CN1094766C - Supercritical processing method of ganoderma spore - Google Patents
Supercritical processing method of ganoderma spore Download PDFInfo
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- CN1094766C CN1094766C CN99123952A CN99123952A CN1094766C CN 1094766 C CN1094766 C CN 1094766C CN 99123952 A CN99123952 A CN 99123952A CN 99123952 A CN99123952 A CN 99123952A CN 1094766 C CN1094766 C CN 1094766C
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Abstract
The present invention relates to a supercritical processing method of glossy ganoderma spores. Glossy ganoderma spore powder is used as raw material, and CO2 inert gas is used as supercritical media, supercritical extraction is carried out for glossy ganoderma spores in a supercritical state, and glossy ganoderma spore oil and degreased glossy ganoderma spore powder are obtained. The present invention has the advantages of simple technical processes and low cost. Effective protoplasma components in the glossy ganoderma spores can not be destroyed, and other harmful substances can not be introduced.
Description
The present invention relates to the Ganoderma spore deep-processing method, specifically belong to a kind of processing method of using supercritical carbon dioxide to Ganoderma spore.
Ganoderma is the treasure in the Chinese medicine and pharmacy treasure-house.Ancient oriental people, especially Chinese are described as " miraculous cure " that can come back to life to Ganoderma, can cure " Herba mesonae chinensis ", " Ganoderma " of all kinds of diseases and ailments, and are considered as its symbol for " having good luck ".In the Ancient Times in China document, the works of many Ganodermas of touching upon is arranged.Shennong's Herbal is included into Ganoderma top grade, promptly effective and nontoxic good medicine.The Compendium of Material Medica of Li Shizhen (1518-1593 A.D.) claim Ganoderma can " main deafness, sharp joint, protect the refreshing beneficial motive, invigorating middle warmer, increase wisdom, hard muscles and bones, good color ", " treat asthenia, control hemorrhoid ", clothes " make light of one's life by commiting suicide and do not prolong life always " for a long time.Ganoderma spore is the seed of Ganoderma, and it has concentrated the elite of Ganoderma.International research new discovery in recent years, Ganoderma spore in antitumor, immunomodulating, anti-radiation, regulate neural, protection cardiovascular system, regulate aspects such as respiratory system, facilitating digestion function significant pharmacological action (modern study of Lin Zhibin Ganoderma) is arranged.Modern science confirms that other of Ganoderma and occurring in nature is biological the same, all has protection offspring's ability, and the skin of Ganoderma spore is the hard chitinous shell of one deck.The absorption of human body wherein speed of protoplasm effective ingredient is too slow, does not often also have the enzymolysis success in digestive tract, and spore is excreted.
Extract from Ganoderma or its spore have biological active substances such as macromolecule polysaccharide, triterpenes, organic germanium, alkaloidal method adopt chemical extraction method in the past.Generally can be divided into two big classes: (1) ethanol extract from water precipitation.This method is first with ethanol or methanol extraction, adds entry and precipitation occurs in extracting solution, gets to be Ganoderma extractum after filtrate concentrates; (2) decoction and alcohol sedimentation technique.This method is to use earlier water extraction, adds alcohol then and produce precipitation in the water extract, gets and is Ganoderma extractum after filtrate concentrates.
Above chemical extraction method can only extract and promptly be dissolved in alcohol water soluble components again in the Ganoderma, is crude extract.Leaching process complexity, cost are higher relatively, and extract the temperature height in the process, effective ingredient partial loss or destruction in the Ganoderma.These class methods will add a large amount of chemical reagent, comprising a large amount of organic solvents, even be processed into other dosage form, still are difficult to avoid the residual of other chemical substance in the final products, influence its product quality and health-care hospital effect greatly.Chemical extraction method also causes environmental pollution to a certain degree inevitably in addition, impairs experimenter's health.
The purpose of this invention is to provide a kind of cost low, extract that temperature is low, the supercritical processing method of free of contamination Ganoderma spore.
The object of the present invention is achieved like this: be raw material with the Ganoderma spore powder, adopt CO
2Noble gas is a supercritical medium, under supercriticality, Ganoderma spore is carried out supercritical extraction, obtains Ganoderma spore oil and defat Ganoderma spore powder.
