CN105638670B - A kind of bactericidal composition containing fluorine bacterium azoles and oxazole - Google Patents
A kind of bactericidal composition containing fluorine bacterium azoles and oxazole Download PDFInfo
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- CN105638670B CN105638670B CN201610162525.4A CN201610162525A CN105638670B CN 105638670 B CN105638670 B CN 105638670B CN 201610162525 A CN201610162525 A CN 201610162525A CN 105638670 B CN105638670 B CN 105638670B
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- Prior art keywords
- oxazole
- bacterium azoles
- fluorine bacterium
- bactericidal composition
- reduces
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Abstract
The invention discloses a kind of bactericidal composition containing fluorine bacterium azoles and oxazole, is made of effective component and insecticides adjuvant；Its effective component is fluorine bacterium azoles and oxazole, and the weight ratio of fluorine bacterium azoles and oxazole is 1：10~10：1, weight percent is 1%~70% in the composition for fluorine bacterium azoles and oxazole weight summation.According to the actual application, bactericidal composition of the present invention can be prepared as one of aqueous emulsion, microemulsion, suspending agent, wettable powder, water dispersible granules, for preventing and treating uncinula necator；Control efficiency of the present invention is significantly improved than single dose, reduces the dosage of pesticide, reduces times for spraying, reduces drug cost, reduces pesticide to the adverse effect of ecological environment.
Description
Technical field
The present invention relates to a kind of bactericidal composition containing fluorine bacterium azoles and oxazole, for preventing and treating uncinula necator.
Background technique
The resistance problem of agricultural disease is a global problem, is always the emphasis class of agricultural science and technology worker concern
Topic.With the continuity year in year out of disease chemical prevention, the increase of Pesticide use amount and not scientifical use pesticide, germ
Resistance is got worse, and the germ type for generating resistance is increasing.Meanwhile high-intensitive use pesticide, lead to agricultural product pesticide
Exceeded, environmental pollution and the increase of peasant's drug cost etc. are remained, agricultural sustainable development is unfavorable for.Therefore, research and development efficiently,
Low toxicity, environmentally friendly bactericide agricultural chemicals have positive effect to agricultural sustainable development.
Fluorine bacterium azoles are sterol synthesis inhibition fungicide, have protection, interior suction and therapeutic activity, to grape, strawberry, Huang
The crop powdery mildews excellent effect such as melon.
Oxazole is sterol synthesis inhibition fungicide, can efficiently control ground leaves not disease by root application
Occur and endanger, can be used for spraying；Oxazole have wide spectrum bactericidal activity, while have protection and therapeutic effect with
And good absorbability, gray mold, powdery mildew excellent effect to various crop.
The mixture of different pesticide species is the common methods for preventing and treating agricultural pest.It is screened, is filtered out by formulation of pesticide
Reasonable formula, can effectively improve practical control efficiency, reduce dosage, reduce cost, delay the generation of pest and disease damage drug resistance,
It is an important means of comprehensive agricultural management.The present inventor has made intensive studies the recipe determination of fluorine bacterium azoles and oxazole,
It was found that fluorine bacterium azoles and oxazole, which carry out mixture, has apparent synergistic effect to a variety of fungies in a certain mix proportion range, pass through
Further research, completes the present invention.
The combination and application of fluorine bacterium azoles and oxazole there is no report at present.
Summary of the invention
The object of the present invention is to provide one kind efficiently, low toxicity and lasting period are long, can effectively prevent agricultural fungal evil
A kind of bactericidal composition containing fluorine bacterium azoles and oxazole.
To solve the above problems, the technical scheme adopted by the invention is that：A kind of killing containing fluorine bacterium azoles and oxazole
Bacteria composition is made of effective component and insecticides adjuvant, and effective component is fluorine bacterium azoles and oxazole, fluorine bacterium azoles and oxazole
Weight ratio be 1：10~10：1, weight percent is 1%~70% in the composition for fluorine bacterium azoles and oxazole weight summation.
The bactericidal composition can be configured to aqueous emulsion, microemulsion, hang according to methods well known to those skilled in the art
One of floating agent, wettable powder, water dispersible granules.
Auxiliary agent needed for the present invention also contains preparation pesticidal preparations, auxiliary agent are solvents, emulsifier, wetting agent, stabilizer, divide
The mixing of one or more of powder, thickener, PH regulator, defoaming agent, antifreezing agent, packing agent etc., is known substance,
It is common various auxiliary agents in pesticidal preparations, can be varied, be not particularly limited according to different situations.
Bactericidal composition of the present invention, for preventing and treating uncinula necator.
Bactericidal composition provided by the invention generallys use spray method use, also can according to need using agriculturally
Other of application use technology.
