CN105879128A - 反向热敏性聚合物在医疗程序后控制生物流体流动的用途 - Google Patents
反向热敏性聚合物在医疗程序后控制生物流体流动的用途 Download PDFInfo
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90281707P | 2007-02-22 | 2007-02-22 | |
| US60/902817 | 2007-02-22 | ||
| CN2008800130296A CN102159274A (zh) | 2007-02-22 | 2008-02-22 | 反向热敏性聚合物在医疗程序后控制生物流体流动的用途 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008800130296A Division CN102159274A (zh) | 2007-02-22 | 2008-02-22 | 反向热敏性聚合物在医疗程序后控制生物流体流动的用途 |
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| CN105879128A true CN105879128A (zh) | 2016-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610444283.8A Pending CN105879128A (zh) | 2007-02-22 | 2008-02-22 | 反向热敏性聚合物在医疗程序后控制生物流体流动的用途 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533937A (zh) * | 2022-02-14 | 2022-05-27 | 北京冠合医疗科技有限公司 | 一种可生物降解温度敏感型栓塞凝胶及其制备方法和应用 |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666459B2 (en) * | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
| US8197499B2 (en) * | 2006-06-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| US8608760B2 (en) * | 2006-06-21 | 2013-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| US8216259B2 (en) | 2006-06-21 | 2012-07-10 | The Board Of Trustees Of The Leland Stanford Jr. University | Compositions and methods for joining non-conjoined lumens |
| CN103933606B (zh) | 2006-12-15 | 2016-08-24 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
| US8808259B2 (en) | 2007-11-21 | 2014-08-19 | T.J. Smith & Nephew Limited | Suction device and dressing |
| JP5336508B2 (ja) | 2007-11-21 | 2013-11-06 | スミス アンド ネフュー ピーエルシー | 創傷被覆材 |
| GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
| US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
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| BRPI0820785A2 (pt) * | 2007-12-20 | 2015-06-16 | Tautona Group L P | Composições e métodos para unir lúmens não unidos |
| GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
| EP2310459B1 (en) | 2008-06-18 | 2014-10-22 | Lifebond Ltd | Improved cross-linked compositions |
| US8563037B2 (en) * | 2009-02-06 | 2013-10-22 | Tautona Group, L.P. | Compositions and methods for joining non-conjoined lumens |
| GB0902816D0 (en) | 2009-02-19 | 2009-04-08 | Smith & Nephew | Fluid communication path |
| EP2515957B1 (en) | 2009-12-22 | 2015-07-29 | Lifebond Ltd | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| CA2787138C (en) | 2010-01-13 | 2019-06-25 | Georg Bischof | Composition for producing a temporary intestinal occlusion |
| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| US20110301456A1 (en) * | 2010-06-07 | 2011-12-08 | Malignext Targeting Technologies, Inc. | Tissue Marking for Lesion Removal |
| GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
| ES2567174T3 (es) | 2010-08-05 | 2016-04-20 | Lifebond Ltd | Composición seca en apósitos y adhesivos para heridas |
| GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
| BR112013012785A2 (pt) | 2010-11-25 | 2020-10-20 | Bluestar Silicones France Sas | composição i - ii e produtos e usos das mesmas |
| US9144450B2 (en) * | 2010-12-22 | 2015-09-29 | Boston Scientific Scimed, Inc. | Fluid sealant compositions and various medical applications pertaining to the same |
| US8845599B2 (en) | 2011-07-11 | 2014-09-30 | Boston Scientific Scimed, Inc. | Medical procedures, devices and kits for the formation and removal of plug-forming compositions |
