CA2679027C - Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure - Google Patents

Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure Download PDF

Info

Publication number
CA2679027C
CA2679027C CA2679027A CA2679027A CA2679027C CA 2679027 C CA2679027 C CA 2679027C CA 2679027 A CA2679027 A CA 2679027A CA 2679027 A CA2679027 A CA 2679027A CA 2679027 C CA2679027 C CA 2679027C
Authority
CA
Canada
Prior art keywords
polymer composition
viscous polymer
composition
viscous
reverse thermosensitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2679027A
Other languages
English (en)
French (fr)
Other versions
CA2679027A1 (en
Inventor
James A. Wilkie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CA2679027A1 publication Critical patent/CA2679027A1/en
Application granted granted Critical
Publication of CA2679027C publication Critical patent/CA2679027C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00641—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closing fistulae, e.g. anorectal fistulae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
CA2679027A 2007-02-22 2008-02-22 Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure Expired - Fee Related CA2679027C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90281707P 2007-02-22 2007-02-22
US60/902,817 2007-02-22
PCT/US2008/054694 WO2008103891A2 (en) 2007-02-22 2008-02-22 Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure

Publications (2)

Publication Number Publication Date
CA2679027A1 CA2679027A1 (en) 2008-08-28
CA2679027C true CA2679027C (en) 2016-05-03

Family

ID=39710760

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2679027A Expired - Fee Related CA2679027C (en) 2007-02-22 2008-02-22 Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure

Country Status (10)

Country Link
US (2) US20080208163A1 (enExample)
EP (1) EP2125092A4 (enExample)
JP (2) JP2010518990A (enExample)
KR (3) KR20160089544A (enExample)
CN (2) CN105879128A (enExample)
AU (2) AU2008218225B2 (enExample)
BR (1) BRPI0807558A2 (enExample)
CA (1) CA2679027C (enExample)
MX (1) MX2009009081A (enExample)
WO (1) WO2008103891A2 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666459B2 (en) * 2001-09-12 2010-02-23 The Procter & Gamble Company Pet food compositions
US8197499B2 (en) 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
AU2007260924A1 (en) 2006-06-21 2007-12-27 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
CN101854960B (zh) 2006-12-15 2014-06-25 生命连结有限公司 明胶-转谷氨酰胺酶止血敷料和密封材料
US8808259B2 (en) 2007-11-21 2014-08-19 T.J. Smith & Nephew Limited Suction device and dressing
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
HUE049431T2 (hu) 2007-11-21 2020-09-28 Smith & Nephew Sebkötözés
US20130096518A1 (en) 2007-12-06 2013-04-18 Smith & Nephew Plc Wound filling apparatuses and methods
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
WO2009086206A2 (en) * 2007-12-20 2009-07-09 Synvascular, Inc. Compositions and methods for joining non-conjoined lumens
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
AU2009261559B2 (en) 2008-06-18 2014-01-16 Lifebond Ltd Improved cross-linked compositions
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
GB0902816D0 (en) 2009-02-19 2009-04-08 Smith & Nephew Fluid communication path
EP2963111A1 (en) 2009-12-22 2016-01-06 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
JP5950307B2 (ja) 2010-01-13 2016-07-13 ビショフ、ゲオルグ 腸を一時的に閉塞するための組成物
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
US20110301456A1 (en) * 2010-06-07 2011-12-08 Malignext Targeting Technologies, Inc. Tissue Marking for Lesion Removal
GB201011173D0 (en) 2010-07-02 2010-08-18 Smith & Nephew Provision of wound filler
DK2600910T3 (en) 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
MX337627B (es) 2010-11-25 2016-03-10 Smith & Nephew Composiciones i-ii y productos y usos de la misma.
GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
US9144450B2 (en) * 2010-12-22 2015-09-29 Boston Scientific Scimed, Inc. Fluid sealant compositions and various medical applications pertaining to the same
US8845599B2 (en) 2011-07-11 2014-09-30 Boston Scientific Scimed, Inc. Medical procedures, devices and kits for the formation and removal of plug-forming compositions
AT511671A1 (de) 2011-07-13 2013-01-15 Bischof Georg Dr Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers
US9060749B2 (en) 2011-08-12 2015-06-23 Boston Scientific Scimed, Inc. Methods, compositions and kits for performing anastomosis procedures in conjunction with a radical prostatectomy procedure
US20150159066A1 (en) 2011-11-25 2015-06-11 Smith & Nephew Plc Composition, apparatus, kit and method and uses thereof
EP2968647B1 (en) 2013-03-15 2022-06-29 Smith & Nephew plc Wound dressing sealant and use thereof
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
AU2014252689A1 (en) * 2013-04-11 2015-10-15 Commonwealth Scientific And Industrial Research Organisation Composition for controlled delivery of bioactive agents
EP2796101B1 (de) 2013-04-23 2016-04-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten
DE202013012275U1 (de) 2013-04-23 2015-12-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten
EP2796100B1 (de) 2013-04-23 2016-04-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Gelbildendes System zum Entfernen von Nierensteinfragmenten
DE202013012287U1 (de) 2013-04-23 2016-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Gelbildendes System zum Entfernen von Nierensteinfragmenten
US11389470B2 (en) * 2016-07-12 2022-07-19 Centre National De La Recherche Scientifique Compositions useful for mucosal healing
CN106267320B (zh) * 2016-08-10 2019-04-19 烟台益诺依生物医药科技有限公司 一种血管吻合剂的制备方法
WO2019092608A1 (en) * 2017-11-08 2019-05-16 Materias S.R.L. In situ gelifying powder
JP6383133B1 (ja) * 2018-02-21 2018-08-29 国立大学法人信州大学 液体塞栓剤組成物
EP3539571B1 (en) 2018-03-16 2023-05-31 Critical Innovations, LLC Systems and methods relating to medical applications of synthetic polymer formulations
CN108498850B (zh) * 2018-04-10 2021-08-31 广州迈普再生医学科技股份有限公司 一种流体止血胶及其制备方法和应用
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
EP3829664A4 (en) 2018-08-03 2022-05-04 Nectero Medical, Inc. PURIFIED PENTAGALLOYGLUCOSE AND DELIVERY DEVICES
WO2020198376A1 (en) * 2019-03-26 2020-10-01 Nectero Medical, Inc. Methods and devices for treatments associated with endovascular grafts
WO2021102241A1 (en) 2019-11-20 2021-05-27 The Regents Of The University Of California Liquid embolic material composition
US12083216B2 (en) * 2020-02-18 2024-09-10 Boston Scientific Scimed, Inc. Hemostatic compositions and related methods
WO2023027412A1 (en) 2021-08-23 2023-03-02 Samsung Electronics Co., Ltd. Method and device for liveness detection
CN114533937B (zh) * 2022-02-14 2023-01-03 北京冠合医疗科技有限公司 一种可生物降解温度敏感型栓塞凝胶及其制备方法和应用
US12410293B2 (en) 2022-11-07 2025-09-09 Critical Innovations Llc Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5567859A (en) * 1991-03-19 1996-10-22 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US4834091A (en) * 1987-04-10 1989-05-30 Ott Douglas E Intrauterine fallopian tube ostial plug and surgical process
EP0576612B1 (en) * 1991-03-19 1999-12-01 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5696298A (en) * 1991-03-19 1997-12-09 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5800711A (en) * 1996-10-18 1998-09-01 Mdv Technologies, Inc. Process for the fractionation of polyoxyalkylene block copolymers
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
ATE502670T1 (de) * 1998-08-14 2011-04-15 Incept Llc Apparat für die in-situ-bildung von hydrogelen
US7335220B2 (en) * 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6179862B1 (en) * 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
WO2000030553A1 (en) * 1998-11-20 2000-06-02 Medical Industries Corp. Hemostatic agent inserting device
US6554851B1 (en) * 1999-05-07 2003-04-29 Scimed Life Systems, Inc. Methods of sealing an injection site
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
JP2001329183A (ja) * 2000-05-22 2001-11-27 Yuichi Mori ゲル化性組成物
US6761824B2 (en) * 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
EP1322234A2 (en) * 2000-09-25 2003-07-02 Cohesion Technologies, Inc. Resorbable anastomosis stents and plugs
JP2002369874A (ja) * 2001-06-14 2002-12-24 Terumo Corp 止血材料
US6592608B2 (en) * 2001-12-07 2003-07-15 Biopsy Sciences, Llc Bioabsorbable sealant
JP4909071B2 (ja) * 2003-03-24 2012-04-04 プルーローメッド, インコーポレイテッド 逆感熱性ポリマーを使用する一時的な塞栓形成
US9289195B2 (en) * 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
CN100435853C (zh) * 2003-09-25 2008-11-26 拉特格斯州立大学 用于栓塞治疗的内在不透射线的聚合产物
US7700086B2 (en) * 2003-11-06 2010-04-20 Pluromed, Inc. Internal clamp for surgical procedures
JP2006141436A (ja) * 2004-11-16 2006-06-08 Mebiol Kk 経皮血管穿刺封止材および経皮血管穿刺封止装置
MX2007013827A (es) * 2005-05-02 2008-04-04 Pluromed Inc Terapia para piedras de rinon no por litiotricia.
JP2010512230A (ja) * 2006-12-11 2010-04-22 プルーロームド インコーポレイテッド 灌流臓器止血法

