CN105832957A - Traditional Chinese medicine composition for treating tumors and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating tumors and preparation method thereof Download PDF

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CN105832957A
CN105832957A CN201610336777.4A CN201610336777A CN105832957A CN 105832957 A CN105832957 A CN 105832957A CN 201610336777 A CN201610336777 A CN 201610336777A CN 105832957 A CN105832957 A CN 105832957A
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于学军
刘宏伟
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention discloses a traditional Chinese medicine composition for treating tumors and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material medicines: common pistache fruits, peach kernels, radix pandani tectorii, herba eupatorii, fortune silene herbs with roots, adenia chevali, viola diffusa, thymeleaf speedwell herbs, symphytum officinale, radix pseudostellariae, medlar, herba cistanches, bambooleaf fig herbs, myrsinaceae embelia laeta, henry clematis roots, lucid ganoderma, flos buddlejae, emarginate stonecrop herbs, fernleaf dichocarpum roots, jasminum laurifolium, cephalotaxus fortunei, ramulus uncariae cum uncis, tufted bracketplant herbs, polygonum sinomontanum and piper cubeba. The traditional Chinese medicine composition and the preparation method thereof disclosed by the invention have the benefits that the traditional Chinese medicine composition has the effects of detoxifying, dissipating blood stasis, eliminating swelling, dredging collaterals, eliminating tumors and smoothing Qi and blood flow and is quick in effects, high in effective rate, definite in treatment effect, short in treatment course, free from toxic and side effects, low in cost and the like.

Description

A kind of Chinese medicine composition treating tumor and preparation method thereof
Technical field
The present invention relates to technical field of medicine, particularly to a kind of Chinese medicine composition treating tumor and preparation side thereof Method.
Background technology
Tumor tissues is no matter in cellular morphology and organizational structure, and the normal group all risen with it is woven with difference in various degree Different, this species diversity is referred to as atypia.Atypia is the performance morphologically of tumor abnormal differentiation.Atypia is little, illustrates to break up journey Degree height, atypia is big, illustrates that differentiation degree is low.The size distinguishing this atypia is diagnosing tumour, determines its good, pernicious master Want histological basis.The atypia of benign tumor cells is inconspicuous, the most similar to its derived tissues.Malignant tumor often has bright Aobvious atypia.
Clinical manifestation: typically the symptom of tumor is divided into local symptom and General Symptoms two parts.
Local symptom: because tumor growth at primary lesion causes this regional anatomic structure and tissue morphology to become Change, cause corresponding changing function therefrom.Tumor forms lump in occupied tissue, its size, profile, boundary, hard Degree, surface condition and adjacent tissue's relation etc. can be as the foundations checked with diagnosing tumour.Lump can cause secondary symptom, as Pain, compressing, ulcer, hemorrhage, infect, block or dysfunction etc., make patient not feel well with painful, particularly oncothlipsis With when invading neural, have pain in various degree.Different according to tumor location, also have many characteristic symptoms, such as pancreas Head cancer, cancer of biliary duct can cause jaundice;The ventricles of the brain, meningeal tumor can cause cranium pressure to rise high.
General Symptoms: the General Symptoms that tumor occurs in early days is the most smaller, limitation;If can be when early symptom occurs Arouse attention, get final product early discovery tumor, treat in time.Early symptom becomes " alarm signal " of malignant tumor;Facing First early symptom attracted attention that malignant tumor occurs particularly is paid attention to, referred to as " onset symptoms " on bed.Different is swollen Tumor " alarm signal " is different from " onset symptoms ".
The General Symptoms of tumor is relevant with stadium and tumorigenic position.Infantile tumour is often without General Symptoms, or only has Slight weak discomfort, inappetence;In, late tumor, owing to tumor consumes a large number of nutrients and produces many toxin, patient Obvious General Symptoms occurs successively, as weight loss, weakness, heating, anemia, edema, ascites, skin and joint diseases, The extensively symptom etc. caused by Organ relative weight.
Pathogenesis: tumor is inherently genopathy.The carcinogenic factor of various E&Hs is with collaborative or sequential Mode causes DNA damage, thus activates proto-oncogene and (or) inactivation tumor suppressor gene, add apoptosis gene and (or) The change of DNA-repair gene, causes the exception of expression then, makes target cell convert.The cell that is converted the most in Clonal hypertrophy, through a very long multistage evolution process, one of them clones the most unconfined amplification, passes through Addition mutation, is formed selectively the sub-clone (heterogeneousization) with different characteristics, thus the ability obtaining infiltration and transfer (is disliked Property convert), formed malignant tumor.
The traditional Chinese medical science thinks that tumor is systemic disease, weakened body resistance blood stasis, and residual poison is the most clearly its pathogenic characteristic, neoplasm metastasis basic Reason is healthy energy virtual loss, accumulates in evil poison.No matter performing the operation or chemotherapeutic treatment, uncharming purpose though having reached effectively to subtract tumor, but The most fundamentally release patient's internal organs, negative and positive, the imbalance of QI and blood function, according to Chinese traditional treatment tumor determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs to be particular about and whole Body is treated, and includes radiotherapy, chemotherapy in dialectical medication category, forms doctor trained in Western medicine and attacks heresy, the general layout of traditional Chinese medical science righting, uses the combination of Chinese and Western medicine Method carry out oncotherapy and tend to obtain preferable effect, Chinese medicine is to the auxiliary therapeutic action of tumor patient the most increasingly To accreditation.
Radiotherapy and chemotherapy are the essential therapeutic arsenals of malignant tumor, but its toxicity is the biggest.Mesh The anti-tumor medicine thing of front Clinical practice all has toxic and side effects in various degree, and they are while killing tumor cell, again Kill the cell of normal structure, especially kill blood, lymphocyte etc. that in human body, growth promoter is vigorous.Cancer therapy drug The mode classification of untoward reaction is a lot, and according to the cancer therapy drug impact on body different system, untoward reaction mainly has blood poison Property, gastrointestinal toxicity, mucosa lesions, liver toxicity, nephrotoxicity etc..
On the basis of traditional medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, for common multiple pulmonary carcinoma, gastric cancer, the treatment of colorectal cancer, in routine On the basis for the treatment of, lack of appetite abdominal distention that during being conceived to tumor chemoradiotherapy, patient occurs, the dependency disease such as indigestion and loss of appetite, sweating is weak Disease, establishes emphasis disease kind diagnosis and treatment specification, sums up and refines the obvious proved recipe of several clinical curative effect and feature therapies, promotes, The attenuation synergistic of the raising of patients ' life quality, the control of symptom and chemotherapeutics is achieved very big effect, real by clinic Summary after trampling, treats peri-operation period, encloses the controlling extent pair of the quality of life of phase patient, clinical symptoms between chemotherapy stage, radiotherapy Curative effect and prognosis play critical effect.
The medicine being presently used for treating tumor is a lot, but there is the defect that side effect is big the most in various degree, serious shadow Ring the treatment of patient and rehabilitation, especially for patient's lack of appetite abdominal distention, the diseases related medicine such as indigestion and loss of appetite, sweating is weak Relatively shortcoming, be presently required a kind of action temperature of development and, untoward reaction is little, can prolonged application, and easy to use, determined curative effect, The new drug for the treatment of tumor.
