pharmacopoeia to suspensoid.
Claims (7)
1, the compound dried suspension of dextromethorphan and guaifenesin and method for making thereof.This dry suspension contains active medicine, thickening agent, suspending agent, stabilizing agent, surfactant and fragrant correctives.Characteristics are to adopt special prescription and preparation technology, make that the medicine mouthfeel that makes is good, drug dissolution is high, be more suitable for the child uses.
2, the compound dried suspension dosage form of described dextromethorphan of claim 1 and guaifenesin, prescription and preparation method thereof.Dextromethorphan is a hydrobromate.
3, every bag of the described dry suspension of claim 1 contains dextromethorphan hydrobromide 2.5～32.5mg, is preferably 5～30mg; Contain guaifenesin 20～400mg, be preferably 50～300mg.
4, the described thickening agent of claim 1, suspending agent are hyprolose, hypromellose, carmethose, Polyethylene Glycol, polyvinyl alcohol, alginate, pectin, arabic gum, silica sol, xanthan gum, 30 POVIDONE K 30 BP/USP 30 etc., can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～7%, be preferably 1%～5%, can the homodisperse suspendible after being added in the water to guarantee dry suspension.
5, the described stabilizing agent of claim 1 can be disodium edetate, ascorbic acid, citric acid etc., can separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～2%, be preferably 1%～1.5%.
6, the described surfactant of claim 1 is tween 80, sodium lauryl sulphate, sucrose fatty acid ester, soybean phospholipid, can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.1～2%, be preferably 0.5%～1.5%.
7, the described fragrant correctives of claim 1 can be sucrose, glycyrrhetate, steviosin, saccharin sodium, synthetic and natural perfume material, can be separately, also can mix use in varing proportions, total consumption be recipe quantity 75～97%, be preferably 80～95%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410075022 CN1628667A (en) | 2004-08-28 | 2004-08-28 | Compound dried suspension of dextromethorphan and gualfenesin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410075022 CN1628667A (en) | 2004-08-28 | 2004-08-28 | Compound dried suspension of dextromethorphan and gualfenesin and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1628667A true CN1628667A (en) | 2005-06-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 200410075022 Pending CN1628667A (en) | 2004-08-28 | 2004-08-28 | Compound dried suspension of dextromethorphan and gualfenesin and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832671A (en) * | 2016-04-13 | 2016-08-10 | 中国药科大学 | Dry suspension for controlled-release of medicine and preparation method of dry suspension |
-
2004
- 2004-08-28 CN CN 200410075022 patent/CN1628667A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105832671A (en) * | 2016-04-13 | 2016-08-10 | 中国药科大学 | Dry suspension for controlled-release of medicine and preparation method of dry suspension |
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