CN105968065B - 一种环氧合酶-2抑制剂帕瑞昔布中间体的制备方法 - Google Patents
一种环氧合酶-2抑制剂帕瑞昔布中间体的制备方法 Download PDFInfo
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- CN105968065B CN105968065B CN201610352395.0A CN201610352395A CN105968065B CN 105968065 B CN105968065 B CN 105968065B CN 201610352395 A CN201610352395 A CN 201610352395A CN 105968065 B CN105968065 B CN 105968065B
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- phenyl
- methyl
- potassium iodide
- reaction
- ammonium acetate
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- 0 CC(C(C(c1ccccc1)=O)c1ccc(*)cc1)=O Chemical compound CC(C(C(c1ccccc1)=O)c1ccc(*)cc1)=O 0.000 description 1
- LLWOSCPRJRUVST-UHFFFAOYSA-N Cc([o]nc1-c2ccccc2)c1-c(cc1)ccc1S(O)(=O)=O Chemical compound Cc([o]nc1-c2ccccc2)c1-c(cc1)ccc1S(O)(=O)=O LLWOSCPRJRUVST-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
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Priority Applications (1)
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CN201610352395.0A CN105968065B (zh) | 2016-05-25 | 2016-05-25 | 一种环氧合酶-2抑制剂帕瑞昔布中间体的制备方法 |
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CN201610352395.0A CN105968065B (zh) | 2016-05-25 | 2016-05-25 | 一种环氧合酶-2抑制剂帕瑞昔布中间体的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105968065A CN105968065A (zh) | 2016-09-28 |
CN105968065B true CN105968065B (zh) | 2018-06-26 |
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CN201610352395.0A Expired - Fee Related CN105968065B (zh) | 2016-05-25 | 2016-05-25 | 一种环氧合酶-2抑制剂帕瑞昔布中间体的制备方法 |
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CN (1) | CN105968065B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329277A (zh) * | 2011-10-24 | 2012-01-25 | 海南霞迪药业有限公司 | 一种制备帕瑞昔布的方法 |
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2016
- 2016-05-25 CN CN201610352395.0A patent/CN105968065B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102329277A (zh) * | 2011-10-24 | 2012-01-25 | 海南霞迪药业有限公司 | 一种制备帕瑞昔布的方法 |
Non-Patent Citations (2)
Title |
---|
帕瑞昔布的合成;王凯 等;《中国医药工业杂志》;20131231;第44卷(第12期);第1207-1209页 * |
帕瑞昔布钠合成路线图解;王凯 等;《中国医药工业杂志》;20130831;第44卷(第8期);第836-838页 * |
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CN105968065A (zh) | 2016-09-28 |
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CB03 | Change of inventor or designer information |
Inventor after: Zhou Xiyan Inventor after: Qu Xianshuang Inventor before: Wang Xiaoyue |
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Effective date of registration: 20180523 Address after: 266024 302 unit 3, 2 building, 37 Zhanzhan Road, Shibei Road, Qingdao, Shandong Applicant after: Zhou Xiyan Applicant after: Qu Xianshuang Address before: 276111 228 group two, Lian Bu Village, Li Zhuang Town, Tancheng County, Linyi, Shandong Applicant before: Wang Xiaoyue |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180626 Termination date: 20200525 |