CN102823599B - Bactericidal composition containing kresoxim-methyl and difenoconazole and application - Google Patents
Bactericidal composition containing kresoxim-methyl and difenoconazole and application Download PDFInfo
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Abstract
The invention relates to a bactericidal composition with a synergic effect. The effective active ingredients of the bactericidal composition include kresoxim-methyl and difenoconazole, wherein the weight ratio of the kresoxim-methyl to the difenoconazole is (50:1)-(1:50). The effective active components can be prepared into wettable powder, suspending agent, emulsion in water and dispersible granules by adding an auxiliary and an excipient, thereby being mainly used for preventing and controlling multiple diseases such as anthracnose, alternaria leaf spot, scab, ring spot, powdery mildew and the like of multiple vegetables and fruit trees. Through the invention, by mixing two bactericides, the bactericidal effect is obviously improved, and the dosage is reduced. The bactericidal spectrum is expanded, the medicament properties have complementary advantages, and the effects of protection and protection are realized on the crops. Meanwhile, the generation and development of the drug resistance of pathogenic bacteria are delayed, and the dosage of organic solvents is reduced, thereby being safer to the crops and environment.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition that contains kresoxim-methyl and Difenoconazole on control vegetables and fruit diseases.
Background technology
Using chemical agent is the most effectively means of control fungal diseases of plants.But long-term use single chemical bactericide continuously high dose, easily cause the problems such as residual, the environmental pollution of medicament and resistance to pesticide resistance fungi development.Reasonably chemical bactericide is composite or be mixed and have expansion fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay actively feature such as Antifungal resistance and drug-fast generation and development etc.And because exploitation new product bactericide price is constantly soaring, by contrast, exploitation is efficient with research, the composite of low toxicity, low-residual has small investment with being mixed, the advantage that the lead time is short and be subject to attention both domestic and external, the numerous and confused dynamics that develops that strengthens.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic bactericide of BASF Aktiengesellschaft's exploitation.Molecular formula: C
18h
19nO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.Kresoxim-methyl belongs to mitochondrial respiratory inhibitor; it is a kind of wide-spectrum bactericide; and the lasting period is long; most of diseases that the pathomycetes such as sac fungi, basidiomycetes, imperfect fungus and oomycetes subclass are caused have protection, treat and root out activity; to crop, people, animal and beneficial organism safety, substantially pollution-free to environment, but the intrinsic pesticide resistance of this series bactericidal agent is higher; easily develop immunity to drugs, and cost is high.
Difenoconazole (difenoconazle), You Ming Difenoconazole, is white solid, 76 ℃ of fusing points, are soluble in organic solvent.Belonging to triazole type systemic fungicide, is sterol demethylation inhibitor, has safety low-poison, high-efficiency broad spectrum, and crop is had to lasting protection and therapeutic action.To ascus guiding principle, Basidiomycetes with comprise that imperfect fungus, Erysiphaceae, Uredinales and some soil-borne pathogen of Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia have lasting protection and therapeutic action.Bitter rot or anthracnose of grape, white rot are also had to good control efficiency.
But due to the long-term a large amount of use of these two kinds of bactericide, germ has produced larger resistance, preventive effect variation, dosage continues to increase, thereby drug cost is improved constantly, and environmental risk is also increasing.The inventor studies have shown that by a series of, and kresoxim-methyl and Difenoconazole are mixed target bacterium is had to very strong synergistic effect, have greatly improved bactericidal activity, thereby have completed the present invention.
Summary of the invention
The object of the invention is to carry out rational mixture by kresoxim-methyl and Difenoconazole, obtain Synergistic bactericidal composition, for preventing and treating the disease in agricultural production, in particular for spot defoliation, scab, ring spot, the anthracnose of control fruit tree.Delay the drug-fast generation of pathogen and development, reduce peasant's drug cost.
For achieving the above object, the invention discloses following technology contents:
A bactericidal composition that contains kresoxim-methyl and Difenoconazole, is characterized in that the weight ratio of this microbicide compositions effective active composition kresoxim-methyl and Difenoconazole is 50:1 to 1:50.
