CN105641161A - 一种抗菌性口香糖及其制备方法 - Google Patents

一种抗菌性口香糖及其制备方法 Download PDF

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CN105641161A
CN105641161A CN201610148125.8A CN201610148125A CN105641161A CN 105641161 A CN105641161 A CN 105641161A CN 201610148125 A CN201610148125 A CN 201610148125A CN 105641161 A CN105641161 A CN 105641161A
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周利
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Abstract

一种抗菌性口香糖，涉及口香糖技术领域，包括以下原料制成：胶基质60-80份、壳聚糖3-5份、甘油20-30份、木糖醇15-25份、山梨糖醇20-30份、软化剂8-10份、白砂糖20-30份、复合维生素3-5份、微量元素3-5份、板蓝根2-4份、金银花3-5份、连翘2-4份、大黄3-5份、牡丹皮1-3份、黄柏2-4份、青蒿3-5份、野菊花2-4份。本发明的有益效果为：本发明配方合理，制备方法简单，制备的口香糖，食用时可以获得传统口香糖的功效，同时内部中成药的植入，起到了抗菌消炎的作用，保证了口腔内部环境的洁净，效果明显。

Description

一种抗菌性口香糖及其制备方法
技术领域
本发明涉及口香糖技术领域，具体涉及一种抗菌性口香糖及其制备方法。
背景技术
口香糖是以天然树胶或甘油树脂为胶体的基础，加入糖浆、薄荷、甜味剂等调和压制而成的一种供人们放入口中嚼咬的糖。是很受世界人民喜爱的一种糖类。既可吃又可玩，深受儿童和青年人喜爱。同时也成为大部分年轻人的扮酷、时尚的新宠。在提升口腔健康的同时，通过咀嚼口香糖带来的面部肌肉运动，在认知学领域也具有多重功效。
口香糖由于各种风味的不同，深受广大人群喜爱，市场上现有的口香糖其不同之处均是采用不同香精及果味进行调配处不同品种，因此其功能还是相对单一。中草药，作为华夏名族的瑰宝，其取材简单，成本低，如果将其用于口香糖制备，定会做出较为不同的元素，由于人类口腔中会存在大量细菌，如果在咀嚼口香糖的同时可以做出抗菌杀菌的功效，定会是一举两得。
发明内容：
本发明所要解决的技术问题在于提供一种配方合理，制备方法简单，口味新颖，抗菌效果显著的抗菌性口香糖及其制备方法。
本发明所要解决的技术问题采用以下技术方案来实现：
一种抗菌性口香糖，其特征在于，由以下组分的原料制成：
胶基质60-80份、壳聚糖3-5份、甘油20-30份、木糖醇15-25份、山梨糖醇20-30份、软化剂8-10份、白砂糖20-30份、复合维生素3-5份、微量元素3-5份、板蓝根2-4份、金银花3-5份、连翘2-4份、大黄3-5份、牡丹皮1-3份、黄柏2-4份、青蒿3-5份、野菊花2-4份。
各原料的优选份量为：胶基质70份、壳聚糖4份、甘油25份、木糖醇20份、山梨糖醇25份、软化剂9份、白砂糖25份、复合维生素4份、微量元素4份、板蓝根3份、金银花4份、连翘3份、大黄4份、牡丹皮2份、黄柏3份、青蒿4份、野菊花3份。
所述的微量元素包括：青霉素G3mg、青霉素V2mg、甲氧西林1mg、氨苄青霉素2mg、羟氨苄青霉素3mg、羧噻吩青霉素4mg、氧哌嗪青霉素1mg。
所述的复合维生素包括：维生素C13mg、维生素E11mg、维生素B23mg。
所述的胶基质通过枇杷胶和明胶按照1:6的重量比，配置而成。
本发明的另一个目的是提供一种制备本发明抗菌性口香糖的方法，其特征在于，包括以下步骤：
