CN103583951A - Ramulus mori flavone buccal tablet and preparation method thereof - Google Patents
Ramulus mori flavone buccal tablet and preparation method thereof Download PDFInfo
- Publication number
- CN103583951A CN103583951A CN201310566993.4A CN201310566993A CN103583951A CN 103583951 A CN103583951 A CN 103583951A CN 201310566993 A CN201310566993 A CN 201310566993A CN 103583951 A CN103583951 A CN 103583951A
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- China
- Prior art keywords
- buccal tablet
- essence
- mulberry twig
- flavone
- ramulus mori
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- Granted
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- 229930003944 flavone Natural products 0.000 title claims abstract description 58
- 235000011949 flavones Nutrition 0.000 title claims abstract description 58
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims abstract description 48
- 150000002212 flavone derivatives Chemical class 0.000 title claims abstract description 48
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 29
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 57
- 229920002472 Starch Polymers 0.000 claims abstract description 22
- 239000008107 starch Substances 0.000 claims abstract description 22
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 16
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000001291 vacuum drying Methods 0.000 claims abstract description 11
- 239000003085 diluting agent Substances 0.000 claims abstract description 10
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 10
- 239000000314 lubricant Substances 0.000 claims abstract description 10
- 235000019698 starch Nutrition 0.000 claims abstract description 10
- 239000003765 sweetening agent Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 240000000249 Morus alba Species 0.000 claims description 45
- 235000008708 Morus alba Nutrition 0.000 claims description 44
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 40
- 239000000686 essence Substances 0.000 claims description 31
- 239000000284 extract Substances 0.000 claims description 31
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 18
- 229930006000 Sucrose Natural products 0.000 claims description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 16
- 239000005720 sucrose Substances 0.000 claims description 16
- 229920001353 Dextrin Polymers 0.000 claims description 14
- 239000004375 Dextrin Substances 0.000 claims description 14
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 14
- 235000019425 dextrin Nutrition 0.000 claims description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 14
- 238000005469 granulation Methods 0.000 claims description 10
- 230000003179 granulation Effects 0.000 claims description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims description 10
- 239000011122 softwood Substances 0.000 claims description 10
- 235000020985 whole grains Nutrition 0.000 claims description 10
- 235000010447 xylitol Nutrition 0.000 claims description 10
- 235000004936 Bromus mango Nutrition 0.000 claims description 8
- 235000014826 Mangifera indica Nutrition 0.000 claims description 8
- 235000009184 Spondias indica Nutrition 0.000 claims description 8
- 235000015203 fruit juice Nutrition 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 235000020418 red date juice Nutrition 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- 244000099147 Ananas comosus Species 0.000 claims description 4
- 235000007119 Ananas comosus Nutrition 0.000 claims description 4
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 4
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 4
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 4
- 239000008116 calcium stearate Substances 0.000 claims description 4
- 235000013539 calcium stearate Nutrition 0.000 claims description 4
- 235000019987 cider Nutrition 0.000 claims description 4
- 235000019534 high fructose corn syrup Nutrition 0.000 claims description 4
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 235000013997 pineapple juice Nutrition 0.000 claims description 4
- 235000013948 strawberry juice Nutrition 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 3
- 229940070765 laurate Drugs 0.000 claims description 3
- 102000011759 adducin Human genes 0.000 claims description 2
- 108010076723 adducin Proteins 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 240000007228 Mangifera indica Species 0.000 claims 2
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 abstract description 18
- 239000003826 tablet Substances 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000007779 soft material Substances 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 229930003935 flavonoid Natural products 0.000 description 17
- 150000002215 flavonoids Chemical class 0.000 description 17
- 235000017173 flavonoids Nutrition 0.000 description 17
- 150000002213 flavones Chemical class 0.000 description 10
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 8
- 241001093152 Mangifera Species 0.000 description 6
- -1 ketone compounds Chemical class 0.000 description 6
- 238000000605 extraction Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000220223 Fragaria Species 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000002058 anti-hyperglycaemic effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- 240000007930 Oxalis acetosella Species 0.000 description 1
- 235000008098 Oxalis acetosella Nutrition 0.000 description 1
- 235000010240 Paullinia pinnata Nutrition 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000002038 ethyl acetate fraction Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical class OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a ramulus mori flavone buccal tablet and a preparation method thereof. The ramulus mori flavone buccal tablet is prepared by raw materials in percentage by weight as follows: 0.5%-5% of ramulus mori flavone, 1%-20% of cyclodextrin or porous starch, 0.5%-5% of a lubricant, 2%-5% of juice, 5%-19.5% of a sweetening agent, 0.05%-0.5% of a sour agent, 0.05%-0.5% of essence and the balance of a diluent. The preparation method of the ramulus mori flavone buccal tablet comprises the steps as follows: the cyclodextrin or porous starch is added to the ramulus mori flavone; the mixture is ground for 30 min until the mixture is uniform; the mixture is mixed with the diluent and the sweetening agent; 95% of ethyl alcohol is added for wetting; the mixture is prepared into a soft material; a pelletizer is used for pelleting, vacuum drying is performed, and pellets are rectified; and the lubricant, the sweetening agent, the sour agent and the essence are added and mixed for tableting, and the tablet is prepared. The ramulus mori flavone is more stable after embedded, can be released slowly and is absorbed directly through oral mucosa, and the stability and the bioavailability of the ramulus mori flavone are improved; and the ramulus mori flavone buccal tablet has the effects of resisting oxidation, regulating blood sugar level and enhancing the body immunity and good healthcare function, and is suitable for all kinds of people and convenient to carry and eat.
