CN105806966A - 一种用于高光学纯度叶酸制备过程的质量控制方法 - Google Patents
一种用于高光学纯度叶酸制备过程的质量控制方法 Download PDFInfo
- Publication number
- CN105806966A CN105806966A CN201410844213.2A CN201410844213A CN105806966A CN 105806966 A CN105806966 A CN 105806966A CN 201410844213 A CN201410844213 A CN 201410844213A CN 105806966 A CN105806966 A CN 105806966A
- Authority
- CN
- China
- Prior art keywords
- folic acid
- optical
- quality control
- chromatographic column
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims abstract description 192
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 96
- 229960000304 folic acid Drugs 0.000 title claims abstract description 96
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 96
- 239000011724 folic acid Substances 0.000 title claims abstract description 96
- 230000003287 optical effect Effects 0.000 title claims abstract description 63
- 238000003908 quality control method Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 46
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- 239000012071 phase Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 239000007791 liquid phase Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 238000005342 ion exchange Methods 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 4
- 229960000583 acetic acid Drugs 0.000 claims description 3
- 239000012362 glacial acetic acid Substances 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- AVBGNFCMKJOFIN-UHFFFAOYSA-N triethylammonium acetate Chemical compound CC(O)=O.CCN(CC)CC AVBGNFCMKJOFIN-UHFFFAOYSA-N 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 2
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims description 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 150000003983 crown ethers Chemical class 0.000 claims 2
- 238000003821 enantio-separation Methods 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 238000005220 pharmaceutical analysis Methods 0.000 abstract description 2
- GADGMZDHLQLZRI-VIFPVBQESA-N N-(4-aminobenzoyl)-L-glutamic acid Chemical compound NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 GADGMZDHLQLZRI-VIFPVBQESA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 53
- 238000012360 testing method Methods 0.000 description 26
- 239000007788 liquid Substances 0.000 description 13
- 230000001276 controlling effect Effects 0.000 description 9
- 150000002224 folic acids Chemical class 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 239000012490 blank solution Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 238000010606 normalization Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- SMZHKGXSEAGRTI-UHFFFAOYSA-N 1,1,1-trichloropropan-2-one Chemical compound CC(=O)C(Cl)(Cl)Cl SMZHKGXSEAGRTI-UHFFFAOYSA-N 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010812 external standard method Methods 0.000 description 2
- 125000003929 folic acid group Chemical group 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000003032 molecular docking Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 description 1
- 238000009874 alkali refining Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- UEHUZQKLOWYOMO-UHFFFAOYSA-N diethylazanium;acetate Chemical compound CC(O)=O.CCNCC UEHUZQKLOWYOMO-UHFFFAOYSA-N 0.000 description 1
- SULORKHFCYQSPZ-UHFFFAOYSA-N diethylazanium;perchlorate Chemical compound CCNCC.OCl(=O)(=O)=O SULORKHFCYQSPZ-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000010829 isocratic elution Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000010193 neural tube defect Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- -1 pteroyl Pidolidone Chemical compound 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000035581 susceptibility to neural tube defects Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
批次 | 对氨基苯甲酰-L-谷氨酸光学纯度 | 叶酸光学纯度 | 相关性 |
120501 | 99.97% | 99.97% | 良好 |
120502 | 99.96% | 99.96% | 良好 |
120503 | 99.98% | 99.98% | 良好 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410844213.2A CN105806966B (zh) | 2014-12-30 | 2014-12-30 | 一种用于高光学纯度叶酸制备过程的质量控制方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410844213.2A CN105806966B (zh) | 2014-12-30 | 2014-12-30 | 一种用于高光学纯度叶酸制备过程的质量控制方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105806966A true CN105806966A (zh) | 2016-07-27 |
CN105806966B CN105806966B (zh) | 2018-03-27 |
Family
ID=56420052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410844213.2A Active CN105806966B (zh) | 2014-12-30 | 2014-12-30 | 一种用于高光学纯度叶酸制备过程的质量控制方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105806966B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108774230A (zh) * | 2018-07-06 | 2018-11-09 | 南通市常海食品添加剂有限公司 | 一种叶酸的纯化方法 |
CN112649524A (zh) * | 2020-12-02 | 2021-04-13 | 重庆华邦胜凯制药有限公司 | 分离检测叶酸中叶酸及叶酸光学异构体的方法 |
