CN105997689A - Dendrobium officinale cream and preparation method thereof - Google Patents

Abstract

The invention discloses dendrobium officinale cream and a preparation method thereof. The preparation method can maintain effective ingredient in the dendrobium officinale. The dendrobium officinale cream is prepared from 8-10 parts by weight of filtered dendrobium officinale extract. The preparation method comprises the following steps: (1) performing cleaning and sterilization pre-treatment; (2) soaking, namely putting dendrobium officinale and a wax-coat-removed microorganism strain into deionized water, stirring and soaking for 10-30 days; (3) filtering; (4) decolorizing, namely, adding activated carbon to decolorize dendrobium officinale filtrate, and filtering to obtain a dendrobium officinale extract; (5) grinding, namely grinding the dendrobium officinale extract and the filtered dendrobium officinale with a homogenizer to obtain a dendrobium officinale extract liquor; and (6) filtering to obtain the filtered dendrobium officinale extract liquor. According to the preparation method, dendrobium officinale serving as a raw material is decolorized and extracted at low temperature, so that the achievement of medicinal effect is prevented from being influenced by the dark color of traditional Chinese medicinal materials, and the effective ingredients of dendrobium officinale can be well maintained.

Description

A kind of Herba Dendrobii emollient cream and preparation method thereof

Technical field

The present invention relates to a kind of emollient cream and preparation method thereof, belong to medicinal plants manufacture field, particularly relate to a kind of ferrum Skin Herba Dendrobii emollient cream and preparation method thereof.

Background technology

Herba Dendrobii is the new of orchid Herba Dendrobii (Dendrobium officinale Kimura et Migo) Fresh stem, belongs to national conservative plant, has health preserving and the medical value of preciousness.Herba Dendrobii obtains because its epidermis is ferrum green Name, successive dynasties Chinese medicine ancient books and records are the most on the books, the classics such as comprehensive Shennong's Herbal, Compendium of Material Medica, " detailed outline is picked up any lost article from the road " and " not Lu " The works discussion to Herba Dendrobii, its primary efficacy is reinforcing YIN-essence benefit essence, clearing away heat and promoting production of body fluid, can tonifying five ZANG-organs asthenia, thick the intestines and stomach, strong muscle Bone, arresting convulsion of calming the nerves, make light of one's life by commiting suicide and prolong life.Taoism regimen classical works " Taoist Scriptures " by Herba Dendrobii, Herba Saussureae Involueratae, three double Radix Ginsengs, The hundred vicennial Radixs Polygoni Multiflori, Fu desert (Poria and Herba Cistanches), remote mountains Ganoderma, seabed Margarita and the Cordyceps of cycle of sixty years are also referred to as China nine Big Herba mesonae chinensis, Herba Dendrobii ranks first.Herba Dendrobii nature and flavor: sweet, are slightly cold, and enter stomach, kidney channel;Property belong to clear and rich, clear in have benefit, invigorating middle warmer Have clear.

Herba Dendrobii also has external efficacy, and modern scientific research shows, Herba Dendrobii is rich in polysaccharide, dendrobine, free Aminoacid, vitamin (vitamin A, vitamin C, vitamin E), chlorophyll and various mould, not only by oral absorption, Herba Dendrobii can also stop blooding, promote wound healing, can be used for outward repairing damaged skin.

Dendrobium officinale polysaccharide has antibacterial, anti-inflammatory effect, the function of enhancing Cell-mediated Immunity, external can resist dirt hide from, The infringement to skin such as antibacterial;Dendrobium officinale polysaccharide external can be stopped blooding, and can promote the growth of skin fiber albumen, thus promotees Enter wound healing, repair damaged skin tissue.Free amino acid can provide skin immune function controlling, regulates moisture, soda acid, equilibrium oil Fat, has the antiallergic ability improving sensitive skin, prevents the generation of wrinkle；Activate Skin Cell superoxide dismutase peroxidating The activity of thing, dispels the free radical that Skin Cell is superfluous, effective delay skin aging；The phagocytic function of activating macrophage, increases Strong lymphoid toxin expelling, function of detoxification, effectively block the extraneous harmful substance infringement to skin；Improve resisting skin allergy energy Power, and internal harmful substance and aged cells are decomposed excretion etc..