Summary of the invention
The technical problem to be solved is, it is provided that a kind of Chinese medicine composition treating tumor and preparation side thereof Method, the present invention has removing toxic substances dissipating blood stasis, changes lump, dredging collateral dispersing tumor and the unobstructed effect of QI and blood, have rapid-action, effective percentage is high, treat Effect is definite, treatment short treating period, have no side effect, the advantages such as price is low.
In order to solve above-mentioned technical problem, the present invention provides a kind of Chinese medicine composition treating tumor, wherein, including following Raw medicinal material: Fructus Pistaciae Verae, Semen Persicae, Radix Pandani Furcati, Herba Eupatorii, Herba silenes fortunei, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep., Climbing Viloet Herb, Herba Veronicae Serpyllifoliae, conveniently perfume, Radix Pseudostellariae, Fructus Lycii Son, five leaf potatos, Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi, Ganoderma, Flos Buddlejae, Herba Sedi Emarginati, Radix Dichocarpi Dalzielii and Herba Jasmini laurifolii.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 Weight portion, Radix Pandani Furcati 9-16 weight portion, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, crawl Volt violet 8-24 weight portion, Herba Veronicae Serpyllifoliae 13-33 weight portion, the most fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12-32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight Amount part, Ganoderma 15-35 weight portion, Flos Buddlejae 11-21 weight portion, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion With Herba Jasmini laurifolii 9-18 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 12 weight portion, Semen Persicae 20 weight Part, Radix Pandani Furcati 15 weight portion, Herba Eupatorii 27 weight portion, Herba silenes fortunei 12 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 30 weight portions, conveniently fragrant 16 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 32 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 8 weight portions, Radix Clematidis Henryi 16 weight portion, Ganoderma 33 weight portion, Flos Buddlejae 20 weight portion, Herba Sedi Emarginati 17 weight portions, Radix Dichocarpi Dalzielii 31 weight portion and Herba Jasmini laurifolii 14 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight Part, Radix Pandani Furcati 13 weight portion, Herba Eupatorii 25 weight portion, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 32 weight portions, conveniently fragrant 17 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 10 weight portions, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portions, Radix Dichocarpi Dalzielii 30 weight portion and Herba Jasmini laurifolii 13 weight portion.
In described Chinese medicine composition, each raw medicinal material also includes: Folium et Ramulus Cephalotaxi, Uncaria tonkinensis Havil., Herba Chlorophyti Comosi, wing handle knotweed and Fructus Litseae.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 Weight portion, Radix Pandani Furcati 9-16 weight portion, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, crawl Volt violet 8-24 weight portion, Herba Veronicae Serpyllifoliae 13-33 weight portion, the most fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12-32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight Amount part, Ganoderma 15-35 weight portion, Flos Buddlejae 11-21 weight portion, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion, Herba Jasmini laurifolii 9-18 weight portion, Folium et Ramulus Cephalotaxi 10-24 weight portion, Uncaria tonkinensis Havil. 14-31 weight portion, Herba Chlorophyti Comosi 7-14 weight portion, wing handle knotweed 12-24 weight portion and Fructus Litseae 7-14 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight Part, Radix Pandani Furcati 13 weight portion, Herba Eupatorii 25 weight portion, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 32 weight portions, conveniently fragrant 17 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 10 weight portions, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portions, Radix Dichocarpi Dalzielii 30 weight portion, Herba Jasmini laurifolii 13 weight portion, Folium et Ramulus Cephalotaxi 13 weight portion, Uncaria tonkinensis Havil. 26 weight portion, Herba Chlorophyti Comosi 12 Weight portion, wing handle knotweed 17 weight portion and Fructus Litseae 12 weight portion.
When the dosage form of described Chinese medicine composition is granule, its preparation method comprises the following steps:
The first step, is mixed each for described Chinese medicine composition raw medicinal material in described ratio, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, and uses percolation with per minute 1～the speed of 2ml Spend slowly percolation, collect percolate, under vacuum 0.06～0.09Mpa, be evaporated to relative density when 50～60 DEG C subsequently It is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, It is ground into powder subsequently, makes dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
When the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:
The first step, mixes Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi and Ganoderma, adds and relative to 3 times of mixture～5 times amount determining alcohols be The alcohol reflux of 55%～65% 2 times～4 times, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG C of relative densities are the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, mistake Filter, is concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C of reduced vacuum are dried, and get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, the containing alcohol of described containing alcohol mastic Amount is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment successively, obtains Dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；
5th step, by adding cane sugar powder, activated carbon in described dealcoholysis mastic, is carried out at heat treated, filtration treatment, dilution successively Reason, obtains semi-finished product；Described dealcoholysis mastic is 1: 0.1～0.3 with the weight ratio of described cane sugar powder；Described dealcoholysis mastic is with described The weight ratio of activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, temperature be 100 DEG C～ 110℃；
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, to obtain final product Described oral liquid finished product.
When the dosage form of described Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36 Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1 The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
The invention has the beneficial effects as follows: the present invention has removing toxic substances dissipating blood stasis, changes the merit that lump, dredging collateral dispersing tumor and QI and blood are unobstructed Effect, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
Detailed description of the invention
The present invention provides a kind of Chinese medicine composition treating tumor, wherein, including following raw medicinal material: Folium et Ramulus Cephalotaxi, unknown Son, Semen Persicae, Radix Pandani Furcati, Herba Eupatorii, Herba silenes fortunei, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep., Climbing Viloet Herb, Herba Veronicae Serpyllifoliae, conveniently perfume, Radix Pseudostellariae, Uncaria tonkinensis Havil., Fructus Lycii, five Leaf potato, Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi, Ganoderma, Flos Buddlejae, Herba Sedi Emarginati, Radix Dichocarpi Dalzielii, Herba Jasmini laurifolii, Herba Chlorophyti Comosi, wing handle knotweed and Fructus Litseae.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Fructus Litseae: source: this product is the drying and ripening fruit of canella cubeb litsen tree Litsea cubeba (Lour.) Pers. Real.Gather during fruit maturation in autumn, remove impurity, dry.Nature and flavor: pungent, temperature.Gui Jing: return spleen, stomach, kidney, bladder warp.Cure mainly: temperature Middle cold expelling, promoting the circulation of QI to relieve pain.For cold syndrome of the stomach vomiting, coldness and pain in the epigastrium, colic of cold type stomachache, stagnancy of cold-damp, turbid urine.
Wing handle knotweed: source: medical material Ji Yuan: for the herb of polygonaceae plant Polygonum sinomontanum Sam..Latin plant animal mineral name: Polygonum sinomontanum Sam. ［ P.bistorta auct.non L. ］ gathers and stores: gather between summer, autumn, Dry.Nature and flavor: micro-sweet；Puckery；Cool in nature.Cure mainly: reason lung cough-relieving；Heat-clearing and toxic substances removing.Main anemopyretic cold；Cough due to lung-heat；Lung abscess；Have loose bowels； Dysentery.