Bactericidal composition of the present invention, wherein the weight ratio of kresoxim-methyl and Difenoconazole is 20:1 to 1:40.
Bactericidal composition of the present invention, wherein the weight ratio of kresoxim-methyl and Difenoconazole is 5:1 to 1:10.
Bactericidal composition of the present invention can be made wetting powder, suspending agent, microemulsion, aqueous emulsion or water dispersible granules.
The present invention further discloses containing kresoxim-methyl and Difenoconazole bactericidal composition and in preparation, prevent and treat the application in various vegetables and fruit diseases as bactericide.Wherein fruit and vegetables disease refers to anthracnose, spot defoliation, scab, ring spot or powdery mildew.
The present invention further discloses containing kresoxim-methyl and Difenoconazole bactericidal composition and in preparation, has prevented and treated the application in various vegetables and fruit tree anthracnose as bactericide; Wherein kresoxim-methyl is 3:1 ~ 1:1 with the weight fraction ratio of Difenoconazole.
The present invention is a kind of by kresoxim-methyl and the composite a kind of bactericidal composition forming of Difenoconazole, by formula indoor, screen virulence test, define the rational formula of the two, be that the mass ratio of kresoxim-methyl and Difenoconazole is at 1:50 ~ 50:1, preferred mass ratio is 1:10 ~ 5:1, the mass percent of active ingredient in preparation is: 1% ~ 80%, and preferred mass degree is 10% ~ 50%, and all the other are in agricultural chemicals, to allow to use and acceptable auxiliary element.Under preferably filling a prescription, the control of the diseases such as the spot defoliation of fruit tree and vegetables, scab, ring spot, anthracnose is reached to good effect.
The present composition can be prepared into by known method any one formulation that is applicable to agricultural use, comprises suspending agent, aqueous emulsion, microemulsion, wetting powder, water dispersible granules, seed coat agent etc.; The auxiliary agent using comprises that dispersant, wetting agent, emulsifier, antifreezing agent, thickener etc. and other are of value to the known substance of active ingredient stable and drug effect performance in preparation, all various compositions conventional in pesticidal preparations or that allow to use, be not particularly limited, concrete composition and consumption can require to determine by test according to formula; The carrier of present composition packet content can be solid or liquid, also can use any carrier used in preparation weeding, desinsection, bactericidal composition that is conventionally used in.
Composition of the present invention comprises following group component composition while making wetting powder: kresoxim-methyl 1% ~ 50%, Difenoconazole 1% ~ 60%, auxiliary agent 5% ~ 50%, filler surplus.Above-mentioned formulation material is mixed, and uniform stirring in stirred tank, is crushed to after particle diameter is less than 44 μ m and mixes through airslide disintegrating mill, can be made into wetting powder.
When making water dispersible granules, the present composition comprises following group component composition: kresoxim-methyl 1% ~ 50%, Difenoconazole 1% ~ 60%, wetting agent 1% ~ 5%, dispersant 3% ~ 12%, disintegrant 1% ~ 4%, filler surplus.Formulation material is mixed, with micro jet, pulverize, through mediating, then add and in fluidized bed prilling dryer, carry out granulation, dry, screening by sample analysis, make water dispersible granules.
Composition of the present invention comprises following group component composition while making suspending agent: kresoxim-methyl 1% ~ 50%, Difenoconazole 1% ~ 60%, emulsifier 1% ~ 10%, dispersant 3% ~ 10%, antifreezing agent 1% ~ 5%, thickener 0.1% ~ 1%, defoamer 0.1% ~ 0.5%, water surplus.By all the other components except thickener and part defoamer in above-mentioned formulation material, through high speed shear, mix, at sand mill medium sand, be milled to particle diameter and be less than 5 μ m, add again thickener and defoamer, shear-mixed is even, makes suspending agent, and suspending agent production technological process is shown in accompanying drawing 1.
