CN105832877B - A kind of health care product and its preparation method and application with liver-protecting efficacy - Google Patents
A kind of health care product and its preparation method and application with liver-protecting efficacy Download PDFInfo
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- CN105832877B CN105832877B CN201610387488.7A CN201610387488A CN105832877B CN 105832877 B CN105832877 B CN 105832877B CN 201610387488 A CN201610387488 A CN 201610387488A CN 105832877 B CN105832877 B CN 105832877B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of health care product and its preparation method and application with liver-protecting efficacy, the health care product be extracted by pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris and Poria cocos by supercritical extract, water, alcohol reflux extracts the technique combined with ultramicro grinding and is prepared.The health care product produces synergistic effect in terms of Protecting Hepatic Injury, has significant protective action to hepatic injury caused by the various chemical substances including alcohol.And pass through process optimization, the effective component in each bulk pharmaceutical chemicals is extracted to the maximum extent, and the effective component is more advantageous to each ingredient being absorbed and utilized in vivo by pulverizing.
Description
Technical field
The present invention relates to a kind of health care product and its preparation method and application with liver-protecting efficacy belongs to application in TCM field.
Background technique
Liver is the organ in body based on metabolic function, and deoxidation is played inside body, stores glycogen, secretory
The effects of synthesis of protein, liver to ex vivo and the external for example various drugs of many non-nutritive substances, poisonous substance and
Internal certain metabolites, have biotransformation.They are thoroughly decomposed by metabolism or is excreted with original shape.
This effect is also referred to as " function of detoxification ", and certain poisonous substances pass through bioconversion, and it is smaller to be changed into nontoxic or toxicity, is easy to
The substance of excretion.Liver is easily accumulated by a variety of substances, poisonous substance and immunologic mjury.
With the rapid development in epoch and the continuous improvement of living standard, living and working environment locating for people occurs
Huge variation, operating pressure is big, life style is not scientific, diet is unhealthy, excessive drinking etc. can all cause not liver
Reversible damage.And hepatic injury is an important factor for causing liver fibrosis or even cirrhosis, liver cancer to occur, and causes hepatopathy
One of the main reason for dead.
Modern medicine is more deep to the research of hepatic injury, but curative effect is still difficult fully up to expectations, and drug used is because of malicious secondary work
With, price is higher the problems such as, limit its clinical application.Traditional Chinese medicine treats the clinical advantage of hepatic injury increasingly by domestic and international
The attention and affirmative of expert.Currently, the liver health product huge number of ingredient is wanted mainly based on the traditional Chinese medicine, for example, Chinese patent
CN200910000241.5 discloses the pure natural health-care capsule of a kind of liver protection, protect liver, toxin expelling, lipid-loweringing, wherein comprising Cordceps militaris,
The more than ten taste Chinese medicines such as quasi- silky ant, fish fat, pearl, live chickens gold, raw hawthorn, Poria cocos, but the medicinal material used is more, the later period is raw
Quality control is more difficult during production.For another example Chinese patent CN200910061279.3 disclose it is a kind of by hoveniae semoveniae semen, pueraria lobata,
The molecular Antialcoholic liver-protecting Chinese prescription of the five tastes, Chinese patent CN201010614393.7 disclose one kind by ganoderma lucidum, pueraria lobata, trifoliate orange
Dulcis, Schisandra chinensis, Radix Glycyrrhizae form liver-protecting and alcoholism-relieving oral solution, but above-mentioned health product is laid particular emphasis on the aspect of dispelling the effects of alcohol more, i.e. alcohol
Property hepatic injury in terms of the effect of, and alcohol is only one of the reason of now resulting in hepatic injury.For this purpose, the invention proposes it is a kind of not
Only there is protective action to alcoholic liver injury, also there is the health care of significant protective action to hepatic injury caused by other chemical substances
Product.
Summary of the invention
The present invention provides a kind of health care product and its preparation method and application with liver-protecting efficacy.
To achieve the above object, on the one hand, the present invention provides a kind of health care products with liver-protecting efficacy.The health care product
It is prepared from the following raw materials in parts by weight:
8-12 parts of pueraria lobata, 6-10 parts of hoveniae semoveniae semen, 4-8 parts of Schisandra chinensis, 3-6 parts of Cordceps militaris, 3-6 parts of Poria cocos.
