CN105769977A - Traditional Chinese medicine composition with anti-pollution effect, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with anti-pollution effect, as well as preparation method and application thereof Download PDFInfo
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- A61K36/06—Fungi, e.g. yeasts
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention relates to a traditional Chinese medicine composition with an anti-pollution effect. The composition is prepared from the following components in parts by weight: 25-30 parts of poria cocos, 20-25 parts of kochia scoparia, 15-20 parts of seaweed, 15-20 parts of herba portulacae and 10-15 parts of mung beans. The invention further relates to a preparation method of the traditional Chinese medicine composition with the anti-pollution effect and application of the traditional Chinese medicine composition in cosmetics. The traditional Chinese medicine composition is reasonable in component formula, is synergistic and can be used for completely cleaning skin and regulating the body, so that the skin immunity can be radically enhanced, and external pollution can be effectively resisted.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, be a kind of Chinese medicine composition with antipollution effect and preparation method thereof and the application in cosmetics.
Background technology
China State of Air pollution is extremely serious, and in city atmospheric environment, TSP concentration generally exceeds standard.Air pollutants are attached to skin surface, if thoroughly do not cleaned, will be collected among pore, cause a series of health problem:
(1) antibacterial therein, fungus and virus very easily cause clogging of pores, acne to occur and skin infection；
(2) dust therein and pollen easily cause human allergy, make people feel pruritus, play erythema welt；
(3) metallicity dust therein is after uv irradiation, it is possible to create the electric charge of polarity, excites free radical, brings out skin cell damage after adhering to skin, even produces skin canceration；
(4) sulphur-containing substance therein is formed acid rain or acid mist can cause the damage of respiratory tract and skin.
Although we cannot change the present situation polluted in environment, but can be by scientific and effective measure to resist the outside contamination injury to skin.
The cardinal principle of existing antipollution series products is infringement skin caused by cleaning reduction to pollute on the market, although has certain effectiveness, but can't fundamentally solve the problem that skin damages.
Summary of the invention
The present invention is directed to the deficiencies in the prior art part, in conjunction with Traditional Chinese medical theory basis, it is provided that a kind of natural safe Chinese medicine composition with antipollution effect.
The second object of the present invention has the preparation method of Chinese medicine composition of antipollution effect described in being to provide.
The third object of the present invention has the application in cosmetics of the Chinese medicine composition of antipollution effect described in being to provide.
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that
A kind of Chinese medicine composition with antipollution effect, is made up of the component including following parts by weight: Poria 25～30, the Fructus Kochiae 20～25, Sargassum 15～20, Herba Portulacae 15～20, Semen phaseoli radiati 10～15.
Preferably, described in there is the Chinese medicine composition of antipollution effect, be made up of the component including following parts by weight: Poria 25～28, the Fructus Kochiae 20～23, Sargassum 18～20, Herba Portulacae 15～20, Semen phaseoli radiati 10～12.
Preferably, described in there is the Chinese medicine composition of antipollution effect, be made up of the component including following parts by weight: Poria 28～30, the Fructus Kochiae 23～25, Sargassum 18～20, Herba Portulacae 15～20, Semen phaseoli radiati 12～14.
Preferably, described in there is the Chinese medicine composition of antipollution effect, be made up of the component including following parts by weight: Poria 30, the Fructus Kochiae 23, Sargassum 18, Herba Portulacae 15, Semen phaseoli radiati 14.
Preferably, described in there is the Chinese medicine composition of antipollution effect, be made up of the component including following parts by weight: Poria 30, the Fructus Kochiae 25, Sargassum 20, Herba Portulacae 15, Semen phaseoli radiati 10.
Preferably, described in there is the Chinese medicine composition of antipollution effect, be made up of the component including following parts by weight: Poria 28, the Fructus Kochiae 25, Sargassum 20, Herba Portulacae 15, Semen phaseoli radiati 12.
The Traditional Chinese medicine composition formula with antipollution effect of the present invention can be added other required active component.
A kind of preparation method of the Chinese medicine composition with antipollution effect, including step as follows:
(1) medical material pretreatment: weigh Poria, the Fructus Kochiae, Sargassum, Herba Portulacae and Semen phaseoli radiati by formula consumption respectively, pulverizes, and mixing obtains medicinal material mixture；
(2) extract: medicinal material mixture is joined in Extraction solvent, and the weight ratio of medicinal material mixture and Extraction solvent is 1:5～1:10, extract 1～3h at 60～80 DEG C, extract 1～3 time, obtain extracting solution；
(3) purification: being filtered by extracting solution, be evaporated to the 1/5～1/10 of former extracting liquid volume at 50～80 DEG C, by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume specific concentration is 20～80% alcoholic solution elution fraction；
(4) concentration: be 1: 1～1: 10 30～50 DEG C of medicinal material mixture weight ratios being evaporated to medicinal liquid and step (1), add with concentrate after medicinal liquid equal quality butanediol dissolve, filter, obtain the Chinese medicine composition extract with antipollution effect.