Processing method of the present invention is as follows:
(1) Ganoderma spore powder is added the mixture of entry, gelatin, starch or wherein a kind of edible additive, addition is as the criterion the Ganoderma spore powder molding bonded, mix homogeneously, extrusion modling at room temperature, natural drying;
(2) during the Ganoderma spore powder of dry aftershaping is packed extractor into, feed CO from the extractor bottom
2, the control temperature is 35-65 ℃, and pressure is 20-35MPa, and the extraction time is 1-35 hour;
(3) flow out the CO that contains Ganoderma spore oil from extractor top
2Enter the decompression separation device, Ganoderma spore oil is emitted CO from decompression separation device bottom
2Gas flows out from the top of decompression separation device;
(4) water in the Ganoderma spore oil and jelly are separated after removing the high-purity Ganoderma spore oil, reclaim the defat Ganoderma spore powder from extractor.
The resulting Ganoderma spore oil of described Ganoderma spore supercritical processing method, can add oil-soluble inhibitor, wait the anti-peroxidation performance that improves unsaturated fatty acid in the Ganoderma spore oil as the tert-butylbenzene diphenol, also can add some other composition, as Oleum Hippophae, walnut oil, support one's family and usually improve its health care or therapeutical effect, the Ganoderma spore oil that adds or do not add other component can further be processed into soft capsule or drop, conveniently to take.
The defat Ganoderma spore powder that obtains of method as mentioned above, can add some other component, improve its health care and therapeutical effect as fungus polysaccharide, vitamin, lecithin, the defat Ganoderma spore powder that adds or do not add other component can further be processed into limb capsule or packed, conveniently to take and to preserve.
The present invention has following advantage:
1. adopt the edible additive to make binding agent, make the Ganoderma spore molding, effectively successfully solved the safety problem that causes system jams owing to Ganoderma spore is little.
2. supercritical carbon dioxide is nontoxic, does not produce chemical action with other composition, so can not inject new harmful substance to product.
3. compare with traditional diamond-making technique, the inventive method technological process is simple, and cost is low, and extraction temperature is low in the process, can not destroy effective protoplasm composition in the Ganoderma spore.
4. isolated with air in the CO 2 supercritical course of processing, can effectively prevent peroxidization, and the supercritical process is a sterilization process.
5. this processing method is all effectively utilized Ganoderma spore, can produce two kinds of products of Ganoderma spore oil and defat Ganoderma spore powder.
Following examples are further described the present invention in conjunction with the accompanying drawings.
Fig. 1 is a process chart of the present invention.
As shown in the figure, A is an extractor, and B, C are the decompression separation device, and D is a condenser, and H is CO
2Hold-up tank, 1,2,3,4,5,6,7,8 is valve, and G is an effusion meter, and F is a compressor pump, and E is a preheater.
Embodiment 1
Selected Ganoderma spore powder (sporoderm-broken rate 95%) is added entry, add the water yield described Ganoderma spore powder can be as the criterion by molding bonded, extrude with banded extruder, take by weighing 100Kg after the drying, extractor A packs into.Open valve 8, carbon dioxide enters compressor pump F through effusion meter G from basin H, and the carbon dioxide after the pressurization enters extractor A through preheater E from the bottom.Controlled pressure 26MPa, 50 ℃ of temperature, continuous extraction 30 hours.The carbon dioxide that has Ganoderma spore oil moisture that comes out from extractor A is behind second depressurized separator B and C, and carbon dioxide returns compressor pump and recycles behind condenser D, also can directly open valve 4 emptying.Can get spore oil 15.8Kg from separator device B and C, water 1.8Kg, extractor collect 84.4Kg defat Ganoderma spore powder.
Embodiment 2
Identical with embodiment 1 operating process, different is that raw material ganoderma lucidium spore powder wall breaking rate is 99.9%, and weight is 1000g, and super critical condition is: pressure 32MPa, and 50 ℃ of temperature, the extraction time is 3 hours.From separator B, get aqueous Ganoderma spore oil 156g, get defat Ganoderma spore powder 844g from extractor.
Embodiment 3
Identical with embodiment 2, unique different be that extracting pressure is 25MPa, continuous extraction can get moisture Ganoderma spore oil 141g after 5 hours, defat Ganoderma spore powder 859g.
Embodiment 4
Identical with embodiment two, unique different be that extracting pressure is 28MPa, continuous extraction can get moisture Ganoderma spore oil 138g after 4 hours, defat Ganoderma spore powder 862g.
Embodiment 5
Identical with embodiment 4, unique different be that raw material is the Ganoderma sporophore article shaped, continuous extraction 2 hours does not obtain Ganoderma spore oil.
Embodiment 6
Identical with embodiment 4, unique different be that extraction temperature is 40 ℃, extract after 4 hours moisture Ganoderma spore oil 128g.