Description
Technical field
The present invention relates to a kind of formula and preparation method with the spacetabs type mulberry twig flavone buccal tablet of hypoglycemic activity, belong to the formula of health food and prepare category.
Background technology
Ramulus mori be Moraceae Morus plant mulberry tree (
morusalba L) spray, dry a kind of natural products of obtaining of section, in ramulus mori, contain more chemical composition, mainly contain yellow ketone compounds ﹑ Coumarins compound, how sugared ﹑ and alkaloid etc.Research shows, the biologically actives such as that mulberry twig flavone has is hypoglycemic, antiulcer, spasmolysis, antibiotic, anti-inflammatory, reducing blood lipid and analgesia are active.Therefore, be developed as spacetabs type mulberry twig flavone buccal tablet, significant to ensureing people's health.
Order east, Nanjing University hole wait people carried out mulberry twig flavone extraction (Kong Lingdong, Yang Cheng, Bao Jianwei, etc. extract of mulberry twig and extracting method thereof and new purposes, CN02113004.3).Get dry ramulus mori medicine materical crude slice, with 7 times of volume 60% ethanol waters, hot reflux three times, each 2 hours, extract is merged to reduced pressure concentration, remove extract after ethanol through polyamide column chromatography, water, 30% ethanol, 60% ethanol and 80% ethanol is wash-out successively, reclaims respectively solvent, and concentrate drying obtains mulberry twig flavone.
University Of Suzhou talks and builds the medium total mulberry twig flavone extraction (Tan Jianzhong that carried out, Wu Zhiping, Peng Shaoping, Deng. extraction process of total mulberry twig flavone CN200510039202.8) to take the RAMULUS MORI of raw half-corkificated be then raw material, airing or oven dry, pulverizing after cleaning, cross 40～50 mesh sieves, obtain RAMULUS MORI meal; Meal is carried after 1 hour by benzinum heat, the ethanol that is 60～65% by 10 times of amounts, concentration of dregs of a decoction volume is as extracting solvent, lixiviate, filtration, merging filtrate reflux under 90 ℃ of water bath with thermostatic control conditions, reduced pressure concentration, by crude extract dilute with water, water alcohol method is removed water-insoluble impurity, with petroleum ether extraction, remove oil-soluble impurities again, mother liquor is extracted with ethyl acetate, and discards Ethyl acetate fraction, mother liquor extracting n-butyl alcohol, reclaim n-butanol, obtain extracting n-butyl alcohol position, the concentrated medicinal extract that to obtain, the dry total mulberry twig flavone that to obtain.
Above 2 pieces of patents, all relate to extraction and the purification process of mulberry twig flavone rather than the preparation method of mulberry twig flavone food.
The guangdong agricultural science Yuan Canyeyu processing of farm products Wu of the research institute bright grade of giving pleasure to is applied extract of mulberry twig that (Wu gives pleasure to bright in preparation has the food of fat-reducing and antihyperglycemic, Zou Yuxiao, Xiao Gengsheng, Deng. extract of mulberry twig, in preparation, there is the purposes in the food of fat-reducing and antihyperglycemic, CN200410077773.6), extract of mulberry twig is prepared into bread and cheese, health food or the medicine with fat-reducing and effect for reducing blood fat.But mulberry twig flavone, after cyclodextrin or porous starch embedding, is equipped with to the edible auxiliary materials such as diluent, lubricant, fruit juice, flavouring, and the buccal tablet product of making through multiple technique, yet there are no bibliographical information.