In a preferred embodiment in accordance with this invention, the health care product is prepared from the following raw materials in parts by weight:
9-11 parts of pueraria lobata, 6-8 parts of hoveniae semoveniae semen, 5-7 parts of Schisandra chinensis, 4-6 parts of Cordceps militaris, 3-5 parts of Poria cocos.
In another preferred embodiment of the present invention, the health care product is prepared from the following raw materials in parts by weight:
11 parts of pueraria lobata, 7 parts of hoveniae semoveniae semen, 5 parts of Schisandra chinensis, 4 parts of Cordceps militaris, 4 parts of Poria cocos.
In another preferred embodiment of the present invention, the health care product is oral solution, tablet or capsule.
On the other hand, the present invention provides the preparation methods of the health care product:
The health care product is to be prepared from the following steps:
(1) pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris, Poria cocos are weighed by weight, removes impurity, are cleaned, are dried, it is standby
With；
(2) Cordceps militaris is crushed, cross 100-200 mesh, obtain Cordceps militaris fine powder, place it in supercritical extraction reactor into
Row carbon dioxide supercritical extraction, extraction conditions are as follows: pressure 20-30Mpa, 50-60 DEG C of extraction temperature, 35-45 DEG C of resolution temperature,
Carbon dioxide flow is 1.0-2.0L/min, extraction time 75-90min, collects extract, and residue is spare；
(3) Poria cocos is crushed into powder, is mixed with residue obtained in step (2), 9-12 times of water is added, it is small that heating water mentions 2-3
When, filtrate is collected in filtering, adds 9-12 times of water for residue obtained, heating water is mentioned 2-3 hours, filtered, and is collected filtrate, is merged
Gained filtrate twice, is concentrated under reduced pressure into thick paste, and gained thick paste is placed at 60-70 DEG C to drying to constant weight, and will get dry extract progress
It pulverizes, smashes it through 200-300 mesh, it is spare；
(4) pueraria lobata, hoveniae semoveniae semen and Schisandra chinensis are mixed, is crushed into powder, be added 8-10 times and measure the ethyl alcohol that concentration is 75-90%
Solution refluxing extraction 2-3 times extracts 2.5-4h every time, and filtering, merging filtrate is concentrated under reduced pressure into thick paste, gained thick paste is placed in
Drying to constant weight at 50-60 DEG C, pulverizes getting dry extract, and smashes it through 200-300 mesh, spare；
(5) step (2)-(4) resulting extract and dried cream powder are mixed, suitable auxiliary material is added, is made and pharmaceutically may be used
The dosage form of receiving.
On the other hand, the application the present invention provides the health care product in the health care product that preparation has hepatoprotective effect.
The health care product of the invention health care product made of the existing pueraria lobata with antialcoholism function, hoveniae semoveniae semen and Schisandra chinensis
On the basis of optimization of C/C composites, joined Cordceps militaris and Poria cocos, synergistic effect produced to Protecting Hepatic Injury, not only excessive drinking is led
The alcoholic liver injury of cause has significant protective action, also has to hepatic injury caused by chemical substance common at present significant anti-
Shield effect.Meanwhile present invention optimizes preparation processes, according to the heterogeneity of active constituent in ingredients, take super face
Boundary's extraction, water are extracted, alcohol reflux extracts the process flow combined with ultramicro grinding, most by the effective component in each bulk pharmaceutical chemicals
It extracts to limits, and is pulverized, be conducive to each ingredient being absorbed and utilized in vivo.
Specific embodiment
Pass through the following implementation technical solution that present invention be described in more detail.It should be pointed out that following explanation
Only to claimed technical solution for example, not to any restrictions of these technical solutions.This hair
Bright protection scope be subject to the appended claims record content.
