CN111991546A - A capsule containing Acer Truncatum Bunge extract and its preparation method - Google Patents
A capsule containing Acer Truncatum Bunge extract and its preparation method Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention discloses a capsule containing acer truncatum bunge extract and a preparation method thereof, relating to the technical field of medicament processing and comprising the following raw materials in parts by weight: 10-20 parts of acer truncatum seed oil, 3-10 parts of a wolfberry fruit extract, 2-8 parts of a wild lotus leaf extract, 6-12 parts of an black fungus extract, 4-12 parts of a ginkgo leaf extract, 3-10 parts of a juniper melon young fruit extract, 4-10 parts of a lotus leaf extract, 4-8 parts of a buckwheat stem extract, 2-8 parts of a Chinese red pine needle extract, 4-12 parts of a bamboo leaf extract, 3-8 parts of a buckwheat leaf and lily extract, 80-120 parts of porous starch and 10-20 parts of maltodextrin. The capsule has the effects of enhancing immunity, promoting brain development, resisting oxidation, aging and tumors, reducing blood pressure and blood fat and the like, can effectively reduce the formation of free radicals and the antioxidant activity of removing the free radicals, adjust the tension and elasticity of blood vessels, improve cardiovascular and cerebrovascular diseases, and provides a health-care medicine with the effects of resisting oxidation, aging and tumors, reducing blood pressure and blood fat and the like for human beings.
Description
Technical Field
The invention relates to the technical field of medicine processing, in particular to a capsule containing acer truncatum bunge extract and a preparation method thereof.
Background
Acer truncatum Bunge is a tree of Aceraceae Acer genus, and is named because the wing fruit looks like a shoe-shaped ingot. The acer truncatum is a special tree species in China, has many and large fruits and wide distribution, is mainly concentrated in various provinces in the middle and lower reaches of the yellow river and the south of the northeast, and breaks through 3.13 ten thousand hm of the area of the acer truncatum artificial forest in the west, the north and the like of China along with the development of the acer truncatum industry2. The acer truncatum bunge is a tree species which integrates edible oil, medical care, chemical raw materials, ornamental and special wood, has high use value and integrates social, economic and ecological values, and has good application and development prospects.
The oil content of acer truncatum seeds is 42.6%, the content of unsaturated fatty acid is 92%, and the content of nervonic acid is 5.52%. The existence of nervonic acid makes the acer truncatum buge oil have more research and development values. Research shows that the acer truncatum buge oil has important functions in enhancing immunity, promoting brain development, resisting tumor, beautifying, etc. The acer truncatum resource is rich in China, the acer truncatum has large bearing capacity, the average bearing capacity of 15-20 years of trees of a single plant is 20-25kg, low-price and sufficient raw materials are provided for developing acer truncatum oil products, and the development potential is huge. At present, the acer truncatum seed oil products are rare in types and uneven in quality, the healthy development of the acer truncatum seed oil is restricted, and the improvement of the quality of the acer truncatum seed oil and the acceleration of the research and development of new acer truncatum products are urgently needed.
Disclosure of Invention
In view of the above, the present invention provides a capsule containing acer truncatum bunge extract and a preparation method thereof, wherein acer truncatum bunge seed oil is combined with a plurality of medicinal materials to prepare the capsule, such that effects of the acer truncatum bunge seed oil are fully exerted, healthy development of the acer truncatum bunge seed oil is promoted, and a health care medicine with effects of oxidation resistance, aging resistance, tumor resistance, blood pressure reduction, blood fat reduction, etc. is provided for human beings.
The invention solves the technical problems by the following technical means:
a capsule containing acer truncatum bunge extract comprises a capsule shell and medicinal powder particles loaded in the capsule shell, wherein the medicinal powder particles comprise the following raw materials in parts by weight: 10-20 parts of acer truncatum seed oil, 3-10 parts of a wolfberry fruit extract, 2-8 parts of a wild lotus leaf extract, 6-12 parts of an black fungus extract, 4-12 parts of a ginkgo leaf extract, 3-10 parts of a juniper melon young fruit extract, 4-10 parts of a lotus leaf extract, 4-8 parts of a buckwheat stem extract, 2-8 parts of a Chinese red pine needle extract, 4-12 parts of a bamboo leaf extract, 3-8 parts of a buckwheat leaf and lily extract, 80-120 parts of porous starch and 10-20 parts of maltodextrin.
Further, the feed comprises the following raw materials in parts by weight: 18 parts of acer truncatum seed oil, 7 parts of a wolfberry fruit extract, 5 parts of a wild lotus seed extract, 9 parts of a black fungus extract, 7 parts of a ginkgo leaf extract, 6 parts of a young fruit extract of holboellia latifolia, 5 parts of a lotus leaf extract, 5 parts of a buckwheat stem extract, 6 parts of a pinus massoniana pine needle extract, 8 parts of a bamboo leaf extract, 4 parts of a lilium brownii extract, 110 parts of porous starch and 15 parts of maltodextrin.