| AT511671A1 (de) * | 2011-07-13 | 2013-01-15 | Bischof Georg Dr | Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers |
| WO2013025436A1 (en) | 2011-08-12 | 2013-02-21 | Boston Scientific Scimed, Inc. | Anastomosis kit for radical prostatectomy procedure |
| US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
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| EP2983716A4 (en) * | 2013-04-11 | 2017-01-25 | Commonwealth Scientific and Industrial Research Organisation | Composition for controlled delivery of bioactive agents |
| EP2796101B1 (de) | 2013-04-23 | 2016-04-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten |
| DE202013012287U1 (de) | 2013-04-23 | 2016-01-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Gelbildendes System zum Entfernen von Nierensteinfragmenten |
| DE202013012275U1 (de) | 2013-04-23 | 2015-12-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten |
| PL2796100T3 (pl) | 2013-04-23 | 2016-08-31 | Fraunhofer Ges Forschung | Układ tworzący żel do usuwania fragmentów kamieni nerkowych |
| US11389470B2 (en) * | 2016-07-12 | 2022-07-19 | Centre National De La Recherche Scientifique | Compositions useful for mucosal healing |
| CN106267320B (zh) * | 2016-08-10 | 2019-04-19 | 烟台益诺依生物医药科技有限公司 | 一种血管吻合剂的制备方法 |
| CN111315812B (zh) * | 2017-11-08 | 2022-11-29 | 马特利艾斯有限责任公司 | 原位凝胶化粉末 |
| US11123453B2 (en) * | 2018-02-21 | 2021-09-21 | Shinshu University | Liquid embolic agent composition |
| EP3539571B1 (en) | 2018-03-16 | 2023-05-31 | Critical Innovations, LLC | Systems and methods relating to medical applications of synthetic polymer formulations |
| CN108498850B (zh) * | 2018-04-10 | 2021-08-31 | 广州迈普再生医学科技股份有限公司 | 一种流体止血胶及其制备方法和应用 |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| CN112770790B (zh) | 2018-08-03 | 2023-07-18 | 奈克塞罗医学有限公司 | 纯化的五没食子酰葡萄糖和递送装置 |
| EP3946173A4 (en) * | 2019-03-26 | 2023-04-12 | Nectero Medical, Inc. | METHODS AND DEVICES FOR TREATMENTS RELATED TO ENDOVASCULAR GRAFT |
| EP4061438B1 (en) * | 2019-11-20 | 2025-07-23 | The Regents of the University of California | Liquid embolic material composition |
| AU2021221971A1 (en) * | 2020-02-18 | 2022-09-01 | Boston Scientific Scimed, Inc. | Hemostatic compositions and related methods |
| US12144655B2 (en) | 2021-08-23 | 2024-11-19 | Samsung Electronics Co., Ltd. | Method and device for liveness detection |
| US12410293B2 (en) | 2022-11-07 | 2025-09-09 | Critical Innovations Llc | Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430505A (zh) * | 2000-03-24 | 2003-07-16 | 生物领域医疗公司 | 用于主动栓塞术的微球体 |
| CN1794980A (zh) * | 2003-03-24 | 2006-06-28 | 生物领域医疗公司 | 利用逆向热敏聚合物的暂时栓塞 |
| CN1856329A (zh) * | 2003-09-25 | 2006-11-01 | 拉特格斯州立大学 | 用于栓塞治疗的内在不透射线的聚合产物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4478822A (en) * | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US5567859A (en) * | 1991-03-19 | 1996-10-22 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US4834091A (en) * | 1987-04-10 | 1989-05-30 | Ott Douglas E | Intrauterine fallopian tube ostial plug and surgical process |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| CA2106474C (en) * | 1991-03-19 | 2004-02-10 | R. Martin Emanuele | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5800711A (en) * | 1996-10-18 | 1998-09-01 | Mdv Technologies, Inc. | Process for the fractionation of polyoxyalkylene block copolymers |
| ZA987019B (en) * | 1997-08-06 | 1999-06-04 | Focal Inc | Hemostatic tissue sealants |