Summary of the invention
The object of this invention is to provide a kind of take mulberry twig flavone as basis, there is buccal tablet of plurality of health care functions and preparation method thereof.
Technical scheme of the present invention is: a kind of buccal tablet made from mulberry twig flavone, it is to be made by the raw material of following weight proportioning: mulberry twig flavone 0.5 ~ 5%, cyclodextrin or porous-starch 1 ~ 20%, lubricant 0.5 ~ 5%, fruit juice 2 ~ 5%, sweetener 5 ~ 19.5%, acid 0.05%-0.5%, essence 0.05%-0.5%, all the other are diluent.
Described diluent is: at least one in dextrin, lactose, starch, microcrystalline cellulose.
Described lubricant is: at least one in magnesium stearate, glycerin monostearate, calcium stearate, hydrogenated vegetable oil, laurate.
Described fruit juice is: at least one in jujube juice, cider, strawberry juice, orange blossom, pineapple juice, mango juice.
Described sweetener is at least one in sucrose, xylitol, glucose, HFCS.
Described acid is at least one in citric acid, malic acid, lactic acid.
Described essence is at least one in red date essence, flavoring apple essence, strawberry essence, orange essence, flavoring pineapple essence, mango essence.
The preparation method of the buccal tablet made from mulberry twig flavone comprises the steps:
(1) dry ramulus mori is pulverized rear, cleaning, adds the ethanol of 8-15 times of 50-95%, and 400 MPa pressure extract 5-10min;
(2) extract, through centrifuge at the separated 20min of 4000rpa, then adopts the ultrafilter of 1 ~ 20,000 molecular weight to carry out ultrafiltration;
(3) ultrafiltration filtered solution Vacuum Concentration at 40 ~ 60 ℃ becomes medicinal extract, medicinal extract flavones content 20-50%;
(4) Flavonoid extract is first added to cyclodextrin or the porous-starch of 2-5 times of quality; the 30min that mills is to evenly, and then with diluent, 2 ~ 5% fruit juice mixes; add 95% ethanol moistening; be prepared as softwood, granulator granulation, vacuum drying; whole grain; then add lubricant, sweetener, acid and essence mixed pressuring plate, the heavy 250mg ~ 500mg of sheet, every containing flavones 0.25 ~ 25mg.
Beneficial effect of the present invention: it is primary raw material that the present invention adopts mulberry twig flavone, first after cyclodextrin, porous starch embedding, be equipped with again the auxiliary materials such as fruit juice, diluent, lubricant, sweetener, acid and essence, by scientific allocation, form, have easily take, feature that mouthfeel is good, and mulberry twig flavone is more stable after embedding, after can slowly discharging, by oral mucosa, directly absorbed, improved stability and the bioavailability of mulberry twig flavone.That product of the present invention has is anti-ageing, anti-oxidant, improve the effects such as human body immunocompetence, and health care is good, is applicable to all kinds of crowds edible, easy for carrying and eating.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
The specific embodiment
Embodiment 1
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 5 kilograms of Flavonoid extracts, 13 kilograms of cyclodextrin, DEXTRIN kilogram, 20 kilograms of microcrystalline celluloses, 6 kilograms of xylitols, 1 kilogram of magnesium stearate, 9 kilograms of sucrose, 0.5 kilogram of citric acid, 5 kilograms of orange blossoms, 0.5 kilogram of orange essence; Flavonoid extract is first added to cyclodextrin; the 30min that mills, to evenly, then mixes with dextrin, microcrystalline cellulose, orange blossom, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add magnesium stearate, xylitol, sucrose, citric acid, orange essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 2.5 ~ 15mg.
Embodiment 2
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 2.5 kilograms of Flavonoid extracts, 7.5 kilograms of porous-starch, DEXTRIN kilogram, 32.6 kilograms of microcrystalline celluloses, 5 kilograms of xylitols, 1 kilogram of magnesium stearate, 9 kilograms of sucrose, 0.3 kilogram of citric acid, 2 kilograms of jujube juices, 0.1 kilogram, red date essence; Flavonoid extract is first added to porous-starch; the 30min that mills, to evenly, then mixes with dextrin, microcrystalline cellulose, jujube juice, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add magnesium stearate, xylitol, sucrose, citric acid, red date essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 1.25 ~ 7.5mg.
