CN105997747A - Sun cream for sensitive skin - Google Patents

Abstract

The invention belongs to the field of cosmetics, and particularly relates to sun cream for sensitive skin. The sun cream for the sensitive skin is characterized by comprising the following raw materials in parts by weight: 30-45 parts of Bama mineral water, 5-8 parts of Caulis Echinopsis Multiplicis extract, 10-15 parts of Folium Pini extract, 1-2 parts of vitamin C, 2-5 parts of vitamin E, 1-3 parts of apigenin, 1-4 parts of acacetin, 2-4 parts of glutathione, 3-5 parts of lycopene, 2-6 parts of glycerol, 2-4 parts of olive oil and 2-5 parts of phenyl phenol. The sun cream for the sensitive skin has the advantages that the natural and non-irritant raw materials without a preservative or sensitization ingredients are selected, UVB and UVA are obstructed effectively, the skin can further be protected against being attacked by free radical, and the sun cream is smooth and anti-irritation, and is particularly suitable for being used as a sunscreen product for highly sensitive skin with poor tolerance.

Description

The sunscreen cream that a kind of sensitivity skin is special

[technical field]

The present invention relates to cosmetic field, particularly to the sunscreen cream that a kind of sensitivity skin is special.

[background technology]

Sensitivity skin is a kind of problem skin, all may have sensitivity skin in any skin quality.Sensitivity skin refers to easily Irriate and cause to a certain degree uncomfortable skin.When change occurs in external environment, and skin cannot be adjusted, and occurs uncomfortable Sensation and allergic phenomena.Aging skin quality, small pox skin quality etc. all may be had just as various skin quality.Easily because of diet, emotion or Cosmetic products used, cause skin surface to be dried, rubescent, play speckle, swelling around the eyes, peel or raw skin sore etc..Sensitive skin Feature: the maximum feature of sensitivity skin is exactly that surface is general red, has burning sensation or sensation of pricking, the most dry but also pain of itching not only, generally occur Occurring using cosmetics or Changes in weather when, in the winter that air drying temp is low, situation is more shown in seriously.If protecting Skin product select misdirection, red swelling of the skin, inflammation etc. more can be caused to infect some people one and wipe cosmetics, just have at once bad instead Should；Some people does not even wipe anything, has untoward reaction yet.It addition, for sense of touch, part sensitivity skin is the most normal Have roughly, the phenomenon of decortication, the most serious situation, it is simply that develop into contact dermatitis or eczema, flow out soup or broken skin.

Sunscreen cream refers to the addition of and can intercept or absorb the sunscreen of ultraviolet and reach to prevent skin by tanned, the cosmetics of sunburn. According to sun-proof principle, sunscreen cream can be divided into physical sunscreen frost, chemical sunscreen frost.Sun-proof articles composition kind in the market Various, but the overwhelming majority all contains preservative, essence and other chemical drugs, and these sun-proof articless all have zest, easily Injury skin, is more not suitable for skin extremely sensitive, poor resistance and uses.

[summary of the invention]

It is an advantage of the invention that natural non-stimulated, the preservative free of selection and the raw material without allergen, effectively intercept UVB and UVA, Skin can also be protected to be less than the invasion and attack of free radical, irritation of releiving, it is particularly suitable as the skin of extremely sensitive and poor resistance Anti-articles for use.

The technical solution adopted in the present invention is: the sunscreen cream that a kind of sensitivity skin is special, and meter by weight includes following former Material: bar horse mineral water 30-45 part, Caulis Echinopsis Multiplicis extract 5-8 part, pine tree leaf extract 10-15 part, vitamin C 1-2 part, Vitamin E2-5 parts, apigenin 1-3 part, acacetin 1-4 part, glutathion 2-4 part, lycopene 3-5 part, glycerol 2-6 part, olive oil 2-4 part and phenyl phenol 2-5 part.

In the present invention, as further illustrating, described Caulis Echinopsis Multiplicis extract is prepared by following method: take Caulis Echinopsis Multiplicis powder 20g Putting in beaker, add the extracting solution of 100mL, soak 5-12h, in 60-85 DEG C of water-bath, hot dipping carries 2-5h, natural cooling After, sucking filtration takes filtrate, and putting in vacuum drying oven at pressure is negative 0.05-0.1MPa, and temperature is dried at being 50-60 DEG C and concentrates 12-24h, then takes out concentrated solution, adds the ethanol solution precipitation that 150mL mass fraction is 60-80%, then at centrifuge With the centrifugation 5-20min of 2000-5000r/min, taking precipitate pure water washs 2 times, is drying with infrared drying oven It is dried 6-12h at 50-70 DEG C, obtains Caulis Echinopsis Multiplicis extract.