Described Extraction solvent is the ethanol water of volume by volume concentration 60～80%.
Preferably, described in there is the Chinese medicine composition of antipollution effect can also add to according to product demand in the products such as water, breast, facial cream, improving the effect simultaneously working as thoroughly cleaning skin and conditioning human body of product efficacy, addition is 0.1～20%.
Preferably, the Chinese medicine composition described in antipollution effect is 10～15% for the addition in cosmetics.
Compared with prior art, there is advantages that and can clean the pollutant being attached to skin surface, effectively suppress pathogenic dermatophytes and bacterial growth, the red swelling of the skin pruritus that allergy of releiving causes, help impaired organization healing, improving skin immunity, make an addition in cosmetics, antipollution effect is notable.
Specific embodiment
In order to set forth present invention better, illustrate with some preferably specific embodiments below.But these specific embodiments are simply to illustrate that present disclosure, rather than present invention is limited.
Principle explanation
Although the reason forming skin problem is various, but strong skin itself can resist environmental stimuli to a certain extent.Chinese medicine beautifying theory is thought, good skin not only needs the modification of outside, and the more important thing is skin health from inside to outside.As can be seen here, traditional Chinese medical science antipollution is actually the process of a comprehensively regulating, is the ability reaching opposing outside contamination by strengthening the immunity of skin.
In inventive formulation, utilizing the theory progress of the traditional Chinese medical science " overall, balance, nature ", with Poria for monarch, the Fructus Kochiae is minister, and Sargassum works in coordination with Herba Portulacae, Semen phaseoli radiati is assistant, and all medicines share, by force this primordial QI reinforcing, nourish conditioning, with strong skin for antipollution originally；To clean toxin expelling, antiinflammatory sterilizes, and antiallergic of releiving is the mark of antipollution.
Five kinds of components that the present invention uses in formula have following effect:
Poria sweet in the mouth, light, property is put down, and ancients think that taking Poria can solid foster the spirit of nobility, spleen invigorating mind calming, jail tooth black hair, life lengthening." book on Chinese herbal medicine is just " says it: " drying by profit key, profit key is happy Fructus Alpiniae Oxyphyllae then, leads turbid promoting the production of body fluid ".The traditional Chinese medical science thinks that Poria can dissolve all black speck cicatrixs, can desalinate again pigmented spots by nutrition skin；
Fructus Kochiae acrid in the mouth, hardship, cold in nature, energy clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, it is usually used in treatment wind skin ulcer scabies, skin pruritus, " book on Chinese herbal medicine is original " says it: " in peeling skin accumulated heat, apart from skin pruritus due to damp pathogen "；
Sargassum bitter in the mouth, salty, cold in nature, nontoxic, can softening the hard mass dissipating blood stasis, diuretic detumescent, " not record " thinks that it can " gather between treatment skin "；
Herba Portulacae have a title of " natural antibiotics ", sour in the mouth, cold in nature, has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anti-inflammation and sterilization, quench the thirst diuresis, and " the southern regions of the Yunnan Province book on Chinese herbal medicine " says it；" QI invigorating, heat of relieving summer heat, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, intestine moistening, removing food stagnancy is stagnant, parasite killing, treats skin ulcer congestion and swelling pain "；
Semen phaseoli radiati sweet in the mouth cool in nature, is a kind of beans that nutritive value is higher, has the important medical value of removing toxic substances, Compendium of Material Medica is said its " can solve metal and stone, arsenicum, all poison of vegetation ", " Kaibao Bencao " is also considered as its " main erysipelas dysphoria with smothery sensation, rubella ... the detumescence therapeutic method to keep the adverse QI flowing downwards, press thermal detoxification ".
Modern medicine is also demonstrated that, containing nutritional labelings such as abundant pachymans in Poria, can effectively supplement skin desired nutritional, remove non-viable non-apoptotic cell, promote the metabolic cycles of human body, enhancing human body immunity power, meanwhile, also have significant antibacterial action；The Fructus Kochiae can effective bactericidal antiphlogistic, alleviate red and swollen and pruritus, promote wound healing；Sargassum parent's glycoprotein energy activated lymphocyte, effectively promotes immune function, the sulfur aminoacid that it contains, methionine and cystine then can chelating heavy metal, effective dispelling toxicity, detoxicating；Herba Portulacae can effectively eliminate toxic dust, it is prevented that phagocyte degeneration and necrosis, simultaneously can also inducing diuresis to remove edema, bactericidal antiphlogistic, promote effect of ulcer healing；Numerous bioactive substances contained by Semen phaseoli radiati such as alkaloid, plant sterol, Saponin etc. can effective enhancing human body immunity function, thus indirectly reaching antiallergic, effect of antibacterial and removing toxic substances.
