CN105919127A - Stable high anthocyanin blueberry buccal tablets and preparation method thereof - Google Patents
Stable high anthocyanin blueberry buccal tablets and preparation method thereof Download PDFInfo
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- CN105919127A CN105919127A CN201610267232.2A CN201610267232A CN105919127A CN 105919127 A CN105919127 A CN 105919127A CN 201610267232 A CN201610267232 A CN 201610267232A CN 105919127 A CN105919127 A CN 105919127A
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- blueberry
- anthocyanin
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- 235000003095 Vaccinium corymbosum Nutrition 0.000 title claims abstract description 222
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- 240000000851 Vaccinium corymbosum Species 0.000 title claims abstract description 173
- 235000010208 anthocyanin Nutrition 0.000 title claims abstract description 122
- 229930002877 anthocyanin Natural products 0.000 title claims abstract description 122
- 239000004410 anthocyanin Substances 0.000 title claims abstract description 122
- 150000004636 anthocyanins Chemical class 0.000 title claims abstract description 122
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 76
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- 239000000287 crude extract Substances 0.000 claims abstract description 31
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 21
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- 238000004108 freeze drying Methods 0.000 claims abstract description 16
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention provides stable high anthocyanin blueberry buccal tablets and a preparation method thereof, and belongs to the technical field of buccal tablet preparation. The stable high anthocyanin blueberry buccal tablets comprise the following components: stable blueberry anthocyanin crude extract, blueberry polysaccharide extract, microcrystalline cellulose, mannitol, citric acids, magnesium stearate and blueberry ethanol solution. At the same time, the present invention also provides a preparation method of the stable high anthocyanin blueberry buccal tablets. The preparation method comprises blueberry beating, centrifuging and separating, blueberry ethanol solution preparing, blueberry pomace ultrasonic extracting, blueberry anthocyanin extract centrifuging, freeze-drying, blueberry anthocyanin crude extract embedding, mixing according to a formula, granulating, drying, sterilizing, tabletting, etc. The stable high anthocyanin blueberry buccal tablets innovatively and comprehensively use all the active ingredients in the blueberries, and the finally prepared blueberry buccal tablets have characteristics of being high in anthocyanin content, stable in anthocyanin storage, rich in nutrient, fresh in taste, convenient in carrying, etc.
Description
Technical field
The present invention relates to a kind of lozenge and preparation method thereof, be specifically related to a kind of stable high anthocyanin blueberry buccal tablets and
Preparation method.
Background technology
Blueberry be Ericaceae (Ericaceae) genus vaccinium (Vaccinium spp.) plant, have another name called blueberry, all persimmon and
Blue berries etc., for evergreen or machaka type fruit tree.At present, blueberry extensive introducing and planting in the world, fruit is approximately
Circle, pericarp is blue, and pulp is fine and smooth, enjoys popular parent to look at.Except rich in carbohydrate, fat, albumen in Blueberry
Outside the multiple bioactive ingredients such as matter, fat, vitamin, trace element and flavones, tannin, phenolic acid, anthocyanin is also blueberries
One of real main composition.
Anthocyanin from Blueberry is a kind of water-soluble natural food coloring widely distributed in nature, safe and nontoxic.Modern medicine
Pharmacological research shows, anthocyanin can obviously improve eyesight, promotes cardio-pulmonary function, prevents cardiovascular and cerebrovascular disease, infectious diseases, prolongs
Slow skin senescence, has the effects such as anticancer, antitumor, is described as continue water, protein, fat, carbohydrate, vitamin, ore deposit
The seventh-largest essential nutrients after material.Nowadays, due to Anthocyanin from Blueberry, there is obvious health-care efficacy so that rich in pattern
The food of glycosides is continuously added in the middle of food as nutrition intensive.