Further, the porous starch is one or more of potato porous starch, oat porous starch and cassava porous starch. Compared with starch such as corn, wheat and the like, the starch granules of potato starch, oat starch and cassava starch are larger and have higher surface area, so that more pore diameters can be formed, and the porous starch is more suitable for producing.
Further, the acer truncatum seed oil is an acer truncatum seed oil ethyl ester product, and the preparation method comprises the following steps:
weighing Acer truncatum seed oil, heating in a reactor, respectively weighing anhydrous ethanol with the weight of 0.9 time of that of the Acer truncatum seed oil and NaOH with the weight of 0.019 time of that of the Acer truncatum seed oil, uniformly mixing to obtain NaOH ethanol mixed liquor, adding the NaOH ethanol mixed liquor after the Acer truncatum seed oil is heated to 75 ℃, keeping the temperature of 75 ℃, stirring and reacting for 4 hours at a constant temperature, after the reaction is finished, washing the reaction liquor by using distilled water with the temperature of 80 ℃, and then dehydrating and drying in vacuum at the temperature of 40-45 ℃ and the pressure of 0.08-0.1MPa to obtain the Acer truncatum seed oil ethyl ester product. The acer truncatum seed oil is processed into an acer truncatum seed oil ethyl ester product, so that the acer truncatum seed oil ethyl ester product is easier to absorb by a human body, and can enrich nervonic acid in the acer truncatum seed oil and improve the concentration of the nervonic acid. The alkaline catalyst is selected to react quickly in the reaction process, the temperature is lower, the decomposition of unsaturated fatty acid can be avoided, the nutrient components of the acer truncatum seed oil can not be damaged, and in addition, the obtained product is clear and light yellow and has the color close to that of the raw material oil.
Further, the preparation method of the porous starch comprises the following steps:
weighing starch, adding a disodium hydrogen phosphate-citric acid buffer solution according to a material-liquid ratio of 1:2 to prepare a slurry, treating the slurry under 600W ultrasonic waves for 1h, centrifugally drying, dissolving the slurry in the disodium hydrogen phosphate-citric acid buffer solution according to a material-liquid ratio of 1:10, adjusting the pH value to 6.5, then adding 1.5 wt% of alpha-amylase of the starch, reacting for 8h in a constant-temperature water bath, stopping the reaction with a 4% NaOH solution, centrifuging the suspension at a rotating speed of 3000r/min for 15min after the reaction is stopped, then drying at 40 ℃ to constant weight, crushing and sieving with a 100-mesh sieve to obtain the porous starch. Under proper ultrasonic intensity and frequency, honeycomb-shaped depressions or pores with different degrees are formed on the surface of the starch granules, the number of the depressions or pores on the surface of the starch granules is increased along with the increase of the action time of the ultrasonic wave, but the number of the depressions or pores on the surface of the starch granules is not increased after a certain time; and the increase of the quantity of the depressions and the small holes on the surface of the powder particles can improve the oil absorption rate of the porous starch.
In addition, the invention also provides a preparation method of the capsule containing the acer truncatum bunge extract, which comprises the following steps:
1) adding acer truncatum seed oil into deionized water according to a material-liquid ratio of 1:20, dispersing uniformly, adding porous starch, fully and uniformly mixing by using a vortex mixer to enable the porous starch to fully adsorb the acer truncatum seed oil solution, then drying the porous starch adsorbing the acer truncatum seed oil under the condition of normal temperature and negative pressure, crushing and sieving by using a 10-mesh sieve, and drying to constant weight by using an electric heating constant-temperature drying oven to obtain the acer truncatum seed oil-carrying porous starch;
2) uniformly mixing a wolfberry fruit extract, a lotus leaf extract, an black fungus extract, a ginkgo leaf extract, a holboellia latifolia immature fruit extract, a lotus leaf extract, a buckwheat stem extract, a pinus massoniana needle extract, a bamboo leaf extract, a buckwheat leaf and lily extract, porous starch, maltodextrin and porous starch carrying acer truncatum seed oil to obtain mixture powder;
3) taking the mixture powder, adding 80% of absolute ethyl alcohol according to the material-liquid ratio of 5:1, fully and uniformly stirring, then placing the mixture into a swing granulator for granulation, drying the mixture to constant weight, and sieving the dried mixture by a 40-mesh sieve to remove fine powder so as to obtain medicinal powder particles;
4) and filling the medicinal powder particles into a capsule shell under the environment that the relative humidity is lower than 60%.