When making aqueous emulsion, the present composition comprises following group of amount composition: kresoxim-methyl 1% ~ 30%, Difenoconazole 1% ~ 40%, solvent 5% ~ 30%, emulsifier 2% ~ 10%, antifreezing agent 1% ~ 5%, thickener 0.1% ~ 2%, defoamer 0.1% ~ 0.5%, water surplus.Above-mentioned formulation material is mixed, active ingredient, solvent, emulsifier, co-emulsifier are added together, make to be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed into homogeneous water.Under high-speed stirred, water is added to oil phase, can make aqueous emulsion.
Surfactant of the present invention can be dispersant, wetting agent or emulsifier, and they can be ionic or nonionic.Wetting agent can be natural products wetting agent or cationic wetting agent, as Tea Saponin, silkworm excrement, bay alcohol radical sodium sulphate, neopelex, pull open one or more in powder, modification polyoxyethylene nonylphenol ether etc.
Dispersant can be industrial by-products or anionic dispersing agent, for example lignosulfite, polycarboxylate, multi-styrene phenylate phosphate, fatty alcohol-polyoxyethylene ether, lignin and derivative sulfonate thereof, one or more in naphthalene and alkyl naphthalene formaldehyde condensate sulfonates, alkylsulfonate.
Emulsifier can be nonionic emulsifier or anionic emulsifier, as the phosphate of polyoxyethylene fatty acid ester, alkylphenol-polyethenoxy (polyoxypropylene) ether, polyoxyethylene fatty amine, castor oil ethylene oxide adduct, alkylphenol polyoxyethylene formaldehyde condensation products and these compounds, alkyl benzene sulphonate (calcium salt or sodium salt) etc.
Above-mentioned surfactant is all materials well known in the art, can obtain by various commercial channel.
Thickener of the present invention has natural and synthetic, as water-soluble high-molecular compound and water-soluble resin gum Arabic, xanthans, methylcellulose, carboxymethyl cellulose etc.
Antifreezing agent is selected from one or more in ethylene glycol, propane diols, glycerine, urea ether diglycol, polyethylene glycol, isopropyl alcohol etc.
Disintegrant comprises one or more in sodium bicarbonate, ammonium sulfate, bentonite, urea, aluminium chloride; Defoamer comprises organic silicone, C
8 ~ 10fatty alcohol, C
10 ~ 20representative examples of saturated aliphatic carboxylic and ester class thereof, ester-ether type compound etc., conventional organic silicone and ester-ether type defoamer.
Solid carrier of the present invention comprises natural clay, silicate, magnesium silicate, aluminium-magnesium silicate, precipitated calcium carbonate, calcium sulphate, ammonium sulfate, synthetic hydrated silica and synthetic calcium silicates or alumina silicate.The solid carrier that is particularly suitable for pulvis comprises the rock dust of natural formation, for example attapulgite, bentonite, montmorillonite, diatomite; Synthetic mineral matter and microdispersed silicic acid or the aluminium oxide of grinding.
Liquid-carrier of the present invention comprises water and organic solvent.Water can be used as solvent or thinner, organic solvent also can be used as secondary solvent or stabilization additives, suitable organic solvent comprises toluene, dimethylbenzene, chlorobenzene, solvent naphtha, turpentine oil, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, butanols, isoamyl alcohol, cyclohexanone, isophorone, acetophenone, ethyl acetate, butyl acetate, DMF, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc.
Composition of the present invention also can be used with other compound with weeding, desinsection or bactericidal property, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The inventor has carried out formula screening study to kresoxim-methyl and Difenoconazole, experimental establishment is in plant protection institute of Agricultural University Of Southwest, after the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule-bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to anthrax bacteria.After 96 hours, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate, by SPSS software, data are carried out to analytic statistics, determine synergy ratio (SR), SR<0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR>1.5 is synergistic effect.Result of the test is as shown in the table:
Table 1 kresoxim-methyl and the Difenoconazole joint toxicity measuring result to anthrax bacteria
As can be seen from the table, kresoxim-methyl and the Difenoconazole EC to anthrax bacteria
50value is respectively 0.8365 and 0.5461, and the two be mixed after its EC
50major part all has obvious reduction, from synergy ratio, kresoxim-methyl and Difenoconazole are mixed, in the scope that is 3:1 ~ 1:1 at mass ratio, anthrax bacteria is all shown as to significant synergistic effect, can improve greatly bactericidal effect, kresoxim-methyl and Difenoconazole are mixed and have reasonability and feasibility.
