CN105873586A - 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 - Google Patents
一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 Download PDFInfo
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Abstract
Description
化合物 | 超分子复合物 |
AHU-377浓度(mmol/L) | 1.89 |
缬沙坦浓度(mmol/L) | 1.94 |
Na+浓度(mmol/L) | 5.73 |
摩尔比(AHU-377:缬沙坦:Na+) | 1:1:3 |
化合物 | 超分子复合物 |
AHU-377浓度(mmol/L) | 2.00 |
缬沙坦浓度(mmol/L) | 2.08 |
Na+浓度(mmol/L) | 6.10 |
摩尔比(AHU-377:缬沙坦:Na+) | 1:1:3 |
相对湿度 | 11% | 32% | 50% |
保存时间 | 1个月 | 1个月 | 1个月 |
晶型 | II | II | II |
温度 | 30℃ | 40℃ | 50℃ | 60℃ |
保存时间 | 1个月 | 1个月 | 2周 | 2周 |
晶型 | II | II | II | II |
Claims (29)
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CN201910761979.7A CN110922366B (zh) | 2014-12-08 | 2015-12-08 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 |
CN201910761992.2A CN110938042B (zh) | 2014-12-08 | 2015-12-08 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 |
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PCT/US2015/064432 WO2016049663A1 (en) | 2014-12-08 | 2015-12-08 | Crystalline forms of trisodium supramolecular complex comprising valsartan and ahu-377 and methods thereof |
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CN201910761979.7A Division CN110922366B (zh) | 2014-12-08 | 2015-12-08 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 |
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CN201580002782.5A Active CN105873586B (zh) | 2014-12-08 | 2015-12-08 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的晶型及其制备方法 |
CN201910761979.7A Active CN110922366B (zh) | 2014-12-08 | 2015-12-08 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的新晶型及其制备方法 |
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US (2) | US9957240B2 (zh) |
EP (2) | EP3229799B1 (zh) |
JP (3) | JP2017537120A (zh) |
CN (3) | CN110938042B (zh) |
AU (1) | AU2015319831B2 (zh) |
CA (1) | CA2970192C (zh) |
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ES (1) | ES2706948T3 (zh) |
HU (1) | HUE043014T2 (zh) |
IL (2) | IL252740A0 (zh) |
MX (1) | MX2017007426A (zh) |
PL (1) | PL3229799T3 (zh) |
PT (1) | PT3229799T (zh) |
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EP3694493A1 (en) | 2017-10-13 | 2020-08-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Tablet containing valsartan and sacubitril |
WO2019239432A1 (en) | 2018-06-14 | 2019-12-19 | Cipla Limited | Trisodium sacubitril valsartan complex and hot-melt extruded pharmaceutical composition comprising thereof |
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US11096918B2 (en) | 2005-11-09 | 2021-08-24 | Novartis Pharmaceuticals Corporation | Amorphous solid form of compounds containing S—N-valeryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and sodium cations |
US11642329B2 (en) | 2005-11-09 | 2023-05-09 | Novartis Pharmaceuticals Corporation | Amorphous solid form of compounds containing S—N-valeryl-N- {[2′-( 1 H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and sodium cations |
CN106414416A (zh) * | 2014-09-09 | 2017-02-15 | 上海翰森生物医药科技有限公司 | 结晶型ARB‑NEPi复合物及其制备方法和应用 |
CN105037289A (zh) * | 2015-07-17 | 2015-11-11 | 华东理工大学 | 血管紧张素受体拮抗剂和中性内肽酶抑制剂超分子复合体的新晶型 |
CN106905253A (zh) * | 2015-12-23 | 2017-06-30 | 正大天晴药业集团股份有限公司 | 一种超分子复合物的结晶 |
CN106905253B (zh) * | 2015-12-23 | 2020-01-03 | 正大天晴药业集团股份有限公司 | 一种超分子复合物的结晶 |
CN107674038A (zh) * | 2017-01-03 | 2018-02-09 | 上海博志研新药物技术有限公司 | ARB‑NEPi复合物、晶型、制备方法及应用 |
CN110713465A (zh) * | 2017-01-03 | 2020-01-21 | 上海博志研新药物技术有限公司 | ARB-NEPi复合物、晶型、制备方法及应用 |
CN111592500A (zh) * | 2017-01-03 | 2020-08-28 | 上海博志研新药物技术有限公司 | ARB-NEPi复合物、晶型、制备方法及应用 |
CN108299323A (zh) * | 2017-01-11 | 2018-07-20 | 上海迪赛诺药业股份有限公司 | 一种抗心衰共晶化合物的新晶型 |
CN111253330A (zh) * | 2020-02-29 | 2020-06-09 | 广州白云山天心制药股份有限公司 | 沙坦类药物的新晶型及其制备方法和用途 |
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CA2970192A1 (en) | 2016-03-31 |
IL252740A0 (en) | 2017-08-31 |
WO2016049663A1 (en) | 2016-03-31 |
TR201900360T4 (tr) | 2019-02-21 |
EP3443960A1 (en) | 2019-02-20 |
EP3229799B1 (en) | 2018-10-17 |
US9957240B2 (en) | 2018-05-01 |
IL276233B1 (en) | 2023-03-01 |
CN105873586B (zh) | 2019-09-13 |
CN110938042B (zh) | 2022-12-13 |
DK3229799T3 (en) | 2019-02-11 |
SI3229799T1 (sl) | 2019-03-29 |
US20180201589A1 (en) | 2018-07-19 |
JP2020203936A (ja) | 2020-12-24 |
MX2017007426A (es) | 2018-04-20 |
HUE043014T2 (hu) | 2019-07-29 |
EP3229799A4 (en) | 2017-10-18 |
CN110922366A (zh) | 2020-03-27 |
PT3229799T (pt) | 2019-01-29 |
JP2018168180A (ja) | 2018-11-01 |
CN110938042A (zh) | 2020-03-31 |
IL276233B2 (en) | 2023-07-01 |
AU2015319831B2 (en) | 2019-02-14 |
EP3229799A1 (en) | 2017-10-18 |
US10508087B2 (en) | 2019-12-17 |
CA2970192C (en) | 2020-08-04 |
JP2017537120A (ja) | 2017-12-14 |
ES2706948T3 (es) | 2019-04-01 |
US20170362189A1 (en) | 2017-12-21 |
PL3229799T3 (pl) | 2019-05-31 |
IL276233A (en) | 2020-09-30 |
CN110922366B (zh) | 2023-02-03 |
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