Further, the dispersion process in 1) was carried out under ultrasonic conditions, the ultrasonic power was 800W, and the treatment time was 30 min.
Further, the drying process in 3) is carried out under vacuum condition, the drying temperature is 60 ℃, and the vacuum degree is 0.08-0.1 Mpa.
It is to be noted that the efficacy of the various components of the invention is as follows:
wolfberry fruit: lycium chinense of Solanaceae has been used as a traditional Chinese herbal medicine for thousands of years, and the medicinal plant Lycium chinense has the main active ingredient of Lycium chinense polysaccharide, is water-soluble protein polysaccharide, and has multiple functions including antioxidation, immunoregulation, anti-inflammation and the like. The wolfberry fruit extract can effectively inhibit the activity reduction of human retinal pigment epithelial cells caused by photoinduced damage, reduce the content of active oxygen in cells and improve the oxidation resistance of retina and serum, thereby protecting the retina from photoinduced damage and having the protection effect on visual neurons.
Yang lotus: the Zingiber striolatum Diels (Zingiber striatum Diels) of Zingiber of Zingiberaceae is planted under the shade of forest and brook at elevation 300-1900 m; the wild lotus is a wild vegetable, can grow for many years after being planted for one year, can stand the milling in a severe environment, has extremely strong vitality, is basically free from plant diseases and insect pests, does not need to use pesticides, and can be cultivated in many places. The herba Avenae Fatuae is rich in chemical components such as herba Avenae Fatuae haematochrome, flavonoids, polysaccharides, saponins, alkaloids, and nutritional components such as dietary fiber, mineral substances and amino acids, and has effects of scavenging free radicals, resisting oxidation, preventing tumor, resisting cancer, reducing blood lipid, and treating cardiovascular disease and cerebrovascular disease.
Black fungus: auricularia (Auricularia auricula Judae), also known as Auricularia auricula, belongs to the edible and medicinal fungi of Basidiomycetes of Eumycota, and is a kind of saprophytic fungi growing on rotten wood. Black fungus contains more protein and 18 amino acids, 8 of which are essential amino acids for human body, and also contains saccharides, multiple vitamins, trace elements and the like, is edible and medicinal fungi with higher nutritional value and is called as king in vegetables and meat in vegetables. The main functional component of the black fungus is polysaccharide, and researches show that the black fungus polysaccharide has the functions of delaying senility, assisting in reducing blood sugar, assisting in reducing blood fat, resisting oxidation, resisting coagulation, resisting cancer, enhancing humoral immunity, cellular immunity and the like.
Ginkgo leaf: ginkgo, also known as Gongsun and gingko, recorded in the compendium of materia medica, has the effects of reducing urination, relieving asthma and benefiting lung qi, and has the effects of promoting blood circulation by removing blood stasis, dredging channels and collaterals, and tonifying qi and restoring consciousness. Modern pharmacological studies show that the ginkgo biloba extract contains ginkgolides, ginkgetin and lactones, has the effects of resisting dementia, aging and oxidation, promoting microcirculation and the like, can effectively remove free radicals, inhibit lipid peroxidation, simultaneously can adjust vascular tension and elasticity, and effectively prevent platelet adhesion.
Young fruit of the holboellia latifolia: the holboellia latifolia (Akebia trifoliate (Thunb.) Koidz.) is a deciduous vine plant of Akebia genus of Akebia family, the fruit of which is also called Akebia seed, Akebia fruit, August fried, fructus Akebiae, etc., is a wild economic plant integrating medicinal and edible purposes, and is distributed in the south, Yangtze river basin and northwest of China. The fruit, leaf, seed and root of the holboellia latifolia are rich in sugar, vitamins, minerals, organic acids, amino acids, oil, lignin, polyphenol, flavone, anti-aging and other components, and have the effects of improving cardiovascular and cerebrovascular diseases, resisting cancer, oxidation, radiation, virus and tumor, regulating the oxidase mechanism of a human body and the like. In addition, a large number of young fruits of the holboellia latifolia are required to be removed and discarded during the planting period, certain pollution is caused to the environment, phenolic components and flavonoid compounds with wide analysis application are extracted from the young fruits of the holboellia latifolia, the problem of environmental pollution caused by the discarding of the young fruits of the holboellia latifolia is effectively solved, a basis is provided for deep processing of byproducts, and the available approach and the economic benefit of the young fruits of the holboellia latifolia are obviously improved.
Lotus leaf: the lotus leaf is the leaf of a perennial aquatic plant lotus (Nelumbucifera Gaertn) in Nymphaeaceae, and is listed in a plant catalogue of homology of medicine and food in China because the lotus leaf contains various biological functional substances such as flavone, polysaccharide, polyphenol, alkaloid and the like. Modern pharmacological studies show that the lotus leaves have the functions of resisting oxidation, resisting aging, clearing heat, reducing blood fat and cholesterol, treating cardiovascular and cerebrovascular diseases and the like.