Lozenge is to be contained in oral cavity slowly to dissolve the tablet playing lasting local therapeutic effects.It has technique simple,
Instant, good stability, drug effect rapidly, absorb the advantages such as fast and bioavilability is high, in good taste, be health food, again
It it is leisure food.The preparation technology of lozenge generally comprise raw material mixing, softwood processed, granulation and be dried, whole grain, compressing tablet, sterilizing and
Packaging.The change of the external environments such as oxygen, oxidant, affinity agent, enzyme, metal ion, temperature, illumination all can be made by Anthocyanin from Blueberry
The change of Anthocyanin from Blueberry structure is become to cause its nutrition and physiological function to decline.Lozenge is eaten as the health care of a kind of permanent preservation
Product and leisure food, its granulation, be dried and sterilization technological temperature higher, easily cause composition be destroyed, especially anthocyanin
The composition of the most oxidized this instability；What is more important, other compositions in the storage shelf life of lozenge, in lozenge
Do not change, and the anthocyanin in lozenge easily due to oxygen, oxidant, affinity agent, enzyme, metal ion, temperature, illumination etc. because of
Element decomposes sex change, loses the biological physiology functions such as its health care, causes the loss of primary healthcare composition in blueberry buccal tablets.
In order to solve in blueberry buccal tablets Anthocyanin from Blueberry content because of in preparation process and storage can cause anthocyanin steady
The problem of qualitative decline, the invention provides the blueberry buccal tablets of a kind of high anthocyanin content, and after depositing a period of time, blueberry contains
Anthocyanin content loss in sheet greatly reduces.
Summary of the invention
The present invention provides a kind of high anthocyanin blueberry buccal tablets and preparation method thereof, and the present invention is accomplished by:
Wherein, the component of the stable high anthocyanin blueberry buccal tablets that the present invention provides includes: stable Anthocyanin from Blueberry crude extract,
Blueberry polyoses extract, microcrystalline cellulose, mannitol, citric acid, magnesium stearate and blueberry ethanol solution.
Further, inventor provide the formula of described stable high anthocyanin blueberry buccal tablets, specific as follows: stable indigo plant
Certain kind of berries anthocyanin crude extract 5 ~ 25 parts, blueberry polyoses extract 10 ~ 20 parts, microcrystalline cellulose 5 ~ 20 parts, 5 ~ 15 parts of mannitol, lemon
Acid 2 ~ 5 parts, magnesium stearate 5 ~ 10 parts, blueberry ethanol solution 5 ~ 20 parts.
Meanwhile, the present invention provides the preparation method of a kind of stable high anthocyanin blueberry buccal tablets, and described preparation method is concrete
Comprise the following steps:
A. blueberry making beating: by Blueberry crushing and beating, after adding pectase, homogenate, enzymolysis 1 ~ 3h, obtain blueberry pulp,
Blueberry pulp adds citric acid；
B. centrifugation: by blueberry pulp centrifugal treating, after being centrifuged, blueberry pulp is separated into blueberry juice and blueberry pomace；
C. the preparation of blueberry ethanol solution: by blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, obtain blueberry ethanol solution；
D. the ultrasonic extraction of blueberry pomace: by blueberry pomace ultrasonic extraction 20-30 min in the ethanol water of pH=2.5 ~ 3.5,
Obtain Anthocyanin from Blueberry extract；
E. it is centrifuged Anthocyanin from Blueberry extract: by Anthocyanin from Blueberry extract centrifugal treating, after filtration, take filtrate, obtains blueberry flower
Look glycosides extract, filter residue is freeze-dried obtains blueberry polyoses extract；
F. freeze-drying: by Anthocyanin from Blueberry extract freeze-drying, obtain Anthocyanin from Blueberry crude extract；
G. embedding Anthocyanin from Blueberry crude extract: Anthocyanin from Blueberry crude extract is joined in carboxymethyl chitosan solution, at magnetic force
After being thoroughly mixed under the effect of agitator, drip chitosan hydrochloride solution, after reaction 1h, centrifugal, collect lower sediment, freezing
It is dried 12-16h, obtains stable Anthocyanin from Blueberry crude extract；
H. raw material mixing: take stable Anthocyanin from Blueberry crude extract, blueberry polyoses extract, microcrystalline cellulose, mannitol, lemon
Acid, magnesium stearate, it is sufficiently mixed, adds blueberry ethanol solution, make blueberry buccal tablets softwood；
I. granulation is with dry: blueberry buccal tablets softwood puts into granulation in granulator, and wet granular is put dry process, obtain indigo plant
Certain kind of berries particle；
J. sterilizing: blueberry particle is irradiated 10 ~ 40min sterilizing under ultraviolet light；
K. compressing tablet: by blueberry particle compressing tablet in gnotobasis of sterilizing, packaging, obtains stable high anthocyanin blueberry buccal tablets and becomes
Product.
