CN105829284B - 制备金刚烷甲酰胺类化合物的方法 - Google Patents

制备金刚烷甲酰胺类化合物的方法 Download PDF

Info

Publication number
CN105829284B
CN105829284B CN201480066979.0A CN201480066979A CN105829284B CN 105829284 B CN105829284 B CN 105829284B CN 201480066979 A CN201480066979 A CN 201480066979A CN 105829284 B CN105829284 B CN 105829284B
Authority
CN
China
Prior art keywords
base
alkylamine
adamantane
reaction
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480066979.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN105829284A (zh
Inventor
B·哈里奇安
J·G·罗萨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever IP Holdings BV
Original Assignee
Unilever Nederland BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nederland BV filed Critical Unilever Nederland BV
Publication of CN105829284A publication Critical patent/CN105829284A/zh
Application granted granted Critical
Publication of CN105829284B publication Critical patent/CN105829284B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CN201480066979.0A 2013-12-09 2014-12-04 制备金刚烷甲酰胺类化合物的方法 Active CN105829284B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13196213.6 2013-12-09
EP13196213 2013-12-09
PCT/EP2014/076583 WO2015086428A1 (en) 2013-12-09 2014-12-04 Process of making adamantanamides

Publications (2)

Publication Number Publication Date
CN105829284A CN105829284A (zh) 2016-08-03
CN105829284B true CN105829284B (zh) 2019-01-22

Family

ID=49766905

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480066979.0A Active CN105829284B (zh) 2013-12-09 2014-12-04 制备金刚烷甲酰胺类化合物的方法

Country Status (8)

Country Link
US (1) US9840466B2 (enExample)
EP (1) EP3080086B1 (enExample)
JP (1) JP6434980B2 (enExample)
CN (1) CN105829284B (enExample)
CA (1) CA2930085C (enExample)
EA (1) EA031458B1 (enExample)
MX (1) MX360957B (enExample)
WO (1) WO2015086428A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3373899B1 (en) * 2015-11-10 2019-09-18 Unilever Plc. Cyclocarboxylic acid containing personal care compositions
US10138199B2 (en) 2016-03-17 2018-11-27 Saudi Arabian Oil Company High aspect ratio layered double hydroxide materials and methods for preparation thereof
US10106482B2 (en) * 2016-03-17 2018-10-23 Saudi Arabian Oil Company Synthesis of magnesium adamantane salts and magnesium oxide nanocomposites, and systems and methods including the salts or the nanocomposites
CN109476505B (zh) * 2016-03-17 2021-06-01 沙特阿拉伯石油公司 过渡金属金刚烷盐和氧化物纳米复合材料的合成
US10252245B2 (en) 2016-03-17 2019-04-09 Saudi Arabian Oil Company High temperature layered mixed-metal oxide materials with enhanced stability
US10087355B2 (en) 2016-03-17 2018-10-02 Saudi Arabian Oil Company Oil-based drilling fluids containing an alkaline-earth diamondoid compound as rheology modifier
US10875092B2 (en) 2017-05-19 2020-12-29 Saudi Arabian Oil Company Methods for preparing mixed-metal oxide diamondoid nanocomposites and catalytic systems including the nanocomposites
JP2020520880A (ja) 2017-05-19 2020-07-16 サウジ アラビアン オイル カンパニーＳａｕｄｉ Ａｒａｂｉａｎ Ｏｉｌ Ｃｏｍｐａｎｙ 遷移金属アダマンタン塩および酸化物ナノ複合体の合成