Also have now and be applied to the effective ingredient in Herba Dendrobii on skin record, if open mouth is 2013 08 month 14 Mouthful, in the Chinese patent of Publication No. CN103239471A, disclosing a kind of skin moistening external preparation, this skin moistening external preparation is by having Effect composition and medically acceptable adjuvant composition, described effective ingredient be molecular weight be that the Herba Dendrobii of 85-90KDa is many Sugar, with only the polysaccharide in Herba Dendrobii, and the utilization rate of Herba Dendrobii is low, during additionally, extract polysaccharide from Herba Dendrobii, Have employed decoction extract, supersound extraction and enzymolysis and extraction these three method at 50 DEG C, these extracting method are for Herba Dendrobii The destruction of the effective ingredient such as vitamin, aminoacid, organized enzyme is the most serious.

The most generally using the method decocted to extract the effective ingredient in Herba Dendrobii, traditional decoction extracting method can be led Causing the destruction of the effective ingredient such as polysaccharide, vitamin, aminoacid, organized enzyme in Herba Dendrobii, polysaccharide, dimension in products obtained therefrom are raw Element, chlorophyll, free amino acid equal size are relatively low, greatly reduce the utilization rate of Herba Dendrobii.Currently there are no one can Retain Herba Dendrobii emollient cream of effective ingredient and preparation method thereof in Herba Dendrobii.

First Herba Dendrobii is clayed into power it addition, also have, the preparation method being then added in the substrate of skin care item, this Although method can retain the effective ingredient of Herba Dendrobii, but owing to Herba Dendrobii Chinese medicine color is deep, for not affecting skin care item Outward appearance, manufacturer the most only adds the most a small amount of Herba Dendrobii, causes the skin-care effect of Herba Dendrobii to be had a greatly reduced quality.

Summary of the invention

For solving above-mentioned technical problem, the technical solution used in the present invention is:

A kind of Herba Dendrobii emollient cream, this Herba Dendrobii emollient cream includes that the raw material of following parts by weight is 45. 0～55.0 parts Water；Herba Dendrobii extract after the filtration of 8.0～10.0 parts；0.18～0.22 part of allantoin；The glucose of 5.0～7.0 parts； The olive oil spermaceti alcohol ester of 3.2～5.2 parts and the mixture of olive oil Pyrusussuriensis alcohol ester；The glycerol of 2.0～4.0 parts；2.0～4.0 Part butanediol；The Flos Rosae Rugosae quintessence oil of 0.2～0.3 part；0.09～0.11 part of hyaluronic acid；The cetearyl alcohol of 2.0～3.0 parts gathers Ether-6 and the mixture of olive oil acid esters；The polydimethylsiloxane of 0.8～1.2 part；1.2～1.8 parts of plant sterol esters；0.2 ～the IPBC of 0.4 part and dimethyloldimethylhydantoin.

A kind of Herba Dendrobii emollient cream, the preparation method of described Herba Dendrobii extract comprises the following steps:

(1) pretreatment: root and the stipes of fresh Herba Dendrobii are cleaned sterilization processing；

(2) soak: Herba Dendrobii is put in deionized water, and add the microorganism fungus kind sloughing wax coat, stir, leaching Steep 10～30 days, in the pigmentolysis of Herba Dendrobii to water；

(3) filter: appeal soak is filtered, obtains Herba Dendrobii and Herba Dendrobii filtrate；

(4) decolouring: activated carbon is added above-mentioned steps (3) Herba Dendrobii filtrate, stirring, decolouring, filter acquisition Herba Dendrobii and carry Take liquid；

(5) grinding step: the Herba Dendrobii after temperature 2～the Herba Dendrobii extracting solution of 10 DEG C and filtration is placed in homogenizer, Herba Dendrobii is 1:4～1:9 with the weight ratio of Herba Dendrobii extracting solution, starts homogenizer and controls discharge fineness 200～300 Below m, obtains Herba Dendrobii extract；

(6) filter progress: thick Herba Dendrobii extract is filtrated to get the Herba Dendrobii extract after filtration.