Herba Chlorophyti Comosi: another name: folding crane is blue (" Chinese Plants illustrated handbook "), bracketplant (" seed plant title "), the orchid that crawls (" the Fujian people Between medical herbs "), tree any of several broadleaf plants melon (" mountain of papers Chinese herbal medicine ").Source: " Fujian traditional herbal medicine ".Source: complete for Bulbus Lilii kind plant Herba Chlorophyti Comosi Grass.Nature and flavor: sweetness and bitterness are flat.1. " Fujian traditional herbal medicine ": " sweet micro-hardship, flat." 2. " mountain of papers Chinese herbal medicine ": " is sweet light, cool." cure mainly: only Cough and reduce phlegm, subduing swelling and detoxicating, synthetism of invigorating blood circulation.Control tracheitis cough with copious phlegm, carbuncle furuncle, swelling and pain of hemorrhoid, fracture, burn.1. " Fujian Traditional herbal medicine ": " eliminating carbuncle detoxifies, and moves back scorching detumescence.Control furuncle swelling toxin, swelling and pain of hemorrhoid." 2. " mountain of papers Chinese herbal medicine ": " relieving cough and resolving phlegm, lives Blood synthetism."
Herba Jasmini laurifolii: another name: big Caulis et Radix Periplocae Forrestii, south of the Five Ridges jasmine.Source: Oleaceae Herba Jasmini laurifolii Jasminum laurifolium Roxb., it is used as medicine with Herb.Nature and flavor: bitter, cold.Cure mainly: heat-clearing and toxic substances removing, antiinflammatory diuresis, dissipating blood stasis of subsiding a swelling.
Flos Buddlejae: another name: Flos Buddlejae, Flos Buddlejae, old Flos Buddlejae, sheep ear piece point, Shui Jinhua, Hemerocallis citrina Baroni Herba Buddlejae Lindleyanae.Source: this product Dry flower and inflorescence thereof for loganiaceae plant Flos Buddlejae Buddleja officinalis Maxim..Spring, flower did not opened Shi Caishou, removes impurity, is dried.Nature and flavor: sweet, are slightly cold.Gui Jing: return Liver Channel.Cure mainly: heat clearing away nourishing the liver, improving acuity of vision and removing nebula.For conjunctival congestion Swell and ache, many tear photophobia, nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.
Radix Dichocarpi Dalzielii: source: " Guizhou medical herbs ".Source: for the root of ranunculaceae plant fern leaf herringbone fruit.The whole year can adopt.Nature and flavor: Cold in nature, the micro-hardship of acrid in the mouth.Cure mainly: detumescence, dissipate poison.
Salty acid: another name: between funeral (" the SHENGCAO property of medicine standby want "), enters Pheretima, tart flavour (" south of the Five Ridges gather medicinal herbs record ").Source: " raw Herbal for wanting ".Source: spend the root of Fructus embeliae laetae for Myrsinacea plant in vain.Nature and flavor: 1. " raw Bi Ji property is standby to be wanted ": " sweet in the mouth acid, Property flat." 2. " book on Chinese herbal medicine asks former ": " Gan Xin is flat." cure mainly: control women's amenorrhea, children's's head sore, traumatic injury.1. " the SHENGCAO property of medicine is standby Want ": " detumescence dissipates poison, pain relieving, manages traumatic injury." 2. " book on Chinese herbal medicine asks former ": " infusing drugs in wine strengthening bone and muscle, washes the rotten head of children's." 3. " gather medicinal herbs in the south of the Five Ridges Record ": " all amenorrhea, with sum lean pork decoction."
Radix Clematidis Henryi: another name: Serpentis Semen Pini (" Zhejiang conventional medical herbs among the people "), Rhizoma Anemones flaccidae, cripple's medicine (" Hunan medicine will ").Source: " Zhejiang Sky over the river mesh Rhizoma Dioscoreae plants will ".Source: for root or the leaf of cohosh henry clematis.Nature and flavor: " Hunan medicine will ": " arduous, Temperature, nontoxic." curing mainly: promoting flow of QI and blood, anti-inflammation, the pain such as enemy, stomach, abdomen, muscle and joint all has analgesic effect.Also control Tracheitis, furuncle swelling toxin, traumatic injury.
Five leaf potatos: another name: hair Canis familiaris L. sweet potato, beautiful Herba Cistanches, Radix Aristolochiae Kaempferi, hair ball, straw rain cape bag, Herba Wedeliae Wallichii, bitter OK a karaoke club.Source: medical material Ji Yuan: for the tuber of Dioscoreaceae plant five leaf Rhizoma Dioscoreae.Latin plant animal mineral name: Dioscorea pentaphylla L. adopts Receiving and storage: summer, autumn excavate, remove stem and leaf and fibrous root, clean, section is dried or using fresh herb.Nature and flavor: sweet；Flat.Cure mainly: spleen reinforcing Kidney tonifying；Inducing diuresis and reducing edema.Main board is suffered from a deficiency of the kidney weak；Edema；Have loose bowels；Puerperal is thin and weak；Hypogalactia；Innominate toxic swelling.
Uncaria tonkinensis Havil.: another name: Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, big ventilation, Ramulus Uncariae Cum Uncis, uncaria tonkinensis.Source: Rubiaceae Uncaria tonkinensis Havil. Uncaria tonkinensis Havil., is used as medicine with root.Nature and flavor: puckery, sweet, are slightly cold.Cure mainly: heat clearing away suppressing the hyperactive liver, endogenous wind stopping spasmolytic, live Blood stimulates the menstrual flow.
Perfume conveniently: another name: perfume (or spice) of washing one's hands, band hands are fragrant, roadside is fragrant, Rhizoma Kaempferiae is fragrant.Source: Acorus of Araceae plant perfume conveniently Acorus gramineus Soland. var. pusillus Engl., f. suaveolens C. Y. Cheng, Mss., with all herbal medicine.The four seasons can adopt, and dries.Nature and flavor: pungent, temperature.Curing mainly: promoting the circulation of QI to relieve pain, dispel the wind by cold, detoxify diuretic, eliminating phlegm Have one's ideas straightened out.For mental confusion due to phlegm, coma, gnathospasma, stomachache uncomfortable in chest, turbid damp obstructing in middle-JIAO, rheumatic arthritis, colic, edema；Outward With controlling innominate toxic swelling.
Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep.: another name: Yunlong party, excessively SHANSHEN, Radix Campanumoeae [Hainan].Source: Passifloraceae Adenia plant Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. Adenia chevaliert Gagnep. is used as medicine with root.The whole year can adopt, and cleans cutting, dries.Nature and flavor: hardship sweet, micro-are cool.Main Control: strengthening by means of tonics, wind-damp dispelling, the meridian dredging.For strengthening the spleen and stomach, invigorating the liver and kidney.
Climbing Viloet Herb: another name: white Viola grypoceras A. Gray, Rhizoma Bergeniae scopulosae, wild Chinese cabbage, Herba Violae Serpentis, Fructus Trichosanthis Cucumeroidis grass, Fructus Cucumidis sativi grass, Matteuccia struthiopteri, Fructus Cucumidis sativi Dish, silver teaspoon, stone Chinese cabbage, green snow.Source: Violaceae Viola plant Herba Violae Diffusae Viola diffusa Ging., with entirely Grass is used as medicine.Spring Mo or autumn end gather herb, dry.Nature and flavor: bitter, micro-pungent, cold.Cure mainly: heat-clearing and toxic substances removing, detumescence and apocenosis.For liver Inflammation, pertussis, conjunctival congestion and swelling pain；Acute mastitis, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury are controlled in external.