In the present invention, as further illustrating, described extracting solution be aqueous solution, mass fraction be 50% ethanol solution, Mass fraction be 20% ethyl acetate solution and acetone soln that mass fraction is 20% in one.

In the present invention, as further illustrating, described pinaster be Pinus massoniana Lamb, Changbai Mountain larch, five-leaved pine, Pinuns densata, One in Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., Pinus densiflora and larch pine, preferably larch pine.

In the present invention, as further illustrating, described pine tree leaf extract is prepared by following method: pulverized by dry and soft leaves, Cross 10 mesh sieves, take 20g and put in 100mL round-bottomed flask, add Extraction solvent pre-soaking 1-3h, hereafter round-bottomed flask is moved Enter in ultrasound reactor, carry out extracting 4-8h at a temperature of the ultrasonic power of 10-30W and 50-80 DEG C, with accurate filter paper Sucking filtration, takes filtrate, and at pressure for bearing 0.05-0.1MPa in vacuum drying oven, temperature is dried at being 50-60 DEG C and concentrates 6-12h, After taking out concentrated solution, put into the ethyl acetate solution that 50-100mL mass fraction is 10-30% at 60-85 DEG C, extract 12-24h, Obtained extract pressure in vacuum drying oven is negative 0.05-0.08MPa, and temperature is dried 6-12h at being 55-65 DEG C, To pine tree leaf extract.

In the present invention, as further illustrating, the preparation method of the sunscreen cream that described a kind of sensitivity skin is special, specifically Step is:

The each raw material of precise, by bar horse mineral water, Caulis Echinopsis Multiplicis extract, pine tree leaf extract, vitamin C, apigenin, Acacetin, glutathion, lycopene and phenyl phenol add in beaker, under 75-95 DEG C of water bath condition, with The speed stirring 30-60min of 200-800r/min, cools to 70 DEG C, is slowly added to vitamin E, glycerol and Fructus Canarii albi while stirring Oil, after stirring 20-30min, puts in vacuum drying oven, is 0.15-0.4MPa at pressure, and temperature is dried at being 50-70 DEG C 6-12h, obtains the sunscreen cream that sensitivity skin is special.

The function introduction of part material is as follows:

Bar horse mineral water is one of mineral water of naturally occurring of minority, containing mineral such as abundant manganese, strontium, metasilicic acid, zinc, selenium Matter and trace element, have aging resistance function.Bar horse mineral water not only Mineral element content enriches, and equalizes, suitably Content and during proportioning, the effect to human body will be more preferable, it is easier to is absorbed by the body.

Pinaster is aiphyllium, and branch is verticillate, and hibernaculum is notable, and perula is most, and imbricate arranges.Long on twig have needle, needle Being raw on the nodular pulvinus of branch and leaf junction, the periphery of every Folium Pini has outside the horny layer and one layer of cured matter that thick layer is thick Film, which reduces the forfeiture of moisture content with pinaster, it is ensured that these species can be survived in the environment of the driest.Cone second Autumn in year is ripe.Timber has Colophonium, and texture is straight or tiltedly, texture is straight or oblique, the moderate exquisiteness of structure, can be used for furniture and makes.

Caulis Echinopsis Multiplicis Caulis Echinopsis Multiplicis is commonly called as grass ball, has another name called long Sheng ball, undercoat ball, for celestial being section perennial many meat herbaceous plant.Stem in Spherical or circular, green, to spend and be born in vertical rib prickly bushes, Caulis Echinopsis Multiplicis is bloomed the most in the morning or dusk, several hours of persistent period By one day.Caulis Echinopsis Multiplicis is natural air freshener, also has attracting dust, purifies the effect of air.It is for the cancer of human body Disease, hypertension, coronary heart disease, pulmonary tuberculosis, gastropathy, diabetes, various hot disease, gynaecopathia etc. all have certain preventing and treating Effect.It can be with efficient solution except the tobacco poisoning in human body, ethanol poison, combustion gas poison, metallic poison and under eating Residues in Vegetables Pesticidal toxin；Make up this blank in the world today's medicinal vegetable history.Thus have " king in dish ", the U.S. of " king in medicine " Claim.