Preferably technical scheme is: above-mentioned Herba Dendrobii emollient cream, described in slough the microorganism fungus kind of wax coat be hydrocarbon oxygen Change bacterium be pseudomonas (Pseudomonas), acinetobacter calcoaceticus (Acinetobacter), sporeformer (Bacillus), bud pole Bacterium (Geobacillus), vibrio (Vibrionaceae), micrococcus luteus (Micrococcus) or arthrobacterium (Arthrobacter) Deng.

In patent of the present invention, further, the microorganism fungus kind quality sloughing wax coat described in accounts for Herba Dendrobii quality 0.05～0.5%.

In patent of the present invention, further, described quality of activated carbon accounts for the 1～3% of Herba Dendrobii filtrate quality.

In patent of the present invention, further, in described step (6), filtration includes coarse filtration step and fine straining step；Described slightly Filter uses 100 mesh nylon filtering cloths to soak filtration；Described fine straining step uses high speed tube centrifuge, and rotating speed is 15000r/min.

A kind of Herba Dendrobii emollient cream preparation method, this preparation method comprises the following steps:

Olive oil spermaceti alcohol ester and the mixture of olive oil Pyrusussuriensis alcohol ester, glycerol, butanediol, the cetearyl alcohol of formula ratio are gathered Ether-6 and the mixture of olive oil acid esters, polydimethylsiloxane, plant sterol ester admixture are heated to 85 DEG C of sterilizings, it is thus achieved that oil Phase；The allantoin of formula ratio, glucose, hyaluronic acid are added to the water, are heated with stirring to 90～100 DEG C, be cooled to 85 DEG C, Obtain aqueous phase；Oil phase is added to stirring and emulsifying in aqueous phase and obtains base material；When dropping to 40～45 DEG C at a temperature of base material, after filtering Herba Dendrobii extract, IPBC and dihydroxymethyl dimethyl second in phthalein urea be added in base material, Stirring, then carry out emulsifying 5min with homogenizer, add Flos Rosae Rugosae quintessence oil, stir, stand cooling and become cream in 12-24 hour, Stop stirring, cooling, obtain Herba Dendrobii emollient cream.

In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:

1, Herba Dendrobii is soaked by the present invention, it is thus achieved that Herba Dendrobii filtrate and Herba Dendrobii, and merges milled processed, This preparation method remains the effective ingredient of Herba Dendrobii as far as possible, extracts with iron-sheet dendrobe fresh product for raw material, effectively Composition is difficult to be destroyed, polysaccharide, vitamin, chlorophyll, free amino acid equal size height in products obtained therefrom；

2, the present invention uses hydrocarbon oxidation bacteria microorganism, decomposes the wax coat on Herba Dendrobii surface, makes Herba Dendrobii and water fully connect Touch, make effective ingredient rapid dispersion in Herba Dendrobii in water；

3, Herba Dendrobii is carried out by the present invention soak operation, by Herba Dendrobii pigment, polysaccharide, dendrobine, aminoacid maximum journey Degree extracts, damage；Use activated carbon that Herba Dendrobii filtrate is decoloured, it is to avoid Chinese medicine color is the deepest simultaneously, Affect the performance of drug effect, it is to avoid affect the using effect of emollient cream；

4, Herba Dendrobii of the present invention profit protects the scientific formulation, rationally of frost, can produce cooperative effect, it is possible to more efficient between composition Given play to effect of polysaccharide, chlorophyll, vitamin and protein in Herba Dendrobii extract, and advantageously in skin absorption Polysaccharide, chlorophyll, vitamin and protein in Herba Dendrobii extract.

