CA2690600C - A drug delivery system for the prevention of cerebral vasospasm - Google Patents
A drug delivery system for the prevention of cerebral vasospasm Download PDFInfo
- Publication number
- CA2690600C CA2690600C CA2690600A CA2690600A CA2690600C CA 2690600 C CA2690600 C CA 2690600C CA 2690600 A CA2690600 A CA 2690600A CA 2690600 A CA2690600 A CA 2690600A CA 2690600 C CA2690600 C CA 2690600C
- Authority
- CA
- Canada
- Prior art keywords
- calcium channel
- vasospasm
- cerebral
- therapeutic agent
- semisolid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 208000001286 intracranial vasospasm Diseases 0.000 title claims abstract description 44
- 230000002265 prevention Effects 0.000 title abstract description 10
- 238000012377 drug delivery Methods 0.000 title description 5
- 206010047163 Vasospasm Diseases 0.000 claims abstract description 110
- 210000001627 cerebral artery Anatomy 0.000 claims abstract description 74
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 47
- 210000002330 subarachnoid space Anatomy 0.000 claims abstract description 46
- 230000000144 pharmacologic effect Effects 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims description 178
- 229940124597 therapeutic agent Drugs 0.000 claims description 116
- 150000001875 compounds Chemical class 0.000 claims description 104
- 101710090554 Transient receptor potential protein Proteins 0.000 claims description 100
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 95
- -1 bamidipine Chemical compound 0.000 claims description 86
- 239000007787 solid Substances 0.000 claims description 84
- 239000000203 mixture Substances 0.000 claims description 69
- 230000000694 effects Effects 0.000 claims description 67
- 239000002308 endothelin receptor antagonist Substances 0.000 claims description 67
- 238000012384 transportation and delivery Methods 0.000 claims description 57
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 claims description 46
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- MOTJMGVDPWRKOC-QPVYNBJUSA-N atrasentan Chemical compound C1([C@H]2[C@@H]([C@H](CN2CC(=O)N(CCCC)CCCC)C=2C=C3OCOC3=CC=2)C(O)=O)=CC=C(OC)C=C1 MOTJMGVDPWRKOC-QPVYNBJUSA-N 0.000 claims description 22
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- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 claims description 8
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 7
- NSVFSAJIGAJDMR-UHFFFAOYSA-N 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound CC=1NC(C)=C(C(=O)OCCN(CC=2C=CC=CC=2)C=2C=CC=CC=2)C(C=2C=C(C=CC=2)[N+]([O-])=O)C=1P1(=O)OCC(C)(C)CO1 NSVFSAJIGAJDMR-UHFFFAOYSA-N 0.000 claims description 7
- XTFPDGZNWTZCMF-DHZHZOJOSA-N 3-o-methyl 5-o-[(e)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC\C=C\C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 XTFPDGZNWTZCMF-DHZHZOJOSA-N 0.000 claims description 7
- NCUCGYYHUFIYNU-UHFFFAOYSA-N Aranidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)=O)C1C1=CC=CC=C1[N+]([O-])=O NCUCGYYHUFIYNU-UHFFFAOYSA-N 0.000 claims description 7
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- XQLWNAFCTODIRK-UHFFFAOYSA-N Gallopamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC(OC)=C(OC)C(OC)=C1 XQLWNAFCTODIRK-UHFFFAOYSA-N 0.000 claims description 7
- WTOVRSWDBLIFHU-UHFFFAOYSA-N Lemildipine Chemical compound COC(=O)C1=C(C)NC(COC(N)=O)=C(C(=O)OC(C)C)C1C1=CC=CC(Cl)=C1Cl WTOVRSWDBLIFHU-UHFFFAOYSA-N 0.000 claims description 7
- FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 claims description 7
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Neurosurgery (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US94312407P | 2007-06-11 | 2007-06-11 | |