Vitamin E is a kind of fatsoluble vitamin, and its hydrolyzate is tocopherol, is one of topmost antioxidant.It is dissolved in In the organic solvents such as fat and ethanol, water insoluble, heat, acid are stablized, unstable to alkali, sensitive to oxygen, insensitive to heat, But Vitamin E activity substantially reduces time fried.Tocopherol can promote sex hormones secretion, makes man's motility of sperm and quantity increase； Make woman's estrogen concentration increase, improve fertility, prevention of miscarriage, it may also be used for prevent and treat male infertility, burn, freeze The aspects such as wound, capillary hemorrhage, climacteric syndrome, beauty treatment.In the most also finding that vitamin E can suppress ocular lens body Lipid peroxidation reaction, make peripheral vasodilation, improve blood circulation, pre-Anti-myopic eye occurs and development.Vitamin E phenyl ring On phenolic hydroxyl group be acetylation, ester is hydrolyzed to after phenolic hydroxyl group as tocopherol.

Vitamin C, also known as L-AA, is the essential nutrients of High Primates animal and other minorities biologies.Vitamin C Acid can manufacture by metabolism at most organism, but the mankind are the most significantly to make an exception.Be widely known by the people most is scarce Weary vitamin C can cause vitamin C deficiency.In vivo, vitamin C is a kind of antioxidant, and protection health avoids free radical Threatening, vitamin C is also a kind of coenzyme simultaneously.

Apigenin belongs to flavonoid, has the carcinogenic activity of suppression carcinogen；Make the inhibitor of map kinase；Treat various inflammation Disease；Antioxidant；Calm, calm the nerves；Blood pressure lowering.Have compared with other Flavonoid substances (Quercetin, Rhizoma Kaempferiae flavone) low toxicity, Without features such as mutagenicitys.

Acacetin is a kind of natural gum derivative, plays the skin that compacts in the sensitivity formula Firm wrinkle resistant water of wrinkle resistant powder/Firm Effect.

Glutathion is a kind of containing γ-amido link with the tripeptides of sulfydryl, is made up of glutamic acid, cysteine and glycine.It is present in Almost each cell of health.Gluathione Toplink assists in keeping normal immune function, and have antioxidation and Integrate Detoxication, glutathion has wide spectrum Detoxication, cannot be only used for medicine, more can as the base material of functional food, Extensively apply at functional foods such as slow down aging, enhancing immunity, antitumor.

Lycopene is a naturally occurring Carotenoids in fruit and vegetable, and carotenoids material is all important Antioxidant, but lycopene is different from beta-carotene and phylloxanthin in many aspects.Lycopene be human body most common and One of the strongest carotenoid antioxygen agent.

Glycerol is without the sweet clear and bright thick liquid of color and taste.Odorless.There is warm sweet taste.Moisture can be absorbed from air, also can absorb sulfuration Hydrogen, Blausure (German) and sulfur dioxide.It is insoluble in benzene, chloroform, carbon tetrachloride, Carbon bisulfide, petroleum ether and oils.Relative density 1.26362.Fusing point 17.8 DEG C.Boiling point 290.0 DEG C.Index of refraction 1.4746.Flash-point 176 DEG C, has acute toxicity.

Olive oil is by the fresh direct cold pressing of Fructus oleae europaeae fruit, the most heated and chemical treatment, remains natural nutrition Composition, olive oil is considered as the oils and fats being best suitable for human nutrition in the oils and fats found so far.

Phenyl phenol is again 2-phenyl phenol, phenyl phenol, ethylene glycol monophenyl ether, ethylene glycol phenyl ether etc., as acetic acid The solvent of cellulose, resin, dyestuff and ink, is also used for synthesizing plasticizer, antibacterial, spice and medicine etc..