Owing to current Herba Dendrobii product is many to take orally, the Herba Dendrobii profit in the present invention is protected frost and has been expanded iron sheet stone The application of dry measure used in former times, substantially more plays it and is worth.

Detailed description of the invention

Below by embodiment, the present invention is described in further detail, the following is embodiment explanation of the invention and The invention is not limited in following example.

Herba Dendrobii emollient cream is joined: 45.0～55.0 parts of water；Herba Dendrobii extract after the filtration of 8.0～10.0 parts； 0.18～0.22 part of allantoin；The glucose of 5.0～7.0 parts；The olive oil spermaceti alcohol ester of 3.2～5.2 parts and olive oil Pyrusussuriensis The mixture of alcohol ester；The glycerol of 2.0～4.0 parts；2.0～4.0 parts of butanediols；The Flos Rosae Rugosae quintessence oil of 0.2～0.3 part；0.09～ 0.11 part of hyaluronic acid；The ceteareth-6 of 2.0～3.0 parts and the mixture of olive oil acid esters；0.8～1.2 part Polydimethylsiloxane；1.2～1.8 parts of plant sterol esters；The IPBC of 0.2～0.4 part and two Methylol dimethyl hydantion.

Embodiment 1.

(1) sterilization processing is cleaned: root and the stipes of fresh Herba Dendrobii are rinsed 3 times with tap water, rush with pure water Wash 2 times, with warm water " quenches " 3～5min, be cut into the segment of 0.5～1.5cm；

(2) soak: the Herba Dendrobii after sterilization is put in deionized water, and adds the microorganism fungus kind vacation list sloughing wax coat Born of the same parents bacterium, stirs, and soaks 10 days, in the pigmentolysis of Herba Dendrobii to water；

(3) filter: appeal soak is filtered, obtains Herba Dendrobii and Herba Dendrobii filtrate:

(4) decolouring: activated carbon is added above-mentioned steps (3) Herba Dendrobii filtrate, decolouring, filter and obtain Herba Dendrobii extracting solution, Put into refrigerator freezing；

(5) grinding step: Herba Dendrobii extracting solution that temperature is 2 DEG C and the Herba Dendrobii after filtering are placed in homogenizer, ferrum The weight ratio of skin Herba Dendrobii and Herba Dendrobii extracting solution is 1:4, starts homogenizer and controls discharge fineness at 200～300 below m, Obtain Herba Dendrobii extract；

(6) filter progress: soaked by l00 mesh nylon filtering cloth, is folded in 2 layers of funnel being laid in vacuum filtration, and edge is placed in Outside funnel, open vacuum filtration machine, then Herba Dendrobii superfine grinding liquid poured in funnel, filter to liquid medicine storage tank, Filtering residue thickness reaches cleaning when 0.5～lcm and once, collects filtering residue otherwise utilized；

Fine straining: start high speed tube centrifuge (rotating speed is 15000r/min) and peristaltic pump, set the rotating speed of peristaltic pump as 150～ 250r/min, by feed pipe to coarse filtration liquid, starts centrifugal filtration to new liquid medicine storage tank.Every centrifugal filtration 200～300L Cleaning filtering residue once, is collected by filtration filtering residue, merges with the filtering residue obtained in coarse filtration, otherwise utilized.The filter obtained after fine straining Liquid is the Herba Dendrobii extract after filtering；

(7) emulsification process: by the olive oil spermaceti alcohol ester of formula ratio and the mixture of olive oil Pyrusussuriensis alcohol ester, glycerol, butanediol, Ceteareth-6 and the mixture of olive oil acid esters, polydimethylsiloxane, plant sterol ester admixture are heated to 85 DEG C sterilizing, it is thus achieved that oil phase；The allantoin of formula ratio, glucose, hyaluronic acid are added to the water, are heated with stirring to 90 DEG C, cold But to 85 DEG C, it is thus achieved that aqueous phase；Oil phase is added to stirring and emulsifying in aqueous phase and obtains base material；When dropping to 40 DEG C at a temperature of base material, will In Herba Dendrobii extract, IPBC and dihydroxymethyl dimethyl second after filtration, phthalein urea is added to base In material, stirring, then carry out emulsifying 5min with homogenizer, add Flos Rosae Rugosae quintessence oil, stir, stand cooling and become for 12 hours Cream, stops stirring, cooling, obtains Herba Dendrobii emollient cream.

