CN105920506A - 一种治疗小儿厌食症的药物组合物 - Google Patents
一种治疗小儿厌食症的药物组合物 Download PDFInfo
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Abstract
本发明提供了一种治疗小儿厌食症的药物组合物，包括以下重量份的原料：砂仁5～15份、苍术2～5份、陈皮3～5份、沉香4～8份、半夏1～5份、白豆蔻1～5份、党参1～5份、蒲公英1～3份、白头翁1～3份、甘草1～3份。本发明组方严谨、用药合理，诸药合用，功在健脾益气，清热化湿，开胃增食，湿热去而脾气健，诸症自愈，对于脾虚兼湿热之小儿厌食症十分有效。
Description
技术领域
本发明属于中药技术领域，具体涉及一种治疗小儿厌食症的药物组合物。
背景技术
小儿厌食是一种小儿时期的常见病、多发病，且病程较长。临床以较长时期的食欲减退，适量减少，厌恶禁食，甚拒食为其特征。中医认为，本病多责于饮食不节，与喂养失当、感受外邪、先天不足、情志失畅等因素亦有明显关系，上述因素引起气机失调，从而阻碍脾胃的正常转化，导致脾胃日趋虚弱。脾虚不运，则易蕴而发热，水湿不行，从而夹湿夹热。患儿除食欲不振外，一般没有其他明显不适，预后良好，但如果长期不愈，病程过长，可使气血生化乏源，机体抵抗力下降，容易罹患他症，严重者可影响生长发育，转化为疳证，甚至导致营养不良，影响智力发育，对儿童危害极大。
发明内容
本发明要解决的技术问题是提供一种治疗小儿厌食症的药物组合物，该药物组合物疗效好。
本发明提供的技术方案是一种治疗小儿厌食症的药物组合物，包括以下重量份的原料：砂仁5～15份、苍术2～5份、陈皮3～5份、沉香4～8份、半夏1～5份、白豆蔻1～5份、党参1～5份、蒲公英1～3份、白头翁1～3份、甘草1～3份。
作为优选，大黄1～3份、枳实1～2份。
进一步优选地，还包括厚朴1～2份。
其制备方法为：将配方量的各原料粉碎，加水煎煮，过滤，将滤液浓缩至浸膏，干燥，即得。
进一步优选，其制备方法为：将配方量的各原料粉碎，加入原料总重8～10倍的水煎煮2～3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1～1.3的浸膏，干燥，即得。
方中砂仁与苍术共为君，砂仁利水渗湿，健脾宁心，苍术益气健脾、燥湿，两者既健脾胃，又可益气燥湿。陈皮和沉香消食和胃，具有消食化积及健脾开胃、和中之功。半夏清理脾胃之湿热，白豆蔻健脾渗湿，两者共奏清热化湿之效，四者共为臣药。党参养阴和胃止呕，蒲公英清热燥湿，可清解所化之热，白头翁清热消积，皆为佐药。甘草补中和药，为使药。诸药合用，功在健脾益气，清热化湿，开胃增食，湿热去而脾气健，诸症自愈，对于脾虚兼湿热之小儿厌食症十分有效。在本方基础上，热盛便秘，加大黄，枳实；气滞腹胀者，加厚朴，可大大增强疗效。
具体实施方式
以下具体实施例对本发明作进一步阐述，但不作为对本发明的限定。
实施例1
配方：砂仁5份、苍术2份、陈皮3份、沉香4份、半夏1份、白豆蔻1份、党参1份、蒲公英1份、白头翁1份、甘草1份。
制备方法为：将配方量的各原料粉碎，加入原料总重8倍的水煎煮2次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1的浸膏，干燥，即得。
实施例2
配方：砂仁15份、苍术5份、陈皮5份、沉香8份、半夏5份、白豆蔻5份、党参5份、蒲公英3份、白头翁3份、甘草3份、大黄3份、枳实2份。
制备方法为：将配方量的各原料粉碎，加入原料总重10倍的水煎煮3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.3的浸膏，干燥，即得。
实施例3
配方：砂仁5份、苍术5份、陈皮3份、沉香8份、半夏1份、白豆蔻5份、党参1份、蒲公英3份、白头翁1份、甘草3份、大黄1份、枳实2份、厚朴1份。