The method have the advantages that

1. the extract from pine needles employed in the present invention contains natural polyphenol, containing the desensitization factor, can suppress the work of histamine deshydroxy enzyme Property, block the source of release of activator, the generation of suppression histamine, stop body that reaction source produces anaphylaxis, Folium Pini simultaneously Extract can find anaphylactogen by targeting automatically, repairs impaired basophilic leukocyte and mastocyte, recovers body function, improve allergy Body constitution, improves cell viability；Meanwhile, Caulis Echinopsis Multiplicis extract can regulate anti-recurrence immune factor, can make allergy damaged part Gradually recover normal；Bar horse mineral water contains abundant trace element and mineral, silicon dioxide that wherein content is higher, calcium and magnesium Ion can resist free valency, skin of releiving, and strengthens skin toleration, desensitising；This three acts on jointly, makes sensitivity The sensitivity of property skin is well improved.

2. the selenium element all contained in the pine tree leaf extract in the present invention and Ba Ma mineral water interacts with vitamin E, jointly Free radical in antagonist, thus reach antioxidation, strengthen passive protective physical fitness immunity, enhance metabolism, just recovering health Often physiological function.

3. the flavone in the anthocyanidin in the pine tree leaf extract in the present invention, flavone and Caulis Echinopsis Multiplicis extract all has uv-resistant work Property, protecting cells from UV-induced intracellular DNA damage, after suppression uv light exposure, collagen is degenerated；In olive oil Oleuropein reduces Cells Induced by Reactive Oxygen Species DNA damage, prevents the generation of skin carcinoma, and both synergism improves uvioresistant The ability of radiation.

[detailed description of the invention]

Embodiment 1:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adds the aqueous solution of 100mL, soaks 5h, In 60 DEG C of water-baths, hot dipping carries 5h, and after natural cooling, sucking filtration takes filtrate, and putting in vacuum drying oven at pressure is negative 0.05MPa, Temperature is dried at being 50-60 DEG C and concentrates 12h, is then taken out by concentrated solution, and adding 150mL mass fraction is the ethanol solution of 60% Precipitation, then at centrifuge with the centrifugation 20min of 2000r/min, taking precipitate pure water washs 2 times, with infrared Drying baker is dried 12h at drying 50 DEG C, obtains Caulis Echinopsis Multiplicis extract.

The preparation of pine tree leaf extract: pulverized by dry Pinus massoniana Lamb leaves, crosses 10 mesh sieves, takes 20g and put in 100mL round-bottomed flask, Add Extraction solvent pre-soaking 1h, hereafter round-bottomed flask is moved in ultrasound reactor, at the ultrasonic power and 50 of 10W Carry out at a temperature of DEG C extracting 8h, with accurate filter paper sucking filtration, take filtrate, at pressure for bearing 0.05MPa in vacuum drying oven, Temperature is to be dried at 50 DEG C to concentrate 12h, takes out after concentrated solution, puts into ethyl acetate solution that 50mL mass fraction is 30% 60 Extracting 24h at DEG C, obtained extract pressure in vacuum drying oven is negative 0.05MPa, and temperature is to be dried 12h at 55 DEG C, Obtain pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 30g bar horse mineral water, 5g Caulis Echinopsis Multiplicis extract, 10g pine tree leaf extract, 1g vitamin C, 2g apigenin, 1g acacetin, 2g glutathion, 3g Lycopene and 2g phenyl phenol add in beaker, under 75 DEG C of water bath condition, stir 60min with the speed of 200r/min, Cool to 70 DEG C, be slowly added to 2g vitamin E, 2g glycerol and 2g olive oil while stirring, after stirring 20min, put into true In empty drying baker, being 0.15MPa at pressure, temperature is to be dried 12h at 50 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Embodiment 2:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adding 100mL mass fraction is the ethanol of 50% Solution, soak 7h, in 65 DEG C of water-baths, hot dipping carries 3h, and after natural cooling, sucking filtration takes filtrate, put in vacuum drying oven Pressure is negative 0.06MPa, and temperature is to be dried at 52 DEG C to concentrate 14h, is then taken out by concentrated solution, adds 150mL mass fraction It is the ethanol solution precipitation of 65%, then at centrifuge with the centrifugation 18min of 2500r/min, the pure washing of taking precipitate Wash 2 times, at drying 55 DEG C, be dried 10h with infrared drying oven, obtain Caulis Echinopsis Multiplicis extract.