Embodiment 1
A kind of Chinese medicine composition with antipollution effect, is made up of the parts by weight Chinese crude drug component in formula as below table:
| Component | Parts by weight |
| Poria | 30 |
| The Fructus Kochiae | 23 |
| Sargassum | 18 |
| Herba Portulacae | 15 |
| Semen phaseoli radiati | 14 |
Preparation method is as follows:
(1) taking Poria 30g, Fructus Kochiae 23g, Sargassum 18g, Herba Portulacae 15g, Semen phaseoli radiati 14g by the proportionate relationship of formula table parts by weight, amount to 100g Chinese crude drug, pulverize, mix homogeneously after 80 mesh sieves, obtains medicinal material mixture excessively；
(2) add 1L volume by volume concentration be 80% ethanol water as Extraction solvent, under the temperature conditions of 80 DEG C extract 3 times, extract 1.5h every time, filter, merging filtrate, obtain extracting solution；
(3) under the temperature conditions of 60 DEG C, extracting solution being evaporated to 200ml, obtain concentrated solution, by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume mark is 70% alcoholic solution elution fraction；
(4) under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, adds 50g butanediol, filters, obtain 100g and have the Chinese medicine composition of antipollution effect after dissolving.
Poria in the Traditional Chinese medicine composition formula with antipollution effect of the present embodiment: the Fructus Kochiae: Sargassum: Herba Portulacae: Semen phaseoli radiati is 30:23:18:15:14, this proportion relation can play extraordinary effect, and this effect also can obtain the checking similar with embodiment 3, embodiment 7 and embodiment 8 in checking embodiment.
Embodiment 2
A kind of Chinese medicine composition with antipollution effect, is made up of the parts by weight Chinese crude drug component in formula as below table:
| Component | Parts by weight |
| Poria | 30 |
| The Fructus Kochiae | 25 |
| Sargassum | 20 |
| Herba Portulacae | 15 |
| Semen phaseoli radiati | 10 |
Preparation method is as follows:
(1) taking Poria 30g, Fructus Kochiae 25g, Sargassum 20g, Herba Portulacae 15g, Semen phaseoli radiati 10g by the proportionate relationship of formula table parts by weight, amount to 100g Chinese crude drug, pulverize, mix homogeneously after 80 mesh sieves, obtains medicinal material mixture excessively；
(2) add 1L volume by volume concentration be 80% ethanol water as Extraction solvent, under the temperature conditions of 80 DEG C extract 3 times, extract 1.5h every time, filter, merging filtrate, obtain extracting solution；
(3) under the temperature conditions of 60 DEG C, extracting solution being evaporated to 200ml, obtain concentrated solution, by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume mark is 70% alcoholic solution elution fraction；
(4) under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, adds 50g butanediol, filters, obtain 100g and have the Chinese medicine composition of antipollution effect after dissolving.
Poria in the Traditional Chinese medicine composition formula with antipollution effect of the present embodiment: the Fructus Kochiae: Sargassum: Herba Portulacae: Semen phaseoli radiati is 6:5:4:3:2, this proportion relation can play extraordinary effect, and this effect also can obtain the checking similar with embodiment 3, embodiment 7 and embodiment 8 in checking embodiment.
Embodiment 3
A kind of Chinese medicine composition with antipollution effect, is made up of the parts by weight Chinese crude drug component in formula as below table:
| Component | Parts by weight |
| Poria | 28 |
| The Fructus Kochiae | 25 |
| Sargassum | 20 |
| Herba Portulacae | 15 |
| Semen phaseoli radiati | 12 |
Preparation method is as follows:
(1) taking Poria 28g, Fructus Kochiae 25g, Sargassum 20g, Herba Portulacae 15g, Semen phaseoli radiati 12g by the proportionate relationship of formula table parts by weight, amount to 100g Chinese crude drug, pulverize, mix homogeneously after 80 mesh sieves, obtains medicinal material mixture excessively；
(2) add 1L volume by volume concentration be 80% ethanol water as Extraction solvent, under the temperature conditions of 80 DEG C extract 3 times, extract 1.5h every time, filter, merging filtrate, obtain extracting solution；
(3) under the temperature conditions of 60 DEG C, extracting solution being evaporated to 200ml, obtain concentrated solution, by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume mark is 70% alcoholic solution elution fraction；
(4) under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution, adds 50g butanediol, filters, obtain 100g and have the Chinese medicine composition of antipollution effect after dissolving.
