CN101028305B - Ganoderic spore extract and its production - Google Patents
Ganoderic spore extract and its production Download PDFInfo
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- CN101028305B CN101028305B CN2007100487205A CN200710048720A CN101028305B CN 101028305 B CN101028305 B CN 101028305B CN 2007100487205 A CN2007100487205 A CN 2007100487205A CN 200710048720 A CN200710048720 A CN 200710048720A CN 101028305 B CN101028305 B CN 101028305B
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Abstract
A health-care medicine is prepared from ganoderma spores through pulverizing, extracting by CO2 at 30.7-78 deg.C under 4.8-28 MPa for 55-75 min, separating the extract from CO2, and proportionally mixing the dried ganoderma spore powder with said extract.
Description
(1) technical field:
The present invention relates to the preparation of natural fungus seed, particularly ganoderic spore extract; The invention still further relates to the preparation method of this ganoderic spore extract.
(2) background technology:
Cancer, hepatopathy and cardiovascular diseases are three big diseases of harm humans health and life, and its morbidity number, death toll and economic loss all are huge.For these years for curing this type of disease, the mankind have made unremitting effort and exploration, develop many medicines and health food, but, many researcheres, patient and developer's sight is still kept a close watch on Ganoderma, this was praised highly more than 2,000 year, was taken as miraculous cure, can cure " Herba mesonae chinensis " of all kinds of diseases and ailments.Modern medicine study shows; Ganoderma is two-ways regulation function of human body balance on the whole; transfer the internal body vigor; regulate human body metabolism function; improve the autoimmune ability; impel whole internal organs or organ function normalization, thereby play that antitumor, detoxifcation protect the liver, blood fat reducing, defying age, improvement sleep, appetite stimulator, blood pressure lowering, prevent and treat diabetes, chronic bronchitis, bronchial asthma, antiallergic, removing skin pigment, skin maintenance effect.Ganoderma spore powder is the elite of Ganoderma, produce naked eyes during for the Ganoderma sporophore maturation and seem brown smog powder, drop and cover or the ground at Ganderma lucidum, it is the spore of shape such as brown Semen Benincasae shape one by one that this powder is examined under a microscope, a large amount of spores is collected in and is called Ganoderma spore powder together, and it contains abundant multiple active ingredients such as the ganoderan with physiologically active, triterpenoid compound, nucleotide and unsaturated fatty acid.But the cell wall of the Ganoderma spore tough and tensile cellulose shell that is one deck, have stronger resistance to chemical attack and radioresistens, so its intracellular active effective ingredient is difficult to be released utilization, therefore if directly take Ganoderma spore powder, though the active ingredient in the Ganoderma spore powder also all enters human body alimentary canal, but in human body alimentary canal, the multiple active ingredient in the Ganoderma spore powder still can't be released, and the human body natural also can't absorb.At present, from Ganoderma spore, obtain various active ingredients such as ganoderan, triterpenes, nucleotide and unsaturated fatty acid, main method be by high-temperature water carry, organic solvent extraction.As behind the water extraction at high temperature, use organic solvent deposit; Or behind the organic solvent extraction, reclaim solvent, obtain the Ganoderma crude extract.But high temperature extraction can destroy the active ingredient of Ganoderma; And organic solvent extraction is difficult to avoid the residual of chemical substance in the final products, thereby has influence on product quality and health-care hospital effect, and chemical extraction method also inevitably causes environmental pollution to a certain degree.For this reason, application number is: 200610033686.X, name is called " a kind of supercritical CO
2The method of Ganoderma Lucidum Spores Oil Extracted " Chinese invention patent, a kind of method with the supercritical carbon dioxide extraction Ganoderma spore oil is disclosed, its preparation method is: selecting Ganoderma spore powder with cellular wall broken for use is raw material, mixes a certain amount of particulate filler; Mixed raw material being put into extraction kettle, feed carbon dioxide, is 10～35MPa at pressure, and temperature is to extract 2～5 hours under 35～55 ℃ of conditions; Separate then, obtain Ganoderma spore oil.With said method Ganoderma spore powder is extracted, the transparency of Ganoderma spore oil and oil yield height are all higher, but the Ganoderma spore pruinescence after the extraction is given it up, and contained various active ingredients are wasted in the Ganoderma spore powder after the feasible extraction, and its effect can't obtain performance.
(3) summary of the invention:
The present invention will disclose a kind of ganoderic spore extract that is rich in the Ganoderma spore active ingredient, has the plurality kinds of health care therapeutical effect; The present invention also will disclose the preparation method of this preparation.
