CN105963242A - 用于预防脑血管痉挛的药物递送系统 - Google Patents
用于预防脑血管痉挛的药物递送系统 Download PDFInfo
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- CN105963242A CN105963242A CN201610281218.8A CN201610281218A CN105963242A CN 105963242 A CN105963242 A CN 105963242A CN 201610281218 A CN201610281218 A CN 201610281218A CN 105963242 A CN105963242 A CN 105963242A
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- calcium
- vasospasm
- endothelin
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94312407P | 2007-06-11 | 2007-06-11 | |
| US60/943124 | 2007-06-11 | ||
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| NZ599430A (en) * | 2007-06-11 | 2014-03-28 | Loch Macdonald R | A drug delivery system for the prevention of cerebral vasospasm |
| US8252302B2 (en) * | 2007-06-11 | 2012-08-28 | Edge Therapeutics, Inc. | Methods and compositions to treat hemorrhagic conditions of the brain |
| US10092524B2 (en) | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| EP2308478A1 (en) | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Delivery system for sustained release of a calcium-channel blocking agent |
| WO2012051116A1 (en) | 2010-10-12 | 2012-04-19 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| US8658676B2 (en) * | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| ES2646720T3 (es) * | 2011-02-11 | 2017-12-15 | Edge Therapeutics, Inc. | Composiciones y métodos para mejorar el pronóstico de un humano con hemorragia subaracnoidea |
| AU2012240131B2 (en) * | 2011-04-05 | 2017-07-20 | Edge Therapeutics | Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow |
| CN102416013A (zh) * | 2011-12-30 | 2012-04-18 | 湖南九典制药有限公司 | 西尼地平的新用途 |
| US9399019B2 (en) * | 2012-05-09 | 2016-07-26 | Evonik Corporation | Polymorph compositions, methods of making, and uses thereof |
| US9655999B2 (en) | 2013-03-12 | 2017-05-23 | Carnegie Mellon University | Coated vaso-occlusive device for treatment of aneurysms |
| CN103211812A (zh) * | 2013-04-02 | 2013-07-24 | 苏州大学附属第一医院 | Skf96365在治疗蛛网膜下腔出血后发生的脑血管痉挛的应用 |
| US10403395B2 (en) * | 2013-10-14 | 2019-09-03 | SecondOpinionExpert, Inc. | Method and apparatus for generating objective medical second opinion |
| CN107427666B (zh) * | 2015-01-30 | 2022-11-04 | 加利福尼亚大学校董 | 脊髓软膜下基因递送系统 |
| JP2018522942A (ja) * | 2015-05-29 | 2018-08-16 | エッジ セラピューティクス インコーポレイテッド | 視力障害を低減するための組成物及び方法 |
| CN116726183A (zh) * | 2015-08-03 | 2023-09-12 | Enb治疗公司 | 用于治疗与etbr激活相关的癌症的组合物和方法 |
| BR112020000506A2 (pt) | 2017-07-11 | 2020-07-14 | Sustained Nano Systems Llc | formulações farmacêuticas hipercomprimidas |
| WO2019140324A1 (en) | 2018-01-12 | 2019-07-18 | Enb Therapeutics, Inc. | Deuterated compounds, compositions, and methods for treating cancers associated with etbr activation |
| US20200163947A1 (en) * | 2018-11-02 | 2020-05-28 | Nortic Holdings Inc. | Methods of treatment using nimodipine parenteral formulations |
| US20200315547A1 (en) * | 2019-04-02 | 2020-10-08 | Tencent America LLC | Vertebral artery dissection risk evaluation method, computer device, and storage medium |
| US11103142B2 (en) | 2019-04-02 | 2021-08-31 | Tencent America LLC | System and method for predicting vertebral artery dissection |
| CA3143636A1 (en) | 2019-07-12 | 2021-01-21 | Michael Lim | Compositions and methods for treating cerebral vasospasm |
| JP7716076B2 (ja) * | 2021-02-04 | 2025-07-31 | 学校法人産業医科大学 | 血管内穿孔によるくも膜下出血モデルの血腫を可視化する方法 |
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| US20060217340A1 (en) | 2005-03-23 | 2006-09-28 | University Of Vermont And State Agricultural College | Methods and products for treating hypertension by modulation of TRPC3 channel activity |
| NZ599430A (en) * | 2007-06-11 | 2014-03-28 | Loch Macdonald R | A drug delivery system for the prevention of cerebral vasospasm |
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2008
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- 2008-06-11 EP EP08770723.8A patent/EP2164497B1/en not_active Not-in-force
- 2008-06-11 AU AU2008261668A patent/AU2008261668C1/en not_active Ceased
- 2008-06-11 US US12/137,320 patent/US8303974B2/en not_active Expired - Fee Related
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- 2008-06-11 CN CN201610281218.8A patent/CN105963242A/zh active Pending
- 2008-06-11 KR KR1020147036026A patent/KR101607244B1/ko not_active Expired - Fee Related
- 2008-06-11 KR KR1020157012919A patent/KR101554258B1/ko not_active Expired - Fee Related
- 2008-06-11 WO PCT/US2008/066576 patent/WO2008154585A1/en not_active Ceased
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- 2008-06-11 CN CN200880101555.8A patent/CN101873858B/zh not_active Expired - Fee Related
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| EP0765659A1 (en) * | 1995-09-18 | 1997-04-02 | Shiseido Company Limited | Delayed drug-releasing microspheres |
| CN1480128A (zh) * | 2003-08-06 | 2004-03-10 | 北京扬新科技有限公司 | 一种透明、隐形的外用药物制剂 |
| CN1856296A (zh) * | 2003-09-30 | 2006-11-01 | 阿库斯菲尔公司 | 可注射的、口服、或局部用缓释药物制剂 |
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| CA2690600A1 (en) | 2008-12-18 |
| KR101607244B1 (ko) | 2016-03-30 |
| US20130022660A1 (en) | 2013-01-24 |
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| CN105055300A (zh) | 2015-11-18 |
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| CA2690600C (en) | 2016-10-11 |
| NZ581836A (en) | 2012-07-27 |
| CN101873858A (zh) | 2010-10-27 |
| KR101554258B1 (ko) | 2015-09-18 |
| AU2008261668C1 (en) | 2014-01-16 |
| EP2164497A1 (en) | 2010-03-24 |
| CN101873858B (zh) | 2016-05-25 |
| US8303974B2 (en) | 2012-11-06 |
| AU2008261668A1 (en) | 2008-12-18 |
| IL202647A0 (en) | 2010-06-30 |
| KR20150061031A (ko) | 2015-06-03 |
| KR20100055385A (ko) | 2010-05-26 |
| US20080305147A1 (en) | 2008-12-11 |
| AU2008261668B2 (en) | 2013-08-29 |
| WO2008154585A1 (en) | 2008-12-18 |
| NZ599430A (en) | 2014-03-28 |
| EP2164497B1 (en) | 2018-08-15 |
| IL202647A (en) | 2015-02-26 |
| JP2010529205A (ja) | 2010-08-26 |
| EP2164497A4 (en) | 2013-05-29 |
| KR20150015514A (ko) | 2015-02-10 |
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