Further, in described step A, the addition of pectase is 0.1 ~ 3mg/g.
Further, the ultrasonic power of the ultrasonic extraction of described blueberry pomace is: 300-400W, and Extracting temperature is: 50 ~ 60 DEG C.
Further, the concentration of described carboxymethyl chitosan solution is 2.0-3.0 mg/mL；Described chitosan hydrochloride solution
Concentration be 0.6-1.2 mg/mL.
Beneficial effect
One:
First, the present invention be a kind of pure natural, the lozenge that has no side effect.In addition to making the basic additive of lozenge, major part
Raw material sources are in blueberry itself, prepared blueberry buccal tablets, and anthocyanin content is relatively up to 0.73mg/g, in preparation process
Specially and the anthocyanin that is effectively protected in blueberry, it is possible to make the anthocyanin content in lozenge close to the content of blueberry itself,
Whole preparation process greatly reduces anthocyanin loss；Meanwhile, it has been found that the anthocyanin of blueberry buccal tablets prepared of the present invention
After long-time storage, its content significantly reduces because of attenuation by oxygen speed, and the result of Acceleration study shows, the present invention can make
In blueberry buccal tablets, the stability of anthocyanin promotes 3 times.By blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, the blueberry obtained
Ethanol solution can be effectively protected the anthocyanin in blueberry buccal tablets, and the content of final anthocyanin is had important impact.
Secondly, instantly, functional food has become as the hot subject of food industry, and anthocyanin is a kind of safety, nothing
The water-soluble food pigment of poison, belongs to flavones polyphenol compound, has stronger anti-oxidant and Scavenging ability, pattern
Glycosides is retained in blueberry buccal tablets, can not only improve eyesight, delay skin aging, promotion cardiopulmonary, and can prevent some chronic diseases
Disease, such as angiocardiopathy, cancer etc..
Finally, the present invention selects blueberry to be raw material, can get anthocyanin content by ultrasonic assistant extraction method higher
Extract, use freeze-drying, obtain the crude extract of Anthocyanin from Blueberry, be aided with the seasoning protective ingredients such as citric acid, develop
Go out and there is the blueberry buccal tablets improving the function such as eyesight, preventing chronic disease.Citric acid is a kind of conventional food additives, can increase
Strong internal eubolism, promotes appetite.Secondly, anthocyanin is the most stable, adds organic acid and can improve pattern
The stability of glycosides.Improve mouthfeel and the local flavor of lozenge simultaneously.
Its two:
The present invention is with blueberry as primary raw material, in the preparation process of blueberry buccal tablets, innovation fully utilize in blueberry all
Active ingredient, it is high that the blueberry buccal tablets being finally made has anthocyanin content, and anthocyanin storage is stable, and lozenge is nutritious, mouthfeel
Clearly, it is convenient for carrying, in particular with ultrasonic wave extraction, the active ingredient in blueberry residue is extracted recycling again,
Turn waste into wealth, fully utilize the various nutritional labelings of blueberries to greatest extent, improve the whole utilization valency of Blueberry
Value, adds economic benefit.
The present invention is simple to operate, the highest to equipment requirement, and production cost is low, and the anthocyanin content of the blueberry buccal tablets obtained is relatively
Height, after long-time storage, anthocyanin content is higher, and blueberry buccal tablets productivity is higher, economical and practical, before having good market
Scape.
Detailed description of the invention.
