CN104116071B - Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof - Google Patents

Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof Download PDF

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CN104116071B
CN104116071B CN201410232902.8A CN201410232902A CN104116071B CN 104116071 B CN104116071 B CN 104116071B CN 201410232902 A CN201410232902 A CN 201410232902A CN 104116071 B CN104116071 B CN 104116071B
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parts
lac regis
regis apis
grifola frondosa
microcapsule
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CN104116071A (en
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黄力群
皮金红
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Wuhan Sinter Food Co., Ltd.
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WUHAN SIWEITE FOOD Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23PSHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00Shaping or working of foodstuffs characterised by the products
    • A23P10/30Encapsulation of particles, e.g. foodstuff additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof, this microcapsule is made up of outer layer glue wall and internal layer core, described internal layer core is calculated by weight as the Lac regis apis of 40~80 parts, the Grifola frondosa extracting solution of 20~40 parts and the litchi nucleus extract fluid of 5~20 parts, and described outer layer glue wall is calculated by weight as the arabic gum of 100~125 parts, the maltodextrin of 100~125 parts, the gelatin of 10~30 parts and the sucrose of 20~35 parts.The method is to be mixed homogeneously with outer wall material by internal layer core, after emulsifying, by pelletize, wall material is solidified, and obtaining particle diameter is 1~20 μm Lac regis apis Semen Litchi Grifola frondosa microcapsules.The polysaccharide that the microcapsule of the present invention contains has the positive role of minimizing blood glucose (sugared).The unsaturated fatty acid being included in Effects of Extracts of Grifola frondosa on Active such as linolein, has the effect of reduction blood glucose, cholesterol and arteriosclerosis equally.

Description

Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof
Technical field
The present invention relates to Lac regis apis microcapsule, in particular to a kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof.
Background technology
Lac regis apis is the bee product that a class component is considerably complicated, and it is along with bee species, age, season, the difference of pollen plant, and its chemical composition is the most different.In general, its composition is: moisture content 64.5~69.5%, crude protein 11~14.5%, carbohydrate 13~15%, lipid 6.0%, mineral 0.4~2%.
Protein accounts for the 50% of Lac regis apis dry, and wherein having 2/3 is albumin, and 1/3 is globulin, and the protein in Lac regis apis has more than 12 kinds, in addition with many small peptides.
Aminoacid accounts for the 1.8% of Lac regis apis dry weight, 8 kinds of essential amino acids required in human body, has existence in Lac regis apis, and wherein proline content a maximum of about of accounts for 63%, has found 20 kinds of aminoacid at present in Lac regis apis.
Lac regis apis contains nucleic acid, wherein the aobvious weight of the micro-gram gram of DNA (deoxyribonucleic acid) (DNA) 201~223, the aobvious weight of ribonucleic acid 3.9~4.9 milligrams per gram.
Containing 20~the saccharide of 30% (dry weight) in Lac regis apis, the most substantially containing fructose 52%. glucose 45%, sucrose 1%, maltose 1%, gentiobiose 1%.
It is the abundantest that Lac regis apis contains more vitamin, especially vitamin B group.Mainly have: thiamine (B1), riboflavin (B2), pyridoxol (B6), vitamin B12, nicotinic acid, pantothenic acid, folic acid, biotin, inositol, vitamin C, vitamin D etc., wherein pantothenic acid content is the highest.
Lac regis apis contains the fatty acid of more than 26 kinds, the most certified have 12 kinds, they are 10-HAD (10-HDA), capric acid, n-nonanoic acid, hendecanoic acid, dodecylic acid, tetradecanoic acid (myristic acid), myristoleic acid, hexadecanoic acid (Palmic acid), octadecanoid acid, palmitoleic acid, arachidic acid and linoleic acid etc., wherein 10-HAD, content is more than 1.4%, owing to nature only having containing this material in Lac regis apis, so also it being referred to as Royal Jelly acid.
Lac regis apis contains 9 kinds of steroid compounds, the most identified go out three kinds, they are stigmasterol, cholesterol and sitoesterol.Additionally possibly together with mineral, ferrum, copper, magnesium, zinc, potassium, sodium etc..