1)将原料中的板蓝根、金银花、连翘、大黄、牡丹皮、黄柏、青蒿和野菊花按配方量投入煎锅中，放入总量20倍的清水，加热升温至沸腾后，持续煎煮20-30min后，去渣留汁，并且将汁液通过600-700目的网筛，过滤后再进行一次澄清处理，得到药液；
2)将胶基质与原料中的壳聚糖、甘油、木糖醇和山梨糖醇进行混合合并，搅拌，然后升温至150-220℃，添加入步骤1中的药液，进行搅拌熬制；
3)将复合维生素、微量元素和白沙糖混合均匀后，搅拌升温至20-30℃，搅拌30-40min后，将原料中的软化剂加入其中，持续搅拌，直至，搅拌均匀；
4)选用一真空薄膜熬糖设备，将步骤2的原料和步骤3中的原料混合后，投入其中，继续搅拌熬制30-40min后，取出；
5)将上述产品取出后，在室温下冷却后，使用相应模具制备成型后，包装即可。
本发明中：
本发明中的板蓝根、金银花、连翘、大黄、牡丹皮、黄柏、青蒿和野菊花作为中成药物，具备食用安全的效能，同时还具有很强的药理药效，具备有抗菌消炎的作用效果，通过将其所有进行煎炸取汁，得到具备同等效应的药液作为糖果熬制的液相，充分的融入糖果中，使得药效得到充分的发挥，与原料中口香糖住配方进行进行协同配置，使得药效更加充分发挥，且还具有一定保健作用，同时原料中的微量元素和复合维生素的添加，保证了效果的更佳。
本发明的有益效果为：本发明配方合理，制备方法简单，制备的口香糖，食用时可以获得传统口香糖的功效，同时内部中成药的植入，起到了抗菌消炎的作用，保证了口腔内部环境的洁净，效果明显。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例1
称取胶基质60kg、壳聚糖3kg、甘油20kg、木糖醇15kg、山梨糖醇20kg、软化剂8kg、白砂糖20kg、复合维生素3kg、微量元素3kg、板蓝根2kg、金银花3kg、连翘2kg、大黄3kg、牡丹皮1kg、黄柏2kg、青蒿3kg、野菊花2kg。
实施例2
称取胶基质80kg、壳聚糖5kg、甘油30kg、木糖醇25kg、山梨糖醇30kg、软化剂10kg、白砂糖30kg、复合维生素5kg、微量元素5kg、板蓝根4kg、金银花5kg、连翘4kg、大黄5kg、牡丹皮3kg、黄柏4kg、青蒿5kg、野菊花4kg。
实施例3
称取胶基质70kg、壳聚糖4kg、甘油25kg、木糖醇20kg、山梨糖醇25kg、软化剂9kg、白砂糖25kg、复合维生素4kg、微量元素4kg、板蓝根3kg、金银花4kg、连翘3kg、大黄4kg、牡丹皮2kg、黄柏3kg、青蒿4kg、野菊花3kg。
制备上述实施例1、实施例2和实施例3的方法，包括以下步骤：
1)将原料中的板蓝根、金银花、连翘、大黄、牡丹皮、黄柏、青蒿和野菊花按配方量投入煎锅中，放入总量20倍的清水，加热升温至沸腾后，持续煎煮20-30min后，去渣留汁，并且将汁液通过600-700目的网筛，过滤后再进行一次澄清处理，得到药液；
2)将胶基质与原料中的壳聚糖、甘油、木糖醇和山梨糖醇进行混合合并，搅拌，然后升温至150-220℃，添加入步骤1中的药液，进行搅拌熬制；
3)将复合维生素、微量元素和白沙糖混合均匀后，搅拌升温至20-30℃，搅拌30-40min后，将原料中的软化剂加入其中，持续搅拌，直至，搅拌均匀；
4)选用一真空薄膜熬糖设备，将步骤2的原料和步骤3中的原料混合后，投入其中，继续搅拌熬制30-40min后，取出；
5)将上述产品取出后，在室温下冷却后，使用相应模具制备成型后，包装即可。
下表为同一人口腔内，咀嚼实施例1、2或者3制备的抗菌性口香糖前后的细菌种类及菌株数量：
种类 食用前 食用后
链球菌(株) 687 124
葡萄球菌(株) 1024 352
乳酸杆菌(株) 112 21
烟草杆菌(株) 1245 254
葡萄球菌(株) 862 245
奈瑟氏菌(株) 334 125
厌氧链球菌(株) 257 89
由上表可以看出，同一人口腔内的各种细菌的菌株数量，在食用本品的口香糖后，有着明显的下降，充分的证明了本品口香糖对口腔内细菌灭杀的优势。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (6)