Embodiment 1
A kind of high anthocyanin blueberry buccal tablets, its raw material includes: blueberry, shitosan, microcrystalline cellulose, mannitol, and citric acid is with hard
Fatty acid magnesium.
Its preparation method specifically includes following steps:
1) blueberry making beating: by Blueberry crushing and beating, after adding 0.1 mg/g pectase, homogenate, enzymolysis time is 1 ~ 3h,
After enzymolysis completes, obtain blueberry pulp, and add the citric acid of blueberry pulp quality 0.38%；
2) centrifugation: by centrifuge, blueberry pulp is separated into blueberry juice and blueberry pomace, at rotating speed 3000 ~ 5000r/
Under conditions of min, centrifugal 10 ~ 20min；
3) preparation of blueberry ethanol solution: by blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, obtain blueberry ethanol solution；
4) the ultrasonic extraction of blueberry pomace: by blueberry pomace according to solid-liquid ratio 1:20g/mL, adds pH=3.0,60%(v/v) ethanol water
Solution, simultaneously under conditions of ultrasonic power 300-400W, Extracting temperature 50 ~ 60 DEG C, ultrasonic extraction 20-30 min, obtain indigo plant
Certain kind of berries anthocyanin extract；
5) centrifugal Anthocyanin from Blueberry extract: by Anthocyanin from Blueberry extract centrifugal treating, under the conditions of rotating speed 3800r/min,
Centrifugal 15min, takes filtrate, obtains Anthocyanin from Blueberry extract after filtration, filter residue is freeze-dried obtains blueberry polyoses extract；
6) freeze-drying: by Anthocyanin from Blueberry extract freeze-drying, obtain Anthocyanin from Blueberry crude extract.
7) embedding Anthocyanin from Blueberry crude extract: 5-10mg Anthocyanin from Blueberry crude extract is added 15 mL concentration is 2.0-
In 3.0 mg/mL carboxymethyl chitosan solution, under magnetic stirring apparatus effect, after reaction 15min, dropwise it is slowly added to 30mL
Concentration is 0.6-1.2 mg/mL chitosan hydrochloride solution, under the effect of magnetic stirring apparatus, after reaction 1h, at rotating speed 10,
Under the conditions of 000 r/min, centrifugal 10min, collects lower sediment.Freeze-drying 12-16h, obtains stable Anthocyanin from Blueberry thick
Extract.
8) raw material mixing: take stable Anthocyanin from Blueberry crude extract 10g, blueberry polyoses extract 15g, microcrystalline cellulose
20g, mannitol 10g, citric acid 2g, magnesium stearate 8g, be sufficiently mixed, and adds and add 10mL blueberry ethanol solution, makes
Blueberry buccal tablets softwood.
9) granulation is with dry: is put in oscillating granulator by blueberry buccal tablets softwood and carries out granulation, wet granular is placed in 30
Being dried in DEG C air dry oven, 20min stirs once, until the moisture in particle is down to 3%, obtains blueberry particle.
10) sterilizing: blueberry particle is irradiated 10 ~ 40min sterilizing under ultraviolet light.
11) compressing tablet: by blueberry particle compressing tablet in gnotobasis of sterilizing, and pack in time, obtain high anthocyanin
Blueberry buccal tablets finished product.
Applicant uses the anthocyanin in HPLC method detection lozenge, specifically comprises the following steps that
Accurately weigh 1g lozenge, be settled in the volumetric flask of 10 mL with distilled water, then with after 0.45 um filtering with microporous membrane,
Side is examined with HPLC.
HPLC condition:
A phase: 0.05% formic acid water, B phase: acetonitrile, sample introduction flow velocity: 1.0 mL/min, column temperature: 35.0 ° of C, use ultraviolet detection
Device, wavelength is 510nm, uses gradient elution.