Effect of Lac regis apis:
1) Lac regis apis contains acetylcholine, and vegetative nerve can be made to recover normal, notable to treatment cardiovascular diseases's effect;
2) Lac regis apis is rich in vitamin B and high quality protein, particularly containing the royal jelly acid that sterilizing power is strong, thus is good medicine for cancer;
3) Lac regis apis has promotion hemopoietic function effect, and developmental children can increase hemoglobin, promotes growth, improves premunition;
4) Lac regis apis is contained within pantothenic acid, can improve rheumatism and joint symptoms;
5) Lac regis apis contains para-insulin, and diabetes are had better effects;
6) Lac regis apis can strengthen adrenal cortex function, regulates human hormone, brain cell between activation, is conducive to treatment climacteric disfunction and chronic prostatitis syndrome;
7) Lac regis apis can strengthen the basis muscle power of people, makes human senility tissue activate, and after clothes, appetite is good, and long spirit, complexion is good;
8) peptide contained by Lac regis apis and protein-based healthy ingredient, can promote intelligent development, thus take and can improve memory;
9) Lac regis apis contains proteohormone, with blood circulation whole body after clothes, contributes to skin histology functional recovery vigor, treatment is scalded effect obvious;
10) Lac regis apis contains plurality of inorganic salt, can promote that glycogen discharges, and promotes metabolism, thus can improve looks, and eliminates speckle.
But, Lac regis apis, to thermoae instability, is placed one day at normal temperatures, and freshness is decreased obviously, about 130 degree inefficacies.But the most stable, can preserve when-2 spend 1 year, the several years can be preserved when-18 spend constant.Lac regis apis exposes in atmosphere, can play oxidation, hydrolysis, and light has catalytic action to Lac regis apis, and its aldehyde radical, ketone group are risen reduction.
nullGrifola frondosa is nutritious,Its nutrient content is done in Grifola frondosa and (is wherein contained amino acid needed by human body 18 kinds 18.68 grams through Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene and the Ministry of Agriculture's each hectogram of Product Quality Verification Centers detection containing 25.2 grams of protein,Wherein must base acid account for 45.5%) fat 3.2 grams、Dietary fiber 33.7 grams、Carbohydrate 21.4 grams,Ash 5.1 grams、Mineral rich in multiple beneficial,Potassium、Phosphorus、Ferrum、Zinc、Calcium、Copper、Selenium、Chromium etc.,Vitamin content enriches,VE109.7 milligram、VB11.47 milligram、VB20.72 milligram、VC17.0 milligram,Carotene 4.5 milligrams. various nutrients occupies first of various edible fungi,Wherein VB1 and VE content is the highest 10~20 times,VC content is 3~5 times that it is similar,Protein and aminoacid are 2 times of Lentinus Edodes,Can promote that children's torso is grown up healthy and sound and intelligent development,In relevant arginine and lysine content relatively Flammulina velutiper (Fr.) Sing, the content of lysine (1.024%) and arginine (1.231%) is high;The Aspartic Acid relevant with delicate flavour and content of glutamic acid are higher, are therefore described as " edible fungi prince " and " North China Radix Ginseng ".
Grifola frondosa has high medical health care function.According to reported in literature, it has suppression hypertension and effect of obesity;Owing to rich in ferrum, copper and vitamin C, it can prevent anemia, vitamin C deficiency, vitiligo, prevent the generation of arteriosclerosis and cerebral thrombosis;Its selenium and chromium content are higher, protected liver, pancreas, prevention liver cirrhosis and the effect of diabetes;Se content height makes it also have and prevents and treats Keshan disease, Kaschin-Beck disease and some cardiopathic function;It is held concurrently calcic and vitamin D, and both coordinate, and can effectively prevent and treat rickets;The favourable brain development of higher Zn content, holding oxyopia, promote wound healing;The vitamin E of high-load and selenium coordinate, and make it defying age, memory reinforcing and sensitivity.