Embodiment 2.

(1) sterilization processing is cleaned: root and the stipes of fresh Herba Dendrobii are rinsed 3 times with tap water, rush with pure water Wash 2 times, with warm water " quenches " 3～5min, be cut into the segment of 0.5～1.5cm；

(2) soak: the Herba Dendrobii after sterilization is put in deionized water, and adds the microorganism fungus kind vacation list sloughing wax coat Born of the same parents bacterium, stirs, and soaks 15 days, in the pigmentolysis of Herba Dendrobii to water；

(3) filter: appeal soak is filtered, obtains Herba Dendrobii and Herba Dendrobii filtrate:

(4) decolouring: activated carbon is added above-mentioned steps (3) Herba Dendrobii filtrate, stirring, decolouring, filter acquisition Herba Dendrobii and carry Take liquid, put into refrigerator freezing；

(5) grinding step: the Herba Dendrobii of Herba Dendrobii extracting solution that temperature is 2 DEG C and filtration is placed in homogenizer, iron sheet Herba Dendrobii is 1:9 with the weight ratio of Herba Dendrobii extracting solution, and startup homogenizer and control discharge fineness, at 200～300 below m, obtain To Herba Dendrobii extract；

(6) filter progress: soaked by l00 mesh nylon filtering cloth, is folded in 2 layers of funnel being laid in vacuum filtration, and edge is placed in Outside funnel, open vacuum filtration machine, then Herba Dendrobii superfine grinding liquid poured in funnel, filter to liquid medicine storage tank, Filtering residue thickness reaches cleaning when 0.5～lcm and once, collects filtering residue otherwise utilized；

Fine straining: start high speed tube centrifuge (rotating speed is 15000r/min) and peristaltic pump, set the rotating speed of peristaltic pump as 150～ 250r/min, by feed pipe to coarse filtration liquid, starts centrifugal filtration to new liquid medicine storage tank.Every centrifugal filtration 200～300L Cleaning filtering residue once, is collected by filtration filtering residue, merges with the filtering residue obtained in coarse filtration, otherwise utilized.The filter obtained after fine straining Liquid is the Herba Dendrobii extract after filtering；

(7) emulsification process: by the olive oil spermaceti alcohol ester of formula ratio and the mixture of olive oil Pyrusussuriensis alcohol ester, glycerol, butanediol, Ceteareth-6 and the mixture of olive oil acid esters, polydimethylsiloxane, plant sterol ester admixture are heated to 85 DEG C sterilizing, it is thus achieved that oil phase；The allantoin of formula ratio, glucose, hyaluronic acid are added to the water, are heated with stirring to 100 DEG C, cold But to 85 DEG C, it is thus achieved that aqueous phase；Oil phase is added to stirring and emulsifying in aqueous phase and obtains base material；When dropping to 45 DEG C at a temperature of base material, will In Herba Dendrobii extract, IPBC and dihydroxymethyl dimethyl second after filtration, phthalein urea is added to base In material, stirring, then carry out emulsifying 5min with homogenizer, add Flos Rosae Rugosae quintessence oil, stir, stand cooling and become for 24 hours Cream, stops stirring, cooling, obtains Herba Dendrobii emollient cream.

