RU2662298C2 - Лечение рака комбинацией плинабулина и таксана - Google Patents
Лечение рака комбинацией плинабулина и таксана Download PDFInfo
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- RU2662298C2 RU2662298C2 RU2016112608A RU2016112608A RU2662298C2 RU 2662298 C2 RU2662298 C2 RU 2662298C2 RU 2016112608 A RU2016112608 A RU 2016112608A RU 2016112608 A RU2016112608 A RU 2016112608A RU 2662298 C2 RU2662298 C2 RU 2662298C2
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- plinabulin
- docetaxel
- treatment
- taxane
- tumor
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10238650B2 (en) | 2015-03-06 | 2019-03-26 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
| US10357491B2 (en) | 2015-03-06 | 2019-07-23 | Beyondspring Pharmaceuticals, Inc. | Method of treating a brain tumor |
| US10550104B2 (en) | 2015-07-13 | 2020-02-04 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| US11400086B2 (en) | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3256130A4 (en) * | 2015-02-12 | 2018-08-01 | Beyondspring Pharmaceuticals, Inc. | Use of plinabulin in combination with immune checkpoint inhibitors |
| AU2017217426B2 (en) | 2016-02-08 | 2022-12-01 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| SG11201810872UA (en) | 2016-06-06 | 2019-01-30 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing neutropenia |
| CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
| ES2942889T3 (es) * | 2017-03-13 | 2023-06-07 | Beyondspring Pharmaceuticals Inc | Composiciones de plinabulina y uso de las mismas |
| CN109498627B (zh) * | 2017-09-15 | 2021-06-04 | 深圳华大海洋科技有限公司 | 一种治疗肿瘤的药物组合物及其应用 |
| CA3089226A1 (en) | 2018-01-24 | 2019-08-01 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
| KR20200116477A (ko) * | 2018-02-01 | 2020-10-12 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린 및 g-csf 제제의 투여를 통해 화학요법-유도된 호중구감소증을 감소시키기 위한 조성물 및 방법 |
| CN108524442B (zh) * | 2018-06-05 | 2022-01-28 | 深圳海王医药科技研究院有限公司 | 一种抗肿瘤药物的注射剂及其制备方法 |
| JP2018199726A (ja) * | 2018-09-26 | 2018-12-20 | ビヨンドスプリング インコーポレイテッド | プリナブリン及びタキサンの組合せがん治療 |
| AU2019378779A1 (en) * | 2018-11-14 | 2021-06-03 | Beyondspring Pharmaceuticals, Inc. | Methods of treating cancer using tubulin binding agents |
| CN110507653B (zh) * | 2019-08-02 | 2022-12-02 | 北京赛而生物药业有限公司 | 多潘立酮及其与紫杉醇联用在制备治疗癌症的药物中的应用 |
| CN113613654B (zh) * | 2019-10-15 | 2024-01-26 | 大连万春布林医药有限公司 | 普那布林在制备增加非转移性乳腺癌患者触珠蛋白的药物中的用途 |
| EP4319751A4 (en) | 2021-04-09 | 2025-02-26 | Beyondspring Pharmaceuticals, Inc. | THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS |
| CN113456643B (zh) * | 2021-08-11 | 2022-04-01 | 遵义医科大学 | 一种含普那布林的药物组合及其应用 |
| CN117860672A (zh) * | 2022-10-11 | 2024-04-12 | 大连万春布林医药有限公司 | 一种普那布林胶束组合物及其制备方法 |
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| WO2005077940A1 (en) * | 2004-02-04 | 2005-08-25 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| RU2011148945A (ru) * | 2009-05-01 | 2013-06-10 | Юниверсити Корт Оф Дзе Юниверсити Оф Данди | Лечение или профилактика пролиферативных состояний |
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| US7141603B2 (en) | 1999-02-19 | 2006-11-28 | The Regents Of The University California | Antitumor agents |
| US7012100B1 (en) | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| ATE374767T1 (de) | 2002-08-02 | 2007-10-15 | Nereus Pharmaceuticals Inc | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| US11285169B2 (en) | 2013-03-13 | 2022-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