Also Published As

Publication number Publication date
EP2125092A1 (en) 2009-12-02
US20080208163A1 (en) 2008-08-28
US20150018872A1 (en) 2015-01-15
KR20150032348A (ko) 2015-03-25
JP2016105845A (ja) 2016-06-16
KR20160089544A (ko) 2016-07-27
KR20090114469A (ko) 2009-11-03
WO2008103891A2 (en) 2008-08-28
AU2008218225B2 (en) 2014-05-15
EP2125092A4 (en) 2012-03-14
CN102159274A (zh) 2011-08-17
CA2679027A1 (en) 2008-08-28
BRPI0807558A2 (pt) 2014-07-01
JP2010518990A (ja) 2010-06-03
MX2009009081A (es) 2009-10-30
AU2014213539A1 (en) 2014-09-04
CN105879128A (zh) 2016-08-24
AU2008218225A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
AU2008218225B2 (en) Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure
JP2010518990A5 (enExample)
JP4909071B2 (ja) 逆感熱性ポリマーを使用する一時的な塞栓形成
US20180117211A1 (en) Perfusive Organ Hemostasis
US20160121030A1 (en) Internal Clamp for Surgical Procedures
US20160346428A1 (en) Methods and kits for treating lacerations and puncture wounds using inverse thermosensitive polymers
JP2006521177A5 (enExample)
WO2009137446A2 (en) Methods of preventing fluid leaks from body cavities during medical imaging procedures

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130220

MKLA Lapsed

Effective date: 20200224