Radix Pandani Furcati: another name: false Fructus Ananadis comosi, Fructus Ananadis comosi, mountain Fructus Ananadis comosi, mother-in-law's saw, pig mother saw, always saw head, Gu, water drag hair worn in a bun or coil.Come Source: Pandanaceae screw pine Radix Pandani Furcati Pandanus tectorius (L.) Parkins., enters with root, fruit and pit Medicine.Root can be adopted the whole year；Really adopt winter, using fresh herb or dry.Nature and flavor: sweet, light are cool.Cure mainly: relieving the exterior syndrome by diaphoresis, heat-clearing and toxic substances removing, diuretic Expectorant.Root: cold, fever, oedema due to nephritis, urinary system infection, lithangiuria, hepatitis, cirrhotic ascites, Infantile Summer Fever, cornea Scorching.Really: dysentery, cough.Pit: orchitis, hemorrhoid.
Fructus Pistaciae Verae: another name: pistachio (supplement to the Herbal).Source: " Haiyao Bencao, Oversea Materia Medica ".Source: for Anacardiaceae plant without The fruit of name wood.Nature and flavor: supplement to the Herbal: " acrid in the mouth, warm, puckery, nontoxic." cure mainly: the kidney warming, warm spleen.Control waist of suffering from a deficiency of the kidney cold, sexual impotence, Insufficiency of the spleen cold-dysentery.1. supplement to the Herbal: " main all dysentery, removes cold air, makes us fertile strong." 2. " Haiyao Bencao, Oversea Materia Medica ": " main waist is cold, and the moon is suffered from a deficiency of the kidney weak, Water is fragrant, Fructus Corni is good." 3. " detailed outline is picked up any lost article from the road ": " dysentery relieving, warming the kidney, appetizing, except intestinal is dirty long-pending；Obtain the Radix Aucklandiae, mountain cornel energy Xing Yang."
Herba Eupatorii: another name: Herba Chlorophyti, Herba Lycopi, circle stalk Herba Lycopi, Ocimum basilicum L. var. pilosum.Source: this product is feverfew Herba Eupatorii Eupatorium The dry aerial parts of fortunei Turcz..Summer, Qiu Erji tap at twice, remove impurity, dry.Nature and flavor: pungent are flat.Return Warp: return spleen, stomach, lung meridian.Cure mainly: removing dampness by means of aromatics, appetizing of being amusing, deliver expelling summer-heat.
Herba Sedi Emarginati: another name: gingival cyst of mucous gland in the newborn Herba Amaranthi tricoloris (" odd-prescription class volume "), beans lobe half, half (" BAICAO mirror ") of drought, beans lobe grass (Wang Even bodyguard " book of gathering medicinal herbs "), beans plate bean grass (" treasured side of Zhou Yisheng family "), ferrum obstruct half, half, mountain (" detailed outline is picked up any lost article from the road "), Herba Sedi Linearis, half Zhi Lian (" Zhejiang traditional herbal medicine "), Semen Sojae Preparatum grass, Serissa foetida, Canis familiaris L. tooth lobe (" Traditional Chinese Medicine in Sichuan will "), (" Zhejiang is among the people often for celestial being's fingernail With medical herbs ").Source: " detailed outline is picked up any lost article from the road ".Source: for the herb of crassulaceae plants Herba hylotelephii erythrosticti.Summer, autumn harvest are adopted.Nature and flavor: acid, Cool.1. " detailed outline is picked up any lost article from the road ": " cold in nature.2. " Zhejiang traditional herbal medicine ": " sour in the mouth, cool in nature, micro-poison." 8. " Traditional Chinese Medicine in Sichuan will ": " is cool in nature, Lightly seasoned, nontoxic." cure mainly: heat-clearing and toxic substances removing, hemostasis, dampness removing.Control carbuncle, furuncle, spit blood, epistaxis, metrorrhagia, leukorrhagia, scrofula, jaundice, Injury from falling down.1. " detailed outline is picked up any lost article from the road ": " subduing inflammation, controls damp and hot, diuretic and blood.Controlling acute appendicitis, anal fistula, Serpentis stings, boil on the lower part of the cheek or below the nose, inguinal bubo, wind Numbness, falls and flutters, jaundice.The speckle that wipes the sweat is the most wonderful." 2. " Traditional Chinese Medicine in Sichuan will ": " heat-clearing and toxic substances removing.Control calentura, spit blood, epistaxis, hematochezia, red collapses And sore is red and swollen."
Herba Fici Stenophyliae: another name: Folium Bambusae Fici hispidae, waterside willow, hundred grass, Archontophoenix alexandrae Wendl et Orude, spire water banyan tree (" commonly use Chinese herbal medicine cromogram Spectrum "), slimleaf fig (" Yunnan Chinese herbal medicine ").Source: " Yunnan Chinese herbal medicine ".Source: for the Herb of moraceae plants Ficus stenophylla Hemsl.Spring, autumn Gather.Clean and dry.Nature and flavor: sweetness and bitterness, temperature.1. " conventional Chinese herbal medicine color atlas ": " sweet and slightly bitter taste, warm in nature." 2. " Yunnan medium-height grass Medicine ": " puckery hardship, temperature." curing mainly: 1. " conventional Chinese herbal medicine color atlas ": " qi invigorating and lung moistening, expelling phlegm for arresting cough, promoting flow of QI and blood.Control traumatic injury Swell and ache, rheumatic ostalgia, women's hypogalactia, five kinds of strain and seven kinds of impairment, chest pain of coughing." 2. " Yunnan Chinese herbal medicine ": " tonifying kidney for preventing miscarriage.Control fetal movement not Peace."
Radix Pseudostellariae: another name: Radix Ginseng, double batches seven, pseudostellaria heterophylla.Source: this product is pinkwort Radix Ginseng The dried root of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm..Summer, stem and leaf was big Part is excavated time withered, cleans, and removes fibrous root, puts and dries or directly dry after slightly scalding in boiling water.Nature and flavor: hardship sweet, micro-are flat.Return Warp: return spleen, lung meridian.Cure mainly: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, Spontaneous perspiration is thirsty, dryness of the lung dry cough.
Ganoderma: another name: Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma Lucidum.Source: this product is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma Lucidum(Leyss.ex Fr.) the dry son of Karst. or Ganoderma Ganoderma sinense Zhao, Xu et Zhang is real Body.The whole year gathers, and removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dry in the shade or 40～50 DEG C of bakings Dry.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Cure mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, cardiopalmus gas Short, asthenia cough with asthma.
Herba Veronicae Serpyllifoliae: another name: purslane speedwell Herba, foster leather and fur (" Shaanxi Chinese herbal medicine ").Source: " Shaanxi medical herbs ".Source: for Radix Scrophulariae kind Plant little Herba veronicae fruit has the herb of insect gall.6～picking fruit has July the herb of insect gall, dry after steaming or using fresh herb.Property Taste: 1. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is pained, and property is put down." 2. " Shaanxi medical herbs ": " sour-puckery flavor, property is put down." cure mainly: promoting blood circulation and hemostasis, clearly Thermal detoxification.Control traumatic injury, menoxenia, wound hemorrhage, aphtha, burn.1. " Shaanxi Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, only Blood, removing toxic substances.Control traumatic injury, inside have blood stasis, traumatic hemorrhage, menoxenia, venom." 2. " Shaanxi medical herbs ": " restrains, only Blood, antiinflammatory.Control burn, aphtha, obstinate pyogenic sore of the skin."