Table 1: condition of gradient elution
Drafting cyaniding 3-0-glucoside calibration curve:
Accurately weigh in 10 mg cyaniding 3-0-glucoside standard items, constant volume and 10 mL volumetric flasks, obtain 1 mg/mL
Cyaniding 3-0-glucoside mother liquor；Prepare respectively 0.02 mg/mL, 0.04 mg/mL,
0.06 mg/mL, the standard liquid of 0.08 mg/mL, use above-mentioned HPLC method to detect anthocyanin, obtain anthocyanin mark
Directrix curve: Y=2*107 X-1413.9 R2=0.9999
After testing, after the embodiment of the present invention 1 blueberry buccal tablets stores 7 days in 40 DEG C of constant incubators, anthocyanin retention rate is
39.47%, and in the Anthocyanin from Blueberry lozenge that additive method makes, anthocyanin retention rate is 10.81%.
Under 40 DEG C of holding conditions, the change of anthocyanidin content
Embodiment 2
A kind of high anthocyanin blueberry buccal tablets, its raw material includes: blueberry, microcrystalline cellulose, mannitol, citric acid and magnesium stearate.
Its preparation method specifically includes following steps:
1) blueberry making beating: by Blueberry crushing and beating, after adding 1mg/g pectase, homogenate, enzymolysis time is 1 ~ 3h, enzyme
After solution completes, obtain blueberry pulp, and add the citric acid of blueberry pulp quality 1.5%；
2) centrifugation: by centrifuge, blueberry pulp is separated into blueberry juice and blueberry pomace, at rotating speed 3000 ~ 5000r/
Under conditions of min, centrifugal 10 ~ 20min；
3) preparation of blueberry ethanol solution: by blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, obtain blueberry ethanol solution；
4) the ultrasonic extraction of blueberry pomace: according to solid-liquid ratio 1:20g/mL, addition pH=3.5, volume fraction of ethanol be by blueberry pomace
55%(v/v) ethanol water, simultaneously under conditions of ultrasonic power 300-400W, Extracting temperature 50 ~ 60 DEG C, ultrasonic extraction 20-
30 min, obtain Anthocyanin from Blueberry extract；
5) centrifugal Anthocyanin from Blueberry extract: by Anthocyanin from Blueberry extract centrifugal treating, under the conditions of rotating speed 3000r/min,
Centrifugal 30min, takes filtrate, obtains Anthocyanin from Blueberry extract after filtration, filter residue is freeze-dried obtains blueberry polyoses extract；
6) freeze-drying: by Anthocyanin from Blueberry extract freeze-drying, obtain Anthocyanin from Blueberry crude extract.
7) embedding Anthocyanin from Blueberry crude extract: 10mg Anthocyanin from Blueberry crude extract is added 15 mL concentration is 3.0 mg/
In mL carboxymethyl chitosan solution, under magnetic stirring apparatus effect, after reaction 15min, being dropwise slowly added to 30mL concentration is
1.2 mg/mL chitosan hydrochloride solution, under magnetic stirring apparatus effect, after reaction 1h, in rotating speed 10,000 r/min condition
Under, centrifugal 10min, collects lower sediment.Freeze-drying 12-16h, obtains stable Anthocyanin from Blueberry crude extract.
8) raw material mixing: take stable Anthocyanin from Blueberry crude extract 5g, blueberry polyoses extract 20g, microcrystalline cellulose
15g, mannitol 15g, citric acid 2.5g, magnesium stearate 5g, be sufficiently mixed, and adds 20mL blueberry ethanol solution, makes blueberry
Lozenge softwood.
9) granulation is with dry: is put in oscillating granulator by blueberry buccal tablets softwood and carries out granulation, wet granular is placed in 30
Being dried in DEG C air dry oven, 20min stirs once, until the moisture in particle is down to 3%, obtains blueberry particle.
10) sterilizing: blueberry particle is irradiated 10 ~ 40min sterilizing under ultraviolet light.
11) compressing tablet: by blueberry particle compressing tablet in gnotobasis of sterilizing, and pack in time, obtain high anthocyanin
Blueberry buccal tablets finished product.
Through detection, suppressing lozenge 0.454g, through detection, contain the anthocyanin of 0.33mg in lozenge, tradition blueberry contains
Sheet cannot detect anthocyanin content.