Buckwheat stems: buckwheat (buckwhaat) is a Fagopyrum plant of Polygonaceae (Polygonaceae) and is a coarse cereal crop with short growth period, barren resistance and wide adaptability, and is widely planted in the world. The buckwheat contains natural active ingredients such as polyphenols, flavonoids and the like, and researches show that the plant polyphenols have a plurality of physiological activities such as anti-tumor, bacteriostasis, antioxidation and the like. Flavonoid compounds represented by rutin (rutin) have unique health promotion function, can be used for treating capillary fragility and permeability hemorrhage, reducing blood lipid and cholesterol, and has antibacterial and radioprotective effects; can be used for preventing and treating hypertension, cerebral hemorrhage, diabetes, retinal hemorrhage, hemorrhagic purpura, etc.
Masson pine needles: the masson pine is an important forest resource in China and one of the most abundant forest varieties in south China, and occupies about 40% of the total forest area in south China. The masson pine needles are also called pine needles because the masson pine needles are leaves of masson pine, are slender and have a leaf-like needle shape. The compendium of materia Medica records: the pine needles are taken for a long time to treat diseases, prevent five internal organs, promote hair growth, resist cold and summer heat, resist wind and rain, lighten the body, tonify qi, keep the middle and avoid cereals and prolong life. The modern technology is utilized to test the pine needle extract, and the main active ingredients in the pine needle are volatile oil, flavonoid compounds, polysaccharide, lignan and the like, and have various biological activities of oxidation resistance, virus resistance, tumor resistance, inflammation resistance and the like.
Bamboo leaf: bamboo leaves are a heat-clearing and detoxifying traditional Chinese medicine used as both medicine and food, and are increasingly paid more attention to by people due to rich nutritional value and good health-care effect, so that the bamboo leaves are often developed into various functional products. It is effective in clearing heart fire and promoting urination, and can be used for treating fever, polydipsia, etc., and has good preventing and treating effect on cardiovascular diseases.
Buckwheat leaf lilium brownie: the lilium cathayanum (Cardiocrinum cathayanum) belongs to perennial monocotyledon plants of Liliaceae (Liliaceae) and belongs to one of the first medicinal and edible plants approved by the national ministry of health. Researches show that the lily has the effects of resisting oxidation, diminishing inflammation, resisting fatigue, resisting depression, reducing blood sugar, improving respiratory function and the like, and the main chemical components of the lily are flavone, polysaccharide, saponin and alkaloid substances. Wherein the flavonoids are a large class of natural products widely existing in plant kingdom, and the ketones have various biological activities, such as antioxidant, antiinflammatory, antivirus, heart tonifying, tranquilizing, pain relieving, antiaging and antitumor effects. The most important of them is that it can reduce formation of free radical and can remove antioxidant activity of free radical, and also has the action of resisting lipid peroxidation, so that it is a natural organic antioxidant which is worthy of extensive research.
The invention has the beneficial effects that: the capsule containing the maple seed oil prepared by the invention has the effects of enhancing immunity, promoting brain development, resisting oxidation, aging, tumors, blood pressure and blood fat, and the like, can effectively reduce the formation of free radicals, eliminate the antioxidant activity of the free radicals, regulate the tension and elasticity of blood vessels, improve cardiovascular and cerebrovascular diseases, and provide a health-care medicine with the effects of resisting oxidation, aging, tumors, blood pressure and blood fat, and the like for human beings; meanwhile, the efficacy of the acer truncatum seed oil is fully exerted, and the healthy development of the acer truncatum seed oil is promoted.
Detailed Description
The present invention will be described in detail with reference to examples below:
example one
A capsule containing acer truncatum bunge extract comprises a capsule shell and medicinal powder particles loaded in the capsule shell, wherein the medicinal powder particles comprise the following raw materials in parts by weight: 100g of acer truncatum seed oil, 30g of wolfberry fruit extract, 20g of wild lotus seed extract, 60g of black fungus extract, 40g of ginkgo leaf extract, 30g of young holboellia latifolia fruit extract, 40g of lotus leaf extract, 40g of buckwheat stem extract, 20g of masson pine needle extract, 40g of bamboo leaf extract, 30g of buckwheat leaf and lilium brownie extract, 800g of potato porous starch and 100g of maltodextrin. The preparation method comprises the following steps:
1) placing acer truncatum seed oil in a reactor for heating, respectively weighing 90g of absolute ethyl alcohol and 1.9g of NaOH, uniformly mixing to obtain NaOH-ethanol mixed liquor, adding the NaOH-ethanol mixed liquor after the acer truncatum seed oil is heated to 75 ℃, keeping the temperature of 75 ℃, stirring and reacting for 4 hours at constant temperature, after the reaction is finished, separating and washing the reaction liquor by using distilled water at 80 ℃, and then performing vacuum dehydration and drying at 40 ℃ and 0.08MPa to obtain the acer truncatum seed oil ethyl ester product.