Further by field control effectiveness test, show: the present composition is when consumption is 20 ~ 30g/ mu, and to ring rot of apple preventive effect, in 80% left and right, and the Difenoconazole single dose preventive effect of same amount is only 60% left and right; The present composition is when consumption is 20 ~ 30g/ mu, to the preventive effect of apple scab, be 70 ~ 90%, and Difenoconazole single dose is when consumption is 30 ~ 40g/ mu, to the preventive effect of apple scab, be 60 ~ 70%, kresoxim-methyl single dose is when consumption is 30 ~ 40g/ mu, to the preventive effect of apple scab, be 50% left and right, all lower than the preventive effect of the present composition; The present composition, when consumption is 30 ~ 40g/ mu, be more than 80%, and the Difenoconazole single dose preventive effect of same amount is only 70% left and right to the preventive effect of cucumber anthracnose.The present composition, when consumption is 30 ~ 40g/ mu, the preventive effect of bitter rot or anthracnose of grape is reached more than 80%, and the Difenoconazole single dose preventive effect of same amount is only 70% left and right; The present composition is when consumption is 20 ~ 30g/ mu, and to the preventive effect of wheat powdery mildew, more than 75%, and contrast medicament carbendazim is when consumption is 50 ~ 60g/ mu, and preventive effect is only also 70%.Therefore, the present composition all has good preventive effect to ring spot, scab, anthracnose and powdery mildew etc., be greatly improved, and consumption still less with respect to single dose preventive effect.
Kresoxim-methyl is generally used for preventing and treating powdery mildew of strawberry, melon powdery mildew, powdery mildew of cucumber, pear scab, powdery mildew of cucumber, the diseases such as downy mildew, Difenoconazole is generally used for preventing and treating pear scab, alternaria leaf spot of apple, tomato drought epidemic disease, the climing rot of watermelon, pepper anthracnose, powdery mildew of strawberry, bitter rot or anthracnose of grape, anthrachose of grape, the diseases such as citrus scab, and the present composition can not only be prevented and treated the disease that each single dose can be prevented and treated, and to rust, leaf spot, brown spot, the diseases such as ring spot have good control efficiency, especially more outstanding to the preventive effect of anthracnose, with respect to not only synergy but also expanded fungicidal spectrum of single dose.
The present invention has following remarkable result and advantage containing kresoxim-methyl and Difenoconazole bactericidal composition:
(1) after kresoxim-methyl and Difenoconazole are mixed, significantly improve bactericidal effect, lowered using dosage.
(2) after kresoxim-methyl and Difenoconazole are mixed, expanded fungicidal spectrum, medicament characteristic has obtained mutual supplement with each other's advantages, and a kind of medicament can be prevented and treated various crop disease, has facilitated peasant's medication.
(3), after kresoxim-methyl and Difenoconazole are mixed, delayed the pesticide resistance of pathogen, significant to the resistance of disease and the comprehensive regulation.
(4), after kresoxim-methyl and Difenoconazole are mixed, reduce dosage, reduced poisoning, reduce residual.
Accompanying drawing explanation:
Fig. 1 is the production technological process of kresoxim-methyl and Difenoconazole composition suspending agent.
Embodiment
Below in conjunction with embodiment, the present invention is described, the scheme of embodiment described here, do not limit the present invention, one of skill in the art can make improvements and change according to spirit of the present invention, these described improvement and variation all should be considered as within the scope of the invention, and scope of the present invention and essence are limited by claim.Contrast medicament 30% kresoxim-methyl SC, 40% Difenoconazole WP, 10% kresoxim-methyl SC, 30% Difenoconazole WP and 50% carbendazim SC are commercially available.
Embodiment 1:
30% kresoxim-methyl Difenoconazole wetting powder
By kresoxim-methyl 20g, Difenoconazole 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, potter's clay adds to 100g and is mixed into row air-flow crushing, through after the assay was approved, packing makes wetting powder automatically.According to the above ratio with method gained preparation at 1500 ~ 2500 times of liquid to the preventive effect of ring rot of apple in 80% left and right, be better than control efficiency when alone.