| US60/943,124 | 2007-06-11 | ||
| US97690207P | 2007-10-29 | 2007-10-29 | |
| US60/976,902 | 2007-10-29 | ||
| PCT/US2008/066576 WO2008154585A1 (en) | 2007-06-11 | 2008-06-11 | A drug delivery system for the prevention of cerebral vasospasm |
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| CA2690600A1 CA2690600A1 (en) | 2008-12-18 |
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| IL (1) | IL202647A (enExample) |
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| WO (1) | WO2008154585A1 (enExample) |
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| US8303974B2 (en) * | 2007-06-11 | 2012-11-06 | Edge Therapeutics, Inc. | Drug delivery system for the prevention of cerebral vasospasm |
| US10092524B2 (en) * | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| US9364432B2 (en) * | 2007-06-11 | 2016-06-14 | Edge Therapeutics, Inc. | Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow |
| EP2308478A1 (en) | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Delivery system for sustained release of a calcium-channel blocking agent |
| WO2011103591A1 (en) * | 2010-02-22 | 2011-08-25 | Edge Therapeutics Inc. | Methods and compositions to treat hemorrhagic conditions of the brain |
| US8658676B2 (en) * | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| PL2627173T5 (pl) | 2010-10-12 | 2019-11-29 | Chiesi Farm Spa | Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom |
| EP2672983B1 (en) * | 2011-02-11 | 2017-04-19 | Edge Therapeutics, Inc. | Compositions and methods for improving prognosis of a human with subarachnoid hemorrhage |
| CN102416013A (zh) * | 2011-12-30 | 2012-04-18 | 湖南九典制药有限公司 | 西尼地平的新用途 |
| US9399019B2 (en) * | 2012-05-09 | 2016-07-26 | Evonik Corporation | Polymorph compositions, methods of making, and uses thereof |
| WO2014165023A1 (en) | 2013-03-12 | 2014-10-09 | Carnegie Mellon University | Coated vaso-occclusive device for treatment of aneurysms |
| CN103211812A (zh) * | 2013-04-02 | 2013-07-24 | 苏州大学附属第一医院 | Skf96365在治疗蛛网膜下腔出血后发生的脑血管痉挛的应用 |
| US10403395B2 (en) * | 2013-10-14 | 2019-09-03 | SecondOpinionExpert, Inc. | Method and apparatus for generating objective medical second opinion |
| JP2018506530A (ja) * | 2015-01-30 | 2018-03-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 脊柱軟膜下遺伝子送達システム |
| GB2556500A (en) * | 2015-05-29 | 2018-05-30 | Edge Therapeutics Inc | Compositions and methods for reducing visual loss |
| CA2994544C (en) | 2015-08-03 | 2021-03-30 | Enb Therapeutics, Llc | Compositions and methods for treating cancers associated with etbr activation |
| BR112020000506A2 (pt) * | 2017-07-11 | 2020-07-14 | Sustained Nano Systems Llc | formulações farmacêuticas hipercomprimidas |
| EA202091630A1 (ru) | 2018-01-12 | 2020-12-04 | Инб Терапьютикс, Инк. | Дейтерированные соединения, композиции и способы для лечения раков, связанных с активацией etbr |
| US20200163947A1 (en) * | 2018-11-02 | 2020-05-28 | Nortic Holdings Inc. | Methods of treatment using nimodipine parenteral formulations |
| US11103142B2 (en) * | 2019-04-02 | 2021-08-31 | Tencent America LLC | System and method for predicting vertebral artery dissection |
| US20200315547A1 (en) * | 2019-04-02 | 2020-10-08 | Tencent America LLC | Vertebral artery dissection risk evaluation method, computer device, and storage medium |
| JP7716076B2 (ja) * | 2021-02-04 | 2025-07-31 | 学校法人産業医科大学 | 血管内穿孔によるくも膜下出血モデルの血腫を可視化する方法 |
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| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| CA2180526A1 (en) | 1994-01-05 | 1995-07-13 | Joseph C. Hogan, Jr. | Method of identifying chemical compounds having selected properties for a particular application |