Embodiment 3
A kind of high anthocyanin blueberry buccal tablets, its raw material includes: blueberry, microcrystalline cellulose, mannitol, citric acid and magnesium stearate.
Its preparation method specifically includes following steps:
1) blueberry making beating: by Blueberry crushing and beating, after adding 3mg/g pectase, homogenate, enzymolysis time is 1 ~ 3h, enzyme
After solution completes, obtain blueberry pulp, and add the citric acid of blueberry pulp quality 0.5%；
2) centrifugation: by centrifuge, blueberry pulp is separated into blueberry juice and blueberry pomace, at rotating speed 3000 ~ 5000r/
Under conditions of min, centrifugal 10 ~ 20min；
3) preparation of blueberry ethanol solution: by blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, obtain blueberry ethanol solution,
Unnecessary blueberry juice filling can prepare blueberry juice product；
4) the ultrasonic extraction of blueberry pomace: according to solid-liquid ratio 1:20g/mL, addition pH=2.5, volume fraction of ethanol be by blueberry pomace
65%(v/v) ethanol water, simultaneously under conditions of ultrasonic power 300-400W, Extracting temperature 50 ~ 60 DEG C, ultrasonic extraction 20-
30 min, obtain Anthocyanin from Blueberry extract；
5) centrifugal Anthocyanin from Blueberry extract: by Anthocyanin from Blueberry extract centrifugal treating, under the conditions of rotating speed 3000r/min,
Centrifugal 30min, takes filtrate, obtains Anthocyanin from Blueberry extract after filtration, filter residue is freeze-dried obtains blueberry polyoses extract；
6) freeze-drying: by Anthocyanin from Blueberry extract freeze-drying, obtain Anthocyanin from Blueberry crude extract.
7) embedding Anthocyanin from Blueberry crude extract: Anthocyanin from Blueberry crude extract is added concentration is 3.0 mg/mL carboxymethyl shells
In glycan solution, under magnetic stirring apparatus effect, after reaction 15min, being dropwise slowly added to concentration is 1.2 mg/mL shitosans
HCI solution, under magnetic stirring apparatus effect, after reaction 1h, under the conditions of rotating speed 10,000 r/min, centrifugal 10min, receives
Collection lower sediment.Freeze-drying 12-16h, obtains stable Anthocyanin from Blueberry crude extract.
8) raw material mixing: take stable Anthocyanin from Blueberry crude extract 25g, blueberry polyoses extract 10g, microcrystalline cellulose
5g, mannitol 5g, citric acid 5g and magnesium stearate 10g, be sufficiently mixed, and adds 5mL blueberry ethanol solution, makes blueberry and contains
Sheet softwood.
9) granulation is with dry: is put in oscillating granulator by blueberry buccal tablets softwood and carries out granulation, wet granular is placed in 30
Being dried in DEG C air dry oven, 20min stirs once, until the moisture in particle is down to 3%, obtains blueberry particle.
10) sterilizing: blueberry particle is irradiated 10 ~ 40min sterilizing under ultraviolet light.
11) compressing tablet: by blueberry particle compressing tablet in gnotobasis of sterilizing, and pack in time, obtain high anthocyanin
Blueberry buccal tablets finished product.
Through detection, suppressing lozenge 0.462g, through detection, contain the anthocyanin of 0.31mg in lozenge, tradition blueberry contains
Sheet cannot detect anthocyanin content.
Claims (6)
1. the preparation method of a stable high anthocyanin blueberry buccal tablets, it is characterised in that described stable high anthocyanin blueberry
The component of lozenge includes: stable Anthocyanin from Blueberry crude extract, blueberry polyoses extract, microcrystalline cellulose, mannitol, lemon
Acid, magnesium stearate and blueberry ethanol solution.