Embodiment 7
Identical with embodiment 4, unique different be that extraction temperature is 60 ℃, extract after 4 hours moisture Ganoderma spore oil 148g
Embodiment 8
Identical with embodiment 4, unique different be that raw material Ganoderma spore powder with cellular wall broken weight is 500g, extracting pressure is 30MPa respectively, extract 1.5 hours, must moisture Ganoderma spore oil 14.5g.
Embodiment 9
Identical with embodiment 4, unique different be that raw material Ganoderma spore powder with cellular wall broken weight is 500g, extracting pressure is 30MPa respectively, extract 1.5 hours, must moisture Ganoderma spore oil 1.6g.
Embodiment 10
Identical with embodiment 8, unique different be that raw material changes the not Ganoderma spore of breaking cellular wall into, just win the moisture Ganoderma spore oil of 1.5g.
Embodiment 11
Identical with embodiment 9, unique different be continuous extraction after 12.5 hours moisture Ganoderma spore oil 21.5g.
Embodiment 12
Identical with embodiment 9, unique different be continuous extraction after 20 hours moisture Ganoderma spore oil 30.5g.
Claims (1)
1. the supercritical processing method of a Ganoderma spore is characterized in that:
(1) Ganoderma spore powder is added the mixture of entry, gelatin, starch or wherein a kind of edible additive, addition is as the criterion the Ganoderma spore powder molding bonded, mix homogeneously, extrusion modling at room temperature, natural drying;
(2) during the Ganoderma spore powder of dry aftershaping is packed extractor into, feed CO from the extractor bottom
2Gas, the control temperature is 35-65 ℃, and pressure is 20-35MPa, and the extraction time is 1-35 hour;
(3) flow out the CO that contains Ganoderma spore oil from extractor top
2Enter the decompression separation device, Ganoderma spore oil is emitted CO from decompression separation device bottom
2Gas flows out from the top of decompression separation device;
(4) water in the Ganoderma spore oil and jelly are separated after removing the high-purity Ganoderma spore oil, reclaim the defat Ganoderma spore powder from extractor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN99123952A CN1094766C (en) | 1999-11-19 | 1999-11-19 | Supercritical processing method of ganoderma spore |
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| Application Number | Priority Date | Filing Date | Title |
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| CN99123952A CN1094766C (en) | 1999-11-19 | 1999-11-19 | Supercritical processing method of ganoderma spore |
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| CN1262957A CN1262957A (en) | 2000-08-16 |
| CN1094766C true CN1094766C (en) | 2002-11-27 |
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| CN99123952A Expired - Lifetime CN1094766C (en) | 1999-11-19 | 1999-11-19 | Supercritical processing method of ganoderma spore |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100430082C (en) * | 2006-06-13 | 2008-11-05 | 上海永昊生物医药研究所 | Glossy ganoderma spore essential oil compound capsules and preparation thereof |
| CN101028305B (en) * | 2007-03-23 | 2010-08-25 | 卢昶年 | Ganoderic spore extract and its production |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099455C (en) * | 2000-12-25 | 2003-01-22 | 中山大学 | Process for extracting lipid matter of ganoderma spore by immersing extraction |
| JP2002275190A (en) * | 2001-03-19 | 2002-09-25 | Chee-Keung Chung Peter | Method for extracting oleaginous substance from ganoderma lucidum spore |
| CN1308011C (en) * | 2003-12-22 | 2007-04-04 | 中国科学院微生物研究所 | Method for extracting ganoderma lucidum spore fat soluble active substance and its specified instrument for preparation |
| CN101269095B (en) * | 2008-04-17 | 2012-03-07 | 吴晓闻 | Supercritical combined processing method of ganoderma lucidum and ganoderma lucidum spore |
| CN101596225B (en) * | 2009-05-18 | 2012-12-26 | 南京中科集团股份有限公司 | Anti-tumour traditional Chinese medicine preparation containing glossy ganoderma spore oil and preparation method thereof |
| CN104324058A (en) * | 2013-11-30 | 2015-02-04 | 钟延华 | Preparation method of ganoderma lucidum spores oil |
-
1999
- 1999-11-19 CN CN99123952A patent/CN1094766C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 华南农业在学报98,19(3) 1998.1.1 马礼金 超临界流体萃取红芝三萜化合物 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100430082C (en) * | 2006-06-13 | 2008-11-05 | 上海永昊生物医药研究所 | Glossy ganoderma spore essential oil compound capsules and preparation thereof |
| CN101028305B (en) * | 2007-03-23 | 2010-08-25 | 卢昶年 | Ganoderic spore extract and its production |
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| Publication number | Publication date |
|---|---|
| CN1262957A (en) | 2000-08-16 |
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