Semen Persicae: source: this product is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus The dry mature seed of davidiana (Carr.) Franch..Gather after fruit maturation, remove sarcocarp and nucleocapsid, take out and plant Son, dries.Nature and flavor: bitter, sweet, flat.Gui Jing: GUIXIN, liver, large intestine channel.Cure mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Folium et Ramulus Cephalotaxi: another name: Semen Torreyae, Resina Draconis, stone Chinese torreya, water cedar seed, Tibetan China fir, Fructus Persicae pine, Canis familiaris L. tail pine, point pine, mountain Chinese torreya, hoary hair China fir, precipice head China fir, rock China fir.Source: Cephalotaxaceae Cephalotaxus plant Folium et Ramulus Cephalotaxi Cephalotaxus fortunei Hook. f., to plant Son and branch, leaf are used as medicine.Seed is plucked autumn；Branch, the leaf four seasons can adopt.Nature and flavor: seed: sweet, puckery are flat.Branch, leaf: bitter, puckery, cold.Main Control: seed: anthelmintic, removing food stagnancy.For ascariasis, ancylostomiasis, food stagnation.Branch, leaf: anticancer.For malignant tumor.Cephalotaxus fortunei total is biological Alkali has preferable curative effect to lymphosarcoma, pulmonary carcinoma etc..
Herba silenes fortunei: another name: wild palmate meadowsweet (" southern Jiangsu seed plant "), CANGYINGHUA (" Chinese medicinal herbal "), water-white ginseng, spend one in vain Bottle, lobule Fel Cyprinus carpio, Herba Dianthi Radix Adenophorae (Radix Glehniae), August is white, spend Herba Dianthi, little purslane speedwell Herba, white calabash, Herba Lycopi (" Zhejiang conventional grass among the people in vain Medicine ").Source: " Jiangsu medical material will ".Source: for the whole herb with root of pinkwort fly grass.Nature and flavor: " Zhejiang conventional grass among the people Medicine ": " pungent puckery, cool." cure mainly: heat clearing away profit alunite, qi-restoratives is invigorated blood circulation.Controlling urinary tract infection, leucorrhea, dysentery, body is empty after being ill, turns round, dampens.① " Jiangsu medical material will ": " strengthening by means of tonics.Control that body is brave or weak few power after being ill." 2. " Zhejiang conventional medical herbs among the people ": " clearing away heat-damp and promoting diuresis, Removing toxic substances and promoting subsidence of swelling."
Fructus Lycii: source: this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, autumn Two season fruit gather when taking on a red color, hot-air seasoning, remove carpopodium.Or dry in the air to rhicnosis, dry, remove carpopodium.Nature and flavor: sweet are flat. Gui Jing: return liver, kidney channel.Cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat disappears Yearningly, blood deficiency and yellow complexion, blurred vision is failed to understand.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 Weight portion, Radix Pandani Furcati 9-16 weight portion, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, crawl Volt violet 8-24 weight portion, Herba Veronicae Serpyllifoliae 13-33 weight portion, the most fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12-32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight Amount part, Ganoderma 15-35 weight portion, Flos Buddlejae 11-21 weight portion, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion With Herba Jasmini laurifolii 9-18 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 12 weight portion, Semen Persicae 20 weight Part, Radix Pandani Furcati 15 weight portion, Herba Eupatorii 27 weight portion, Herba silenes fortunei 12 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 30 weight portions, conveniently fragrant 16 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 32 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 8 weight portions, Radix Clematidis Henryi 16 weight portion, Ganoderma 33 weight portion, Flos Buddlejae 20 weight portion, Herba Sedi Emarginati 17 weight portions, Radix Dichocarpi Dalzielii 31 weight portion and Herba Jasmini laurifolii 14 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight Part, Radix Pandani Furcati 13 weight portion, Herba Eupatorii 25 weight portion, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 32 weight portions, conveniently fragrant 17 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 10 weight portions, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portions, Radix Dichocarpi Dalzielii 30 weight portion and Herba Jasmini laurifolii 13 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 Weight portion, Radix Pandani Furcati 9-16 weight portion, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, crawl Volt violet 8-24 weight portion, Herba Veronicae Serpyllifoliae 13-33 weight portion, the most fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12-32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight Amount part, Ganoderma 15-35 weight portion, Flos Buddlejae 11-21 weight portion, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion, Herba Jasmini laurifolii 9-18 weight portion, Folium et Ramulus Cephalotaxi 10-24 weight portion, Uncaria tonkinensis Havil. 14-31 weight portion, Herba Chlorophyti Comosi 7-14 weight portion, wing handle knotweed 12-24 weight portion and Fructus Litseae 7-14 weight portion.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight Part, Radix Pandani Furcati 13 weight portion, Herba Eupatorii 25 weight portion, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Puckery 32 weight portions, conveniently fragrant 17 weight portions, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Oryza sativa L. Clear 14 weight portions, salty sour 10 weight portions, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portions, Radix Dichocarpi Dalzielii 30 weight portion, Herba Jasmini laurifolii 13 weight portion, Folium et Ramulus Cephalotaxi 13 weight portion, Uncaria tonkinensis Havil. 26 weight portion, Herba Chlorophyti Comosi 12 Weight portion, wing handle knotweed 17 weight portion and Fructus Litseae 12 weight portion.
When the dosage form of described Chinese medicine composition is granule, its preparation method comprises the following steps:
The first step, is mixed each for described Chinese medicine composition raw medicinal material in described ratio, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, and uses percolation with per minute 1～the speed of 2ml Spend slowly percolation, collect percolate, under vacuum 0.06～0.09Mpa, be evaporated to relative density when 50～60 DEG C subsequently It is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, It is ground into powder subsequently, makes dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
When the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:
The first step, mixes Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi and Ganoderma, adds and relative to 3 times of mixture～5 times amount determining alcohols be The alcohol reflux of 55%～65% 2 times～4 times, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG C of relative densities are the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, mistake Filter, is concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C of reduced vacuum are dried, and get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, the containing alcohol of described containing alcohol mastic Amount is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment successively, obtains Dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；
5th step, by adding cane sugar powder, activated carbon in described dealcoholysis mastic, is carried out at heat treated, filtration treatment, dilution successively Reason, obtains semi-finished product；Described dealcoholysis mastic is 1: 0.1～0.3 with the weight ratio of described cane sugar powder；Described dealcoholysis mastic is with described The weight ratio of activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, temperature be 100 DEG C～ 110℃；
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, to obtain final product Described oral liquid finished product.
When the dosage form of described Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36 Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1 The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
The manufacturing process of granule of the present invention is: take Fructus Pistaciae Verae 120g, Semen Persicae 200g, Radix Pandani Furcati 150g, Herba Eupatorii 270g, Herba silenes fortunei 120g, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 300g, Climbing Viloet Herb 220g, Herba Veronicae Serpyllifoliae 300g, the most fragrant 160g, Radix Pseudostellariae 320g, Fructus Lycii 260g, five leaf potatos 320g, Herba Fici Stenophyliae 140g, salty acid 80g, Radix Clematidis Henryi 160g, Ganoderma 330g, Flos Buddlejae 200g, Herba Sedi Emarginati 170g, Radix Dichocarpi Dalzielii 310g and Herba Jasmini laurifolii 140g；
The first step, is mixed each for described Chinese medicine composition raw medicinal material in described ratio, adds the determining alcohol relative to 6 times of mixture It is the ethanol of 90%, is heated to boiling reflux 4 hours, filter, use percolation with the speed slowly percolation of 1.5ml per minute, receive Collection percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.07Mpa is the mastic of 1.07, is spray-dried, The inlet temperature of spray dryer 170 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder；
Second step, adds the cane sugar powder relative to dried cream powder quality 0.3 times and the dextrin of 0.15 times in the dried cream powder obtained, system Become granule, be dried in 45 DEG C, it is thus achieved that granule.