The preparation method of stable high anthocyanin blueberry buccal tablets the most according to claim 1, it is characterised in that described stable
The formula of high anthocyanin blueberry buccal tablets as follows: stable Anthocyanin from Blueberry crude extract 5 ~ 25 parts, blueberry polyoses extract 10 ~ 20
Part, microcrystalline cellulose 5 ~ 20 parts, 5 ~ 15 parts of mannitol, citric acid 2 ~ 5 parts, magnesium stearate 5 ~ 10 parts, blueberry ethanol solution 5 ~ 20
Part.
The preparation method of the most stable high anthocyanin blueberry buccal tablets, it is characterised in that described preparation side
Method specifically includes following steps:
Blueberry is pulled an oar: by Blueberry crushing and beating, after adding pectase, and homogenate, enzymolysis 1 ~ 3h, obtain blueberry pulp, in indigo plant
Certain kind of berries pulp adds citric acid；
Centrifugation: by blueberry pulp centrifugal treating, after being centrifuged, blueberry pulp is separated into blueberry juice and blueberry pomace；
The preparation of blueberry ethanol solution: by blueberry juice according to 1:2(v/v) and absolute ethyl alcohol mixing, obtain blueberry ethanol solution；
Ultrasonic extraction blueberry pomace: by blueberry pomace ultrasonic extraction 20-30 min in the ethanol water of pH=2.5 ~ 3.5,
To Anthocyanin from Blueberry extract；
Centrifugal Anthocyanin from Blueberry extract: by Anthocyanin from Blueberry extract centrifugal treating, take filtrate after filtration, obtain blueberry pattern
Glycosides extract, filter residue is freeze-dried obtains blueberry polyoses extract；
Freeze-drying: by Anthocyanin from Blueberry extract freeze-drying, obtain Anthocyanin from Blueberry crude extract；
Embedding Anthocyanin from Blueberry crude extract: Anthocyanin from Blueberry crude extract is joined in carboxymethyl chitosan solution, is thoroughly mixed
After, add chitosan hydrochloride solution, centrifugal, collect lower sediment, freeze-drying 12-16h, obtain stable Anthocyanin from Blueberry
Crude extract；
Raw material mixes: take stable Anthocyanin from Blueberry crude extract, blueberry polyoses extract, microcrystalline cellulose, mannitol, lemon
Acid, magnesium stearate, it is sufficiently mixed, adds blueberry ethanol solution, make blueberry buccal tablets softwood；
Granulation is with dry: blueberry buccal tablets softwood puts into granulation in granulator, and wet granular is put dry process, obtain blueberry
Particle；
Sterilizing: blueberry particle is irradiated 10 ~ 40min sterilizing under ultraviolet light；
Compressing tablet: by blueberry particle compressing tablet in gnotobasis of sterilizing, packaging, obtains stable high anthocyanin blueberry buccal tablets and becomes
Product.
The preparation method of the most stable high anthocyanin blueberry buccal tablets, it is characterised in that described step A
In, the addition of pectase is 0.1 ~ 3mg/g.
The preparation method of the most stable high anthocyanin blueberry buccal tablets, it is characterised in that described blueberries
The ultrasonic power of the ultrasonic extraction of slag is: 300-400W, and Extracting temperature is: 50 ~ 60 DEG C.
The preparation method of the most stable high anthocyanin blueberry buccal tablets, it is characterised in that described carboxymethyl
The concentration of chitosan solution is 2.0-3.0 mg/mL；The concentration of described chitosan hydrochloride solution is 0.6-1.2 mg/mL.
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| CN114479141A (en) * | 2022-01-27 | 2022-05-13 | 安徽农业大学 | Preparation and application of anthocyanin-rich semi-refined blueberry pectin edible film |
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| CN114479141A (en) * | 2022-01-27 | 2022-05-13 | 安徽农业大学 | Preparation and application of anthocyanin-rich semi-refined blueberry pectin edible film |
| CN115530370A (en) * | 2022-09-02 | 2022-12-30 | 沈阳农业大学 | Purple corn anthocyanin composite nutritional chewable tablet and preparation method thereof |
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| CN115886255B (en) * | 2022-10-31 | 2024-07-02 | 中国农业大学 | High-stability blueberry anthocyanin binary gel tablet and preparation method thereof |
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