Embodiment 3
Mulberry twig flavone buccal tablet: take weight kilogram Ji， unit as kilogram, take respectively 0.5 kilogram of Flavonoid extract, 20 kilograms of cyclodextrin, 40 kilograms of starch, 32 kilograms of microcrystalline celluloses, 5 kilograms of sucrose, 0.5 kilogram of calcium stearate, 0.05 kilogram of malic acid, 2 kilograms of ciders, 0.05 kilogram of flavoring apple essence; Flavonoid extract is first added to cyclodextrin; the 30min that mills, to evenly, then mixes with starch, microcrystalline cellulose, cider, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add calcium stearate, sucrose, malic acid, flavoring apple essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 0.25 ~ 1.5mg.
Embodiment 4
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 3 kilograms of Flavonoid extracts, 1 kilogram of porous-starch, DEXTRIN kilogram, 33.5 kilograms of lactose, 5 kilograms of glucose, 5 kilograms of glycerin monostearates, 9 kilograms of sucrose, 0.3 kilogram of citric acid, 3 kilograms of strawberry juices, 0.2 kilogram of strawberry essence; Flavonoid extract is first added to porous-starch; the 30min that mills, to evenly, then mixes with dextrin, lactose, strawberry juice, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add glycerin monostearate, glucose, sucrose, citric acid powder, strawberry essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 1.5 ~ 9mg.
Embodiment 5
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 4 kilograms of Flavonoid extracts, 20 kilograms of cyclodextrin, 40 kilograms of starch, 9.07 kilograms of microcrystalline celluloses, 19.5 kilograms of HFCSs, 3 kilograms of hydrogenated vegetable oils, 0.4 kilogram of citric acid, 4 kilograms of pineapple juice, 0.03 kilogram of flavoring pineapple essence; Flavonoid extract is first added to cyclodextrin; the 30min that mills, to evenly, then mixes with starch, microcrystalline cellulose, pineapple juice, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add hydrogenated vegetable oil, HFCS, citric acid, flavoring pineapple essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 2 ~ 12mg.
Embodiment 6
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 5 kilograms of Flavonoid extracts, 15 kilograms of porous-starch, 35 kilograms, dextrin, 20.8 kilograms of lactose, 10 kilograms of glucose, 2.5 kilograms of laurates, 6 kilograms of sucrose, 0.2 kilogram of lactic acid, 3 kilograms of mango juices, 0.5 kilogram, mango essence; Flavonoid extract is first added to porous-starch; the 30min that mills, to evenly, then mixes with dextrin, lactose, mango juice, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add laurate, glucose, sucrose, lactic acid, mango essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 2.5 ~ 15mg.
Embodiment 7
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 4 kilograms of Flavonoid extracts, 13 kilograms of cyclodextrin, 35 kilograms, dextrin, 21 kilograms of microcrystalline celluloses, 8 kilograms of xylitols, 2 kilograms of magnesium stearates, 10 kilograms of sucrose, 0.5 kilogram of citric acid, 5 kilograms of orange blossoms, 0.5 kilogram of orange essence; Flavonoid extract is first added to cyclodextrin; the 30min that mills, to evenly, then mixes with dextrin, microcrystalline cellulose, orange blossom, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add magnesium stearate, xylitol, sucrose, citric acid, orange essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 2 ~ 12mg.
Embodiment 8
Mulberry twig flavone buccal tablet: in weight kilogram, unit is kilogram, take respectively 2.5 kilograms of Flavonoid extracts, 9 kilograms of porous-starch, 25 kilograms, dextrin, 30.3 kilograms of microcrystalline celluloses, 10 kilograms of xylitols, 4 kilograms of magnesium stearates, 5 kilograms of sucrose, 0.1 kilogram of citric acid, 4 kilograms of jujube juices, 0.1 kilogram, red date essence; Flavonoid extract is first added to porous-starch; the 30min that mills, to evenly, then mixes with dextrin, microcrystalline cellulose, jujube juice, adds 95% ethanol moistening; be prepared as softwood; granulator granulation, vacuum drying, whole grain; then add magnesium stearate, xylitol, sucrose, citric acid, red date essence to mix; compressing tablet, the heavy 250mg ~ 500mg of sheet, every containing flavones 1.25 ~ 7.5mg.