Embodiment 1:
The health care product is prepared from the following raw materials in parts by weight:
11 parts of pueraria lobata, 7 parts of hoveniae semoveniae semen, 5 parts of Schisandra chinensis, 4 parts of Cordceps militaris, 4 parts of Poria cocos；
The preparation method comprises the following steps:
(1) pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris, Poria cocos are weighed by weight, removes impurity, are cleaned, are dried, it is standby
With；
(2) Cordceps militaris is crushed, crosses 200 meshes, obtains Cordceps militaris fine powder, place it in and carry out two in supercritical extraction reactor
Carbonoxide supercritical extract, extraction conditions are as follows: pressure 25Mpa, 55 DEG C of extraction temperature, 40 DEG C of resolution temperature, carbon dioxide flow
For 1.0L/min, extraction time 85min, extract is collected, residue is spare；
(3) Poria cocos being crushed into powder, is mixed with residue obtained in step (2), 10 times of water are added, heating water mentions 2.5 hours,
Filtrate is collected in filtering, adds 9 times of water for residue obtained, heating water is mentioned 2 hours, filtered, and collects filtrate, merges gained twice
Filtrate is concentrated under reduced pressure into thick paste, and gained thick paste is placed at 60 DEG C to drying to constant weight, pulverizes getting dry extract, powder
300 meshes are crossed after broken, it is spare；
(4) pueraria lobata, hoveniae semoveniae semen and Schisandra chinensis are mixed, is crushed into powder, the ethanol solution that 10 times of amount concentration are 75% is added
Refluxing extraction 3 times, 2.5h is extracted every time, is filtered, and merging filtrate is concentrated under reduced pressure into thick paste, gained thick paste is placed at 50 DEG C and is dried
It does to constant weight, is pulverized getting dry extract, smash it through 300 meshes, it is spare；
(5) step (2)-(4) resulting extract and dried cream powder are mixed, appropriate magnesium stearate is added and is uniformly mixed, uses
75% ethanol solution softwood crosses the granulation of 20 meshes, and by wet granular in 55 DEG C of dryings, whole grain is fitted into capsule shells to get capsule
Agent.
Embodiment 2:
The health care product is prepared from the following raw materials in parts by weight:
9 parts of pueraria lobata, 6 parts of hoveniae semoveniae semen, 6 parts of Schisandra chinensis, 5 parts of Cordceps militaris, 3 parts of Poria cocos；
The preparation method comprises the following steps:
(1) pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris, Poria cocos are weighed by weight, removes impurity, are cleaned, are dried, it is standby
With；
(2) Cordceps militaris is crushed, is sieved with 100 mesh sieve, obtain Cordceps militaris fine powder, placed it in and carry out two in supercritical extraction reactor
Carbonoxide supercritical extract, extraction conditions are as follows: pressure 30Mpa, 60 DEG C of extraction temperature, 45 DEG C of resolution temperature, carbon dioxide flow
For 1.5L/min, extraction time 75min, extract is collected, residue is spare；
(3) Poria cocos is crushed into powder, is mixed with residue obtained in step (2), 11 times of water are added, heating water mentions 2 hours, mistake
Filtrate is collected in filter, adds 10 times of water for residue obtained, heating water is mentioned 2 hours, filtered, and collects filtrate, merges gained filter twice
Liquid is concentrated under reduced pressure into thick paste, and gained thick paste is placed at 65 DEG C to drying to constant weight, pulverizes getting dry extract, and crushes
300 meshes are crossed afterwards, it is spare；
(4) pueraria lobata, hoveniae semoveniae semen and Schisandra chinensis are mixed, is crushed into powder, the ethanol solution that 9 times of amount concentration are 85% is added and returns
Stream extracts 3 times, extracts 3h every time, filters, and merging filtrate is concentrated under reduced pressure into thick paste, gained thick paste is placed at 55 DEG C and is dried to
Constant weight is pulverized getting dry extract, and smashes it through 300 meshes, spare；
(5) step (2)-(4) resulting extract and dried cream powder are mixed, appropriate magnesium stearate is added and is uniformly mixed, uses
75% ethanol solution softwood crosses the granulation of 20 meshes, and by wet granular in 55 DEG C of dryings, whole grain is fitted into capsule shells to get capsule
Agent.