制备方法为：将配方量的各原料粉碎，加入原料总重8倍的水煎煮3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1的浸膏，干燥，即得。
实施例4
配方：砂仁15份、苍术2份、陈皮5份、沉香4份、半夏5份、白豆蔻1份、党参5份、蒲公英1份、白头翁3份、甘草1份、大黄3份、枳实1份、厚朴2份。
制备方法为：将配方量的各原料粉碎，加入原料总重9倍的水煎煮2次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.2的浸膏，干燥，即得。
通过以下临床试验验证本发明的有益效果：
1、门诊病例
选取小儿厌食症临床治疗病例250例，年龄在1～6岁之间，女孩150例，男孩100例，随机分为5组，分别为实验组1～4和对照组，每组50人。
2、诊断标准
2.1西医诊断标准
参照胡亚美等2005年主编的《诸福棠实用儿科学》第七版：
1)较长期的食欲不振，见食不贪，入量较病前减少1/3-1/2以上；
2)病程为3个月以上，有不良饮食喜欢或不当喂养史；
3)排除其他系统疾病，体重增长停滞或减轻。
2.2中医诊断标准
参照2003年苏树蓉主编《中医儿科学》：
1)长期食欲不振，适量明显少于同龄正常儿童；
2)面色少华，形体偏瘦，但精神尚好，活动如常；
3)有喂养不当史，排除外感及其他器质性病变。
2.3中医辨证标准
参照2002年医药科技出版社出版的《中药新药临床研究指导原则(试行)》及《中医儿科学》教材中相关标准制定的中医辨证标准，属脾虚兼湿热证者。
主症：食欲减退，食量减少；
次症：1)面色萎黄，形体消瘦；2)神疲懒言，体倦乏力；3)大便稀溏或夹有不消化食物；4)口中异味，易呕吐，呕吐物酸臭；5)易出汗；6)食后腹胀；7)舌质淡，苔白腻或微黄腻，脉细滑或指纹紫滞。
3、纳入标准
1)临床符合西医诊断标准；
2)临床症状符合中医诊断标准和辨证标准者；
3)微量元素测定属锌缺乏者；
4)病程3个月以上；
2)年龄在1～6岁。
4、排除标准：
伴有器质性病变患者，或伴有其他心血管、肝肾、血液、神经系统疾病患儿；
5、用药方法
实验组1～4服用实施例1～4的药物组合物，每次服用相当于生药0.1g，每日3次。一周为一个疗程。
对照组给予双歧杆菌四联活菌片(思连康，杭州龙达新科生物制药有限公司，0.5g×24)和葡萄糖酸锌口服液(哈药集团制药六厂，10ml/支)。双歧杆菌四联活菌片口服，每次3片，每日3次，葡萄糖酸锌口服液口服，每次1支，每日1次。
6、症状体征量化标准
7、综合疗效判定标准：
痊愈：体温正常，症候总积分减少大于95％；
显效：体温正常，症候总积分减少70～95％；
有效：体温正常或降低1℃以上，症候总积分减少30～70％(不包括70％)；
无效：体温没有降低，症候总积分减少＜30％。
8、实验结果
注：与对照组相比，*P＜0.05，**P＜0.01。
对治疗前后患者血常规、肝功能、肾功能及尿常规的检测，未见异常。
Claims (5)
1.一种治疗小儿厌食症的药物组合物，其特征在于：包括以下重量份的原料：砂仁5～15份、苍术2～5份、陈皮3～5份、沉香4～8份、半夏1～5份、白豆蔻1～5份、党参1～5份、蒲公英1～3份、白头翁1～3份、甘草1～3份。
2.根据权利要求1所述的治疗小儿厌食症的药物组合物，其特征在于：还包括大黄1～3份、枳实1～2份。
3.根据权利要求1所述的治疗小儿厌食症的药物组合物，其特征在于：还包括厚朴1～2份。
4.根据权利要求1所述的治疗小儿厌食症的药物组合物，其特征在于：其制备方法为：将配方量的各原料粉碎，加水煎煮，过滤，将滤液浓缩至浸膏，干燥，即得。
5.根据权利要求4所述的的治疗治疗小儿厌食症的药物组合物，其特征在于：其制备方法为：将配方量的各原料粉碎，加入原料总重8～10倍的水煎煮2～3次，合并煎煮液，过滤，将滤液浓缩至60℃时相对密度为1.1～1.3的浸膏，干燥，即得。
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