The preparation of pine tree leaf extract: pulverized by dry Changbai Mountain larch leaves, crosses 10 mesh sieves, takes 20g and put into 100mL round bottom In flask, add Extraction solvent pre-soaking 2h, hereafter round-bottomed flask is moved in ultrasound reactor, in the ultrasound wave merit of 15W Carry out at a temperature of rate and 55 DEG C extracting 7h, with accurate filter paper sucking filtration, take filtrate, be negative at pressure in vacuum drying oven 0.07MPa, temperature is to be dried at 52 DEG C to concentrate 10h, after taking out concentrated solution, puts into the acetic acid second that 60mL mass fraction is 15% Ester solution extracts 22h at 65 DEG C, and obtained extract pressure in vacuum drying oven is negative 0.06MPa, and temperature is 57 DEG C Under be dried 10h, obtain pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 33g bar horse mineral water, 6g Caulis Echinopsis Multiplicis extract, 11g pine tree leaf extract, 2g vitamin C, 2g apigenin, 1g acacetin, 3g glutathion, 4g Lycopene and 3g phenyl phenol add in beaker, under 80 DEG C of water bath condition, stir 50min with the speed of 350r/min, Cool to 70 DEG C, be slowly added to 3g vitamin E, 3g glycerol and 2g olive oil while stirring, after stirring 22min, put into true In empty drying baker, being 0.18MPa at pressure, temperature is to be dried 10h at 55 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Embodiment 3:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adding 100mL mass fraction is the acetic acid of 20% Ethyl ester solution, soaks 8h, and in 70 DEG C of water-baths, hot dipping carries 3h, and after natural cooling, sucking filtration takes filtrate, puts into vacuum drying oven In be negative 0.08MPa at pressure, temperature is to be dried at 54 DEG C to concentrate 18h, is then taken out by concentrated solution, adds 150mL mass Number is the ethanol solution precipitation of 70%, and then at centrifuge with the centrifugation 12min of 3000r/min, taking precipitate is with pure Water washs 2 times, is dried 8h with infrared drying oven, obtains Caulis Echinopsis Multiplicis extract at drying 60 DEG C.

The preparation of pine tree leaf extract: pulverized by dry five-leaved pine leaves, crosses 10 mesh sieves, takes 20g and put in 100mL round-bottomed flask, Add Extraction solvent pre-soaking 1h, hereafter round-bottomed flask is moved in ultrasound reactor, at the ultrasonic power and 60 of 20W Carry out at a temperature of DEG C extracting 7h, with accurate filter paper sucking filtration, take filtrate, at pressure for bearing 0.08MPa in vacuum drying oven, Temperature is to be dried at 55 DEG C to concentrate 10h, takes out after concentrated solution, puts into ethyl acetate solution that 70mL mass fraction is 18% 72 Extracting 20h at DEG C, obtained extract pressure in vacuum drying oven is negative 0.06MPa, and temperature is to be dried 8h at 60 DEG C, Obtain pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 38g bar horse mineral water, 7g Caulis Echinopsis Multiplicis extract, 12g pine tree leaf extract, 2g vitamin C, 1g apigenin, 3g acacetin, 4g glutathion, 5g Lycopene and 3g phenyl phenol add in beaker, under 82 DEG C of water bath condition, stir 45min with the speed of 500r/min, Cool to 70 DEG C, be slowly added to 3g vitamin E, 2g glycerol and 3g olive oil while stirring, after stirring 25min, put into true In empty drying baker, being 0.25MPa at pressure, temperature is to be dried 8h at 60 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Embodiment 4:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adding 100mL mass fraction is the acetone of 20% Solution, soak 9h, in 75 DEG C of water-baths, hot dipping carries 4h, and after natural cooling, sucking filtration takes filtrate, put in vacuum drying oven Pressure is negative 0.08MPa, and temperature is to be dried at 57 DEG C to concentrate 18h, is then taken out by concentrated solution, adds 150mL mass fraction It is the ethanol solution precipitation of 70%, then at centrifuge with the centrifugation 10min of 3500r/min, the pure washing of taking precipitate Wash 2 times, at drying 62 DEG C, be dried 9h with infrared drying oven, obtain Caulis Echinopsis Multiplicis extract.