Table 2
30% kresoxim-methyl Difenoconazole WP prevents and treats 7 days preventive effects (%) (Yizheng, Jiangsu) after ring rot of apple medicine
| Process |  |  |  |  | On average |
| 1500 times | 92.28 | 88.81 | 88.38 | 91.69 | 90.29 |
| 2000 times | 86.64 | 87.43 | 88.89 | 86.00 | 87.24 |
| 2500 times | 79.13 | 78.66 | 80.22 | 77.95 | 78.99 |
| 30% 2000 times of kresoxim-methyl SC | 72.68 | 72.19 | 72.35 | 69.31 | 71.63 |
| 40% 2000 times of Difenoconazole WP | 61.58 | 59.81 | 60.23 | 59.34 | 60.24 |
Embodiment 2:
45% kresoxim-methyl Difenoconazole wetting powder
By kresoxim-methyl 40g, Difenoconazole 5g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) after 3g, dispersant calcium lignosulfonate 3g, wetting agent lauryl sodium sulfate 3g, white carbon 5g, precipitated calcium carbonate add to 100g and mix and pulverize by Roughpulverizer, entering airslide disintegrating mill is fully pulverized and mixed, through after the assay was approved, be automatically packaged to be made wetting powder.According to the above ratio with method gained preparation at 2000 ~ 3000 times of liquid to the preventive effect of apple scab 70% ~ 90%, be better than control efficiency when alone.
Table 3
45% kresoxim-methyl Difenoconazole WP prevents and treats 14 days preventive effects (Wuxue City, Hubei) after apple scab medicine
| Process |  | On average | |||
| 2000 times | 87.71 | 87.67 | 87.05 | 91.97 | 88.60 |
| 2500 times | 77.11 | 75.91 | 77.32 | 77.63 | 76.99 |
| 3000 times | 70.30 | 72.12 | 70.71 | 69.98 | 70.78 |
| 10% 2500 times of kresoxim-methyl SC | 64.21 | 65.82 | 66.04 | 64.81 | 65.22 |
| 30% 2000 times of Difenoconazole WP | 52.20 | 52.64 | 51.02 | 51.74 | 51.90 |
Embodiment 3:
10% kresoxim-methyl difenoconazole suspending agent
Kresoxim-methyl 6g, Difenoconazole 4g, dispersant multi-styrene phenylate phosphate 3g, dispersant dodecyl naphthalene sulfonic acids calcium 3g, suspending agent aluminium-magnesium silicate 1g, antifreezing agent propane diols 5g, silicone defoaming agent AF-9903 0.3g, thickener xanthans 0.1g, deionized water are added to 100g.Above-mentioned material is added in batching kettle and is mixed in proportion, after clipper is just pulverized, enter sand mill sand milling and make suspending agent after particle diameter is less than 5 μ m, through after the assay was approved, carry out packing and get product, suspending agent production technological process is shown in accompanying drawing 1.The preventive effect of apple scab is reached more than 80% at 1000 ~ 2000 times of liquid with method gained preparation according to the above ratio, be better than alone preventive effect.
Table 4
10% kresoxim-methyl Difenoconazole SC prevents and treats 14 days preventive effects (Wuxue City, Hubei) after apple scab medicine
| Process |  |  | On average | ||
| 1000 times | 91.12 | 90.36 | 90.56 | 88.76 | 90.20 |
| 1500 times | 84.23 | 84.27 | 86.29 | 85.69 | 85.12 |
| 2000 times | 79.69 | 82.75 | 82.98 | 81.34 | 81.69 |
| 10% 2000 times of kresoxim-methyl SC | 70.96 | 68.62 | 69.92 | 71.38 | 70.22 |
| 30% 2000 times of Difenoconazole WP | 59.57 | 59.35 | 58.13 | 56.95 | 58.50 |
Embodiment 4:
20% kresoxim-methyl difenoconazole suspending agent
Kresoxim-methyl 5g, Difenoconazole 15g, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 3g, alkylnaphthalene sulfonate 2g, antifreeze glycol 5g, suspending agent aluminium-magnesium silicate 0.5g, defoamer organic silicone (8431) 3g, thickener 0.15g, deionized water are added to 100g.Above-mentioned material is added in batching kettle and is mixed in proportion, after clipper is just pulverized, enter sand mill sand milling and make suspending agent after particle diameter is less than 5 μ m, through after the assay was approved, carry out packing and get product, suspending agent production technological process is shown in accompanying drawing 1.According to the above ratio with method gained preparation at 2000 ~ 2500 times of liquid to the preventive effect of ring rot of apple in 80% left and right, be better than control efficiency when alone.