Embodiment 2 oral liquid
The manufacturing process of oral liquid of the present invention is: take Fructus Pistaciae Verae 100g, Semen Persicae 150g, Radix Pandani Furcati 130g, Herba Eupatorii 250g, Herba silenes fortunei 140g, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 300g, Climbing Viloet Herb 220g, Herba Veronicae Serpyllifoliae 320g, the most fragrant 170g, Radix Pseudostellariae 320g, Fructus Lycii 260g, five leaf potatos 300g, Herba Fici Stenophyliae 140g, salty acid 100g, Radix Clematidis Henryi 150g, Ganoderma 320g, Flos Buddlejae 170g, Herba Sedi Emarginati 220g, Radix Dichocarpi Dalzielii 300g and Herba Jasmini laurifolii 130g；
The first step, mixes Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi and Ganoderma, and adding relative to mixture 4 times amount determining alcohol is 60% Alcohol reflux 3 times, each 2.5 hours, filters, and filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is 1.31 Mastic, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times amount water, boils 3 hours, filters, and concentrates It is the mastic of 1.28 to 70 DEG C of relative densities；
3rd step, the described mastic mixing first step, second step obtained, 60 DEG C of reduced vacuum are dried, and get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, the containing alcohol of described containing alcohol mastic Amount is 70%；Described containing alcohol mastic is carried out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment successively, obtains dealcoholysis cream Body, wherein, the chilling treatment time is 35 hours；
5th step, by adding cane sugar powder, activated carbon in described dealcoholysis mastic, is carried out at heat treated, filtration treatment, dilution successively Reason, obtains semi-finished product；Described dealcoholysis mastic is 1: 0.25 with the weight ratio of described cane sugar powder；Described dealcoholysis mastic and described activity The weight ratio of charcoal is 1: 0.0015；The time of described heat treated is 30 minutes, and temperature is 105 DEG C；
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, to obtain final product Described oral liquid finished product.
Embodiment 3 injectable powder
The manufacturing process of the injectable powder of the present invention is: take Fructus Pistaciae Verae 100g, Semen Persicae 150g, Radix Pandani Furcati 130g, Herba Eupatorii 250g, de-power Grass 140g, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 300g, Climbing Viloet Herb 220g, Herba Veronicae Serpyllifoliae 320g, the most fragrant 170g, Radix Pseudostellariae 320g, Fructus Lycii 260g, five leaf potatos 300g, Herba Fici Stenophyliae 140g, salty acid 100g, Radix Clematidis Henryi 150g, Ganoderma 320g, Flos Buddlejae 170g, Herba Sedi Emarginati 220g, Radix Dichocarpi Dalzielii 300g, Herba Jasmini laurifolii 130g, Folium et Ramulus Cephalotaxi 130g, Uncaria tonkinensis Havil. 260g, Herba Chlorophyti Comosi 120g, wing handle knotweed 170g and Fructus Litseae 120g；
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into the micro-of 7 μm volume average particle size in super micron mill The mixed powder that scale particles and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixed powder Obtain powder rate and be at least 95%；
Second step, the determining alcohol adding the quality 4 times relative to described mixed powder in the mixed powder that the first step obtains is The ethanol of 90%, stirring and dissolving obtain ethanol solution, ethanol solution is stood 32 hours under conditions of 7 DEG C, employing percolation with The speed of 1.5ml per minute slowly percolation, collects percolate, is concentrated and dried, and puts into pulverizing 50 in super micron mill at this Minute, it is thus achieved that the micron particles of 5 μm volume average particle size and particle diameter are less than the nano-scale particle group of 0.1 μm volume average particle size The mixed powder become, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it molten Solve, inject water to 1000ml further, add 1.5g needle-use activated carbon, be sufficiently stirred for 40 minutes；Decarbonization filtering；With 0.23 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
Injection toxicity test:
(1) animal selects
Cleaning grade kunming mice 40, male and female half and half, body weight 18-22 g；Laboratory observation 1 week, fasting 4 h before being every time administered, Can't help water.
(2) test packet
By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice that clinical observation result is healthy was random It is divided into two groups, often 20 (male and female half and half) of group.One of which is set as experimental group, and another group is set as matched group.
(3) medication and dosage
Mouse tail vein injection, experimental group is to give continuously in maximum (former) concentration of the embodiment of the present invention 3 and maximum volume 24 h Medicine 3 times, gives 0.6 ml/20g(Mouse Weight) medicine, the injection 1.8g of mouse tail vein injection embodiment 3 in i.e. 24 h (crude drug amount)/20g(Mouse Weight)；Matched group is to the injection normal saline of same volume.
(4) observational technique and index
Weigh the weight of animals before being administered and observe feed intake and drinking-water situation；After administration, every day weighs animal body in the identical time Weight, feed intake and undue toxicity's symptom, Continuous Observation 14 d.Observation index is as follows: 1. take action, as unease, many dynamic, send out Sound；2. nervous system reaction, as lifted tail, chatter, spasm, movement disorder, attitude extremely；3. autonomic nervous system reaction, such as eye Ball is prominent, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration；4. drinking-water and appetite change, defecation and Color, whether nose, eye, oral cavity be with or without abnormal secretion thing, body weight change；5. death condition.
(5) experimental result
By the observation of 14 d, two groups all do not have undue toxicity to react appearance, the most do not occur animal dead phenomenon.Cause This, the injection of the embodiment of the present invention 3 has no side effect.
Long term toxicity test: by the granule of the embodiment of the present invention 1 to mice by 6.43,15.72 and 36.41g crude drugs/kg After 16 weeks (1.0ml/100g body weight, every day 2 times) of continuous use and drug withdrawal 4 weeks, result shows: Chinese medicine composition of the present invention is to little The indexs such as the hair of Mus, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, Internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is equal Without substantially changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, should By safety.
Cumulative toxicity test is reported: test method: selects 20 healthy mices, female, male each 10, implements with the present invention The oral liquid of example 2 is object, and dose design is a phase in every 5 days, each issue dosage be respectively 0.10LD50,0.15LD50, 0.22LD50,0.34LD 50,0.50LD50, the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, press 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, and off-test, by ascending-dose to tested material 20 After it, female, buck all occurs without death condition.
Clinical data:
Case selection: select in October, 2014 to outpatient service in October, 2016 or be in hospital 200 example patient with breast cancers, age 35-57 Year, medical history 7 months-3 years；200 example patient with breast cancers are randomly divided into Granules in Treating group, oral liquid treatment group, injectable powder are controlled Treatment group and matched group, each experimental group 50 people.
Therapeutic Method:
In medication therapy groups:
Granules in Treating group: use the embodiment of the present invention 1 to prepare granule, three times a day, once a bag, every bag of 6g, within every 25 days, be One course for the treatment of；
Oral liquid treatment group: take the embodiment of the present invention 2 preparation oral liquid, three times a day, 20ml/ time, every bottle of 20ml, every 25 It is a course for the treatment of；
Injectable powder treatment group: use the injectable powder intravenous drip of the embodiment of the present invention 3 preparation, the most molten with appropriate water for injection Solving, then dilute with 5% glucose injection 500ml, every day 1 time, each per kilogram of body weight 30mg, every 25 days is a course for the treatment of.
