CN105848484A - 用于免疫治疗的多克隆γδ T细胞 - Google Patents
用于免疫治疗的多克隆γδ T细胞 Download PDFInfo
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- CN105848484A CN105848484A CN201480063632.0A CN201480063632A CN105848484A CN 105848484 A CN105848484 A CN 105848484A CN 201480063632 A CN201480063632 A CN 201480063632A CN 105848484 A CN105848484 A CN 105848484A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- A61P31/12—Antivirals
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- A61P31/20—Antivirals for DNA viruses
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/54—Pancreas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
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- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895626P | 2013-10-25 | 2013-10-25 | |
| US61/895,626 | 2013-10-25 | ||
| PCT/US2014/062191 WO2015061694A2 (en) | 2013-10-25 | 2014-10-24 | Polyclonal gamma delta t cells for immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105848484A true CN105848484A (zh) | 2016-08-10 |
Family
ID=52993756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480063632.0A Pending CN105848484A (zh) | 2013-10-25 | 2014-10-24 | 用于免疫治疗的多克隆γδ T细胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9907820B2 (enExample) |
| EP (1) | EP3060059A4 (enExample) |
| JP (1) | JP2016539929A (enExample) |
| KR (1) | KR20160068960A (enExample) |
| CN (1) | CN105848484A (enExample) |
| AU (2) | AU2014339926B2 (enExample) |
| CA (1) | CA2926859A1 (enExample) |
| WO (1) | WO2015061694A2 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019020089A1 (zh) * | 2017-07-27 | 2019-01-31 | 上海细胞治疗研究院 | 高效扩增car-t细胞的人工抗原递呈细胞及其用途 |
| CN109589336A (zh) * | 2017-10-03 | 2019-04-09 | 生倍科技股份有限公司 | 用于t细胞免疫疗法的组合及其用途 |
| WO2019214290A1 (zh) * | 2018-05-09 | 2019-11-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN111647070A (zh) * | 2020-06-17 | 2020-09-11 | 深圳豪石生物科技有限公司 | T细胞受体或其抗原结合片段及应用 |
| CN113260629A (zh) * | 2018-09-19 | 2021-08-13 | 拉法医疗有限公司 | 用于治疗恶性血液病的新双特异性抗体 |
| CN113966231A (zh) * | 2019-05-08 | 2022-01-21 | 詹森生物科技公司 | 用于调节t细胞介导的免疫力的材料和方法 |
| CN114645022A (zh) * | 2022-05-13 | 2022-06-21 | 首都医科大学宣武医院 | 靶向CD5的CAR-γ δ T细胞及其制备方法与应用 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008521406A (ja) | 2004-11-24 | 2008-06-26 | フレッド ハッチンソン キャンサー リサーチ センター | 養子免疫療法のためのil−21の使用法および腫瘍抗原の同定法 |
| KR102238226B1 (ko) | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (car) t-세포의 인간 적용 |
| WO2014190273A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| EP3215534B1 (en) | 2014-11-05 | 2020-04-15 | Board of Regents, The University of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| US11135245B2 (en) | 2014-11-17 | 2021-10-05 | Adicet Bio, Inc. | Engineered γδ T-cells |
| US20220280564A1 (en) * | 2014-11-21 | 2022-09-08 | Immatics US, Inc. | Methods for expanding t cells for the treatment of cancer and related malignancies |
| WO2016138091A2 (en) | 2015-02-24 | 2016-09-01 | Board Of Regents, The University Of Texas System | Selection methods for genetically-modified t cells |
| CN107532174A (zh) | 2015-03-11 | 2018-01-02 | 得克萨斯州大学系统董事会 | 转座酶多肽及其用途 |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CA3021226A1 (en) * | 2015-05-11 | 2016-11-17 | University Health Network | Method for expansion of double negative regulatory t cells |
| WO2016183153A1 (en) * | 2015-05-12 | 2016-11-17 | Memorial Sloan Kettering Cancer Center | Methods of treating epstein-barr virus-associated lymphoproliferative disorders by t cell therapy |
| PT3307875T (pt) * | 2015-06-09 | 2022-03-21 | Lymphact Lymphocyte Activation Tech S A | Métodos para a produção de células t tcr gamma delta+ |
| JP6799895B2 (ja) * | 2015-06-09 | 2020-12-16 | リンファクト−リンフォサイト アクティベイション テクノロジーズ エス.エー. | TCRγδ+T細胞の生産方法 |
| KR20180041229A (ko) * | 2015-08-25 | 2018-04-23 | 유에이비 리서치 파운데이션 | 줄기 세포 이식을 위한 방법 |
| CN105112370B (zh) * | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| KR20180042449A (ko) | 2015-09-15 | 2018-04-25 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | T 세포 수용체(tcr) 결합 항체 및 이의 용도 |
| CN105624107B (zh) * | 2015-09-21 | 2020-06-12 | 杭州优善生物科技有限公司 | 一种多种淋巴细胞亚群的扩增方法及其应用 |
| US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
| AU2016344779B2 (en) | 2015-10-30 | 2023-01-05 | Cancer Research Technology Limited | Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells |
| JP7210286B2 (ja) * | 2016-05-12 | 2023-01-23 | アディセット バイオ, インコーポレイテッド | γδT細胞集団の選択的増殖方法及びその組成物 |
