AU2013402794B2 - Cancer treatment with combination of plinabulin and taxane - Google Patents

Cancer treatment with combination of plinabulin and taxane Download PDF

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Publication number
AU2013402794B2
AU2013402794B2 AU2013402794A AU2013402794A AU2013402794B2 AU 2013402794 B2 AU2013402794 B2 AU 2013402794B2 AU 2013402794 A AU2013402794 A AU 2013402794A AU 2013402794 A AU2013402794 A AU 2013402794A AU 2013402794 B2 AU2013402794 B2 AU 2013402794B2
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Australia
Prior art keywords
docetaxel
plinabulin
npi
tumor
combination
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AU2013402794A
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English (en)
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AU2013402794A1 (en
Inventor
Lan Huang
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BeyondSpring Inc
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BeyondSpring Inc
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Assigned to BEYONDSPRING INC. reassignment BEYONDSPRING INC. Request for Assignment Assignors: BEYONDSPRING PHARMACEUTICALS, INC.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013402794A 2013-10-11 2013-10-11 Cancer treatment with combination of plinabulin and taxane Active AU2013402794B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/085075 WO2015051543A1 (en) 2013-10-11 2013-10-11 Cancer treatment with combination of plinabulin and taxane

Publications (2)

Publication Number Publication Date
AU2013402794A1 AU2013402794A1 (en) 2016-05-12
AU2013402794B2 true AU2013402794B2 (en) 2020-02-27

Family

ID=52812462

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013402794A Active AU2013402794B2 (en) 2013-10-11 2013-10-11 Cancer treatment with combination of plinabulin and taxane

Country Status (18)

Country Link
US (2) US10596169B2 (enExample)
EP (1) EP3076972B1 (enExample)
JP (1) JP6411523B2 (enExample)
KR (1) KR102225371B1 (enExample)
CN (1) CN105705148B (enExample)
AU (1) AU2013402794B2 (enExample)
BR (1) BR112016007946A2 (enExample)
CA (1) CA2926771C (enExample)
DK (1) DK3076972T3 (enExample)
ES (1) ES2902665T3 (enExample)
IL (1) IL244984B (enExample)
MX (1) MX384751B (enExample)
MY (1) MY185650A (enExample)
NZ (1) NZ719049A (enExample)
RU (1) RU2662298C2 (enExample)
SG (1) SG11201602637QA (enExample)
WO (1) WO2015051543A1 (enExample)
ZA (1) ZA201602380B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX394865B (es) * 2015-02-12 2025-03-24 Beyondspring Pharmaceuticals Inc Uso de plinabulina en combinación con inhibidores de punto de control inmunitario
WO2016144636A1 (en) 2015-03-06 2016-09-15 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
HK1249052A1 (zh) 2015-03-06 2018-10-26 BeyondSpring Pharmaceuticals Inc. 治疗与ras突变相关的癌症的方法
EP3334726B1 (en) * 2015-07-13 2022-03-16 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
US10912748B2 (en) 2016-02-08 2021-02-09 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
CN109475524A (zh) 2016-06-06 2019-03-15 万春药业公司 用于减少中性粒细胞减少症的组合物和方法
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
KR20190109479A (ko) * 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
BR112019018880A2 (pt) * 2017-03-13 2020-04-14 Beyondspring Pharmaceuticals, Inc. composições de plinabulina e seu uso
CN109498627B (zh) * 2017-09-15 2021-06-04 深圳华大海洋科技有限公司 一种治疗肿瘤的药物组合物及其应用
WO2019147615A1 (en) * 2018-01-24 2019-08-01 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia via the administration of plinabulin
BR112020015758A2 (pt) * 2018-02-01 2020-12-08 Beyondspring Pharmaceuticals, Inc. Composição e método para reduzir neutropenia induzida por quimioterapia através da administração de plinabulina e agente de g-csf
CN108524442B (zh) * 2018-06-05 2022-01-28 深圳海王医药科技研究院有限公司 一种抗肿瘤药物的注射剂及其制备方法
JP2018199726A (ja) * 2018-09-26 2018-12-20 ビヨンドスプリング インコーポレイテッド プリナブリン及びタキサンの組合せがん治療
AU2019378779A1 (en) * 2018-11-14 2021-06-03 Beyondspring Pharmaceuticals, Inc. Methods of treating cancer using tubulin binding agents
CN110507653B (zh) * 2019-08-02 2022-12-02 北京赛而生物药业有限公司 多潘立酮及其与紫杉醇联用在制备治疗癌症的药物中的应用
CN113613654B (zh) * 2019-10-15 2024-01-26 大连万春布林医药有限公司 普那布林在制备增加非转移性乳腺癌患者触珠蛋白的药物中的用途
EP4319751A4 (en) 2021-04-09 2025-02-26 Beyondspring Pharmaceuticals, Inc. THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS
CN113456643B (zh) * 2021-08-11 2022-04-01 遵义医科大学 一种含普那布林的药物组合及其应用
CN117860672A (zh) * 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077940A1 (en) * 2004-02-04 2005-08-25 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
AU2003302721B2 (en) 2002-08-02 2009-10-08 Beyondspring Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CA2905418C (en) 2013-03-13 2023-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077940A1 (en) * 2004-02-04 2005-08-25 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Millward, M et al (2012) "Phase 1 study of the novel vascular disrupting agent plinabulin (NPI-2358) and docetaxel" Invest New Drugs 30: 1065–1073 *
Mita, AC et al (2010) "Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC)" Journal of Clinical Oncology 28: 7592-7592 *

Also Published As

Publication number Publication date
MX384751B (es) 2025-03-14
WO2015051543A1 (en) 2015-04-16
CA2926771C (en) 2022-07-05
EP3076972A4 (en) 2017-12-20
IL244984A0 (en) 2016-05-31
NZ719049A (en) 2020-06-26
KR20160078987A (ko) 2016-07-05
RU2662298C2 (ru) 2018-07-25
WO2015051543A8 (en) 2016-04-21
US20200281921A1 (en) 2020-09-10
EP3076972B1 (en) 2021-10-06
RU2016112608A (ru) 2017-11-16
AU2013402794A1 (en) 2016-05-12
ES2902665T3 (es) 2022-03-29
US20160250209A1 (en) 2016-09-01
CN105705148B (zh) 2021-03-23
MY185650A (en) 2021-05-27
SG11201602637QA (en) 2016-05-30
DK3076972T3 (da) 2022-01-03
KR102225371B1 (ko) 2021-03-10
US10596169B2 (en) 2020-03-24
CA2926771A1 (en) 2015-04-16
ZA201602380B (en) 2022-05-25
MX2016004441A (es) 2016-10-28
JP2016536352A (ja) 2016-11-24
IL244984B (en) 2022-05-01
BR112016007946A2 (pt) 2017-09-12
CN105705148A (zh) 2016-06-22
EP3076972A1 (en) 2016-10-12
JP6411523B2 (ja) 2018-10-24

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Owner name: BEYONDSPRING INC.

Free format text: FORMER APPLICANT(S): BEYONDSPRING PHARMACEUTICALS, INC.

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