2) Weighing 1000g of starch, adding 2L of disodium hydrogen phosphate-citric acid buffer solution to prepare slurry, treating the slurry under 600W of ultrasonic waves for 1h, centrifugally drying, dissolving in 10L of disodium hydrogen phosphate-citric acid buffer solution, adjusting the pH value to 6.5, adding 15g of alpha-amylase, reacting in a constant-temperature water bath for 8h, stopping the reaction by using 4% NaOH solution, centrifuging the suspension at the rotating speed of 3000r/min for 15min after the reaction is stopped, drying at the temperature of 40 ℃ to constant weight, crushing, and sieving by using a 100-mesh sieve to obtain porous starch.
3) Adding the acer truncatum seed oil ethyl ester product into 2L of deionized water, performing ultrasonic dispersion treatment at 800W for 30min, adding 800g of potato porous starch, fully and uniformly mixing by using a vortex mixer to enable the porous starch to fully adsorb the acer truncatum seed oil solution, then placing the porous starch adsorbing the acer truncatum seed oil under the conditions of normal temperature and negative pressure for drying, crushing and sieving by using a 10-mesh sieve, and drying by using an electrothermal constant-temperature drying oven to constant weight to obtain the porous starch carrying the acer truncatum seed oil ethyl ester product.
4) Mixing fructus Lycii extract, herba Avenae Fatuae extract, Auricularia extract, folium Ginkgo extract, young fruit extract of fructus Akebiae, folium Nelumbinis extract, caulis Fagopyri Esculenti extract, folium Pini extract of Pinus massoniana, folium Bambusae extract, Bulbus Lilii extract of folium Fagopyri Esculenti, porous starch, maltodextrin and porous starch of Acer Truncatum Bunge seed oil ethyl ester product uniformly to obtain mixture powder.
5) Taking the mixture powder, adding 270mL of 80% absolute ethyl alcohol, fully and uniformly stirring, placing in a swing granulator for granulation, drying at 60 ℃, under the vacuum condition of 0.08-0.1Mpa to constant weight, and sieving by a 40-mesh sieve to remove fine powder, thus obtaining the medicinal powder granules.
6) And filling the medicinal powder particles into a capsule shell under the environment that the relative humidity is lower than 60%.
Example two
A capsule containing acer truncatum bunge extract comprises a capsule shell and medicinal powder particles loaded in the capsule shell, wherein the medicinal powder particles comprise the following raw materials in parts by weight: 180g of acer truncatum seed oil, 70g of wolfberry fruit extract, 50g of wild lotus seed extract, 90g of black fungus extract, 70g of ginkgo leaf extract, 60g of young fruit extract of holboellia latifolia, 50g of lotus leaf extract, 50g of buckwheat stem extract, 60g of masson pine needle extract, 80g of bamboo leaf extract, 40g of buckwheat leaf and lilium brownie extract, 1100g of oat porous starch and 150g of maltodextrin. The preparation method comprises the following steps:
1) weighing acer truncatum seed oil, placing the acer truncatum seed oil in a reactor, heating, respectively weighing 162g of absolute ethyl alcohol and 3.4g of NaOH, uniformly mixing to obtain a NaOH-ethanol mixed solution, adding the NaOH-ethanol mixed solution after the acer truncatum seed oil is heated to 75 ℃, keeping the temperature of 75 ℃, stirring and reacting for 4 hours at a constant temperature, after the reaction is finished, separating and washing the reaction solution with 80 ℃ of distilled water, and then performing vacuum dehydration and drying at 43 ℃ and 0.09MPa to obtain the acer truncatum seed oil ethyl ester product.
2) Weighing 1000g of starch, adding 2L of disodium hydrogen phosphate-citric acid buffer solution to prepare slurry, treating the slurry under 600W of ultrasonic waves for 1h, centrifugally drying, dissolving in 10L of disodium hydrogen phosphate-citric acid buffer solution, adjusting the pH value to 6.5, adding 15g of alpha-amylase, reacting in a constant-temperature water bath for 8h, stopping the reaction by using 4% NaOH solution, centrifuging the suspension at the rotating speed of 3000r/min for 15min after the reaction is stopped, drying at the temperature of 40 ℃ to constant weight, crushing, and sieving by using a 100-mesh sieve to obtain porous starch.