The preparation of pine tree leaf extract: pulverized by dry Pinuns densata leaves, crosses 10 mesh sieves, takes 20g and put in 100mL round-bottomed flask, Add Extraction solvent pre-soaking 2h, hereafter round-bottomed flask is moved in ultrasound reactor, at the ultrasonic power and 70 of 23W Carry out at a temperature of DEG C extracting 7h, with accurate filter paper sucking filtration, take filtrate, at pressure for bearing 0.09MPa in vacuum drying oven, Temperature is to be dried at 57 DEG C to concentrate 9h, takes out after concentrated solution, puts into ethyl acetate solution that 80mL mass fraction is 25% 80 Extracting 16h at DEG C, obtained extract pressure in vacuum drying oven is negative 0.07MPa, and temperature is to be dried 8h at 61 DEG C, Obtain pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 40g bar horse mineral water, 7g Caulis Echinopsis Multiplicis extract, 13g pine tree leaf extract, 1g vitamin C, 3g apigenin, 4g acacetin, 4g glutathion, 3g Lycopene and 4g phenyl phenol add in beaker, under 87 DEG C of water bath condition, stir 40min with the speed of 600r/min, Cool to 70 DEG C, be slowly added to 4g vitamin E, 5g glycerol and 3g olive oil while stirring, after stirring 27min, put into true In empty drying baker, being 0.3MPa at pressure, temperature is to be dried 8h at 65 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Embodiment 5:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adding 100mL mass fraction is the ethanol of 50% Solution, soak 10h, in 82 DEG C of water-baths, hot dipping carries 2h, and after natural cooling, sucking filtration takes filtrate, put in vacuum drying oven Pressure is negative 0.09MPa, and temperature is to be dried at 58 DEG C to concentrate 14h, is then taken out by concentrated solution, adds 150mL mass fraction It is the ethanol solution precipitation of 75%, then at centrifuge with the centrifugation 8min of 4000r/min, the pure washing of taking precipitate Wash 2 times, at drying 68 DEG C, be dried 8h with infrared drying oven, obtain Caulis Echinopsis Multiplicis extract.

The preparation of pine tree leaf extract: pulverized by dry Pinus densiflora leaves, crosses 10 mesh sieves, takes 20g and put in 100mL round-bottomed flask, add Enter Extraction solvent pre-soaking 3h, hereafter round-bottomed flask is moved in ultrasound reactor, the ultrasonic power of 28W and 78 DEG C At a temperature of carry out extracting 7h, with accurate filter paper sucking filtration, take filtrate, be negative 0.09MPa, temperature at pressure in vacuum drying oven It is to be dried at 59 DEG C to concentrate 6h, takes out after concentrated solution, put into ethyl acetate solution that 90mL mass fraction is 28% at 82 DEG C Extraction 12h, obtained extract pressure in vacuum drying oven is negative 0.08MPa, and temperature is to be dried 8h at 62 DEG C, obtains Pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 42g bar horse mineral water, 7g Caulis Echinopsis Multiplicis extract, 13g pine tree leaf extract, 2g vitamin C, 3g apigenin, 4g acacetin, 4g glutathion, 5g Lycopene and 4g phenyl phenol add in beaker, under 90 DEG C of water bath condition, stir 35min with the speed of 700r/min, Cool to 70 DEG C, be slowly added to 4g vitamin E, 6g glycerol and 4g olive oil while stirring, after stirring 28min, put into true In empty drying baker, being 0.35MPa at pressure, temperature is to be dried 7h at 68 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Embodiment 6:

(1) preparation of raw material:

The preparation of Caulis Echinopsis Multiplicis extract: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, adds 100mL aqueous solution, soaks 12h, In 85 DEG C of water-baths, hot dipping carries 2h, and after natural cooling, sucking filtration takes filtrate, and putting in vacuum drying oven at pressure is negative 0.1MPa, temperature Degree is to be dried at 60 DEG C to concentrate 12h, is then taken out by concentrated solution, adds the ethanol solution precipitation that 150mL mass fraction is 80%, Then at centrifuge with the centrifugation 5min of 5000r/min, taking precipitate pure water washs 2 times, exists with infrared drying oven It is dried 6h at drying 70 DEG C, obtains Caulis Echinopsis Multiplicis extract.