1.一种抗菌性口香糖，其特征在于，由以下组分的原料制成：
胶基质60-80份、壳聚糖3-5份、甘油20-30份、木糖醇15-25份、山梨糖醇20-30份、软化剂8-10份、白砂糖20-30份、复合维生素3-5份、微量元素3-5份、板蓝根2-4份、金银花3-5份、连翘2-4份、大黄3-5份、牡丹皮1-3份、黄柏2-4份、青蒿3-5份、野菊花2-4份。
2.根据权利要求1所述的一种抗菌性口香糖，其特征在于，各原料的优选份量为：胶基质70份、壳聚糖4份、甘油25份、木糖醇20份、山梨糖醇25份、软化剂9份、白砂糖25份、复合维生素4份、微量元素4份、板蓝根3份、金银花4份、连翘3份、大黄4份、牡丹皮2份、黄柏3份、青蒿4份、野菊花3份。
3.根据权利要求1所述的一种抗菌性口香糖，其特征在于：所述的微量元素包括：青霉素G3mg、青霉素V2mg、甲氧西林1mg、氨苄青霉素2mg、羟氨苄青霉素3mg、羧噻吩青霉素4mg、氧哌嗪青霉素1mg。
4.根据权利要求1所述的一种抗菌性口香糖，其特征在于：所述的复合维生素包括：维生素C13mg、维生素E11mg、维生素B23mg。
5.根据权利要求1所述的一种抗菌性口香糖，其特征在于：所述的胶基质通过枇杷胶和明胶按照1:6的重量比，配置而成。
6.制备权利要求1或2中一种抗菌性口香糖的方法，其特征在于，包括以下步骤：
1)将原料中的板蓝根、金银花、连翘、大黄、牡丹皮、黄柏、青蒿和野菊花按配方量投入煎锅中，放入总量20倍的清水，加热升温至沸腾后，持续煎煮20-30min后，去渣留汁，并且将汁液通过600-700目的网筛，过滤后再进行一次澄清处理，得到药液；
2)将胶基质与原料中的壳聚糖、甘油、木糖醇和山梨糖醇进行混合合并，搅拌，然后升温至150-220℃，添加入步骤1中的药液，进行搅拌熬制；
3)将复合维生素、微量元素和白沙糖混合均匀后，搅拌升温至20-30℃，搅拌30-40min后，将原料中的软化剂加入其中，持续搅拌，直至，搅拌均匀；
4)选用一真空薄膜熬糖设备，将步骤2的原料和步骤3中的原料混合后，投入其中，继续搅拌熬制30-40min后，取出；
5)将上述产品取出后，在室温下冷却后，使用相应模具制备成型后，包装即可。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106071027A (zh) * 2016-06-13 2016-11-09 中国人民解放军第四军医大学 一种复方抗菌口香糖及其制备方法
CN107950739A (zh) * 2017-12-15 2018-04-24 阜阳健诺生物科技有限公司 一种预防牙菌斑清口糖及其制备方法
WO2023226063A1 (zh) * 2022-05-27 2023-11-30 张鹏程 一种抗毒抑菌消炎组合物、干粉及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101147523A (zh) * 2007-11-08 2008-03-26 何光伟 一种功能型木糖醇无糖口香糖的配方
CN102948578A (zh) * 2011-08-22 2013-03-06 天津尖峰弗兰德医药科技发展有限公司 一种具有补益作用的口香糖及制备方法
CN103918865A (zh) * 2014-04-21 2014-07-16 孙贵香 一种中药保健口香糖及其制备方法
CN104146139A (zh) * 2014-05-30 2014-11-19 重庆海立云科技有限公司 司机口香糖

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101147523A (zh) * 2007-11-08 2008-03-26 何光伟 一种功能型木糖醇无糖口香糖的配方
CN102948578A (zh) * 2011-08-22 2013-03-06 天津尖峰弗兰德医药科技发展有限公司 一种具有补益作用的口香糖及制备方法
CN103918865A (zh) * 2014-04-21 2014-07-16 孙贵香 一种中药保健口香糖及其制备方法
CN104146139A (zh) * 2014-05-30 2014-11-19 重庆海立云科技有限公司 司机口香糖

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《孙学全针灸临证经验集》: "《孙学全针灸临证经验集》", 31 January 2015, 北京：中国中医药出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106071027A (zh) * 2016-06-13 2016-11-09 中国人民解放军第四军医大学 一种复方抗菌口香糖及其制备方法
CN107950739A (zh) * 2017-12-15 2018-04-24 阜阳健诺生物科技有限公司 一种预防牙菌斑清口糖及其制备方法
WO2023226063A1 (zh) * 2022-05-27 2023-11-30 张鹏程 一种抗毒抑菌消炎组合物、干粉及应用

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