3) Adding the acer truncatum seed oil ethyl ester product into 3.6L of deionized water, performing ultrasonic dispersion treatment at 800W for 30min, adding 1100g of oat porous starch, fully and uniformly mixing by using a vortex mixer to enable the porous starch to fully adsorb the acer truncatum seed oil solution, then placing the porous starch adsorbing the acer truncatum seed oil under the conditions of normal temperature and negative pressure for drying, crushing and sieving by using a 10-mesh sieve, and drying by using an electrothermal constant-temperature drying oven to constant weight to obtain the porous starch carrying the acer truncatum seed oil ethyl ester product.
4) Mixing fructus Lycii extract, herba Avenae Fatuae extract, Auricularia extract, folium Ginkgo extract, young fruit extract of fructus Akebiae, folium Nelumbinis extract, caulis Fagopyri Esculenti extract, folium Pini extract of Pinus massoniana, folium Bambusae extract, Bulbus Lilii extract of folium Fagopyri Esculenti, porous starch, maltodextrin and porous starch of Acer Truncatum Bunge seed oil ethyl ester product uniformly to obtain mixture powder.
5) Taking the mixture powder, adding 410mL of 80% absolute ethyl alcohol, fully and uniformly stirring, placing the mixture into a swing granulator for granulation, drying the mixture at 60 ℃ under the vacuum condition of 0.08-0.1Mpa to constant weight, and sieving the mixture by a 40-mesh sieve to remove fine powder, thereby obtaining medicinal powder granules.
6) And filling the medicinal powder particles into a capsule shell under the environment that the relative humidity is lower than 60%.
EXAMPLE III
A capsule containing acer truncatum bunge extract comprises a capsule shell and medicinal powder particles loaded in the capsule shell, wherein the medicinal powder particles comprise the following raw materials in parts by weight: 200g of acer truncatum seed oil, 100g of wolfberry fruit extract, 80g of wild lotus seed extract, 120g of black fungus extract, 120g of ginkgo leaf extract, 100g of young fruit extract of holboellia latifolia, 100g of lotus leaf extract, 80g of buckwheat stem extract, 80g of masson pine needle extract, 120g of bamboo leaf extract, 80g of buckwheat leaf and lilium brownie extract, 1200g of cassava porous starch and 200g of maltodextrin. The preparation method comprises the following steps:
1) weighing acer truncatum seed oil, placing the acer truncatum seed oil in a reactor, heating, respectively weighing 180g of absolute ethyl alcohol and 3.8g of NaOH, uniformly mixing to obtain a NaOH-ethanol mixed solution, adding the NaOH-ethanol mixed solution after the acer truncatum seed oil is heated to 75 ℃, keeping the temperature of 75 ℃, stirring and reacting for 4 hours at a constant temperature, after the reaction is finished, separating and washing the reaction solution with 80 ℃ distilled water, and then performing vacuum dehydration and drying at 45 ℃ and 0.1MPa to obtain the acer truncatum seed oil ethyl ester product.
2) Weighing 1000g of starch, adding 2L of disodium hydrogen phosphate-citric acid buffer solution to prepare slurry, treating the slurry under 600W of ultrasonic waves for 1h, centrifugally drying, dissolving in 10L of disodium hydrogen phosphate-citric acid buffer solution, adjusting the pH value to 6.5, adding 15g of alpha-amylase, reacting in a constant-temperature water bath for 8h, stopping the reaction by using 4% NaOH solution, centrifuging the suspension at the rotating speed of 3000r/min for 15min after the reaction is stopped, drying at the temperature of 40 ℃ to constant weight, crushing, and sieving by using a 100-mesh sieve to obtain porous starch.
3) Adding the acer truncatum seed oil ethyl ester product into 4L of deionized water, performing ultrasonic dispersion treatment at 800W for 30min, adding 800g of potato porous starch, fully and uniformly mixing by using a vortex mixer to enable the porous starch to fully adsorb the acer truncatum seed oil solution, then placing the porous starch adsorbing the acer truncatum seed oil under the conditions of normal temperature and negative pressure for drying, crushing and sieving by using a 10-mesh sieve, and drying by using an electrothermal constant-temperature drying oven to constant weight to obtain the porous starch carrying the acer truncatum seed oil ethyl ester product.
4) Mixing fructus Lycii extract, herba Avenae Fatuae extract, Auricularia extract, folium Ginkgo extract, young fruit extract of fructus Akebiae, folium Nelumbinis extract, caulis Fagopyri Esculenti extract, folium Pini extract of Pinus massoniana, folium Bambusae extract, Bulbus Lilii extract of folium Fagopyri Esculenti, porous starch, maltodextrin and porous starch of Acer Truncatum Bunge seed oil ethyl ester product uniformly to obtain mixture powder.