Claims (8)
1. a buccal tablet made from mulberry twig flavone, it is characterized in that: it is to be made by the raw material of following weight proportioning: mulberry twig flavone 0.5 ~ 5%, cyclodextrin or porous-starch 1 ~ 20%, lubricant 0.5 ~ 5%, fruit juice 2 ~ 5%, sweetener 5 ~ 19.5%, acid 0.05%-0.5%, essence 0.05%-0.5%, all the other are diluent.
2. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described diluent is: at least one in dextrin, lactose, starch, microcrystalline cellulose.
3. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described lubricant is: at least one in magnesium stearate, glycerin monostearate, calcium stearate, hydrogenated vegetable oil, laurate.
4. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described fruit juice is: at least one in jujube juice, cider, strawberry juice, orange blossom, pineapple juice, mango juice.
5. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described sweetener is at least one in sucrose, xylitol, glucose, HFCS.
6. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described acid is at least one in citric acid, malic acid, lactic acid.
7. the buccal tablet made from mulberry twig flavone according to claim 1, is characterized in that: described essence is at least one in red date essence, flavoring apple essence, strawberry essence, orange essence, flavoring pineapple essence, mango essence.
8. according to the preparation method of the buccal tablet made from mulberry twig flavone described in any one in claim 1-7, it is characterized in that: comprise the steps:
(1) prepare mulberry twig flavone: dry ramulus mori is pulverized to rear, cleaning, add the ethanol of 8-15 times of 50-95%, 400 MPa pressure extract 5-10min; Extract at the separated 20min of 4000rpa, then adopts the ultrafilter of 1 ~ 20,000 molecular weight to carry out ultrafiltration through centrifuge; Ultrafiltration filtered solution Vacuum Concentration at 40 ~ 60 ℃ becomes medicinal extract, makes mulberry twig flavone;
(2) in mulberry twig flavone, add cyclodextrin or porous-starch; the 30min that mills is to even; then mix with diluent, fruit juice, add 95% ethanol moistening, be prepared as softwood; granulator granulation; vacuum drying, whole grain, then adds lubricant, sweetener, acid and essence; mixed pressuring plate, makes buccal tablet.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919127A (en) * | 2016-04-27 | 2016-09-07 | 安徽农业大学 | Stable high anthocyanin blueberry buccal tablets and preparation method thereof |
| CN107801904A (en) * | 2017-11-27 | 2018-03-16 | 中国农业科学院农产品加工研究所 | A kind of anti-caries tooth removes compound lozenge of halitosis quinoa and preparation method thereof |
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| CN1726963A (en) * | 2005-07-25 | 2006-02-01 | 正安医药(天津)药物研究发展有限公司 | Oral taking preparation of mulberry leaves possessing function for lowering blood sugar, and detection method |
| CN1742803A (en) * | 2005-08-11 | 2006-03-08 | 原爱红 | Chinese medicine extract with function of reducing blood-sugar and preparing method |
| CN103159807A (en) * | 2013-03-27 | 2013-06-19 | 苏州大学 | Ramulus mori extract and preparation method thereof |
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| CN1706837A (en) * | 2005-04-30 | 2005-12-14 | 苏州大学 | Extraction process of total mulberry twig flavone |
| CN1726963A (en) * | 2005-07-25 | 2006-02-01 | 正安医药(天津)药物研究发展有限公司 | Oral taking preparation of mulberry leaves possessing function for lowering blood sugar, and detection method |
| CN1742803A (en) * | 2005-08-11 | 2006-03-08 | 原爱红 | Chinese medicine extract with function of reducing blood-sugar and preparing method |
| CN103159807A (en) * | 2013-03-27 | 2013-06-19 | 苏州大学 | Ramulus mori extract and preparation method thereof |
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| CN105919127A (en) * | 2016-04-27 | 2016-09-07 | 安徽农业大学 | Stable high anthocyanin blueberry buccal tablets and preparation method thereof |
| CN105919127B (en) * | 2016-04-27 | 2019-02-05 | 安徽农业大学 | A kind of stable high anthocyanin blueberry buccal tablets and preparation method thereof |
| CN107801904A (en) * | 2017-11-27 | 2018-03-16 | 中国农业科学院农产品加工研究所 | A kind of anti-caries tooth removes compound lozenge of halitosis quinoa and preparation method thereof |
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| CN103583951B (en) | 2015-03-11 |
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