Claims (7)

1. Herba Dendrobii emollient cream, it is characterised in that: this emollient cream includes the raw material 45. 0～55.0 of following parts by weight Part water；Herba Dendrobii extract after the filtration of 8.0～10.0 parts；0.18～0.22 part of allantoin；The Fructus Vitis viniferae of 5.0～7.0 parts Sugar；The olive oil spermaceti alcohol ester of 3.2～5.2 parts and the mixture of olive oil Pyrusussuriensis alcohol ester；The glycerol of 2.0～4.0 parts；2.0～ 4.0 parts of butanediols；The Flos Rosae Rugosae quintessence oil of 0.2～0.3 part；0.09～0.11 part of hyaluronic acid；The cetearyl alcohol of 2.0～3.0 parts Polyethers-6 and the mixture of olive oil acid esters；The polydimethylsiloxane of 0.8～1.2 part；1.2～1.8 parts of plant sterol esters； The IPBC of 0.2～0.4 part and dimethyloldimethylhydantoin.

2. Herba Dendrobii emollient cream, it is characterised in that: the preparation method of described Herba Dendrobii extract comprises the following steps:

(1) pretreatment: root and the stipes of fresh Herba Dendrobii are cleaned sterilization processing；

(2) soak: the Herba Dendrobii after sterilization is put in deionized water, and adds the microorganism fungus kind sloughing wax coat, stir Mix uniformly, soak 10～30 days, in the pigmentolysis of Herba Dendrobii to water；

(3) filter: appeal soak is filtered, obtains Herba Dendrobii and Herba Dendrobii filtrate；

(4) decolouring: activated carbon is added above-mentioned steps (3) Herba Dendrobii filtrate, decolouring, filter and obtain Herba Dendrobii extracting solution；

(5) grinding step: the Herba Dendrobii after temperature 2～the Herba Dendrobii extracting solution of 10 DEG C and filtration is placed in homogenizer, Herba Dendrobii is 1:4～1:9 with the weight ratio of Herba Dendrobii extracting solution, starts homogenizer and controls discharge fineness 200～300 Below m, obtains Herba Dendrobii extract；

(6) filter progress: thick Herba Dendrobii extract is filtrated to get the Herba Dendrobii extract after filtration.

Herba Dendrobii emollient cream the most according to claim 2, it is characterised in that the microorganism fungus kind sloughing wax coat described in: is Hydrocarbon oxidation bacteria be pseudomonas, acinetobacter calcoaceticus, sporeformer, bud pole bacterium, vibrio, micrococcus luteus or arthrobacterium.

Herba Dendrobii emollient cream the most according to claim 2, it is characterised in that slough the microorganism fungus kind matter of wax coat described in: Amount accounts for the 0.05～0.5% of Herba Dendrobii quality.

Herba Dendrobii emollient cream the most according to claim 2, it is characterised in that: quality of activated carbon accounts for Herba Dendrobii filtrate quality 1～3%.

Herba Dendrobii emollient cream the most according to claim 2, it is characterised in that: described step (6) filters and includes that coarse filtration walks Rapid and fine straining step；Described coarse filtration uses 100 mesh nylon filtering cloths to soak filtration；Described fine straining step uses high speed tubular type to be centrifuged Machine, rotating speed is 15000r/min.

7. Herba Dendrobii emollient cream preparation method, it is characterised in that: this preparation method is:

Olive oil spermaceti alcohol ester and the mixture of olive oil Pyrusussuriensis alcohol ester, glycerol, butanediol, the cetearyl alcohol of formula ratio are gathered Ether-6 and the mixture of olive oil acid esters, polydimethylsiloxane, plant sterol ester admixture are heated to 85 DEG C of sterilizings, it is thus achieved that oil Phase；The allantoin of formula ratio, glucose, hyaluronic acid are added to the water, are heated with stirring to 90～100 DEG C, be cooled to 85 DEG C, Obtain aqueous phase；Oil phase is added to stirring and emulsifying in aqueous phase and obtains base material；When dropping to 40～45 DEG C at a temperature of base material, after filtering Herba Dendrobii extract, IPBC and dihydroxymethyl dimethyl second in phthalein urea be added in base material, Stirring, then carry out emulsifying 5min with homogenizer, add Flos Rosae Rugosae quintessence oil, stir, stand cooling and become cream in 12-24 hour, Stop stirring, cooling, obtain Herba Dendrobii emollient cream.