| US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| JP2909418B2 (ja) * | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| WO1997033552A1 (en) | 1996-03-12 | 1997-09-18 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
| US6123956A (en) | 1997-07-10 | 2000-09-26 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
| US6284283B1 (en) * | 1999-10-21 | 2001-09-04 | Alkermes Controlled Therapeutics, Inc. | Method of producing sub-micron particles of biologically active agents and uses thereof |
| JP2002003406A (ja) * | 2000-06-21 | 2002-01-09 | Sankyo Co Ltd | 脳血管攣縮予防製剤 |
| US20030032676A1 (en) * | 2001-08-09 | 2003-02-13 | Kimelberg Harold K. | Drugs for treatment of cerebral injury and methods of use thereof |
| US20040224030A1 (en) * | 2003-05-06 | 2004-11-11 | Shastri Venkatram R. | Microsphere delivery systems |
| CA2533592C (en) * | 2003-07-23 | 2015-11-10 | Pr Pharmaceuticals, Inc. | Controlled release compositions |
| CN1480128A (zh) * | 2003-08-06 | 2004-03-10 | 北京扬新科技有限公司 | 一种透明、隐形的外用药物制剂 |
| CN1856296A (zh) * | 2003-09-30 | 2006-11-01 | 阿库斯菲尔公司 | 可注射的、口服、或局部用缓释药物制剂 |
| US20060205733A1 (en) * | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
| US7829527B2 (en) * | 2005-02-02 | 2010-11-09 | University Of Vermont And State Agricultural College | Emergence of a R-type Ca2+ channel (Cav 2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage |
| US20060217340A1 (en) * | 2005-03-23 | 2006-09-28 | University Of Vermont And State Agricultural College | Methods and products for treating hypertension by modulation of TRPC3 channel activity |
| US8303974B2 (en) * | 2007-06-11 | 2012-11-06 | Edge Therapeutics, Inc. | Drug delivery system for the prevention of cerebral vasospasm |
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2008
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- 2008-06-11 NZ NZ581836A patent/NZ581836A/en not_active IP Right Cessation
- 2008-06-11 KR KR1020157012919A patent/KR101554258B1/ko not_active Expired - Fee Related
- 2008-06-11 CN CN201510300314.8A patent/CN105055300A/zh active Pending
- 2008-06-11 KR KR1020107000554A patent/KR101554250B1/ko not_active Expired - Fee Related
- 2008-06-11 NZ NZ599430A patent/NZ599430A/en not_active IP Right Cessation
- 2008-06-11 EP EP08770723.8A patent/EP2164497B1/en not_active Not-in-force
- 2008-06-11 CN CN201610281218.8A patent/CN105963242A/zh active Pending
- 2008-06-11 CN CN200880101555.8A patent/CN101873858B/zh not_active Expired - Fee Related
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Also Published As
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| KR101554250B1 (ko) | 2015-09-18 |
| AU2008261668A1 (en) | 2008-12-18 |
| KR101554258B1 (ko) | 2015-09-18 |
| KR20150015514A (ko) | 2015-02-10 |
| EP2164497B1 (en) | 2018-08-15 |
| JP5576790B2 (ja) | 2014-08-20 |
| AU2008261668B2 (en) | 2013-08-29 |
| CA2690600A1 (en) | 2008-12-18 |
| KR20150061031A (ko) | 2015-06-03 |
| EP2164497A4 (en) | 2013-05-29 |
| US8303974B2 (en) | 2012-11-06 |
| CN105963242A (zh) | 2016-09-28 |
| IL202647A (en) | 2015-02-26 |
| AU2008261668C1 (en) | 2014-01-16 |
| IL202647A0 (en) | 2010-06-30 |
| NZ599430A (en) | 2014-03-28 |
| CN101873858A (zh) | 2010-10-27 |
| KR101607244B1 (ko) | 2016-03-30 |
| CN105055300A (zh) | 2015-11-18 |
| JP2010529205A (ja) | 2010-08-26 |
| US20130022660A1 (en) | 2013-01-24 |
| EP2164497A1 (en) | 2010-03-24 |
| US20080305147A1 (en) | 2008-12-11 |
| NZ581836A (en) | 2012-07-27 |
| WO2008154585A1 (en) | 2008-12-18 |
| KR20100055385A (ko) | 2010-05-26 |
| CN101873858B (zh) | 2016-05-25 |
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