5) Taking the mixture powder, adding 516mL of 80% absolute ethyl alcohol, fully and uniformly stirring, placing in a swing granulator for granulation, drying at 60 ℃, under the vacuum condition of 0.08-0.1Mpa to constant weight, and sieving by a 40-mesh sieve to remove fine powder, thus obtaining the medicinal powder granules.
6) And filling the medicinal powder particles into a capsule shell under the environment that the relative humidity is lower than 60%.
The medicinal powder particles prepared in the first to third examples are respectively subjected to acute toxicity test and long-term toxicity test.
First, acute toxicity test
Preparation of a test sample: and (3) respectively taking the medicinal powder particles prepared in the first to third examples, and adding water to prepare 30% (g/v) medicinal powder particle suspension.
1. Half lethal dose (LD50) determination:
one-time oral administration is carried out by filling, and the medicinal powder particle suspension is filled into the white mice according to the dose of 6.1-15g/kg, wherein no white mouse dies within seven days, and no toxic reaction is observed after administration. The test failed to detect LD50 in mice that were orally administered with the drug powder suspension of the present invention by a single gavage, since the administration concentration was 30% and the administration volume (1.0 ml/mouse) was maximized.
2. Maximum tolerated dose determination: mice were gavaged three times over 24 hours, each time animals received a maximum volume (1ml/20g) dose (15g/kg) at a maximum concentration (30%), 7 hours apart, and none of the mice died and had a toxic response within seven days.
Second, Long term toxicity test
1. Animal grouping: wistar germ line healthy white rats with 60 animals and half animals are selected and randomly divided into three groups, wherein each group comprises 20 animals and 10 animals.
2. Dose, route:
low dose group: 2.4g/kg dose;
high dose group: 4.8g/kg dose;
blank control group: 0g/kg dose;
the suspension of the medicinal powder particles prepared in the first to third examples is respectively infused into the big white rat once a day according to the dosage, the concentration of the suspension of the medicinal powder particles is 24% (g/v), and the medicine amount is 2mL/100g of body weight, and the suspension is continuously infused for 4 weeks.
3. And (4) checking results: at 24 hours after the last administration, half of the animals in each group were killed, the organs of the animals were fixed with 10% formalin, covered with paraffin, sliced, and HE-stained, and the pathological histological examination of the blank control group and the high dose group was performed with an optical microscope, and the results showed that the organs of the heart, liver, spleen, lung, kidney, stomach, brain, adrenal gland, testis, ovary, small intestine, etc. of the high dose group did not show toxic pathological changes compared with the blank control group. Although the low dose group had stored the material, no histological examination was performed since no abnormal lesion was found at the high dose.
According to the experimental results of acute toxicity tests and long-term toxicity tests, the medicinal powder particle capsule prepared by the invention has no toxic or side effect on mice, and can ensure the safe use of human bodies.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.
Claims (8)
1. A capsule containing acer truncatum bunge extract comprises a capsule shell and medicinal powder particles loaded in the capsule shell, and is characterized in that the medicinal powder particles comprise the following raw materials in parts by weight: 10-20 parts of acer truncatum seed oil, 3-10 parts of a wolfberry fruit extract, 2-8 parts of a wild lotus leaf extract, 6-12 parts of an black fungus extract, 4-12 parts of a ginkgo leaf extract, 3-10 parts of a juniper melon young fruit extract, 4-10 parts of a lotus leaf extract, 4-8 parts of a buckwheat stem extract, 2-8 parts of a Chinese red pine needle extract, 4-12 parts of a bamboo leaf extract, 3-8 parts of a buckwheat leaf and lily extract, 80-120 parts of porous starch and 10-20 parts of maltodextrin.
2. The capsule containing the acer truncatum bunge extract as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of acer truncatum seed oil, 7 parts of a wolfberry fruit extract, 5 parts of a wild lotus seed extract, 9 parts of a black fungus extract, 7 parts of a ginkgo leaf extract, 6 parts of a young fruit extract of holboellia latifolia, 5 parts of a lotus leaf extract, 5 parts of a buckwheat stem extract, 6 parts of a pinus massoniana pine needle extract, 8 parts of a bamboo leaf extract, 4 parts of a lilium brownii extract, 110 parts of porous starch and 15 parts of maltodextrin.
3. The capsule containing the acer truncatum bunge extract as claimed in claim 2, wherein the porous starch is one or more of potato porous starch, oat porous starch and cassava porous starch.
