CN105646372A - 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 - Google Patents
一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 Download PDFInfo
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- CN105646372A CN105646372A CN201610179180.3A CN201610179180A CN105646372A CN 105646372 A CN105646372 A CN 105646372A CN 201610179180 A CN201610179180 A CN 201610179180A CN 105646372 A CN105646372 A CN 105646372A
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- amino
- formamidopyrimidine
- reaction
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- pyrimidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201610179180.3A CN105646372B (zh) | 2016-03-25 | 2016-03-25 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
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CN201610179180.3A CN105646372B (zh) | 2016-03-25 | 2016-03-25 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
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CN105646372A true CN105646372A (zh) | 2016-06-08 |
CN105646372B CN105646372B (zh) | 2019-12-10 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109180501A (zh) * | 2018-08-01 | 2019-01-11 | 青岛泰玛新材料科技有限公司 | 一种4,4’-二氨基二苯醚的合成方法 |
CN112062726A (zh) * | 2020-11-11 | 2020-12-11 | 苏州开元民生科技股份有限公司 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
CN113292507A (zh) * | 2021-06-25 | 2021-08-24 | 潍坊奥通药业有限公司 | 一种2-氨基-6-氯鸟嘌呤及其中间体的制备方法 |
CN114644590A (zh) * | 2020-12-17 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644593A (zh) * | 2020-12-18 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644591A (zh) * | 2020-12-17 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN117050024A (zh) * | 2023-10-13 | 2023-11-14 | 苏州开元民生科技股份有限公司 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103936681A (zh) * | 2014-04-04 | 2014-07-23 | 苏州开元民生科技股份有限公司 | 2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
WO2015090292A1 (de) * | 2013-12-19 | 2015-06-25 | Henkel Ag & Co. Kgaa | Mittel zum oxidativen färben von keratinfasern enthaltend neue tetrasubstituierte derivate des pyrimidins |
-
2016
- 2016-03-25 CN CN201610179180.3A patent/CN105646372B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015090292A1 (de) * | 2013-12-19 | 2015-06-25 | Henkel Ag & Co. Kgaa | Mittel zum oxidativen färben von keratinfasern enthaltend neue tetrasubstituierte derivate des pyrimidins |
CN103936681A (zh) * | 2014-04-04 | 2014-07-23 | 苏州开元民生科技股份有限公司 | 2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
Non-Patent Citations (2)
Title |
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ANTONIO MARCHAL ET AL.: "Alkoxy-5-nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds", 《EUR.J.ORG.CHEM.》 * |
ELIŠKA PROCHÁZKOVÁ ET AL.: "Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109180501A (zh) * | 2018-08-01 | 2019-01-11 | 青岛泰玛新材料科技有限公司 | 一种4,4’-二氨基二苯醚的合成方法 |
CN109180501B (zh) * | 2018-08-01 | 2021-03-16 | 青岛泰玛新材料科技有限公司 | 一种4,4’-二氨基二苯醚的合成方法 |
CN112062726A (zh) * | 2020-11-11 | 2020-12-11 | 苏州开元民生科技股份有限公司 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法 |
CN114644590A (zh) * | 2020-12-17 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644591A (zh) * | 2020-12-17 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644590B (zh) * | 2020-12-17 | 2023-12-26 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644591B (zh) * | 2020-12-17 | 2023-12-29 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644593A (zh) * | 2020-12-18 | 2022-06-21 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN114644593B (zh) * | 2020-12-18 | 2023-12-12 | 北京颖泰嘉和生物科技股份有限公司 | 二氯嘧啶的制备方法 |
CN113292507A (zh) * | 2021-06-25 | 2021-08-24 | 潍坊奥通药业有限公司 | 一种2-氨基-6-氯鸟嘌呤及其中间体的制备方法 |
CN117050024A (zh) * | 2023-10-13 | 2023-11-14 | 苏州开元民生科技股份有限公司 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法 |
CN117050024B (zh) * | 2023-10-13 | 2024-01-05 | 苏州开元民生科技股份有限公司 | 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法 |
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CN105646372B (zh) | 2019-12-10 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: A preparation method of 2-amino-4,6-dichloro-5-formamide pyrimidine Effective date of registration: 20201202 Granted publication date: 20191210 Pledgee: Zhongguancun Beijing technology financing Company limited by guarantee Pledgor: BEIJING INSIGHT FINECHEM Co.,Ltd.|HUBEI HUIDA TECHNOLOGY DEVELOPMENT Co.,Ltd. Registration number: Y2020990001404 |
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Date of cancellation: 20221223 Granted publication date: 20191210 Pledgee: Zhongguancun Beijing technology financing Company limited by guarantee Pledgor: BEIJING INSIGHT FINECHEM CO.,LTD.|HUBEI HUIDA TECHNOLOGY DEVELOPMENT Co.,Ltd. Registration number: Y2020990001404 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of 2-amino-4,6-dichloro-5-formamidopyrimidine Effective date of registration: 20230329 Granted publication date: 20191210 Pledgee: Zhongguancun Beijing technology financing Company limited by guarantee Pledgor: BEIJING INSIGHT FINECHEM CO.,LTD.|HUBEI HUIDA TECHNOLOGY DEVELOPMENT Co.,Ltd. Registration number: Y2023990000178 |