CN105683179B - 血浆激肽释放酶的抑制剂 - Google Patents

血浆激肽释放酶的抑制剂 Download PDF

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Publication number
CN105683179B
CN105683179B CN201480055925.4A CN201480055925A CN105683179B CN 105683179 B CN105683179 B CN 105683179B CN 201480055925 A CN201480055925 A CN 201480055925A CN 105683179 B CN105683179 B CN 105683179B
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methyl
pyridine
aminoisoquinolin
formula
alkyl
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CN105683179A (zh
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汉娜·乔伊·爱德华兹
戴维·米歇尔·埃万斯
普雷姆吉·梅根尼
安德鲁·理查德·诺瓦克
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Kalvista Pharmaceuticals Ltd
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/04—Ortho-condensed systems

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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201480055925.4A 2013-08-14 2014-08-14 血浆激肽释放酶的抑制剂 Expired - Fee Related CN105683179B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361865756P 2013-08-14 2013-08-14
US201361865732P 2013-08-14 2013-08-14
US61/865,756 2013-08-14
US61/865,732 2013-08-14
PCT/GB2014/052510 WO2015022546A1 (en) 2013-08-14 2014-08-14 Inhibitors of plasma kallikrein

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CN105683179A CN105683179A (zh) 2016-06-15
CN105683179B true CN105683179B (zh) 2018-10-26

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US (1) US10221161B2 (enExample)
EP (1) EP3033336B1 (enExample)
JP (1) JP6527147B2 (enExample)
CN (1) CN105683179B (enExample)
CA (1) CA2920815C (enExample)
ES (1) ES2674088T3 (enExample)
HU (1) HUE14755117T2 (enExample)
MX (1) MX366498B (enExample)
PL (1) PL3033336T3 (enExample)
RU (1) RU2674028C2 (enExample)
WO (1) WO2015022546A1 (enExample)

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US20160168123A1 (en) 2016-06-16
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RU2016108753A3 (enExample) 2018-05-03
CA2920815C (en) 2021-09-21
MX366498B (es) 2019-07-11
CN105683179A (zh) 2016-06-15
RU2016108753A (ru) 2017-09-19
RU2674028C2 (ru) 2018-12-04
EP3033336B1 (en) 2018-05-30
EP3033336A1 (en) 2016-06-22
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