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- 2013-10-11 SG SG11201602637QA patent/SG11201602637QA/en unknown
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- 2013-10-11 CN CN201380080185.5A patent/CN105705148B/zh active Active
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- 2013-10-11 US US15/028,376 patent/US10596169B2/en active Active
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- 2013-10-11 NZ NZ719049A patent/NZ719049A/en unknown
- 2013-10-11 MY MYPI2016000620A patent/MY185650A/en unknown
- 2013-10-11 WO PCT/CN2013/085075 patent/WO2015051543A1/en not_active Ceased
- 2013-10-11 KR KR1020167012255A patent/KR102225371B1/ko active Active
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2016
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2020
- 2020-03-17 US US16/821,348 patent/US20200281921A1/en not_active Abandoned
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| WO2005077940A1 (en) * | 2004-02-04 | 2005-08-25 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| RU2011148945A (ru) * | 2009-05-01 | 2013-06-10 | Юниверсити Корт Оф Дзе Юниверсити Оф Данди | Лечение или профилактика пролиферативных состояний |
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| MILLWARD M. et al. "Phase 1 study of the novel vascular disrupting agent plinabulin (NPI-2358) and docetaxel". Invest New Drugs 2012; 30: 1071, левый столбец, найдено 17.10.2017 из Интернет: https://rd.springer.com/article/10.1007/s10637-011-9642-4. * |
| MILLWARD M. et al. "Phase 1 study of the novel vascular disrupting agent plinabulin (NPI-2358) and docetaxel". Invest New Drugs 2012; 30: 1071, левый столбец, найдено 17.10.2017 из Интернет: https://rd.springer.com/article/10.1007/s10637-011-9642-4. WILT JA et al. "Anal cancer in Alaska; a retrospective study of incidence, treatment, and outcomes". Alaska Med 2002 Jul-Sep; 44(3): 56-9, 62, реферат, найдено 17.10.2017 из PubMed PMID:12497665. * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10238650B2 (en) | 2015-03-06 | 2019-03-26 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
| US10357491B2 (en) | 2015-03-06 | 2019-07-23 | Beyondspring Pharmaceuticals, Inc. | Method of treating a brain tumor |
| US10550104B2 (en) | 2015-07-13 | 2020-02-04 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| US11400086B2 (en) | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
Also Published As
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| MX2016004441A (es) | 2016-10-28 |
| SG11201602637QA (en) | 2016-05-30 |
| CN105705148A (zh) | 2016-06-22 |
| RU2016112608A (ru) | 2017-11-16 |
| CA2926771A1 (en) | 2015-04-16 |
| CA2926771C (en) | 2022-07-05 |
| EP3076972A4 (en) | 2017-12-20 |
| WO2015051543A1 (en) | 2015-04-16 |
| EP3076972B1 (en) | 2021-10-06 |
| JP2016536352A (ja) | 2016-11-24 |
| AU2013402794A1 (en) | 2016-05-12 |
| IL244984B (en) | 2022-05-01 |
| CN105705148B (zh) | 2021-03-23 |
| JP6411523B2 (ja) | 2018-10-24 |
| ZA201602380B (en) | 2022-05-25 |
| KR102225371B1 (ko) | 2021-03-10 |
| NZ719049A (en) | 2020-06-26 |
| US20160250209A1 (en) | 2016-09-01 |
| MX384751B (es) | 2025-03-14 |
| US10596169B2 (en) | 2020-03-24 |
| MY185650A (en) | 2021-05-27 |
| AU2013402794B2 (en) | 2020-02-27 |
| WO2015051543A8 (en) | 2016-04-21 |
| IL244984A0 (en) | 2016-05-31 |
| EP3076972A1 (en) | 2016-10-12 |
| KR20160078987A (ko) | 2016-07-05 |
| US20200281921A1 (en) | 2020-09-10 |
| BR112016007946A2 (pt) | 2017-09-12 |
| DK3076972T3 (da) | 2022-01-03 |
| ES2902665T3 (es) | 2022-03-29 |
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