Poria in the Traditional Chinese medicine composition formula with antipollution effect of the present embodiment: the Fructus Kochiae: Sargassum: Herba Portulacae: Semen phaseoli radiati is 28:25:20:15:12, this proportion relation can play extraordinary effect, being specifically shown in following checking embodiment, this effect also can obtain similar checking in other embodiments.
Embodiment 4
A kind of Chinese medicine composition with antipollution effect, is made up of the parts by weight Chinese crude drug component in formula as below table:
| Component | Parts by weight |
| Poria | 25～28 |
| The Fructus Kochiae | 20～23 |
| Sargassum | 18～20 |
| Herba Portulacae | 15～20 |
| Semen phaseoli radiati | 10～12 |
Embodiment 5
A kind of Chinese medicine composition with antipollution effect, is made up of the parts by weight Chinese crude drug component in formula as below table:
Embodiment 6
The Chinese medicine composition with antipollution effect of embodiment 4 and embodiment 5, it is possible to adopt following preparation method:
(1) medical material pretreatment: weigh Poria, the Fructus Kochiae, Sargassum, Herba Portulacae and Semen phaseoli radiati by the proportionate relationship of formula table parts by weight respectively, mixes after pulverizing, obtains medicinal material mixture；
(2) extract: medicinal material mixture is joined in Extraction solvent, and the weight ratio of medicinal material mixture and Extraction solvent is 1:6～1:8, extract 1～3h at 65～75 DEG C, extract 1～3 time, obtain extracting solution；
(3) purification: being filtered by extracting solution, be evaporated to the 1/6～1/8 of former extracting liquid volume at 60～70 DEG C, by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume specific concentration is 40～70% alcoholic solution elution fraction；
(4) concentration: be 1: 0.6～1: 8 30～50 DEG C of medicinal material mixture weight ratios being evaporated to medicinal liquid and step (1), add with concentrate after medicinal liquid equal quality butanediol dissolve, filter, obtain the Chinese medicine composition extract with antipollution effect.
Although the product that the Chinese medicine composition with antipollution effect of embodiment 4 and embodiment 5 prepares under different component proportion relation exists certain difference in effect, but the Chinese medicine composition with antipollution effect of the two embodiment all has good skin sensitivity of releiving, reparation keratodermatitis, enhancing skin immunity and resists outside contamination effect.
Embodiment 7
A kind of facial cleaning cream with antipollution effect Chinese medicine composition, is made up of the component of following mass percent:
Preparation method is as follows:
(1) cocos nucifera oil acyl isethionic acid ester sodium and methyl cocoyl sulphonic acid sodium are heated in advance; then oil cauldron is put into together with the lauric acid in oil phase raw material, myristic acid, cetearyl alcohol, glyceryl stearate and PEG-100 stearate; it is warming up to 75～80 DEG C of stirring and dissolving to fully transparent, standby.
(2) deionized water (total amount 60%) in Aqueous Phase Raw Material, glycerol and EDETATE SODIUM are put into emulsifying pot, be warming up to 75～80 DEG C of stirring and dissolving uniform.
(3) by quick for the oil phase raw material of step (1) suction emulsifying pot, continuously stirred with the speed of 30～50rpm, saponification 1.5h, emulsion process is maintained at 75～80 DEG C.
(4) after saponification terminates, putting into cocoyl glycine betaine and olive oil PEG-7 esters to emulsifying pot, stirring and dissolving uniformly starts cooling,
(5) being disperseed by hydroxypropyl methyl cellulose deionized water, treat that temperature is down to 60 DEG C, put into emulsifying pot, stirring and dissolving is uniform.
(6) treating that temperature is cooled to 45 DEG C, have the Chinese medicine composition extract of antipollution effect to emulsifying pot input DMDM Hydantoin and embodiment 1, stirring is to being uniformly dissolved.
(7) treating that temperature is down to 35 DEG C, vacuum defoamation, 200 orders filter discharging after the assay was approved.
Embodiment 8
A kind of facial cream with antipollution effect Chinese medicine composition, is made up of the component of following mass percent:
Preparation method is as follows:
(1) 1,3 butylene glycol in Aqueous Phase Raw Material and hyaluronate sodium are evenly stirred until transparent in advance, the carbomer added in phase raw material is made into the aqueous dispersions that mass fraction is 1%.
(2) the arachidic alcohol glucoside in oil phase raw material, PEG-100 stearate, glyceryl stearate, cetearyl glucoside, shea butter, white Limnanthes Alba Seed Oil, Parleam, Cyclomethicone, polydimethylsiloxane, methyl hydroxybenzoate and propyl hydroxybenzoate being put into oil cauldron heat to 80 DEG C, stirring is to dissolving completely.
