CN105683215A - 高稳定性的t细胞受体及其制法和应用 - Google Patents

高稳定性的t细胞受体及其制法和应用 Download PDF

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CN105683215A
CN105683215A CN201480036288.6A CN201480036288A CN105683215A CN 105683215 A CN105683215 A CN 105683215A CN 201480036288 A CN201480036288 A CN 201480036288A CN 105683215 A CN105683215 A CN 105683215A
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amino acid
tcr
variable domain
acid sequence
chains
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CN105683215B (zh
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李懿
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Xiangxue Life Science Technology (Guangdong) Co.,Ltd.
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GUANGZHOU XIANGXUE PHARMACEUTICAL CO Ltd
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Abstract

本发明提供了一种高稳定性的T细胞受体，所述T细胞受体在其疏水芯区域发生了突变，引起了其稳定性的提高。本发明还提供了所述T细胞受体的制备方法和应用。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201480036288.6A 2013-06-26 2014-06-25 高稳定性的t细胞受体及其制法和应用 Active CN105683215B (zh)

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CN201310263384 2013-06-26
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PCT/CN2014/080773 WO2014206304A1 (zh) 2013-06-26 2014-06-25 高稳定性的t细胞受体及其制法和应用

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JP (1) JP6549564B2 (zh)
KR (1) KR101904385B1 (zh)
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AU (2) AU2014301777B2 (zh)
CA (1) CA2916960C (zh)
IL (1) IL243365B (zh)
MX (1) MX2016000231A (zh)
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WO (1) WO2014206304A1 (zh)

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CN109890837A (zh) * 2016-10-20 2019-06-14 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN111278854A (zh) * 2017-09-04 2020-06-12 艾吉纳斯公司 与混合谱系白血病(mll)特异性磷酸肽结合的t细胞受体和其使用方法
WO2021043284A1 (zh) * 2019-09-05 2021-03-11 广东香雪精准医疗技术有限公司 一种识别ssx2的高亲和力t细胞受体
CN114502578A (zh) * 2019-09-06 2022-05-13 伊莱利利公司 包含t-细胞受体恒定结构域的蛋白
WO2023241391A1 (zh) * 2022-06-17 2023-12-21 香雪生命科学技术（广东）有限公司 一种结合ssx2抗原的tcr分子及其应用

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