Fructus Litchi (formal name used at school Litchi chinensis) is a kind of subtropical fruit tree that SOUTHERN CHINA is produced.Fructus Litchi is the important fruit crops in south China, and annual output is more than 1,000,000 tons.It is again separated branch.Trees are tall and big, and leaves does not falls, and fruit is ripe in five Junes.Poet's Pai Chu-yi once described: " if this fruit leaves trunk, then complexion changed, then fragrant change on the two, then taste change on the three on the one, after four or five days, color is not the most deposited, so name separated branch.”
The seed that source is sapindaceous plant Fructus Litchi Litchi chinensis Sonn. of Semen Litchi extract.Seed is contained within Saponin (1.12%), tannin (3.43%) and alpha-methylene cyclopropylglycine.And isolate the volatile oil of trace, wherein contain 3-Hydroxybutanone, 2,3-butanediol, cluck (king's bar) alkene, cis-Flos Caryophylli alkene, fragrant alkene, oxalene, δ-cubeb, α-curcumene, xanthorrhizol etc..
At present, it is not the most that raw material preparation produces the product obtaining as being prepared as microcapsule by these three material.
Summary of the invention
It is an object of the invention to overcome above-mentioned existing industry prejudice, and a kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule is provided, the component of sensitivity in Lac regis apis is coated, isolating oxygen, light, ultraviolet, prevent oxidation deterioration, reduce the external environment impact on capsule core material.Meanwhile, the core that Lac regis apis is mixed to prepare with Grifola frondosa extracting solution and litchi nucleus extract fluid, give full play to its health-care effect.
For solving above-mentioned technical problem, a kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule that the present invention provides, this microcapsule is made up of outer layer glue wall and internal layer core, described internal layer core is calculated by weight as the Lac regis apis of 40~80 parts, the Grifola frondosa extracting solution of 20~40 parts and the litchi nucleus extract fluid of 5~20 parts, and described outer layer glue wall is calculated by weight as the arabic gum of 100~125 parts, the maltodextrin of 100~125 parts, the gelatin of 10~30 parts and the sucrose of 20~35 parts.
Further, described internal layer core is calculated by weight as the Lac regis apis of 60~80 parts, the Grifola frondosa extracting solution of 20~30 parts and the litchi nucleus extract fluid of 10~20 parts.
Yet further, described internal layer core is calculated by weight as the Lac regis apis of 80 parts, the Grifola frondosa extracting solution of 20 parts and 15 parts of litchi nucleus extract fluids, and described outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts.
Present invention also offers the preparation method of a kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, comprise the following steps:
1) based on above-mentioned parts by weight, weigh Lac regis apis, Grifola frondosa extracting solution and litchi nucleus extract fluid, mix homogeneously, obtain internal layer core;
2) based on above-mentioned parts by weight, weigh arabic gum, maltodextrin, gelatin and sucrose, obtain outer wall material;
3) being mixed homogeneously with outer wall material by internal layer core, after emulsifying, by pelletize, wall material is solidified, obtaining particle diameter is 1~20 μm Lac regis apis Semen Litchi Grifola frondosa microcapsules.
The beneficial effects of the present invention is:
1, the polysaccharide that the microcapsule of the present invention contains has the positive role of minimizing blood glucose (sugared).The unsaturated fatty acid being included in Effects of Extracts of Grifola frondosa on Active such as linolein, has the effect of reduction blood glucose, cholesterol and arteriosclerosis equally.
2, the microcapsule of the present invention is prepared from by Lac regis apis, Grifola frondosa extracting solution and litchi nucleus extract fluid, this microcapsule also has a lot of polysaccharide, polysaccharide can activated immune response such as macrophage, natural killer cell, T-lymphocyte, and lymphokine and interleukin.These character make it can be used for prophylaxis of cancer.Research shows that it can reduce chemotherapeutic side effect.
3, microcapsule contains Saponin and effectively reduces blood glucose, and its mechanism of action is to improve body and the surrounding tissue utilization rate to glucose.
4, after micro encapsulation, material inside and outside capsule can be isolated by cyst wall, therefore can stop generation chemical reaction between active substance.