(3) 1,3 butylene glycol that will process through step (1), hyaluronate sodium, and glycerol, EDTA-2Na and deionized water (total amount 60%) put into emulsifying pot and heat to 80 DEG C, stirring is to dissolving completely.
(4) by quick for the oil phase raw material of step (2) suction emulsifying pot, after addition, with the speed emulsifying 5～10min of 4000～6000rpm, emulsifying is continuously stirred with the speed of 1000～2000rpm and start cooling after terminating.
(5), when being down to 65 DEG C, the aqueous dispersions that mass fraction is 1% prepared through step (1) is added, with the speed homogenizing 2min of 4000～6000rpm.
(6) treating that temperature is cooled to 45 DEG C, add phenoxyethanol, aminomethyl propanol, essence and the embodiment 1 added in phase raw material and have the Chinese medicine composition extract of antipollution effect, stirring is to being uniformly dissolved.
(7) treating that temperature is down to 35 DEG C of final vacuum deaerations, 200 orders filter discharging after the assay was approved.
Comparative example 1-5
(1) weighing Chinese crude drug Poria 100g, Fructus Kochiae 100g, Sargassum 100g, Herba Portulacae 100g and Semen phaseoli radiati 100g respectively, pulverize respectively, mix homogeneously after mistake 80 mesh sieves, obtains respective medicinal material mixture respectively；
(2) be separately added into 1L volume by volume concentration be 80% ethanol water as Extraction solvent, extract 3 times under the temperature conditions of 80 DEG C respectively, extract equal 1.5h every time, filter, merging filtrate, obtain respective extracting solution；
(3) respectively extracting solution is evaporated to 200ml under the temperature conditions of 60 DEG C, obtain respective concentrated solution, respectively by the macroporous resin column purification that resin type number on concentrated solution is D101 or AB-8, collected volume mark is 70% alcoholic solution elution fraction respectively；
(4) under 50 DEG C of conditions, concentrating under reduced pressure obtains 50g concentrated solution respectively, adds 50g butanediol, filters, obtain Poria, the Fructus Kochiae, Sargassum, Herba Portulacae and each 100g of Semen phaseoli radiati single medicinal material extract after dissolving.
Comparative example 6
A kind of present invention that do not contain has the facial cleaning cream of antipollution effect Chinese medicine composition, is made up of the component of following mass percent:
Preparation method is as follows:
(1) cocos nucifera oil acyl isethionic acid ester sodium and methyl cocoyl sulphonic acid sodium are heated in advance; then oil cauldron is put into together with the lauric acid in oil phase raw material, myristic acid, cetearyl alcohol, glyceryl stearate and PEG-100 stearate; it is warming up to 75～80 DEG C of stirring and dissolving to fully transparent, standby.
(2) deionized water (total amount 60%) in Aqueous Phase Raw Material, glycerol and EDETATE SODIUM are put into emulsifying pot, be warming up to 75～80 DEG C of stirring and dissolving uniform.
(3) by quick for the oil phase raw material of step (1) suction emulsifying pot, continuously stirred with the speed of 30～50rpm, saponification 1.5h, emulsion process is maintained at 75～80 DEG C.
(4) after saponification terminates, put into cocoyl glycine betaine and olive oil PEG-7 esters to emulsifying pot, after stirring and dissolving is uniform, start cooling,
(5) being disperseed by hydroxypropyl methyl cellulose deionized water, treat that temperature is down to 60 DEG C, put into emulsifying pot, stirring and dissolving is uniform.
(6) treating that temperature is cooled to 45 DEG C, put into DMDM Hydantoin to emulsifying pot, stirring is to being uniformly dissolved.
(7) treating that temperature is down to 35 DEG C, vacuum defoamation, 200 orders filter discharging after the assay was approved.
Comparative example 7
A kind of present invention that do not contain has the facial cream of antipollution effect Chinese medicine composition, is made up of the component of following mass percent:
Preparation method is as follows:
(1) 1,3 butylene glycol in Aqueous Phase Raw Material and hyaluronate sodium are evenly stirred until transparent in advance, the carbomer added in phase raw material is made into the aqueous dispersions that mass fraction is 1%.
(2) the arachidic alcohol glucoside in oil phase raw material, PEG-100 stearate, glyceryl stearate, cetearyl glucoside, shea butter, white Limnanthes Alba Seed Oil, Parleam, Cyclomethicone, polydimethylsiloxane, methyl hydroxybenzoate and propyl hydroxybenzoate being put into oil cauldron heat to 80 DEG C, stirring is to dissolving completely.