4. The capsule containing the acer truncatum bunge extract as claimed in claim 3, wherein the acer truncatum bunge seed oil is obtained from acer truncatum bunge seed oil ethyl ester, and the preparation method comprises the following steps:
weighing Acer truncatum seed oil, heating in a reactor, respectively weighing anhydrous ethanol with the weight of 0.9 time of that of the Acer truncatum seed oil and NaOH with the weight of 0.019 time of that of the Acer truncatum seed oil, uniformly mixing to obtain NaOH ethanol mixed liquor, adding the NaOH ethanol mixed liquor after the Acer truncatum seed oil is heated to 75 ℃, keeping the temperature of 75 ℃, stirring and reacting for 4 hours at a constant temperature, after the reaction is finished, washing the reaction liquor by using distilled water with the temperature of 80 ℃, and then dehydrating and drying in vacuum at the temperature of 40-45 ℃ and the pressure of 0.08-0.1MPa to obtain the Acer truncatum seed oil ethyl ester product.
5. The capsule containing acer truncatum bunge extract as claimed in claim 4, wherein the preparation method of the porous starch is as follows:
weighing starch, adding a disodium hydrogen phosphate-citric acid buffer solution according to a material-liquid ratio of 1:2 to prepare a slurry, treating the slurry under 600W ultrasonic waves for 1h, centrifugally drying, dissolving the slurry in the disodium hydrogen phosphate-citric acid buffer solution according to a material-liquid ratio of 1:10, adjusting the pH value to 6.5, then adding 1.5 wt% of alpha-amylase of the starch, reacting for 8h in a constant-temperature water bath, stopping the reaction with a 4% NaOH solution, centrifuging the suspension at a rotating speed of 3000r/min for 15min after the reaction is stopped, then drying at 40 ℃ to constant weight, crushing and sieving with a 100-mesh sieve to obtain the porous starch.
6. A method for preparing the acer truncatum bunge extract-containing capsule as claimed in claim 5, which comprises the following steps:
1) adding acer truncatum seed oil into deionized water according to a material-liquid ratio of 1:20, dispersing uniformly, adding porous starch, fully and uniformly mixing by using a vortex mixer to enable the porous starch to fully adsorb the acer truncatum seed oil solution, then drying the porous starch adsorbing the acer truncatum seed oil under the condition of normal temperature and negative pressure, crushing and sieving by using a 10-mesh sieve, and drying to constant weight by using an electric heating constant-temperature drying oven to obtain the acer truncatum seed oil-carrying porous starch;
2) uniformly mixing a wolfberry fruit extract, a lotus leaf extract, an black fungus extract, a ginkgo leaf extract, a holboellia latifolia immature fruit extract, a lotus leaf extract, a buckwheat stem extract, a pinus massoniana needle extract, a bamboo leaf extract, a buckwheat leaf and lily extract, porous starch, maltodextrin and porous starch carrying acer truncatum seed oil to obtain mixture powder;
3) taking the mixture powder, adding 80% of absolute ethyl alcohol according to the material-liquid ratio of 5:1, fully and uniformly stirring, then placing the mixture into a swing granulator for granulation, drying the mixture to constant weight, and sieving the dried mixture by a 40-mesh sieve to remove fine powder so as to obtain medicinal powder particles;
4) and filling the medicinal powder particles into a capsule shell under the environment that the relative humidity is lower than 60%.
7. The method for preparing the capsule containing the acer truncatum bunge extract as claimed in claim 6, wherein the dispersion process in 1) is carried out under ultrasonic conditions, the ultrasonic power is 800W, and the treatment time is 30 min.
8. The method for preparing the capsule containing the acer truncatum bunge extract as claimed in claim 7, wherein the drying process in 3) is performed under vacuum condition, the drying temperature is 60 ℃, and the vacuum degree is 0.08-0.1 Mpa.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114558117A (en) * | 2022-02-21 | 2022-05-31 | 沈阳药大生物科技有限公司 | Youth element composition for nourishing and beautifying and preparation method thereof |
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| CN102516612A (en) * | 2011-12-20 | 2012-06-27 | 海南大学 | Preparation method for porous starch/natural rubber compound |
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| CN105434491A (en) * | 2015-12-07 | 2016-03-30 | 山东永春堂集团有限公司 | Acer truncatum seed oil and ginkgo biloba extract composite preparation |
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| CN101092344A (en) * | 2007-07-06 | 2007-12-26 | 杨凌七彩生物科技有限公司 | Method for extracting nervonic acid from oil of Mono Maple by using technique of molecular distillation |
| CN102516612A (en) * | 2011-12-20 | 2012-06-27 | 海南大学 | Preparation method for porous starch/natural rubber compound |
| CN104027494A (en) * | 2014-05-28 | 2014-09-10 | 项蔚南 | Traditional Chinese medicinal composition with effects of delaying senescence and protecting health |
| CN105434491A (en) * | 2015-12-07 | 2016-03-30 | 山东永春堂集团有限公司 | Acer truncatum seed oil and ginkgo biloba extract composite preparation |
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