One kind provided by the invention has the advantages that containing fluorine bacterium azoles and oxazole composition：
1, bactericidal composition provided by the invention shows apparent synergy or summation action within a certain ratio range,
Composition is significantly improved to the control efficiency of germ than single dose, reduces the dosage of pesticide, reduces times for spraying,
Drug cost is reduced, reduces pesticide to the adverse effect of ecological environment.
2, bactericidal composition provided by the invention, two kinds of effective ingredient mechanism of action are not quite identical, can overcome long-term
Single use is easy to produce the shortcomings that resistance, extends the service life of medicament, has important meaning to the comprehensive treatment of germ resistance
Justice.
3, bactericidal composition provided by the invention, drug effect play rapidly, and the lasting period is long, and use cost is low, easy to use, save
Shi Shengli, popularization and application have huge economic benefit and social benefit.
Specific embodiment
In order to keep the objectives, technical solutions, and advantages of the present invention more concise, present invention following specific embodiments
It is illustrated, however, the present invention is by no means limited to these examples.The following is only the preferred embodiment of the present invention, is used only for
The description present invention, should not be understood as limiting the scope of the present invention.It should be pointed out that all in the spirit and principles in the present invention
Within any modifications, equivalent replacements, and improvements etc. done, should all be included in the protection scope of the present invention.Therefore, this hair
The scope of protection shall be subject to the appended claims for bright patent.
Content as described in the examples is weight percentage.
Embodiment 1：11% fluorine bacterium azoles oxazole suspending agent
First other auxiliary agents are mixed, shear-mixed is uniform in cutter, and fluorine bacterium azoles and oxazole is then added, is grinding
2-3h is ground in ball machine, is below 5mm a diameter, can be prepared by 11% fluorine bacterium azoles oxazole suspending agent.
Embodiment 2：30% fluorine bacterium azoles oxazole aqueous emulsion
First fluorine bacterium azoles and oxazole, trimethylbenzene, Sorbitan aliphatic ester are mixed, dissolution becomes uniform
Oily phase.Part water and other auxiliary agents are mixed again, dissolution becomes uniform water phase.Then high-speed stirred in a kettle
While the oil phase is added to the aqueous phase, slowly add water to and reach phase inversion point, carry out high speed shear later, and remaining water is added, cut
About 30min is cut, can be prepared by 30% fluorine bacterium azoles oxazole aqueous emulsion.
Embodiment 3：12% fluorine bacterium azoles oxazole microemulsion
Fluorine bacterium azoles and oxazole are completely dissolved with fatty acid methyl ester first, then add other auxiliary agents, are uniformly mixed,
It is eventually adding water, after being sufficiently stirred, can be prepared by 12% fluorine bacterium azoles oxazole microemulsion.
Embodiment 4：60% fluorine bacterium azoles oxazole wettable powder
Fluorine bacterium azoles and oxazole, other auxiliary agents are sufficiently stirred in a stirring kettle, are mixed after being smashed by air jet mill
Uniformly, it can be prepared by 60% fluorine bacterium azoles oxazole wettable powder.
Embodiment 5：32% fluorine bacterium azoles oxazole water dispersible granules
To there are fluorine bacterium azoles and oxazole, other auxiliary agents to be uniformly mixed, be crushed with micro jet, be added after mediating
After being granulated, dried in fluidized bed granulating and drying machine, being sieved, 32% fluorine bacterium azoles oxazole water-dispersible grain can be prepared by
Agent.
Embodiment 6：18% fluorine bacterium azoles oxazole suspending agent
First other auxiliary agents are mixed, shear-mixed is uniform in cutter, and fluorine bacterium azoles and oxazole is then added, is grinding
2-3h is ground in ball machine, is below 5mm a diameter, can be prepared by 18% fluorine bacterium azoles oxazole suspending agent.
Embodiment 7：55% fluorine bacterium azoles oxazole wettable powder
Fluorine bacterium azoles and oxazole, other auxiliary agents are sufficiently stirred in a stirring kettle, are mixed after being smashed by air jet mill
Uniformly, it can be prepared by 55% fluorine bacterium azoles oxazole wettable powder.
Embodiment 8：Synergy measurement.
Uncinula necator test uses field grape stem and leaf spray-on process to be administered (having water membrane to be advisable with blade surface), in
Progress on May 15th, 2015 spraying treatment, spray instrument use hand sprayer (liquid capacity about 2.0L), sprayed every 10 days
Once, continuous spray 2 times.Every processing selects uniform 20 blades of tendril of morbidity as efficacy of medicine observing object, each processing 3 times
It repeats.