(3) 1,3 butylene glycol that will process through step (1), hyaluronate sodium, and glycerol, EDTA-2Na and deionized water (total amount 60%) put into emulsifying pot and heat to 80 DEG C, stirring is to dissolving completely.
(4) by quick for the oil phase raw material of step (2) suction emulsifying pot, after addition, with the speed emulsifying 5～10min of 4000～6000rpm, emulsifying is continuously stirred with the speed of 1000～2000rpm and start cooling after terminating.
(5), when being down to 65 DEG C, the aqueous dispersions that mass fraction is 1% prepared through step (1) is added, with the speed homogenizing 2min of 4000～6000rpm.
(6) treating that temperature is cooled to 45 DEG C, add the phenoxyethanol, aminomethyl propanol and the essence that add in phase raw material, stirring is to being uniformly dissolved.
(7) treating that temperature is down to 35 DEG C of final vacuum deaerations, 200 orders filter discharging after the assay was approved.
Test example 1 suppresses propionibacterium acnes efficacy assessments
Propionibacterium acnes (Propionibacteriumacnes) is to cause one of topmost cause of disease of acne, by testing propionibacterium acnes is killed the average evaluation Chinese medicine composition of the present invention rejection ability to the acne caused by the reasons such as clogging of pores or antibacterial infection, acne.
The sampling of 1.1 propionibacterium acness
Before test, first choosing the volunteer 30 suffering from pustular acne skin, the age, men and women half and half at 20～35 years old.It is randomly divided into 3 groups, often 5 male, 5 women of group.Within before recipient site 2～3 days, any product can not be used, such as cosmetics or topical drug or health product for oral administration etc..It is 75% ethanol disinfection face skin lesion place by volumetric concentration, then chooses acne content by sterile needle, infiltrate sterile swab with Sterile Saline and then dip acne content, detect in time.By three Bu Shi culture plates of specimen inoculation, after three rides, to ensure to grow single bacterium colony.Use airbag method that strain is placed in 35 DEG C of constant temperature CO2Incubator cultivates 48h.1.0 × 10 are become with normal saline dilution5The bacteria suspension of CFU/mL concentration.Inoculation takes part acne content smear, gram stain microscopy simultaneously, and the propionibacterium acnes of specimen is identified.
The preparation of 1.2 Chinese medicine extraction matter samples
The Chinese medicine extract that embodiment 3 has antipollution effect Chinese medicine composition extract and comparative example embodiment 1～5 is all formulated as the aqueous solution that mass fraction is 0.5%, 1.0%, 1.5% and 2.0%, standby.
The method of testing of 1.3 pairs of propionibacterium acnes rejection ability
Respectively take above-mentioned 6 sample aqueous solution 1mL, be added separately in sterile glass test tube, topple over respectively in 8mL previously prepared improvement GAM broth bouillon test tube, do negative control with a teat glass without bacteria suspension.Every kind of extract culture medium, all from low concentration, inoculates propionibacterium acnes successively, is placed in 35 DEG C of constant temperature CO after inoculation as early as possible2Incubator cultivates 48h.After cultivation, the liquid first extracted in human body culture medium carries out preliminary identification experiment, analyzes system again through VITEK full automatic microorganism, the situation of killing of propionibacterium acnes determined by ANI Identification of Anaerobic Bacteria card, and result is as shown in the table:
Note :+positive, there is fungistatic effect ,-negative, without fungistatic effect
Result shows, embodiment 3 has antipollution effect Chinese medicine composition and is better than comparative example 1-5 containing single medicinal material extract and blank example, in embodiment 3 formula, synergism between each compositions is notable, to the rejection ability of acne apparently higher than containing single medicinal material extract.
Therefore, propionibacterium acnes is had obvious inhibition by the Chinese medicine composition with antipollution effect of the present invention,
Test example 2 cleaning effect functional evaluation
Dust floating in air and microorganism etc. are attached to skin surface can affect the performance of skin normal function, acne and infection can be caused, if the face cleaning process of every day can not remove the dirt being attached to skin surface, if things go on like this having a strong impact on the health of skin, this test is to skin oil and fat content and the index that clearance rate is detection cleaning capacity with the relatively staphylococcus aureus of High pathogenicity.
2.1 oil stain removing rates measure
The numeric ratio that the Scavenging activity of face cleaning product can be quantified by the test of skin oil and fat clearance rate is relatively.
2.1.1 test instrunment
The skin oil and fat content Sebumeter test probe that Courage+Khazaka company of Germany (CK company of Germany) manufactures.