The preparation of pine tree leaf extract: pulverized by dry larch pine leaves, crosses 10 mesh sieves, takes 20g and put into 100mL round-bottomed flask In, add Extraction solvent pre-soaking 3h, hereafter round-bottomed flask is moved in ultrasound reactor, 30W ultrasonic power and Carry out at a temperature of 80 DEG C extracting 4h, with accurate filter paper sucking filtration, take filtrate, at pressure for bearing 0.1MPa in vacuum drying oven, Temperature is to be dried at 60 DEG C to concentrate 6h, takes out after concentrated solution, puts into ethyl acetate solution that 100mL mass fraction is 30% 85 Extracting 12h at DEG C, obtained extract pressure in vacuum drying oven is negative 0.08MPa, and temperature is to be dried 6h at 65 DEG C, Obtain pine tree leaf extract.

(2) preparation method of the sunscreen cream that sensitivity skin is special: each raw material of precise, by 45g bar horse mineral water, 8g Caulis Echinopsis Multiplicis extract, 15g pine tree leaf extract, 1g vitamin C, 1g apigenin, 2g acacetin, 4g glutathion, 4g Lycopene and 5g phenyl phenol add in beaker, under 95 DEG C of water bath condition, stir 60min with the speed of 800r/min, Cool to 70 DEG C, be slowly added to 5g vitamin E, 5g glycerol and 4g olive oil while stirring, after stirring 30min, put into true In empty drying baker, being 0.4MPa at pressure, temperature is to be dried 6h at 70 DEG C, obtains the sunscreen cream that sensitivity skin is special.

Comparative example 1:

By common sunscreen frost, it is not added with the embodiment of bar horse mineral water, is not added with the embodiment of Caulis Echinopsis Multiplicis extract, is not added with pine Embodiment and embodiment 1-6 of leaf extract carry out absorbance detection, hyalomitome at ultraviolet spectrophotometer at 270-350nm Acid enzyme body outer suppressioning test, human body patch test, erythrocyte hemolytic test and to the shadow of guinea pig skin pruritus caused by histamine phosphate The test rung, the results are shown in Table 1.

Table 1:

The result of table 1 shows: absorbance is the highest, illustrates that the ability of the ultra-violet radiation resisting of sample is the strongest；Absorbance is from high to low Arrangement: embodiment 6 > embodiment 5 > embodiment 2 > embodiment 3 > embodiment 4 > embodiment 1 > it is not added with the enforcement of pine tree leaf extract Example > it is not added with the embodiment of Caulis Echinopsis Multiplicis extract > it is not added with the embodiment of bar horse mineral water > common sunscreen frost；

Hyaluronidase extracorporeal inhibiting rate is the highest, illustrates that the antiallergic effect of sample is strong；Hyaluronidase extracorporeal inhibiting rate is from high to low Arrangement: embodiment 3=embodiment 4=embodiment 5=embodiment 6 > embodiment 2 > embodiment 1 > it is not added with the enforcement of Caulis Echinopsis Multiplicis extract Example > it is not added with the embodiment of bar horse mineral water > it is not added with the embodiment of pine tree leaf extract > common sunscreen frost；

Patch test negative rate is the highest, illustrates that sample reduces for the stimulation degree in ectogenic sensitive source, and the toleration of skin carries High；Patch test negative rate arranges from high to low: embodiment 6 > embodiment 5 > embodiment 2 > embodiment 3 > embodiment 4 > embodiment 1 > embodiment of pine tree leaf extract it is not added with > it is not added with the embodiment of Caulis Echinopsis Multiplicis extract > it is not added with the embodiment of bar horse mineral water > common sunscreen frost；

Erythrocyte hemolysis rate is the lowest, illustrates that hemocyte injuries is the fewest, and the damage to skin is the least, the sensitization of sample The least, safety is the highest；Erythrocyte hemolysis rate arranges from low to high: embodiment 6 < embodiment 5 < embodiment 2 < embodiment 3 < < < embodiment being not added with bar horse mineral water < is not added with celestial being to be not added with the embodiment of pine tree leaf extract for embodiment 4 < embodiment 1 Embodiment < the common sunscreen frost of ball extract；

The highest to the itch-threshold of guinea pig skin pruritus caused by histamine phosphate, illustrate that the number of times of pruritus is the fewest, also illustrate that skin simultaneously Sensitivity reduce, toleration improve；The itch-threshold of guinea pig skin pruritus caused by histamine phosphate is arranged from high to low: embodiment 6 > embodiment 5 > embodiment 2 > embodiment 3 > embodiment 4 > embodiment 1 > it is not added with the embodiment of Caulis Echinopsis Multiplicis extract > it is not added with bar The embodiment of horse mineral water extract > it is not added with the embodiment of pine tree leaf extract > common sunscreen frost.