Table 5
20% kresoxim-methyl Difenoconazole SC prevents and treats 7 days preventive effects (%) (Yizheng, Jiangsu) after ring rot of apple medicine
| Process |  |  |  |  | On average |
| 2000 times | 87.34 | 86.96 | 83.46 | 83.67 | 85.36 |
| 2500 times | 83.05 | 80.67 | 81.32 | 79.84 | 81.22 |
| 3000 times | 78.17 | 75.39 | 77.50 | 77.46 | 77.13 |
| 30% 2000 times of kresoxim-methyl SC | 69.90 | 69.29 | 70.45 | 70.40 | 70.01 |
| 40% 2000 times of Difenoconazole WP | 62.71 | 61.51 | 61.56 | 63.19 | 62.24 |
Embodiment 5:
30% kresoxim-methyl difenoconazole suspending agent
Kresoxim-methyl 20g, Difenoconazole 10g, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 3g, alkylnaphthalene sulfonate 2g, suspending agent aluminium-magnesium silicate 0.5g, antifreeze glycol 5g, defoamer organic silicone (8431) 3g, thickener 0.15g, deionized water are added to 100g.Above-mentioned material is added in batching kettle and is mixed in proportion, after clipper is just pulverized, enter sand mill sand milling and make suspending agent after particle diameter is less than 5 μ m, through after the assay was approved, carry out packing and get product, suspending agent production technological process is shown in accompanying drawing 1.According to the above ratio with the preparation of method preparation at 2500 ~ 3000 times of liquid to the preventive effect of wheat powdery mildew more than 75%, be better than preventive effect when alone.
Table 6
7 days preventive effects (%) (jiangsu wuxi) after 30% kresoxim-methyl Difenoconazole SC control wheat powdery mildew medicine
| Process |  |  | On average | ||
| 3000 times | 61.72 | 59.87 | 62.18 | 59.35 | 60.78 |
| 2500 times | 74.04 | 74.02 | 76.81 | 77.89 | 75.69 |
| 2000 times | 85.40 | 85.77 | 84.29 | 88.22 | 85.92 |
| 50% 400 times of carbendazim SC | 69.61 | 69.81 | 69.37 | 75.13 | 70.98 |
Embodiment 6:
45% kresoxim-methyl difenoconazole suspending agent
Kresoxim-methyl 30g, Difenoconazole 15g, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 3g, alkylnaphthalene sulfonate 2g, suspending agent aluminium-magnesium silicate 0.5g, antifreeze glycol 5g, defoamer organic silicone (8431) 3g, thickener 0.15g, deionized water are added to 100g.Above-mentioned material is added in batching kettle and is mixed in proportion, after clipper is just pulverized, enter sand mill sand milling and make suspending agent after particle diameter is less than 5 μ m, through after the assay was approved, carry out packing and get product, suspending agent production technological process is shown in accompanying drawing 1.1500 ~ 2500 times of liquid of preparation that are made into method according to the above ratio all more than 80%, are better than the alone control efficiency of medicament to the preventive effect of cucumber anthrax.