2.1.2 facial area forehead oil stain removing rate method of testing
Choosing the volunteer 30 of oily skin, the age, men and women half and half at 20～35 years old.Volunteer can not use any control oil product in first 30 days of on-test, such as cosmetics or topical drug or health product for oral administration etc..Before test, enter temperature 22 ± 2 DEG C, sit quietly in the constant temperature and humidity room of humidity 50 ± 5% 30min, the left and right forehead of volunteer is chosen by random table, taking glabella center line with the cross point from upper eyebrow edge 1cm parallel lines is test midpoint, then put in testing and respectively test a position to from left to right side by side, take the meansigma methods oils and fats data as forehead 0h of 3 values, then require that experimenter uses sample clean 30min after cleaning by random table respectively at cheek one side, left and right, 2h, 4h, 6h, the each time point of 8h carries out oils and fats test, blank is for only cleaning with deionized water.
2.1.3 test result is as shown in the table:
| Forehead oils and fats minimizing amount (%) | Embodiment 7 | Comparative example 6 | Blank |
| 30min | 42.3 | 18.8 | 7.1 |
| 2h | 32.9 | 6.8 | -3.6 |
| 4h | 27.8 | 1.2 | -6.8 |
| 6h | 21.8 | -2.5 | -5.1 |
| 8h | 16.8 | -5.6 | -15.2 |
2.2 staphylococcus aureus clearance rate measure
2.2.1 test instrunment
The HVE250 type autoclave sterilizer that HIRAYA-MA company of Japan manufactures；The BHS-1300 II A/B3 biologic cleanliness safety cabinet that Purifying Equipment Co., Ltd., Suzhou manufactures.
2.2.2 facial area staphylococcus aureus method of testing
Test condition is ibid, nasolabial fold side, the left and right cheek scraping volunteer with sterilized sampler respectively takes bacterium, taking the meansigma methods data as 0h of 2 values, experimenter presses random table and uses sample clean respectively at cheek one side, left and right, and after cleaning respectively at 30min, 2h, the each time point of 4h, 6h, 8h takes bacterium, using EasyStamp to cultivate to cultivate 48 hours based on 37 DEG C, the pink S. aureus colonies that media surface is produced counts.
2.2.3 test result is as shown in the table:
| Clump count reducing amount (%) | Embodiment 7 | Comparative example 6 | Blank |
| 30min | 86.4 | 66.9 | 23.3 |
| 2h | 85.3 | 60.6 | 17.4 |
| 4h | 83.8 | 53.7 | 11.9 |
| 6h | 81.5 | 47.5 | 5.7 |
| 8h | 79.7 | 40.6 | -1.2 |
Result shows, embodiment 7 has the facial cleaning cream of antipollution effect Chinese medicine composition containing the present invention and is better than comparative example 6 and does not contain the present invention and have the common facial cleaning cream of antipollution effect Chinese medicine composition and blank example, by the synergism between component in embodiment 7 formula, effectively remove skin excess oil regulation of skin fat secretion, staphylococcus aureus is also had the effect significantly removing and suppressing its growth.
Therefore, the Chinese medicine composition with antipollution effect of the present invention has good cleaning action.
Test example 3 facial area lactic acid stimulates efficacy assessment
Skin is subject to the stimulation of xenobiotic pollutants; often can cause redness, pruritus; play the situations such as erythema welt; in the course of time can reduce cutaneous autoimmune function and form sensitivity skin; seriously damage skin health; so repairing impaired and to strengthen skin immunization power be resist external source to pollute the most basic mode, stimulated antipollution effect of efficacy assessment test Chinese medicine composition by skin lactic acid.
3.1 facial area lactic acid stimulate method of testing
Respectively by the common facial cream contrast test of the antipollution facial cream of embodiment 8 and comparative example 7.Experiment carries out half of face test by random table, side is embodiment 8, opposite side is comparative example 7, experimenter's nasolabial fold position is selected to test, 10% lactic acid solution 50ul is dropped on the monolayer filter paper that diameter is 0.8cm, experimenter's sensation of pricking is inquired respectively at 3min, 4min and 5min, being undertaken marking by 4 point-scores, (0 is divided into and does not have sensation of pricking, 1 is divided into slight twinge, 2 are divided into moderate twinge, 3 are divided into severe twinge), the scoring of record experimenter stimulates scoring (D0) as this side lactic acid.After test terminates, experimenter by use, need to carry out product for 2 times and smear every day sooner or later, 28 days on probation continuously, and requires that the 14th day (D14) and the 28th day (D28) of test pays a return visit.