| US6514534B1 (en) * | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6179862B1 (en) * | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| US7790192B2 (en) * | 1998-08-14 | 2010-09-07 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
| EP1104324B8 (en) * | 1998-08-14 | 2011-06-22 | Incept Llc | Apparatus for in situ formation of hydrogels |
| US6152943A (en) * | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| JP4391699B2 (ja) * | 1998-11-20 | 2009-12-24 | 株式会社ネクスト | 止血剤挿入装置 |
| US6554851B1 (en) * | 1999-05-07 | 2003-04-29 | Scimed Life Systems, Inc. | Methods of sealing an injection site |
| JP2001329183A (ja) * | 2000-05-22 | 2001-11-27 | Yuichi Mori | ゲル化性組成物 |
| US6761824B2 (en) * | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
| WO2002024114A2 (en) * | 2000-09-25 | 2002-03-28 | Cohesion Technologies, Inc. | Resorbable anastomosis stents and plugs |
| JP2002369874A (ja) * | 2001-06-14 | 2002-12-24 | Terumo Corp | 止血材料 |
| US6592608B2 (en) * | 2001-12-07 | 2003-07-15 | Biopsy Sciences, Llc | Bioabsorbable sealant |
| US9289195B2 (en) * | 2003-06-04 | 2016-03-22 | Access Closure, Inc. | Auto-retraction apparatus and methods for sealing a vascular puncture |
| US7700086B2 (en) * | 2003-11-06 | 2010-04-20 | Pluromed, Inc. | Internal clamp for surgical procedures |
| JP2006141436A (ja) * | 2004-11-16 | 2006-06-08 | Mebiol Kk | 経皮血管穿刺封止材および経皮血管穿刺封止装置 |
| CA2831752A1 (en) * | 2005-05-02 | 2006-11-09 | Pluromed, Inc. | Non-lithotripsic kidney-stone therapy |
| WO2008073938A2 (en) * | 2006-12-11 | 2008-06-19 | Pluromed, Inc. | Perfusive organ hemostasis |
-
2008
- 2008-02-22 MX MX2009009081A patent/MX2009009081A/es unknown
- 2008-02-22 US US12/035,703 patent/US20080208163A1/en not_active Abandoned
- 2008-02-22 KR KR1020167019631A patent/KR20160089544A/ko not_active Ceased
- 2008-02-22 KR KR1020097019728A patent/KR20090114469A/ko not_active Ceased
- 2008-02-22 EP EP08730487A patent/EP2125092A4/en not_active Ceased
- 2008-02-22 WO PCT/US2008/054694 patent/WO2008103891A2/en not_active Ceased
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- 2014-10-02 US US14/505,076 patent/US20150018872A1/en not_active Abandoned
-
2016
- 2016-03-10 JP JP2016046758A patent/JP2016105845A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430505A (zh) * | 2000-03-24 | 2003-07-16 | 生物领域医疗公司 | 用于主动栓塞术的微球体 |
| CN1794980A (zh) * | 2003-03-24 | 2006-06-28 | 生物领域医疗公司 | 利用逆向热敏聚合物的暂时栓塞 |
| CN1856329A (zh) * | 2003-09-25 | 2006-11-01 | 拉特格斯州立大学 | 用于栓塞治疗的内在不透射线的聚合产物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533937A (zh) * | 2022-02-14 | 2022-05-27 | 北京冠合医疗科技有限公司 | 一种可生物降解温度敏感型栓塞凝胶及其制备方法和应用 |
| CN114533937B (zh) * | 2022-02-14 | 2023-01-03 | 北京冠合医疗科技有限公司 | 一种可生物降解温度敏感型栓塞凝胶及其制备方法和应用 |
Also Published As
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| CA2679027A1 (en) | 2008-08-28 |
| KR20090114469A (ko) | 2009-11-03 |
| EP2125092A4 (en) | 2012-03-14 |
| AU2014213539A1 (en) | 2014-09-04 |
| JP2010518990A (ja) | 2010-06-03 |
| AU2008218225B2 (en) | 2014-05-15 |
| CN102159274A (zh) | 2011-08-17 |
| US20080208163A1 (en) | 2008-08-28 |
| BRPI0807558A2 (pt) | 2014-07-01 |
| KR20150032348A (ko) | 2015-03-25 |
| KR20160089544A (ko) | 2016-07-27 |
| MX2009009081A (es) | 2009-10-30 |
| WO2008103891A2 (en) | 2008-08-28 |
| EP2125092A1 (en) | 2009-12-02 |
| US20150018872A1 (en) | 2015-01-15 |
| CA2679027C (en) | 2016-05-03 |
| AU2008218225A1 (en) | 2008-08-28 |
| JP2016105845A (ja) | 2016-06-16 |
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