Table 7
45% kresoxim-methyl Difenoconazole SC control cucumber anthracnose is 8 days preventive effects (%) (Shandong Binzhou) after medicine for the third time
| Process |  |  |  |  | On average |
| 1500 times | 92.83 | 92.80 | 91.73 | 87.92 | 91.32 |
| 2000 times | 88.12 | 87.79 | 84.83 | 83.30 | 86.01 |
| 2500 times | 81.70 | 82.85 | 79.88 | 79.21 | 80.91 |
| 40% 2000 times of Difenoconazole WP | 72.61 | 71.05 | 74.29 | 71.97 | 72.48 |
Embodiment 7:
45% kresoxim-methyl difenoconazole water dispersible granule
By kresoxim-methyl 5g, Difenoconazole 40g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) 3g, sodium lignin sulfonate 3g, wetting agent lauryl sodium sulfate 3g, disintegrant sodium bicarbonate 5g, kaolin mends to 100g.Above-mentioned mixing of materials is evenly become to wetting powder through air-flow crushing, then add suitable quantity of water to carry out granulation and obtain water dispersible granules.1500 ~ 2000 times of liquid of preparation that are made into method according to the above ratio more than 80%, are better than the conventional carbendazim control efficiency of using to the preventive effect of wheat powdery mildew.
Table 8
7 days preventive effects (%) (jiangsu wuxi) after 45% kresoxim-methyl Difenoconazole WDG control wheat powdery mildew medicine
| Process |  |  |  | On average | |
| 1500 times | 83.64 | 84.72 | 85.91 | 85.13 | 84.85 |
| 2000 times | 81.31 | 79.89 | 81.92 | 78.04 | 80.29 |
| 2500 times | 72.72 | 70.35 | 72.32 | 71.97 | 71.84 |
| 50% 400 times of carbendazim SC | 66.70 | 64.39 | 65.76 | 67.11 | 65.99 |
Embodiment 8:
60% kresoxim-methyl difenoconazole water dispersible granule
By kresoxim-methyl 50g, Difenoconazole 10g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) 3g, sodium lignin sulfonate 3g, wetting agent lauryl sodium sulfate 4g, disintegrant sodium bicarbonate 5g, kaolin mends to 100g.Above-mentioned mixing of materials is evenly become to wetting powder through air-flow crushing, then add suitable quantity of water to carry out granulation and obtain water dispersible granules.1000 ~ 2000 times of liquid of preparation that are made into method according to the above ratio all more than 80%, are better than the alone control efficiency of medicament to the preventive effect of bitter rot or anthracnose of grape.
Table 9
60% kresoxim-methyl Difenoconazole WDG prevents and treats 8 days preventive effects (%) (Changli, Hebei) after bitter rot or anthracnose of grape medicine
| Process |  |  |  |  | On average |
| 1000 times | 92.83 | 92.83 | 94.25 | 93.09 | 93.25 |
| 1500 times | 86.85 | 88.21 | 86.33 | 89.09 | 87.62 |
| 2000 times | 80.69 | 82.33 | 80.26 | 84.64 | 81.98 |
| 40% 2000 times of Difenoconazole WP | 71.19 | 72.79 | 70.47 | 70.87 | 71.33 |
Embodiment 9:
20% kresoxim-methyl difenoconazole water emulsion
Kresoxim-methyl 10g, Difenoconazole 10g, polyoxyethylene nonylphenol ether 4g, Span-80 3g, Tween-20 3g, ethylene glycol 3g, defoamer 8431 1g, thickener xanthans 0.1g, deionized water are mended to 100g.Above-mentioned material is added in batching kettle and mixes and make aqueous emulsion through high-speed shearing machine, through after the assay was approved, carry out metering, distributing, packaging and get product.1500 ~ 2000 times of liquid of preparation that are made into method according to the above ratio more than 80%, are better than the conventional carbendazim control efficiency of using to the preventive effect of wheat powdery mildew.
