CN105705148B - 使用普那布林和紫杉烷的组合的癌症疗法 - Google Patents

使用普那布林和紫杉烷的组合的癌症疗法 Download PDF

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Publication number
CN105705148B
CN105705148B CN201380080185.5A CN201380080185A CN105705148B CN 105705148 B CN105705148 B CN 105705148B CN 201380080185 A CN201380080185 A CN 201380080185A CN 105705148 B CN105705148 B CN 105705148B
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docetaxel
plinabulin
group
tumor
treatment
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Chinese (zh)
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CN105705148A (zh
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黄岚
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Dalian Wanchun Brin Pharmaceutical Co ltd
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Dalian Wanchun Brin Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380080185.5A 2013-10-11 2013-10-11 使用普那布林和紫杉烷的组合的癌症疗法 Active CN105705148B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/085075 WO2015051543A1 (en) 2013-10-11 2013-10-11 Cancer treatment with combination of plinabulin and taxane

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CN105705148A CN105705148A (zh) 2016-06-22
CN105705148B true CN105705148B (zh) 2021-03-23

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US (2) US10596169B2 (enExample)
EP (1) EP3076972B1 (enExample)
JP (1) JP6411523B2 (enExample)
KR (1) KR102225371B1 (enExample)
CN (1) CN105705148B (enExample)
AU (1) AU2013402794B2 (enExample)
BR (1) BR112016007946A2 (enExample)
CA (1) CA2926771C (enExample)
DK (1) DK3076972T3 (enExample)
ES (1) ES2902665T3 (enExample)
IL (1) IL244984B (enExample)
MX (1) MX384751B (enExample)
MY (1) MY185650A (enExample)
NZ (1) NZ719049A (enExample)
RU (1) RU2662298C2 (enExample)
SG (1) SG11201602637QA (enExample)
WO (1) WO2015051543A1 (enExample)
ZA (1) ZA201602380B (enExample)

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KR20170117113A (ko) * 2015-02-12 2017-10-20 비욘드스프링 파마수티컬스, 인코포레이티드. 면역 관문 저해제와 조합한 플리나불린의 용도
RU2728796C2 (ru) 2015-03-06 2020-07-31 Бейондспринг Фармасьютикалс, Инк. Способ лечения опухоли головного мозга
SG10202008673WA (en) * 2015-03-06 2020-10-29 Beyondspring Pharmaceuticals Inc Method of treating cancer associated with a ras mutation
CN109516981B (zh) * 2015-07-13 2019-10-22 大连万春布林医药有限公司 普那布林组合物
US10912748B2 (en) 2016-02-08 2021-02-09 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
KR20240091084A (ko) * 2016-06-06 2024-06-21 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증을 줄이는 조성물 및 방법
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
IL268305B2 (en) * 2017-02-01 2024-08-01 Beyondspring Pharmaceuticals Inc Plinabulin in combination with one or more g-csf drug for use in the therapeutic treatment of docetaxel-induced
BR112019018880A2 (pt) * 2017-03-13 2020-04-14 Beyondspring Pharmaceuticals Inc composições de plinabulina e seu uso
CN109498627B (zh) * 2017-09-15 2021-06-04 深圳华大海洋科技有限公司 一种治疗肿瘤的药物组合物及其应用
US11786523B2 (en) 2018-01-24 2023-10-17 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia
AU2019216305B2 (en) * 2018-02-01 2024-11-21 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing chemotherapy-induced neutropenia via the administration of plinabulin and a G-CSF agent
CN108524442B (zh) * 2018-06-05 2022-01-28 深圳海王医药科技研究院有限公司 一种抗肿瘤药物的注射剂及其制备方法
JP2018199726A (ja) * 2018-09-26 2018-12-20 ビヨンドスプリング インコーポレイテッド プリナブリン及びタキサンの組合せがん治療
CN113661253B (zh) * 2018-11-14 2024-03-12 大连万春布林医药有限公司 微管蛋白结合剂治疗癌症的方法
CN110507653B (zh) * 2019-08-02 2022-12-02 北京赛而生物药业有限公司 多潘立酮及其与紫杉醇联用在制备治疗癌症的药物中的应用
JP2022552011A (ja) * 2019-10-15 2022-12-14 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 鉄障害を処置するための方法及び組成物
JP2024513505A (ja) 2021-04-09 2024-03-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 腫瘍を治療するための組成物及び方法
CN113456643B (zh) * 2021-08-11 2022-04-01 遵义医科大学 一种含普那布林的药物组合及其应用
CN117860672A (zh) 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
MXPA05001217A (es) 2002-08-02 2005-05-16 Nereus Pharmaceuticals Inc Deshidrofenilahistinas y sus analogos y la sintesis de deshidrofenilahistinas y sus analogos.
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
CA2553630A1 (en) * 2004-02-04 2005-08-25 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
EP2968536B1 (en) 2013-03-13 2023-06-28 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for modulating chemotherapeutic cytotoxicity

Also Published As

Publication number Publication date
IL244984A0 (en) 2016-05-31
EP3076972A1 (en) 2016-10-12
WO2015051543A1 (en) 2015-04-16
ZA201602380B (en) 2022-05-25
MY185650A (en) 2021-05-27
IL244984B (en) 2022-05-01
CA2926771C (en) 2022-07-05
MX2016004441A (es) 2016-10-28
KR20160078987A (ko) 2016-07-05
JP2016536352A (ja) 2016-11-24
DK3076972T3 (da) 2022-01-03
WO2015051543A8 (en) 2016-04-21
SG11201602637QA (en) 2016-05-30
MX384751B (es) 2025-03-14
AU2013402794B2 (en) 2020-02-27
EP3076972A4 (en) 2017-12-20
NZ719049A (en) 2020-06-26
BR112016007946A2 (pt) 2017-09-12
JP6411523B2 (ja) 2018-10-24
KR102225371B1 (ko) 2021-03-10
CN105705148A (zh) 2016-06-22
US20200281921A1 (en) 2020-09-10
EP3076972B1 (en) 2021-10-06
US10596169B2 (en) 2020-03-24
US20160250209A1 (en) 2016-09-01
RU2016112608A (ru) 2017-11-16
CA2926771A1 (en) 2015-04-16
ES2902665T3 (es) 2022-03-29
AU2013402794A1 (en) 2016-05-12
RU2662298C2 (ru) 2018-07-25

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