Embodiment 3:
The health care product is prepared from the following raw materials in parts by weight:
8 parts of pueraria lobata, 9 parts of hoveniae semoveniae semen, 8 parts of Schisandra chinensis, 5 parts of Cordceps militaris, 6 parts of Poria cocos；
The preparation method comprises the following steps:
(1) pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris, Poria cocos are weighed by weight, removes impurity, are cleaned, are dried, it is standby
With；
(2) Cordceps militaris is crushed, is sieved with 100 mesh sieve, obtain Cordceps militaris fine powder, placed it in and carry out two in supercritical extraction reactor
Carbonoxide supercritical extract, extraction conditions are as follows: pressure 20Mpa, 50 DEG C of extraction temperature, 40 DEG C of resolution temperature, carbon dioxide flow
For 2.0L/min, extraction time 90min, extract is collected, residue is spare；
(3) Poria cocos is crushed into powder, is mixed with residue obtained in step (2), 12 times of water are added, heating water mentions 3 hours, mistake
Filtrate is collected in filter, adds 11 times of water for residue obtained, heating water is mentioned 2.5 hours, filtered, and collects filtrate, merges gained twice
Filtrate is concentrated under reduced pressure into thick paste, and gained thick paste is placed at 60 DEG C to drying to constant weight, pulverizes getting dry extract, powder
300 meshes are crossed after broken, it is spare；
(4) pueraria lobata, hoveniae semoveniae semen and Schisandra chinensis are mixed, is crushed into powder, the ethanol solution that 9 times of amount concentration are 80% is added and returns
Stream extracts 3 times, extracts 3.5h every time, filters, and merging filtrate is concentrated under reduced pressure into thick paste, gained thick paste is placed at 55 DEG C and is dried
It to constant weight, is pulverized getting dry extract, smashes it through 300 meshes, it is spare；
(5) step (2)-(4) resulting extract and dried cream powder are mixed, appropriate magnesium stearate is added and is uniformly mixed, uses
75% ethanol solution softwood crosses the granulation of 20 meshes, and by wet granular in 55 DEG C of dryings, whole grain is fitted into capsule shells to get capsule
Agent.
Comparative example 1
Capsule is prepared according to the method in Chinese patent CN 200910061279.3:
Raw material: 8 parts of hoveniae semoveniae semen, 6 parts of pueraria lobata, 3 parts of Schisandra chinensis
Preparation method the following steps are included:
A, respectively crush hoveniae semoveniae semen, pueraria lobata, three taste medicinal material of Schisandra chinensis, cross 40 meshes, by smashed hoveniae semoveniae semen, pueraria lobata,
Schisandra chinensis is mixed in 8: 6: 3 ratio；
It B, is that 70% (v/v) alcohol reflux extracts for the first time with concentration, the time is 90 minutes；
C, it is filtered while hot at 95 DEG C；
It D, is that 70% (v/v) alcohol reflux extracts second with concentration, the time is 60 minutes；
E, it is filtered while hot at 95 DEG C；
F, merge No. 2 extracting solutions, carry out rotary evaporation to no alcohol taste；
G, ethyl alcohol is recycled；
H, the medical fluid extracted is cooled to room temperature in 80 DEG C of dry 3h, dislocation drier, obtains dry extract；
I: being broken into fine powder for dry extract, and appropriate magnesium stearate is added and is uniformly mixed, with 75% ethanol solution softwood, mistake
The granulation of 20 meshes, by wet granular in 55 DEG C of dryings, whole grain is fitted into capsule shells to get capsule.
Comparative example 2
Capsule is made in Cordceps militaris and Poria cocos:
Raw material: 5 parts of Cordceps militaris, 6 parts of Poria cocos；
Preparation method the following steps are included:
(1) Cordceps militaris and Poria cocos are weighed by weight, removes impurity, are cleaned, are dried, it is spare；
(2) Cordceps militaris and Poria cocos are crushed into powder, are uniformly mixed, 10 times of water are added, heating water is mentioned 3 hours, filtered, collects
Filtrate adds 9 times of water for residue obtained, and heating water is mentioned 2.5 hours, filtered, and collects filtrate, and merge gained filtrate twice,
It is concentrated under reduced pressure into thick paste, gained thick paste is placed at 60 DEG C to drying to constant weight, gained dry cream is ground into fine powder, it is spare；
(3) appropriate magnesium stearate is added in Xiang Shangshu dried cream powder to be uniformly mixed, with 75% ethanol solution softwood, crosses 20 mesh
Sieve granulation, by wet granular in 55 DEG C of dryings, whole grain is fitted into capsule shells to get capsule.