| TWI788307B (zh) * | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| WO2018081784A1 (en) * | 2016-10-31 | 2018-05-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells for expanding immune cells for immunotherapy |
| WO2018147805A1 (en) * | 2017-02-08 | 2018-08-16 | Agency For Science, Technology And Research | Gamma delta t cells and a method of augmenting the tumoricidal activity of the same |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| US20200297871A1 (en) * | 2017-09-15 | 2020-09-24 | King's College London | Compositions and methods for enhancing gamma delta t cells in the gut |
| CN107794269A (zh) * | 2017-09-30 | 2018-03-13 | 成都美杰赛尔生物科技有限公司 | 促进基因编辑t细胞活化及扩增的生物膜、制法及应用 |
| WO2019071358A1 (en) | 2017-10-12 | 2019-04-18 | Mcmaster University | Y182T MUTATION T CELL ANTIGEN COUPLEUR AND METHODS AND USES THEREOF |
| IL274640B1 (en) | 2017-11-15 | 2025-10-01 | Adicet Bio Inc | Methods for selective expansion of delta 3 gamma-delta T-cell populations and preparations thereof |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| EP3856206A1 (en) * | 2018-09-27 | 2021-08-04 | Phosphogam, Inc. | Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells |
| EA202190926A1 (ru) | 2018-10-01 | 2021-06-25 | Эдисет Био, Инк. | Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения гематологических опухолей |
| KR20210087458A (ko) | 2018-10-01 | 2021-07-12 | 아디셋 바이오, 인크. | 고형 종양 치료를 위한 조작된 및 비-조작된 γδ-T 세포에 관한 조성물 및 방법 |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| CA3130442A1 (en) * | 2019-02-24 | 2020-08-27 | Gamida Cell Ltd. | Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy |
| WO2021016652A1 (en) * | 2019-07-29 | 2021-02-04 | The University Of Melbourne | METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS |
| WO2021050789A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| IL300530A (en) * | 2020-08-12 | 2023-04-01 | Univ Central Florida Res Found Inc | Methods and preparations for stimulating GAMMA DELTA T cells |
| KR20240037892A (ko) | 2021-06-01 | 2024-03-22 | 트리움비라 이뮤놀로직스 유에스에이, 인크. | 클라우딘 18.2 t 세포-항원 커플러 및 이의 용도 |
| WO2023069322A1 (en) * | 2021-10-20 | 2023-04-27 | University Of Pittsburgh – Of The Commonwealth System Of Higher Education | Methods and materials for expanding tumor infiltrating gamma-delta t cells |
| EP4433068A4 (en) * | 2021-11-18 | 2025-11-12 | Univ Minnesota | LARGE-SCALE MULTIPLICATION OF MODIFIED HUMAN GAMMA T LYMPHOCYTES |
| EP4183871A1 (en) | 2021-11-23 | 2023-05-24 | Université d'Aix-Marseille | Process for preparing a composition comprising a combined cell population |
| JP2025506506A (ja) | 2022-02-16 | 2025-03-11 | プリオセラ エスエーエス | S1p受容体モジュレーターと組み合わせたcar細胞を用いた処置方法 |
| JP2025511408A (ja) * | 2022-04-04 | 2025-04-15 | ガンマデルタ セラピューティクス リミティッド | 新規遺伝子アーマリング |
| WO2025046256A1 (en) | 2023-08-31 | 2025-03-06 | Universite D'aix-Marseille | Process for preparing a composition comprising a combined cell population |
| CN118064364B (zh) * | 2024-04-19 | 2024-07-05 | 赛德特生物制药有限公司 | 一种γδT细胞的制备方法 |
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| WO2019020089A1 (zh) * | 2017-07-27 | 2019-01-31 | 上海细胞治疗研究院 | 高效扩增car-t细胞的人工抗原递呈细胞及其用途 |
| CN109337872A (zh) * | 2017-07-27 | 2019-02-15 | 上海细胞治疗研究院 | 高效扩增car-t细胞的人工抗原递呈细胞及其用途 |
| CN109589336A (zh) * | 2017-10-03 | 2019-04-09 | 生倍科技股份有限公司 | 用于t细胞免疫疗法的组合及其用途 |
| WO2019214290A1 (zh) * | 2018-05-09 | 2019-11-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN113260629A (zh) * | 2018-09-19 | 2021-08-13 | 拉法医疗有限公司 | 用于治疗恶性血液病的新双特异性抗体 |
| CN113966231A (zh) * | 2019-05-08 | 2022-01-21 | 詹森生物科技公司 | 用于调节t细胞介导的免疫力的材料和方法 |
| CN111647070A (zh) * | 2020-06-17 | 2020-09-11 | 深圳豪石生物科技有限公司 | T细胞受体或其抗原结合片段及应用 |
| CN114645022A (zh) * | 2022-05-13 | 2022-06-21 | 首都医科大学宣武医院 | 靶向CD5的CAR-γ δ T细胞及其制备方法与应用 |
Also Published As
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|---|---|
| US9907820B2 (en) | 2018-03-06 |
| AU2014339926B2 (en) | 2018-02-08 |
| WO2015061694A3 (en) | 2015-06-18 |
| US20180200299A1 (en) | 2018-07-19 |
| EP3060059A4 (en) | 2017-11-01 |
| US20160256487A1 (en) | 2016-09-08 |
| CA2926859A1 (en) | 2015-04-30 |
| AU2014339926A1 (en) | 2016-04-28 |
| AU2018202976B2 (en) | 2020-10-29 |
| US20210187028A1 (en) | 2021-06-24 |
| AU2018202976A1 (en) | 2018-05-31 |
| JP2016539929A (ja) | 2016-12-22 |
| WO2015061694A2 (en) | 2015-04-30 |
| EP3060059A2 (en) | 2016-08-31 |
| KR20160068960A (ko) | 2016-06-15 |
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