The preparation method of ganoderic spore extract of the present invention is to be raw material with the Ganoderma spore powder, and the employing carbon dioxide is a supercritical medium, under supercriticality, Ganoderma spore is carried out supercritical extraction, obtain Ganoderma spore extract and the Ganoderma spore powder after extraction, its concrete steps are as follows:
1) Ganoderma spore is pulverized; For example can gather Ganoderma spore with the Ganoderma spore bagging earlier, Ganoderma spore be carried out selected, oven dry, and then pulverize; As Ganoderma spore being crushed to diameter is 6～8 microns; Also can adopt mechanical activation comminution or ground physics breaking method etc. to carry out pulverization process;
2) get the Ganoderma spore ground product and place in the extraction kettle, feed carbon dioxide and carry out supercritical carbon dioxide extraction, temperature is controlled at 30.7～78 ℃, and pressure is 4.8～28MPa, and the extraction time is 55～75 minutes; In general, every interval fed 3～4 liters of carbon dioxide in 5～8 minutes in the clockwise extraction kettle, and the time that at every turn feeds carbon dioxide is 6～7 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains the Ganoderma spore extract;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get Ganoderma spore powder and 0.8～4 weight portion Ganoderma spore extract mix homogeneously after 2～10 weight portions extractions, obtain ganoderic spore extract.
The method applied in the present invention can fully extract the multiple active ingredient that is difficult in the Ganoderma spore discharge, extract, and the active ingredient that extracts is not destroyed, no solvent residue yet.Ganoderic spore extract of the present invention is rich in multiple active ingredients such as ganoderan, polypeptide, organic germanium, triterpenes, alkaloid, organized enzyme.And the applicant determines through repetition test, the Ganoderma spore powder after the extraction and the Ganoderma spore extract of gained are used, and both proportionings are controlled at above-mentioned scope, the various active ingredients that contain separately among them are influenced each other, better bring into play synergism, thereby bring into play more powerful, more stable antitumor, immunomodulating, blood sugar lowering, blood fat reducing, antioxidation and senile-resistant efficacy, also make the various active ingredients in the Ganoderma spore powder all obtain effectively, farthest utilize; And the various active ingredients in the Ganoderma spore extract are more prone to be absorbed by the body than the various active ingredients in the Ganoderma spore powder after extracting, so the active ingredient meeting of the Ganoderma spore powder after the active ingredient of Ganoderma spore extract and the receipts extraction is by human body elder generation, post-absorption, thereby make that absorption is more reasonable, reach better assimilation effect; In addition, this proportional quantity meets the intake standard of human body to various active ingredients in the Ganoderma spore powder, neither can cause human body to the waste that its various active ingredients absorb, and can not cause harmful effect to the user again.
Because ganoderic spore extract of the present invention has the effect of good health care and treatment various diseases, therefore can be applied to various medicaments preparation, makes capsule in the capsulae vacuus as ganoderic spore extract is inserted; Or, make powder, granule etc. with ganoderic spore extract and adjuvant mix homogeneously, also can be made into said other dosage form on the various pharmaceuticss.The present invention with the ganoderic spore extract be the preparation of active ingredient have consolidate set upright, calm the nerves keep fit, fatigue alleviating, hepatoprotective, activated T cell, enhancing immunity, suppress the effects such as side effect that tumor generates, breeds and shift, alleviate chemotherapy or take medicine for a long time and bring, be specially adapted to diabetics, tumor patient etc.And ganoderic spore extract of the present invention is to be that feedstock production forms with the natural plants Ganoderma spore, and extraction process is simple, and cost is lower, and the preparation compatibility of gained is scientific and reasonable, without any side effects, is a kind of safe and reliable, the health care medicine of taking for a long time.
(4) specific embodiment:
Embodiment 1:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then Ganoderma spore powder is placed pulverizing mill, being ground into diameter is 6 microns;
2) getting 1000 kilograms of Ganoderma spore ground product places in the extraction kettle, feeding is in supercritical carbon dioxide, be that every interval fed the 4L carbon dioxide in the clockwise extraction kettle in 5 minutes, each time that feeds carbon dioxide is 6 minutes, temperature is controlled at 30.7 ℃, pressure is 4.8MPa, and the extraction time is 75 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 398 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get 200 kilograms of Ganoderma spore powder and 80 kilograms of Ganoderma spore extract mix homogeneously after the extraction, obtain ganoderic spore extract.