CN113063889A (zh) * | 2021-03-12 | 2021-07-02 | 北京斯利安药业有限公司 | 一种叶酸对映异构体含量的检测方法 |
CN114002352A (zh) * | 2021-10-29 | 2022-02-01 | 四川汇宇制药股份有限公司 | 叶酸与其光学异构体的分离检测方法 |
CN115078613A (zh) * | 2022-05-26 | 2022-09-20 | 河北冀衡药业股份有限公司 | 一种叶酸及其杂质d-叶酸的hplc检测方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060063768A1 (en) * | 2002-02-26 | 2006-03-23 | Thomas Mueller | Use of folates for producing a preparation suitable for preventing and treating inflammation and diseases associated with inflammation, especially for influencing the inflammation markers crp and saa |
CN102012408A (zh) * | 2010-10-28 | 2011-04-13 | 上海师范大学 | 液相色谱分析n-对氨基苯甲酰-l-谷氨酸纯度的方法 |
-
2014
- 2014-12-30 CN CN201410844213.2A patent/CN105806966B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060063768A1 (en) * | 2002-02-26 | 2006-03-23 | Thomas Mueller | Use of folates for producing a preparation suitable for preventing and treating inflammation and diseases associated with inflammation, especially for influencing the inflammation markers crp and saa |
CN102012408A (zh) * | 2010-10-28 | 2011-04-13 | 上海师范大学 | 液相色谱分析n-对氨基苯甲酰-l-谷氨酸纯度的方法 |
Non-Patent Citations (5)
Title |
---|
HAYRULLAH YILMAZ 等: "Resolution of (±)-βMethylphenylethylamine by a Novel Chiral Stationary Phase for Pirkle-Type Column Chromatography", 《CHIRALITY》 * |
JIRI PLOCEK 等: "Capillary zone electrophoresis of oligosaccharides derivatized with N-(4-aminobenzoyl)-c-glutamic acid for ultraviolet absorbance detection", 《JOURNAL OF CHROMATOGRAPHY A》 * |
M. JAMIL AKHTAR 等: "High performance liquid chromatographic determination of folic acid and its photodegradation products in the presence of riboflavin", 《JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS》 * |
刘树彬 等: "反相高效液相色谱法测定叶酸及其相关物质", 《分析实验室》 * |
袁杰 等: "催化加氢合成对氨基苯甲酰谷氨酸新工艺", 《化工生产与技术》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108774230A (zh) * | 2018-07-06 | 2018-11-09 | 南通市常海食品添加剂有限公司 | 一种叶酸的纯化方法 |
CN112649524A (zh) * | 2020-12-02 | 2021-04-13 | 重庆华邦胜凯制药有限公司 | 分离检测叶酸中叶酸及叶酸光学异构体的方法 |
CN113063889A (zh) * | 2021-03-12 | 2021-07-02 | 北京斯利安药业有限公司 | 一种叶酸对映异构体含量的检测方法 |
CN114002352A (zh) * | 2021-10-29 | 2022-02-01 | 四川汇宇制药股份有限公司 | 叶酸与其光学异构体的分离检测方法 |
CN114002352B (zh) * | 2021-10-29 | 2023-01-24 | 四川汇宇制药股份有限公司 | 叶酸与其光学异构体的分离检测方法 |
CN115078613A (zh) * | 2022-05-26 | 2022-09-20 | 河北冀衡药业股份有限公司 | 一种叶酸及其杂质d-叶酸的hplc检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105806966B (zh) | 2018-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104655751B (zh) | 一种检测达泊西汀中有机溶剂残留的方法 | |
CN105806966A (zh) | 一种用于高光学纯度叶酸制备过程的质量控制方法 | |
CN107037153B (zh) | 高效液相色谱法检测al58805原料药或药物制剂中基因毒性杂质的方法 | |
CN105334274B (zh) | 枸橼酸托法替布含量及其有关物质的反相高效液相色谱法测定方法 | |
CN104965041B (zh) | 一种帕瑞昔布钠异构体的高效液相色谱检测方法 | |
CN104020241A (zh) | 动物血、脑样品中痕量烟碱及其主要代谢物的同步分析方法 | |
CN106918676B (zh) | 分离测定他扎罗汀倍他米松乳膏中两种药物含量及有关物质的方法 | |
CN104749269A (zh) | 一种利用hplc测定阿格列汀原料药及制剂中对映异构体杂质的方法 | |
CN104777243B (zh) | 一种同时测定半夏中有机酸、核苷和麻黄碱的hplc方法 | |
CN105891357A (zh) | 一种动态示踪监测动物体内烟碱及其代谢物的分析方法 | |
CN103698424B (zh) | 一种测定难溶性铝盐药物中有机溶剂的检测方法 | |
CN109212048A (zh) | 一种伏立康唑中杂质含量的检测方法 | |
CN110068644A (zh) | 高效液相色谱串联质谱测定血浆中奥氮平浓度的方法 | |
CN114280176B (zh) | 一种hplc检测恶拉戈利中有关物质的方法 | |
CN109307716B (zh) | 一种依匹哌唑有关物质的检测方法 | |
CN109142585B (zh) | 一种泛酸钠异构体的检测方法 | |
CN110927279A (zh) | 一种盐酸咪达普利有关物质的分离方法 | |
CN106290600B (zh) | 一种用液相色谱法分离康尼替尼及有关物质的方法 | |
CN109991334A (zh) | 一种测定血浆中洛索洛芬及其反式羟基体浓度的方法 | |
CN105572240A (zh) | 一种采用高效液相色谱法检测药用辅料胭脂红含量的方法 | |
CN114324642A (zh) | 一种氢溴酸右美沙芬有关物质的测定方法 | |
CN106855542B (zh) | 高效液相色谱检测美他多辛有关物质的方法 | |
CN109781894B (zh) | 一种利非司特r异构体的检测方法 | |
CN109283263B (zh) | 用于雷替曲塞合成质量控制的检测分析方法 | |
CN106483205A (zh) | 一种采用高效液相色谱法检测药用辅料胭脂红含量的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Quality control method for high optical purity folic acid preparation process Effective date of registration: 20200325 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020980000995 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210316 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020980000995 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A quality control method for the preparation of folic acid with high optical purity Effective date of registration: 20210316 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000235 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220309 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000235 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A quality control method for the preparation process of high optical purity folic acid Effective date of registration: 20220309 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2022990000138 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230330 Granted publication date: 20180327 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2022990000138 |