3.2 test results are as shown in the table:
Result shows, the comparative example 7 that is better than that embodiment 8 has antipollution effect Chinese medicine composition containing the present invention is not contained the present invention and is had the common facial cream of antipollution effect Chinese medicine composition, by the synergism between component in embodiment 8 formula, can releive well skin sensitivity, substantially alleviate the red and swollen twinge symptom after allergy, keratodermatitis is had certain repair simultaneously, fundamentally strengthens the immunity of skin, effectively reach the ability of opposing outside contamination.
Therefore, the Chinese medicine composition with antipollution effect of the present invention has the good ability resisting outside contamination.
In sum, the present invention has the Chinese medicine composition of antipollution effect while thoroughly cleaning skin by the conditioning of body, fundamentally strengthens the immunity of skin, effectively reaches the ability of opposing outside contamination.
It should be noted that the source of raw material that the present invention uses and reagent is commercially available, the experimental technique of the unreceipted actual conditions of the present invention, generally conventionally condition carries out, or condition recommended by the manufacturer carries out.
Above-described embodiment is the present invention preferably embodiment; but embodiments of the present invention are also not restricted to the described embodiments; the change made under other any spirit without departing from the present invention and principle, modification, replacement, combination, simplification; all should be equivalent replacement mode, be included within protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition with antipollution effect, it is characterised in that: it is made up of the component including following parts by weight: Poria 25～30, the Fructus Kochiae 20～25, Sargassum 15～20, Herba Portulacae 15～20, Semen phaseoli radiati 10～15.
2. a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that: it is made up of the component including following parts by weight: Poria 25～28, the Fructus Kochiae 20～23, Sargassum 18～20, Herba Portulacae 15～20, Semen phaseoli radiati 10～12.
3. a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that: it is made up of the component including following parts by weight: Poria 28～30, the Fructus Kochiae 23～25, Sargassum 18～20, Herba Portulacae 15～20, Semen phaseoli radiati 12～14.
4. a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that be made up of the component including following parts by weight: Poria 30, the Fructus Kochiae 23, Sargassum 18, Herba Portulacae 15, Semen phaseoli radiati 14.
5. a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that be made up of the component including following parts by weight: Poria 30, the Fructus Kochiae 25, Sargassum 20, Herba Portulacae 15, Semen phaseoli radiati 10.
6. a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that be made up of the component including following parts by weight: Poria 28, the Fructus Kochiae 25, Sargassum 20, Herba Portulacae 15, Semen phaseoli radiati 12.
7. the preparation method of a kind of Chinese medicine composition with antipollution effect according to claim 1, it is characterised in that the step included is as follows:
(1) medical material pretreatment: weigh Poria, the Fructus Kochiae, Sargassum, Herba Portulacae and Semen phaseoli radiati by formula consumption respectively, pulverizes, and mixing obtains medicinal material mixture；
(2) extract: medicinal material mixture is joined in Extraction solvent, and the weight ratio of medicinal material mixture and Extraction solvent is 1:5～1:10, extract 1～3h at 60～80 DEG C, extract 1～3 time, obtain extracting solution；
(3) purification: filtered by extracting solution, is evaporated to the 1/5～1/10 of former extracting liquid volume, purified concentration liquid at 50～80 DEG C, collects elution fraction；
(4) concentration: be 1: 1～1: 10 30～50 DEG C of medicinal material mixture weight ratios being evaporated to medicinal liquid and step (1), adds butanediol and dissolves.
8. the preparation method of a kind of Chinese medicine composition with antipollution effect according to claim 7, it is characterised in that: described Extraction solvent is volume by volume concentration is the ethanol water of 60～80%.
9. a kind of Chinese medicine composition with antipollution effect according to claim 1 or 7, it is characterised in that: in cosmetics, its addition is 0.1～20%.
10. a kind of Chinese medicine composition with antipollution effect according to claim 1 or 7, it is characterised in that: in cosmetics, its addition is 10～15%.
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| KR20070000675A (en) * | 2005-06-28 | 2007-01-03 | 주식회사 엘지생활건강 | Composition containing mung bean extract, bletillae tuber extract and black cohosh extract and use thereof |
| CN104257816A (en) * | 2014-10-09 | 2015-01-07 | 无锡市人民医院 | Composition for treating cosmetic dermatitis and preparation method thereof |
| CN105147773A (en) * | 2015-09-21 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of restraining acne and preparation method and application of traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070000675A (en) * | 2005-06-28 | 2007-01-03 | 주식회사 엘지생활건강 | Composition containing mung bean extract, bletillae tuber extract and black cohosh extract and use thereof |
| CN104257816A (en) * | 2014-10-09 | 2015-01-07 | 无锡市人民医院 | Composition for treating cosmetic dermatitis and preparation method thereof |
| CN105147773A (en) * | 2015-09-21 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of restraining acne and preparation method and application of traditional Chinese medicine composition |
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