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352912A (en) * 1963-07-24 1967-11-14 Du Pont Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953596A (en) * 1973-06-14 1976-04-27 Ici United States Inc. 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and method of alleviating pain in animals
US4956481A (en) 1988-10-21 1990-09-11 International Flavors & Fragrances Inc. Adamantane derivatives, compositions of matter containing same, processes for preparing said adamantane derivatives and said compositions, and organoleptic and deodorancy uses of said adamantane derivatives and said compositions
JP2612645B2 (ja) 1991-04-05 1997-05-21 東洋インキ製造株式会社 カルボン酸アミド化合物の製造方法
JP2006522744A (ja) 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法
JP2006522750A (ja) 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
US20060057083A1 (en) 2004-09-09 2006-03-16 Estelle Mathonneau Cosmetic composition comprising at least one diamantoid to improve the mechanical properties of some materials
GB0506133D0 (en) * 2005-03-24 2005-05-04 Sterix Ltd Compound
US20060251597A1 (en) 2005-05-04 2006-11-09 Yu Ruey J Anti-odor compositions and therapeutic use
EA200801492A1 (ru) 2005-11-01 2008-10-30 Транстек Фарма Фармацевтическое применение замещенных амидов
WO2008054144A1 (en) 2006-11-03 2008-05-08 Amorepacific Corporation Skin external composition containing cathepsin g inhibitors for preventing skin aging and the screening method for development of antiaging materials
DE102007055265A1 (de) 2007-11-20 2009-05-28 Clariant International Ltd. Verfahren zur Herstellung von Acylglycinaten
MY144409A (en) 2009-04-09 2011-09-15 Malaysian Palm Oil Board A method of producing derivatives of azelaic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352912A (en) * 1963-07-24 1967-11-14 Du Pont Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antibiocorrosive covers and conservators based on new carbofunctional oligosiloxanes and biologically active compounds;N Lekishvili et al.;《Oxidation Communications》;20101231;第33卷(第1期);104-124 *

Also Published As

Publication number Publication date
MX2016006540A (es) 2016-08-03
US9840466B2 (en) 2017-12-12
MX360957B (es) 2018-11-23
WO2015086428A1 (en) 2015-06-18
JP2016540774A (ja) 2016-12-28
EA201690696A1 (ru) 2016-11-30
JP6434980B2 (ja) 2018-12-05
EA031458B1 (ru) 2019-01-31
CA2930085A1 (en) 2015-06-18
CN105829284A (zh) 2016-08-03
CA2930085C (en) 2021-11-02
EP3080086A1 (en) 2016-10-19
US20170029375A1 (en) 2017-02-02
EP3080086B1 (en) 2017-07-05

Similar Documents

Publication Publication Date Title
CN105829284B (zh) 制备金刚烷甲酰胺类化合物的方法
JP2019524827A (ja) オラパリブの製造方法
TW200920743A (en) New process for the synthesis of strontium ranelate and its hydrates
CN103435575A (zh) 1-（ 3-（ 3-（ 4-氯苯基）丙氧基）丙基）哌啶盐酸盐的制备方法
CN104591959B (zh) 一种二苯乙烯类化合物的制备方法
CN103012176A (zh) 一种长链烷基四羧基阴离子表面活性剂的制备方法
CN104844593A (zh) 一种阿哌沙班药物中间体的合成方法
TW200403335A (en) Process for preparation of spirofluorenols
CN104529960A (zh) 一种普芦卡必利中间体的制备方法
CN107001250B (zh) 一种制备奥当卡替中间体的方法
CN105330585B (zh) 一种米格列奈钙的制备方法
CN102206187B (zh) 6-苄基-1-乙氧甲基-5-异丙基尿嘧啶及其类似物的合成方法
CN103601781B (zh) 制备19-去甲-5(10)-雄烯酮化合物的方法
CN106220617A (zh) 一种达卡他韦的合成新方法
SE415970B (sv) Nytt forfarande for framstellning av n-(trans-4-hydroxicyklohexyl)-(2-amino-3,5-dibrom-bensyl)-amin
CN100355769C (zh) 2＇－甲氧基腺苷的制备方法
CN113527117A (zh) Aeea的制备方法
CN111039838A (zh) 一种3-乙酰巯基-2-甲基丙酸的制备方法
CN104447567B (zh) 一种1位取代苯并咪唑衍生物的制备方法
CN102491941B (zh) N-甲氧基-n-甲基-1-对甲苯磺酰基哌啶-4-酰胺的制备方法
CN113382982B (zh) 一种辛波莫德的制备方法
CN111217709A (zh) 一种（1-氟环丙基）甲胺盐酸盐的制备方法
CN109134364B (zh) 一种2-脂肪族磺酰基喹啉衍生物的合成方法
CN103922910A (zh) 一种1,5-二（邻溴间甲氧基苯基）-3-戊酮的合成方法
CN107488195A (zh) 一种磷酸酯的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210902

Address after: Rotterdam

Patentee after: Unilever Intellectual Property Holdings Ltd.

Address before: Rotterdam

Patentee before: Netherlands Unilever Co.,Ltd.