Matched group: take Tegafur Tablet, three times a day, one time 4, within every 30 days, be a course for the treatment of.
The standard of curative effect evaluation: cure: lump is wholly absent, more than 5 years life cycle；Effective: lump area reduces, and periodically examines Survey without spread risk, 5 years life cycles；Invalid: lump is without disappearing sign or have the trend of deterioration, and even patient's short time is the most dead Die.
Therapeutic outcome:
See Tables 1 and 2, as it can be seen from table 1 using the Chinese medicine composition of the present invention is that thing treats tumor, relative to traditional drugs Thing, on therapeutic effect, has and is markedly improved；From table 2 it can be seen that use the Drug therapy tumor of the present invention, relative to biography System medicine, significantly shortens on the course for the treatment of treating.
Table 1 is respectively organized and is treated Clinical efficacy comparison example after 4 courses for the treatment of respectively
Group Number of cases Cure number Significant figure Invalid number Total effective rate (%)
Granules in Treating group 50 21 15 14 72%
Oral liquid treatment group 50 22 16 12 76%
Injectable powder treatment group 50 24 16 10 80%
Matched group 50 2 17 31 38%
2 four groups of table is cured and efficiently individual quantity time comparative example (%) after treating 4 courses for the treatment of respectively
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Granules in Treating group 36 7(19.4%) 9(25%) 9(25%) 11(30.6%)
Oral liquid treatment group 38 8(21.1%) 9(23.7%) 10(26.3%) 11(28.9%)
Injectable powder treatment group 40 9(22.5%) 10(25%) 10(25%) 11(27.5%)
Matched group 19 1(5.3%) 2(10.5%) 4(21.1%) 12(63.2%)
According to the clinical statistics in above table, the medicine that the present invention provides have rapid-action, effective percentage is high, curative effect is true Cut, safety is high, have no side effect；Treatment group is cured simultaneously and 114 examples of efficiently individual quantity and matched group are cured and effectively 19 example follow-up of patients 5 years half, result adds up, and cures 21 examples without recurrence, without multiple in effective 15 examples in Granules in Treating group 36 example Sending out 2 examples, relapse rate is 5.6%；Oral liquid treatment group 38 example is cured 22 examples without recurrence, 1 case relapsed in effective 16 examples, relapse rate It is 2.6%；Curing 24 examples and effective 16 examples in injectable powder treatment group 40 example all without recurrence, relapse rate is 0%；Matched group cure and Efficiently individual quantity 19 example, 1 case relapsed in 2 example patients of healing, recurs 13 examples, relapse rate 73.7% in effective 17 example patients；Above-mentioned After recurrence refers to that patient outcomes reaches to cure or be effective, 5 years half followed up a case by regular visits to substantially occur the symptom before treatment.
Model case: Wang, women, 45 years old, be diagnosed as right breast carcinoma, do resection operation subsequently in commune hospital, postoperative enter Go the chemotherapy of four courses for the treatment of；Because finding that right neck and right chest have portion's lump, going to hospital to check, pathology shows and meets in lymph node Cancerometastasis, and carried out 12 radiotherapy immediately, to become thin, yellowish complexion, weak, right cervical region is burned black because of radiotherapy skin, right cervical region dull pain, hands Touching has obvious lump, left breast to have pain once in a while, uses Chinese medicine composition embodiment 1 of the present invention to prepare granule, three times a day, and one Secondary one bag, medication is substantially effective for one course for the treatment of, and appetite increases, and action is strong, continues medication and cures for two months, has rosy cheeks, muddy Body is strong, and the burned black skin color of right cervical region shoals, and right cervical region, left breast are all obviously reduced without right neck region lump of keenly feeling, and follow up a case by regular visits to 5 years half Do not recur.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (10)

1. Chinese medicine composition treating tumor and preparation method thereof, it is characterised in that include following raw medicinal material: unknown Son, Semen Persicae, Radix Pandani Furcati, Herba Eupatorii, Herba silenes fortunei, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep., Climbing Viloet Herb, Herba Veronicae Serpyllifoliae, conveniently perfume, Radix Pseudostellariae, Fructus Lycii, five leaf potatos, water Rice acid clear, salty, Radix Clematidis Henryi, Ganoderma, Flos Buddlejae, Herba Sedi Emarginati, Radix Dichocarpi Dalzielii and Herba Jasmini laurifolii.
The Chinese medicine composition for the treatment of tumor the most according to claim 1, it is characterised in that described Chinese medicine composition is by following The raw medicinal material of parts by weight is made: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 weight portion, Radix Pandani Furcati 9-16 weight portion, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, Climbing Viloet Herb 8-24 weight portion, Herba Veronicae Serpyllifoliae 13-33 weight Amount part, conveniently fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12-32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight portion, Ganoderma 15-35 weight portion, Flos Buddlejae 11- 21 weight portions, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion and Herba Jasmini laurifolii 9-18 weight portion.
The Chinese medicine composition for the treatment of tumor the most according to claim 1 and 2, it is characterised in that described Chinese medicine composition by The raw medicinal material of following parts by weight is made: Fructus Pistaciae Verae 12 weight portion, Semen Persicae 20 weight portion, Radix Pandani Furcati 15 weight portion, Herba Eupatorii 27 Weight portion, Herba silenes fortunei 12 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Herba Veronicae Serpyllifoliae 30 weight portion, conveniently fragrant 16 weight Part, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 32 weight portions, Herba Fici Stenophyliae 14 weight portion, salty sour 8 weight portions, Radix Clematidis Henryi 16 weight portion, Ganoderma 33 weight portion, Flos Buddlejae 20 weight portion, Herba Sedi Emarginati 17 weight portion, Radix Dichocarpi Dalzielii 31 weight portion and Herba Jasmini laurifolii 14 weight portion.
4. according to the Chinese medicine composition of the treatment tumor described in any one of claim 1-3, it is characterised in that described Chinese medicine composition Thing is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight portion, Radix Pandani Furcati 13 weight portion, pendant Blue 25 weight portions, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Herba Veronicae Serpyllifoliae 32 weight portion, conveniently perfume 17 Weight portion, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Herba Fici Stenophyliae 14 weight portion, salty sour 10 weights Amount part, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portion, Radix Dichocarpi Dalzielii 30 weight Part and Herba Jasmini laurifolii 13 weight portion.
5. according to the Chinese medicine composition of the treatment tumor described in any one of claim 1-4, it is characterised in that described Chinese medicine composition In thing, each raw medicinal material also includes: Folium et Ramulus Cephalotaxi, Uncaria tonkinensis Havil., Herba Chlorophyti Comosi, wing handle knotweed and Fructus Litseae.