Animal experiment study
1. animal
SD rat, each half of female, cleaning grade, weight 160-200g, totally 100.After animal is bought back, female rats and hero
Property rat raise respectively, animal room temperature is controlled at 20-25 DEG C, and relative humidity control carries out animal housing regular in 50-60%
Disinfection.
2. experimental drug and reagent
Trial drug: capsule made from embodiment 1.
Drugs compared 1: capsule made from comparative example 1.
Drugs compared 2: capsule made from comparative example 2.
The content of above-mentioned experiment capsule is taken out, is dissolved in physiological saline.Trial drug is divided into high, medium and low dose
Amount group, dosage are respectively 8,4,2g/kg, and the dosage of drugs compared 1 and 2 is respectively 4g/kg.
Carbon tetrachloride: AR grades, food grade soybean oil is added, 30% carbon tetrachloride soybean oil solution is made, makes for modeling
With.
3. animal packet, modeling and administration
Randomly select 88 SD rats, half male and half female is randomly divided into 8 groups, every group 11, i.e. Normal group, model pair
According to group, trial drug high dose group (8g/kg), trial drug middle dose group (4g/kg), trial drug low dose group (2g/kg),
1 group of drugs compared (4g/kg), 2 groups of drugs compared (4g/kg).Except Normal group fabric, remaining each group presses 0.5mL/100g
The weight of animals subcutaneous injection gives 30% carbon tetrachloride soybean oil solution, 2 times a week, successive administration 8 weeks.After modeling 2 weeks, fill
Stomach administration, Normal group and model control group give isometric physiological saline, and other groups are administered by respective dosage, own
Dosage group is administered daily 1 time, and successive administration 6 weeks.
4. the index of detection
Animal weighing before experiment terminates, fasting 12 hours, each group rat aorta took blood, and centrifuging and taking serum measures paddy
Careless transaminase (AST), glutamic-pyruvic transaminase (ALT), albumin (ALB) and total protein (TP) content.After putting to death animal, separately take appropriate
Liver organization illustrates according to kit, measures hydroxyproline (Hyp) content in liver organization, is then convert into collagen and contains
Amount
5. statistical analysis
As a result it is indicated using mean+SD.All statistical analysis carry out t check analysis, p < by SPSS software
0.05 is statistically significant for difference tool, and p < 0.01 is that difference has highly significant statistical significance.
6. result
The influence (x ± s) of 6.1 pairs of rats deaths and weight
From animal mortality, the high, medium and low dosage group of trial drug and 2 groups of drugs compared have the tendency that reduction,
But there was no significant difference (p > 0.05).Model control group weight gain is slower, and the high, medium and low dosage group of trial drug
Weight has faster growth, and has significant difference (p < 0.05) compared with model control group.Although 1 group of drugs compared and
The weight that 2 groups of drugs compared also increased, but compared with model control group, there was no significant difference (p < 0.05).Referring to table
1。
Influence (x ± s) of the table 1 to rats death and weight
Note: compared with model control group, * p < 0.05.
The influence of 6.2 pairs of Serum ALTs, AST, TP, ALB and hepatic tissue collagen
Model control group Serum ALT, AST are significantly raised, and TB, ALB are reduced, compared with Normal group, p < 0.01；
Each dosage group Serum ALT, AST decrease, and wherein the high, medium and low dosage group of trial drug reduces degree and anticipates with conspicuousness
Justice.Each dosage group TB, ALB has to be increased to a certain degree, and wherein the high, medium and low dosage group elevated-levels of trial drug have significant
Property meaning.Referring to table 2.
Model control group collagen content increases, and after giving trial drug, collagen content decline, trial drug
High, medium and low dosage group has significant difference compared with model control group.Referring to table 2.
Influence (x ± s) of the table 2 to blood parameters and hepatic tissue collagen
Note: compared with model control group, * p < 0.05, * * p < 0.01.
It is above-mentioned the experimental results showed that, carbon tetrachloride can make rat ALT, AST increase, TP, ALB reduce, hepatic tissue collagen egg
White raising shows modeling success.And after giving the high, medium and low dosage of trial drug, Serum ALT, AST can be significantly reduced, is increased
TP, ALB reduce hepatic tissue collagen, and its degree is significantly better than 1 group of drugs compared and 2 groups of drugs compared, have apparent
Hepatoprotective effect.