Embodiment 2:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then it is crushed to diameter is 8 microns;
2) getting 6500 kilograms of Ganoderma spore ground product places in the extraction kettle, by being in supercritical carbon dioxide, be that every interval fed the 3L carbon dioxide in the clockwise extraction kettle in 8 minutes, each time that feeds carbon dioxide is 7 minutes, temperature is controlled at 78 ℃, pressure is 28MPa, and the extraction time is 55 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 2589 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get Ganoderma spore powder and 40 kilograms of Ganoderma spore extract mix homogeneously after the double centner extraction, obtain ganoderic spore extract.
Embodiment 3:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then it is crushed to diameter is 8 microns;
2) getting 40000 kilograms of Ganoderma spore ground product places in the extraction kettle, feeding is in supercritical carbon dioxide, be that every interval fed the 4L carbon dioxide in the clockwise extraction kettle in 8 minutes, each time that feeds carbon dioxide is 6 minutes, temperature is controlled at 30.7 ℃, pressure is 28MPa, and the extraction time is 55 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 15560 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get 200 kilograms of Ganoderma spore powder and 400 kilograms of Ganoderma spore extract mix homogeneously after the extraction, obtain ganoderic spore extract;
6) get 94 kilograms of Ganoderma spore powder preparations and 3 kilograms of mannitol, 3 kilograms of lactose place mixing and blending machine; stir, make soft material, with soft material in the granulator corning; with the board-like steam drying case drying of heating, sterilization, granulate, tabletting, obtain the ganoderic spore extract tablet.
Embodiment 4:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then it is crushed to diameter is 8 microns;
2) getting 7500 kilograms of Ganoderma spore ground product places in the extraction kettle, feeding is in supercritical carbon dioxide, be that every interval fed the 3L carbon dioxide in the clockwise extraction kettle in 6 minutes, each time that feeds carbon dioxide is 7 minutes, temperature is controlled at 58 ℃, pressure is 20MPa, and the extraction time is 60 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 2887 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get 800 kilograms of Ganoderma spore powder and 400 kilograms of Ganoderma spore extract mix homogeneously after the extraction, obtain ganoderic spore extract.
6) get 75 kilograms of Ganoderma spore powder preparations and 60 kilograms of white sugars, 6 kilograms of maltodextrins place mixing and blending machine; stir; make soft material; the soft material that makes is granulated with granulator; with the board-like steam drying case drying of heating, sterilization, granulate, screening, obtain the ganoderic spore extract granule.
Embodiment 5:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then it is crushed to diameter is 8 microns;
2) getting 7500 kilograms of Ganoderma spore ground product places in the extraction kettle, feeding is in supercritical carbon dioxide, be that every interval fed the 3L carbon dioxide in the clockwise extraction kettle in 6 minutes, each time that feeds carbon dioxide is 7 minutes, temperature is controlled at 58 ℃, pressure is 20MPa, and the extraction time is 60 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 2887 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get 500 kilograms of Ganoderma spore powder and 400 kilograms of Ganoderma spore extract mix homogeneously after the extraction, obtain ganoderic spore extract;
6) ganoderic spore extract is inserted in the capsulae vacuus, obtained the ganoderic spore extract capsule.
Embodiment 6:
1) gather Ganoderma spore with the Ganoderma spore bagging, Ganoderma spore is carried out selected, oven dry, and then it is crushed to diameter is 8 microns;
2) get 6500 kilograms of Ganoderma spore ground product and place in the extraction kettle, by being in supercritical carbon dioxide, temperature is controlled at 30 ℃, and pressure is 28MPa, and the extraction time is 55 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains 2580 kilograms of Ganoderma spore extracts;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get 50 kilograms of Ganoderma spore powder and 20 kilograms of Ganoderma spore extract mix homogeneously after the extraction, obtain ganoderic spore extract.
Experimental example 1:
Experiment crowd: get embodiment 4 described Ganoderma preparation granular preparations and allow 112 people take respectively, tumor patient convalescent periods 29 people wherein, diabetics 43 people, insobriety person 17 people, carry out skin maintenance experimenter 23 people, every patient takes granule 1 gram of the present invention at every turn, takes every day 3 times.
Experimental result:
Wherein, after 29 tumor patient convalescent periods take above-mentioned Ganoderma preparation granule, have 25 patients' spirit to take a turn for the better, appetite increases, and health is improved;
Wherein, 43 diabeticss are taken above-mentioned Ganoderma preparation granule, and total effective rate reaches 84%, takes 1 month, have more than 31 people's the blood glucose decline 1mmol/L, when taking 2 months, 37 people are arranged near the euglycemia level;
Wherein, insobriety person 17 people took above-mentioned Ganoderma preparation granule after 1 month, had 16 people's complexions to be clearly better, and the disease of gastrointestinal upset is eliminated, and hands is no longer trembled.