6. according to the Chinese medicine composition of the treatment tumor described in any one of claim 1-5, it is characterised in that described Chinese medicine composition Thing is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 7-14 weight portion, Semen Persicae 12-22 weight portion, Radix Pandani Furcati 9-16 weight Amount part, Herba Eupatorii 15-35 weight portion, Herba silenes fortunei 11-21 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 14-32 weight portion, Climbing Viloet Herb 8-24 weight portion, puckery Puckery 13-33 weight portion, the most fragrant 12-24 weight portion, Radix Pseudostellariae 15-35 weight portion, Fructus Lycii 14-28 weight portion, five leaf potato 12- 32 weight portions, Herba Fici Stenophyliae 8-16 weight portion, salty acid 7-14 weight portion, Radix Clematidis Henryi 9-17 weight portion, Ganoderma 15-35 weight portion, Flos Buddlejae 11-21 weight portion, Herba Sedi Emarginati 15-25 weight portion, Radix Dichocarpi Dalzielii 16-32 weight portion, Herba Jasmini laurifolii 9-18 weight portion, three Point China fir 10-24 weight portion, Uncaria tonkinensis Havil. 14-31 weight portion, Herba Chlorophyti Comosi 7-14 weight portion, wing handle knotweed 12-24 weight portion and Fructus Litseae 7- 14 weight portions.
7. according to the Chinese medicine composition of the treatment tumor described in any one of claim 1-7, it is characterised in that described Chinese medicine composition Thing is made up of the raw medicinal material of following parts by weight: Fructus Pistaciae Verae 10 weight portion, Semen Persicae 15 weight portion, Radix Pandani Furcati 13 weight portion, pendant Blue 25 weight portions, Herba silenes fortunei 14 weight portion, Adenia heterophylla (Bl.) Koord.[A.che-ualieri Gagnep. 30 weight portion, Climbing Viloet Herb 22 weight portion, Herba Veronicae Serpyllifoliae 32 weight portion, conveniently perfume 17 Weight portion, Radix Pseudostellariae 32 weight portion, Fructus Lycii 26 weight portion, five leaf potato 30 weight portions, Herba Fici Stenophyliae 14 weight portion, salty sour 10 weights Amount part, Radix Clematidis Henryi 15 weight portion, Ganoderma 32 weight portion, Flos Buddlejae 17 weight portion, Herba Sedi Emarginati 22 weight portion, Radix Dichocarpi Dalzielii 30 weight Part, Herba Jasmini laurifolii 13 weight portion, Folium et Ramulus Cephalotaxi 13 weight portion, Uncaria tonkinensis Havil. 26 weight portion, Herba Chlorophyti Comosi 12 weight portion, wing handle knotweed 17 weight portion With Fructus Litseae 12 weight portion.
8. according to the preparation method of the Chinese medicine composition of the treatment tumor described in any one of claim 1-7, it is characterised in that when When the dosage form of described Chinese medicine composition is granule, its preparation method comprises the following steps:
The first step, is mixed each for described Chinese medicine composition raw medicinal material in described ratio, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, and uses percolation with per minute 1～the speed of 2ml Spend slowly percolation, collect percolate, under vacuum 0.06～0.09Mpa, be evaporated to relative density when 50～60 DEG C subsequently It is the mastic of 1.04～1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, It is ground into powder subsequently, makes dried cream powder；
Second step, adds relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and 0.1～0.2 times in the dried cream powder obtained Dextrin, make granule, in 40～50 DEG C be dried, it is thus achieved that granule.
9. according to the preparation method of the Chinese medicine composition of the treatment tumor described in any one of claim 1-7, it is characterised in that when When the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:
The first step, mixes Herba Fici Stenophyliae, salty acid, Radix Clematidis Henryi and Ganoderma, adds and relative to 3 times of mixture～5 times amount determining alcohols be The alcohol reflux of 55%～65% 2 times～4 times, each 2 hours～3 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into 70 DEG C of relative densities are the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, mistake Filter, is concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing first step, second step obtained, 55 DEG C～65 DEG C of reduced vacuum are dried, and get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, the containing alcohol of described containing alcohol mastic Amount is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation process, filtration treatment, dealcoholation treatment successively, obtains Dealcoholysis mastic, wherein, the chilling treatment time is 30～40 hours；
5th step, by adding cane sugar powder, activated carbon in described dealcoholysis mastic, is carried out at heat treated, filtration treatment, dilution successively Reason, obtains semi-finished product；Described dealcoholysis mastic is 1: 0.1～0.3 with the weight ratio of described cane sugar powder；Described dealcoholysis mastic is with described The weight ratio of activated carbon is 1: 0.001～0.002；The time of described heat treated is 20～40 minutes, temperature be 100 DEG C～ 110℃；
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, to obtain final product Described oral liquid finished product.
10. according to the preparation method of the Chinese medicine composition of the treatment tumor described in any one of claim 1-7, it is characterised in that When the dosage form of described Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, puts into and is ground into 0.1～10 μm volume average particle in super micron mill The mixed powder that the micron particles in footpath and particle diameter form less than the nano-scale particle of 0.1 μm volume average particle size, described mixing The powder rate that obtains of powder is at least 95%；
Second step, adds the quality 3 relative to described mixed powder～the determining alcohol of 5 times in the mixed powder that the first step obtains Being the ethanol of 85%～95%, stirring and dissolving obtains ethanol solution, and ethanol solution stands under conditions of 5 DEG C～10 DEG C 24～36 Hour, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, be concentrated and dried, and put at this Super micron mill is pulverized 40～60 minutes, it is thus achieved that the micron particles of 0.1～10 μm volume average particle size and particle diameter are less than 0.1 The mixed powder of the nano-scale particle composition of μm volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, Stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 Minute；Decarbonization filtering；With 0.22～0.24 μm filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding.
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041317A (en) * 2013-01-22 2013-04-17 宋洪增 Traditional Chinese medicine composition for treating tumors and preparation method thereof
CN104958546A (en) * 2015-06-25 2015-10-07 庞艳杰 Traditional Chinese medicine for treating damp-heat depressive-poison type cervical cancer and preparation method
CN105031262A (en) * 2015-08-18 2015-11-11 乔娜 Traditional Chinese medicine for treating chronic endometritis and preparation method of traditional Chinese medicine
CN105055532A (en) * 2015-07-22 2015-11-18 宋庆春 Traditional Chinese medicine for treating stomach cancer with syndromes of stomach heat and yin deficiency and preparation method of traditional Chinese medicine
CN105169039A (en) * 2015-09-15 2015-12-23 薛素莉 Traditional Chinese medicine for treating acute endometritis due to heat-toxin with stasis and preparation method thereof
CN105250748A (en) * 2015-10-08 2016-01-20 谭真 Traditional Chinese medicine for treating cervical cancer and preparation method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041317A (en) * 2013-01-22 2013-04-17 宋洪增 Traditional Chinese medicine composition for treating tumors and preparation method thereof
CN104958546A (en) * 2015-06-25 2015-10-07 庞艳杰 Traditional Chinese medicine for treating damp-heat depressive-poison type cervical cancer and preparation method
CN105055532A (en) * 2015-07-22 2015-11-18 宋庆春 Traditional Chinese medicine for treating stomach cancer with syndromes of stomach heat and yin deficiency and preparation method of traditional Chinese medicine
CN105031262A (en) * 2015-08-18 2015-11-11 乔娜 Traditional Chinese medicine for treating chronic endometritis and preparation method of traditional Chinese medicine
CN105169039A (en) * 2015-09-15 2015-12-23 薛素莉 Traditional Chinese medicine for treating acute endometritis due to heat-toxin with stasis and preparation method thereof
CN105250748A (en) * 2015-10-08 2016-01-20 谭真 Traditional Chinese medicine for treating cervical cancer and preparation method

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Application publication date: 20160810