Described above is the detailed description for the preferable possible embodiments of the present invention, but embodiment is not limited to the special of the present invention Profit application range, the equal change completed under the technical spirit suggested by all present invention or modification change, the present invention all should be belonged to Contained the scope of the claims.

Claims (6)

1. the sunscreen cream that a sensitivity skin is special, it is characterised in that: meter by weight includes following raw material: Ba Makuang Spring water 30-45 part, Caulis Echinopsis Multiplicis extract 5-8 part, pine tree leaf extract 10-15 part, vitamin C 1-2 part, vitamin E2-5 Part, apigenin 1-3 part, acacetin 1-4 part, glutathion 2-4 part, lycopene 3-5 part, glycerol 2-6 part, Fructus Canarii albi Oil 2-4 part and phenyl phenol 2-5 part.

The sunscreen cream that a kind of sensitivity skin the most according to claim 1 is special, it is characterised in that: described Caulis Echinopsis Multiplicis carries Take thing to be prepared by following method: take Caulis Echinopsis Multiplicis powder 20g and put in beaker, add the extracting solution of 100mL, soak 5-12h, In 60-85 DEG C of water-bath, hot dipping carries 2-5h, and after natural cooling, sucking filtration takes filtrate, and it is negative for putting in vacuum drying oven at pressure 0.05-0.1MPa, temperature is dried at being 50-60 DEG C and concentrates 12-24h, then taken out by concentrated solution, add 150mL mass fraction Ethanol solution for 60-80% precipitates, then at centrifuge with the centrifugation 5-20min of 2000-5000r/min, taking precipitate Wash 2 times with pure water, at drying 50-70 DEG C, be dried 6-12h with infrared drying oven, obtain Caulis Echinopsis Multiplicis extract.

The sunscreen cream that a kind of sensitivity skin the most according to claim 2 is special, it is characterised in that: described extracting solution is Aqueous solution, mass fraction be 50% ethanol solution, mass fraction be 20% ethyl acetate solution and mass fraction be the third of 20% One in ketone solution.

The sunscreen cream that a kind of sensitivity skin the most according to claim 1 is special, it is characterised in that: described pinaster is horse One in tail pine, Changbai Mountain larch, five-leaved pine, Pinuns densata, Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., Pinus densiflora and larch pine.

The sunscreen cream that a kind of sensitivity skin the most according to claim 1 is special, it is characterised in that: described Folium Pini carries Taking thing to be prepared by following method: pulverized by dry and soft leaves, cross 10 mesh sieves, take 20g and put in 100mL round-bottomed flask, addition carries Take solvent pre-soaking 1-3h, hereafter round-bottomed flask is moved in ultrasound reactor, at ultrasonic power and the 50-80 of 10-30W Carry out at a temperature of DEG C extracting 4-8h, with accurate filter paper sucking filtration, take filtrate, be negative at pressure in vacuum drying oven 0.05-0.1MPa, temperature is dried at being 50-60 DEG C and concentrates 6-12h, and after taking out concentrated solution, putting into 50-100mL mass fraction is The ethyl acetate solution of 10-30% extracts 12-24h at 60-85 DEG C, and obtained extract pressure in vacuum drying oven is negative 0.05-0.08MPa, temperature is dried 6-12h at being 55-65 DEG C, obtains pine tree leaf extract.

6. according to the preparation method of the special sunscreen cream of a kind of sensitivity skin described in claim 1-5 any one, its feature It is: concretely comprise the following steps:

The each raw material of precise, by bar horse mineral water, Caulis Echinopsis Multiplicis extract, pine tree leaf extract, vitamin C, apigenin, Acacetin, glutathion, lycopene and phenyl phenol add in beaker, under 75-95 DEG C of water bath condition, with The speed stirring 30-60min of 200-800r/min, cools to 70 DEG C, is slowly added to vitamin E, glycerol and Fructus Canarii albi while stirring Oil, after stirring 20-30min, puts in vacuum drying oven, is 0.15-0.4MPa at pressure, and temperature is dried at being 50-70 DEG C 6-12h, obtains the sunscreen cream that sensitivity skin is special.