The foregoing is merely the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise of not departing from raw material of the present invention, several improvements and modifications can also be made, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (5)
1. a kind of health care product with liver-protecting efficacy, which is characterized in that the health care product is prepared from the following raw materials in parts by weight:
8-12 parts of pueraria lobata, 6-10 parts of hoveniae semoveniae semen, 4-8 parts of Schisandra chinensis, 3-6 parts of Cordceps militaris, 3-6 parts of Poria cocos, it is characterised in that the guarantor
Strong product are to be prepared from the following steps: (1) by the parts by weight weigh pueraria lobata, hoveniae semoveniae semen, Schisandra chinensis, Cordceps militaris, Poria cocos,
Impurity is removed, cleans, dries, it is spare；(2) Cordceps militaris is crushed, crosses 100-200 mesh, obtains Cordceps militaris fine powder, place it in
Carbon dioxide supercritical extraction, extraction conditions are carried out in supercritical extraction reactor are as follows: pressure 20-30Mpa, 50-60 DEG C of extraction temperature,
35-45 DEG C of resolution temperature, carbon dioxide flow 1.0-2.0L/min, extraction time 75-90min, extract is collected, residue is standby
With；(3) Poria cocos is crushed into powder, is mixed with residue obtained in step (2), 9-12 times of water is added, heating water mentions 2-3 hours, mistake
Filtrate is collected in filter, adds 9-12 times of water for residue obtained, heating water is mentioned 2-3 hours, filtered, and is collected filtrate, is merged institute twice
Filtrate, be concentrated under reduced pressure into thick paste, gained thick paste be placed at 60-70 DEG C to drying to constant weight, will get dry extract and carry out Ultramicro-powder
It is broken, 200-300 mesh is smashed it through, it is spare；(4) pueraria lobata, hoveniae semoveniae semen and Schisandra chinensis are mixed, is crushed into powder, be added 8-10 times
Ethanol solution refluxing extraction 2-3 times that concentration is 75-90% is measured, extracts 2.5-4h every time, is filtered, merging filtrate, is concentrated under reduced pressure
To thick paste, gained thick paste is placed at 50-60 DEG C to drying to constant weight, is pulverized getting dry extract, smashes it through 200-
300 meshes, it is spare；(5) step (2)-(4) resulting extract and dried cream powder are mixed, suitable auxiliary material is added, pharmacy is made
Upper acceptable dosage form.
2. health care product according to claim 1, which is characterized in that the health care product by following parts by weight bulk pharmaceutical chemicals system
At: 9-11 parts of pueraria lobata, 6-8 parts of hoveniae semoveniae semen, 5-7 parts of Schisandra chinensis, 4-6 parts of Cordceps militaris, 3-5 parts of Poria cocos.
3. health care product according to claim 1, which is characterized in that the health care product by following parts by weight bulk pharmaceutical chemicals system
At: 11 parts of pueraria lobata, 7 parts of hoveniae semoveniae semen, 5 parts of Schisandra chinensis, 4 parts of Cordceps militaris, 4 parts of Poria cocos.
4. health care product according to claim 1, which is characterized in that the health care product is oral solution, tablet or capsule.
5. application of the health care product described in any one of -3 in the health care product that preparation has liver-protecting efficacy according to claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101513463A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN103040971A (en) * | 2012-12-28 | 2013-04-17 | 吉林省蚕业科学研究院 | Dealcoholic liver-protecting preparation and preparation process thereof |
| CN103479683A (en) * | 2012-06-12 | 2014-01-01 | 上海国宝企业发展中心 | North cordyceps sinensis sporophores cultivated in large scale and health care and pharmaceutical application thereof |
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2016
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101513463A (en) * | 2009-03-27 | 2009-08-26 | 武汉大学 | Chinese medicine composition for relieving alcoholism and protecting liver and preparation method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN103479683A (en) * | 2012-06-12 | 2014-01-01 | 上海国宝企业发展中心 | North cordyceps sinensis sporophores cultivated in large scale and health care and pharmaceutical application thereof |
| CN103040971A (en) * | 2012-12-28 | 2013-04-17 | 吉林省蚕业科学研究院 | Dealcoholic liver-protecting preparation and preparation process thereof |
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