5, the maximum feature of microcapsule be can control release within be wrapped material so that it is out or the most gradually discharge in a certain abrupt release.Abrupt release be by extruding, rub, melting, the effect such as dissolving make shell disintegrate;It is then that outside housing, gradually infiltration or shell gradually dissolve, degrade and make Release of core material out by core by ashamed release.After Lac regis apis, Grifola frondosa extracting solution and litchi nucleus extract fluid are made microcapsule, not only convenient oral, it is often more important that it can be made slowly to discharge, make effect lasting, thus can reduce and take number of times and dose, reduce physiological side effects, improve effect value that microcapsule is immediately used by the body.
Detailed description of the invention
In order to preferably explain the present invention, it is further elucidated with the main contents of the present invention below in conjunction with specific embodiment, but present disclosure is not limited solely to following example.
Embodiment 1
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 80 parts, the Grifola frondosa extracting solution of 20 parts and the litchi nucleus extract fluid of 20 parts, and outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 30 parts and the sucrose of 20 parts.
The preparation method of Lac regis apis Semen Litchi Grifola frondosa microcapsule, comprises the following steps:
1) based on above-mentioned parts by weight, weigh Lac regis apis, Grifola frondosa extracting solution and litchi nucleus extract fluid, mix homogeneously, obtain internal layer core;
2) based on above-mentioned parts by weight, weigh arabic gum, maltodextrin, gelatin and sucrose, obtain outer wall material;
3) being mixed homogeneously with outer wall material by internal layer core, after emulsifying, by spray drying method pelletize, wall material is solidified, obtaining particle diameter is 1~20 μm Lac regis apis Semen Litchi Grifola frondosa microcapsules.
Embodiment 2
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 40 parts, the Grifola frondosa extracting solution of 40 parts and the litchi nucleus extract fluid of 20 parts, and outer layer glue wall is calculated by weight as the arabic gum of 100 parts, the maltodextrin of 100 parts, the gelatin of 30 parts and the sucrose of 35 parts.
Its preparation method is same as in Example 1.
Embodiment 3
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 60 parts, the Grifola frondosa extracting solution of 30 parts and the litchi nucleus extract fluid of 20 parts, and outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts.
Its preparation method is same as in Example 1.
Embodiment 3
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 80 parts, the Grifola frondosa extracting solution of 20 parts and the litchi nucleus extract fluid of 15 parts, and outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts.
Its preparation method is same as in Example 1.
Embodiment 4
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 40 parts, the Grifola frondosa extracting solution of 40 parts and the litchi nucleus extract fluid of 10 parts, and outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts.
Its preparation method is same as in Example 1.
Embodiment 5
A kind of Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is made up of outer layer glue wall and internal layer core, internal layer core is calculated by weight as the Lac regis apis of 80 parts, the Grifola frondosa extracting solution of 20 parts and the litchi nucleus extract fluid of 5 parts, and outer layer glue wall is calculated by weight as the arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts.
Its preparation method is same as in Example 1.
Below by contrast experiment Lac regis apis Semen Litchi Grifola frondosa microcapsule that embodiment 3 the prepares effectiveness comparison in terms of regulation hyperlipidemia, cholesterol, hyperglycemia is described:
Hyperlipidemia, cholesterol, hyperglycemia patient is chosen by four age brackets, wherein, 30~within 40 years old, to choose 300 examples, 40~50 years old and choose 300 examples, 50~60 years old and choose 300 people, 60~70 years old to choose the M-F of 300 four age brackets of people be 11, female 43 people, according to exceeding country blood fat, cholesterol, the standard of blood glucose, by four age bracket random assortment three groups, in each group, each age bracket has 100 people, and first group of patient is that 400 people, second group of patient are 400 people and the 3rd group of patient is 400 people.Wherein T-CHOL TCHO normal value: 3.0~5.7mmol/L;Triglyceride TG normal value: 0.5~1.7mmol/L;Blood glucose normal value: on an empty stomach less than 6.2, is less than 7.8 in two hours after the meal.
First group (matched group): drink tradition Lac regis apis, every day is the most each once, and each Lac regis apis Folium Camelliae sinensis 5 grams, early, middle and late three warm water brew to be drunk.It was a cycle with one month, within three months, is a course for the treatment of.