Wherein, 23 people take the skin maintenance of above-mentioned Ganoderma preparation granule, and total effective rate reaches 91.04%, and the colour of skin is clearly better 14 people, and 4 people that the colour of skin bleaches become 3 smooth people.
Experimental example 2:
The Lipu * * bamboo and wood products's company limited Tan * * because of long-term excessive consumption of alcohol, causing gastrointestinal upset, mouth goes out saliva clearly, and hands is shaken, the face blackout.Take embodiment 4 described Ganoderma preparation granules from every day, day clothes 3 times are taken 1 gram at every turn, and the sense of gastrointestinal upset is eliminated after 2 months, and mouth also no longer goes out saliva clearly, and hands is not trembled, the white HONGGUANG profit of face.
Claims (2)
1. the preparation method of ganoderic spore extract, its step is as follows:
1) Ganoderma spore is crushed to 6～8 microns;
2) get the Ganoderma spore ground product and place in the extraction kettle, feed carbon dioxide, temperature is controlled at 30.7～78 ℃, and pressure is 4.8～28MPa, and the extraction time is 55～75 minutes; The mode that wherein feeds carbon dioxide is that every interval fed 3～4L carbon dioxide in the clockwise extraction kettle in 5～8 minutes, and the time that at every turn feeds carbon dioxide is 6～7 minutes;
3) the effusive CO 2 fluid that contains extract enters in the separating still from extraction kettle, and decompression cooling back carbon dioxide separates with extract, obtains the Ganoderma spore extract;
4) from extraction kettle, take out the Ganoderma spore powder that process extracts, carry out drying, the Ganoderma spore powder after must extracting;
5) get Ganoderma spore powder and 0.8～4 weight portion Ganoderma spore extract mix homogeneously after 2～10 weight portions extractions, obtain ganoderic spore extract.
2. the ganoderic spore extract of the described method of claim 1 preparation.
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| CN2007100487205A CN101028305B (en) | 2007-03-23 | 2007-03-23 | Ganoderic spore extract and its production |
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| CN2007100487205A CN101028305B (en) | 2007-03-23 | 2007-03-23 | Ganoderic spore extract and its production |
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| CN101028305B true CN101028305B (en) | 2010-08-25 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103285048A (en) * | 2012-02-27 | 2013-09-11 | 德阳仙鹤生物技术有限公司 | Lucid ganoderma composition, preparation with effect of improving immune function and preparation method of preparation |
| CN105754714A (en) * | 2016-03-10 | 2016-07-13 | 广东粤微食用菌技术有限公司 | Method for extracting ganoderma spore oil without granulation supercritical CO2 |
| CN116036159B (en) * | 2022-12-14 | 2024-02-13 | 南京中科药业有限公司 | A method for preparing Chinese medicinal composition extract containing Ganoderma spore oil and semen Ziziphi Spinosae oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1290554A (en) * | 2000-10-09 | 2001-04-11 | 中山大学 | Extracting method for effective active matter of lucid ganoderma spore |
| CN1094766C (en) * | 1999-11-19 | 2002-11-27 | 中国科学院南京地理与湖泊研究所科技开发公司 | Supercritical processing method of ganoderma spore |
| CN1631431A (en) * | 2003-12-22 | 2005-06-29 | 中国科学院微生物研究所 | Method for extracting ganoderma lucidum spore fat soluble active substance and its specified instrument for preparation |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094766C (en) * | 1999-11-19 | 2002-11-27 | 中国科学院南京地理与湖泊研究所科技开发公司 | Supercritical processing method of ganoderma spore |
| CN1290554A (en) * | 2000-10-09 | 2001-04-11 | 中山大学 | Extracting method for effective active matter of lucid ganoderma spore |
| CN1631431A (en) * | 2003-12-22 | 2005-06-29 | 中国科学院微生物研究所 | Method for extracting ganoderma lucidum spore fat soluble active substance and its specified instrument for preparation |
Non-Patent Citations (4)
| Title |
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| 胡洪涛等.灵芝孢子的研究.药学进展26 3.2002,26(3),160-162. |
| 胡洪涛等.灵芝孢子的研究.药学进展26 3.2002,26(3),160-162. * |
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| 陈萍.灵芝孢子粉研究进展.食品研究与开发20 2.1999,20(2),11-14. * |
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Assignee: Guilin Sanbao Pharmaceutical Co., Ltd. Assignor: Lu Changnian|Lu Zhaokai Contract record no.: 2011450000026 Denomination of invention: Ganoderic spore extract and its production Granted publication date: 20100825 License type: Exclusive License Open date: 20070905 Record date: 20110614 |
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