Investigation method：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for 5% or less entire leaf area；
3 grades：Lesion area accounts for the 6%-15% of entire leaf area；
5 grades：Lesion area accounts for the 16%-25% of entire leaf area；
7 grades：Lesion area accounts for the 26%-50% of entire leaf area；
9 grades：Lesion area accounts for 50% or more of entire leaf area.
According to survey data, the disease index and control efficiency of each processing are calculated.
Disease index is calculated by formula, and calculated result retains 2 significant digits：
When carrying out drug combination toxicity test, this test calculates the coefficient of synergism (SR) of mixture, evaluation using Wadley method
The synergy type of mixture.
Wadley method：The synergistic effect of pharmacy mix, i.e. SR are evaluated according to coefficient of synergism (SR)<0.5 is antagonism,
0.5≤SR≤1.5 are summation action, SR>1.5 be synergistic function.Coefficient of synergism (SR) is calculated by formula (1), (2)：
In formula：
X1------------- mixture EC50Theoretical value, unit are milligrams per liter (mg/L)；
PA--- --- percentage composition of A in --- ----mixture, unit are percentage (%)；
PB--- --- percentage composition of B in --- ----mixture, unit are percentage (%)；
The EC of A in A--------------- mixture50Value, unit are milligrams per liter (mg/L)；
The EC of B in B--------------- mixture50Value, unit are milligrams per liter (mg/L).
In formula：
The coefficient of synergism of SR------------- mixture；
The EC of X1-------------- mixture50Theoretical value, unit are milligrams per liter (mg/L)；
The EC of X2-------------- mixture50Measured value, unit are milligrams per liter (mg/L).
The synergy measurement result of table 1, fluorine bacterium azoles and oxazole to uncinula necator germ
As can be seen from Table 1, fluorine bacterium azoles and oxazole are 1:10-10:It is compounded in the range of 1, to uncinula necator table
It is now synergistic effect.
Embodiment 9：Prevent and treat uncinula necator field trial.
Test site is located at Hunan Province Huarong County, using spray-on process.Made using 30% fluorine bacterium azoles WP, 25% oxazole EC
For comparison medicament, test sets 9 chemicals treatments altogether, and 4 repetitions of each processing investigate the grape disease number of sheets, 7 after application before application
It, 15 days each control efficiency of investigation, record the sick number of sheets, calculate control efficiency, test result is as shown in table 2.
Table 2, fluorine bacterium azoles and oxazole combination prevention and treatment uncinula necator field test results
As can be seen from Table 2, the effect that the present invention prevents and treats is better than the processing of each control single dose.Illustrate fluorine bacterium azoles and oxazole
Compounding can improve control efficiency, reduce the dosage of pesticide, reduce influence of the pesticide to environment, reduce medication at
This.
Claims (1)
1. a kind of bactericidal composition containing fluorine bacterium azoles and oxazole, is made of, feature exists effective component and insecticides adjuvant
It is in weight ratio：Fluorine bacterium azoles 10%, oxazole 1%, alkylnaphthalene sulfonate 3.5%, sodium lignin sulfonate 4%, propylene glycol
3%, xanthan gum 2%, methanol 1%, potassium hydroxide 0.1%, water surplus；First other auxiliary agents are mixed, the shear-mixed in cutter
Uniformly, fluorine bacterium azoles and oxazole is then added, 2-3h is ground in ball crusher, a diameter is below 5mm, obtains
11% fluorine bacterium azoles oxazole suspending agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610162525.4A CN105638670B (en) | 2016-03-21 | 2016-03-21 | A kind of bactericidal composition containing fluorine bacterium azoles and oxazole |
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| CN201610162525.4A CN105638670B (en) | 2016-03-21 | 2016-03-21 | A kind of bactericidal composition containing fluorine bacterium azoles and oxazole |
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| Publication Number | Publication Date |
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| CN105638670A CN105638670A (en) | 2016-06-08 |
| CN105638670B true CN105638670B (en) | 2018-11-20 |
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| CN106035348A (en) * | 2016-06-28 | 2016-10-26 | 山东农业大学 | Bactericidal composition containing SYP-Z048 and triflumizole |
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| AU770077B2 (en) * | 1999-03-11 | 2004-02-12 | Dow Agrosciences Llc | Heterocyclic substituted isoxazolidines and their use as fungicides |
| CN101822260A (en) * | 2004-12-23 | 2010-09-08 | 巴斯夫欧洲公司 | Fungicidal mixture |
| CN102067858A (en) * | 2011-01-18 | 2011-05-25 | 河北省农林科学院植物保护研究所 | Compound bactericide for mainly treating grey mold of fruits and vegetables |
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