Second group (experimental group): take Lac regis apis Semen Litchi Grifola frondosa microcapsule of the present invention, three times a day, each microcapsule 3, early, middle and late three warm water are taken.The microcapsule wherein prepared with embodiment 3 is taken, and the proportion of composing of amount part is 1:1.It was a cycle with one month, within three months, is a course for the treatment of.
3rd group (blank group): drink boiled water, do not drink other beverages and medicine.It was a cycle with one month, within three months, is a course for the treatment of.
Meanwhile, in the trimestral course for the treatment of, it is ensured that the diet situation of the patient in age-grade stage is consistent.
Standard of comparison is set to, and (1) has effective: refer to that within trimestral time blood fat, cholesterol, blood glucose have the decline of bigger degree, already close to, substantially close to or reached standard value.(2) effective: to refer to that within trimestral time blood fat, cholesterol, blood glucose have the decline of bigger degree, have the development trend close to or up standard value.(3) invalid: to refer to that degree that within trimestral time blood fat, cholesterol, blood glucose decline is less or substantially without decline.
As can be known from the above table: by statistical analysis experimental group of the present invention compared with matched group and blank group, have significant difference with matched group having in effective number.Efficiently individual quantity has significant difference with matched group.Invalid number is that matched group is compared and also had significant difference.Meanwhile, best in 30~40 age bracket effects, it is possible to the recovery capability of the patient of 30~40 age brackets is strong, but knowable to three contrasts, Lac regis apis Semen Litchi Grifola frondosa microcapsule health-care effect is more preferable.Other unspecified part is prior art.Although above-described embodiment is made that detailed description to the present invention; but its a part of embodiment that is only the present invention; rather than whole embodiments, people can also obtain other embodiments according to the present embodiment under without creative premise, and these embodiments broadly fall into scope.

Claims (2)

1. a Lac regis apis Semen Litchi Grifola frondosa microcapsule, this microcapsule is by outer layer glue wall and interior Layer core composition, described internal layer core be calculated by weight as 80 parts Lac regis apis, 20 parts Grifola frondosa extracting solution and 15 parts of litchi nucleus extract fluids, described outer layer glue wall is calculated by weight as The arabic gum of 125 parts, the maltodextrin of 125 parts, the gelatin of 20 parts and the sucrose of 30 parts; It is characterized in that: the preparation method of described Lac regis apis Semen Litchi Grifola frondosa microcapsule, including following Step:
1) based on above-mentioned parts by weight, weigh Lac regis apis, Grifola frondosa extracting solution and Semen Litchi extract Liquid, mix homogeneously, obtain internal layer core;
2) based on above-mentioned parts by weight, arabic gum, maltodextrin, gelatin and sucrose are weighed, Obtain outer wall material;
3) internal layer core is mixed homogeneously with outer wall material, after emulsifying, make wall by pelletize Material solidifies, and obtaining particle diameter is 1~20 μm Lac regis apis Semen Litchi Grifola frondosa microcapsules.
2. a preparation method for Lac regis apis Semen Litchi Grifola frondosa microcapsule described in claim 1, It is characterized in that: comprise the following steps:
1) based on above-mentioned parts by weight, weigh Lac regis apis, Grifola frondosa extracting solution and Semen Litchi extract Liquid, mix homogeneously, obtain internal layer core;
2) based on above-mentioned parts by weight, arabic gum, maltodextrin, gelatin and sucrose are weighed, Obtain outer wall material;
3) internal layer core is mixed homogeneously with outer wall material, after emulsifying, make wall by pelletize Material solidifies, and obtaining particle diameter is 1~20 μm Lac regis apis Semen Litchi Grifola frondosa microcapsules.
CN201410232902.8A 2014-05-29 2014-05-29 Lac regis apis Semen Litchi Grifola frondosa microcapsule and preparation method thereof Active CN104116071B (en)

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CN106551422A (en) * 2016-11-30 2017-04-05 湖北中烟工业有限责任公司 Preparation method and application of the cigarette with Semen Ziziphi Spinosae extractum
CN110432492A (en) * 2019-08-26 2019-11-12 江南大学 A kind of hypoglycemic nano-clathrate and preparation method thereof

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