Table 10
7 days preventive effects (%) (Distributions in Liaocheng of Shandong Province) after 20% kresoxim-methyl Difenoconazole EW control wheat powdery mildew medicine
| Process |  |  |  |  | On average |
| 1500 times | 87.04 | 86.82 | 86.34 | 87.69 | 86.97 |
| 2000 times | 82.26 | 81.70 | 80.81 | 85.83 | 82.65 |
| 2500 times | 74.35 | 77.12 | 73.65 | 76.12 | 75.31 |
| 50% 400 times of carbendazim SC | 63.98 | 63.90 | 64.30 | 65.15 | 64.33 |
Embodiment 10:
30% kresoxim-methyl difenoconazole water emulsion
Kresoxim-methyl 20g, Difenoconazole 10g, polyoxyethylene nonylphenol ether 4g, Span-80 4g, Tween-20 4g, ethylene glycol 2g, defoamer 622 1g, thickener WJZ-04 0.1g, deionized water are mended to 100g.Above-mentioned material is added in batching kettle and mixes and make aqueous emulsion through high-speed shearing machine, through after the assay was approved, carry out metering, distributing, packaging and get product.
1000 ~ 2000 times of liquid of preparation that are made into method according to the above ratio all more than 80%, are better than the alone control efficiency of medicament to the preventive effect of bitter rot or anthracnose of grape.
Table 11
30% kresoxim-methyl Difenoconazole WDG prevents and treats 8 days preventive effects (%) (Changli, Hebei) after bitter rot or anthracnose of grape medicine
| Process |  |  |  | On average | |
| 1000 times | 91.08 | 89.79 | 89.79 | 86.18 | 89.21 |
| 1500 times | 81.93 | 80.56 | 82.47 | 83.93 | 82.22 |
| 2000 times | 80.79 | 81.67 | 81.35 | 76.23 | 80.01 |
| 40% 2000 times of Difenoconazole WP | 71.38 | 73.30 | 74.68 | 73.19 | 73.14 |
Embodiment 11:
61.2% kresoxim-methyl difenoconazole water dispersible granule
By kresoxim-methyl 1.2g, Difenoconazole 60g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) 3g, sodium lignin sulfonate 3g, wetting agent lauryl sodium sulfate 4g, disintegrant sodium bicarbonate 5g, kaolin mends to 100g.Above-mentioned mixing of materials is evenly become to wetting powder through air-flow crushing, then add suitable quantity of water to carry out granulation and obtain water dispersible granules.1000 ~ 2000 times of liquid of preparation that are made into method according to the above ratio all more than 85%, are better than the alone control efficiency of medicament to the preventive effect of bitter rot or anthracnose of grape.
Table 12
61.2% kresoxim-methyl Difenoconazole WDG prevents and treats 8 days preventive effects (%) (Changli, Hebei) after bitter rot or anthracnose of grape medicine
| Process |  |  |  |  | On average |
| 1000 times | 93.40 | 92.61 | 92.82 | 90.97 | 92.45 |
| 1500 times | 87.93 | 87.97 | 90.08 | 89.46 | 88.86 |
| 2000 times | 83.87 | 87.10 | 87.33 | 85.61 | 85.98 |
| 40% 2000 times of Difenoconazole WP | 73.61 | 71.19 | 72.54 | 74.05 | 72.85 |
Embodiment 12:
51% kresoxim-methyl Difenoconazole wetting powder
By kresoxim-methyl 50g, Difenoconazole 1g, dispersant NNO(sodium methylene bis-naphthalene sulfonate) after 3g, dispersant calcium lignosulfonate 3g, wetting agent lauryl sodium sulfate 3g, white carbon 5g, precipitated calcium carbonate add to 100g and mix and pulverize by Roughpulverizer, entering airslide disintegrating mill is fully pulverized and mixed, through after the assay was approved, be automatically packaged to be made wetting powder.According to the above ratio with method gained preparation at 2000 ~ 3000 times of liquid to the preventive effect of apple scab more than 80%, be better than control efficiency when alone.
Table 13
51% kresoxim-methyl Difenoconazole WP prevents and treats 14 days preventive effects (Wuxue City, Hubei) after apple scab medicine
| Process |  |  |  |  | On average |
| 2000 times | 92.30 | 91.89 | 88.19 | 88.42 | 90.20 |
| 2500 times | 87.80 | 85.29 | 85.98 | 84.41 | 85.87 |
| 3000 times | 83.24 | 80.28 | 82.52 | 82.48 | 82.13 |
| 10% 2500 times of kresoxim-methyl SC | 67.78 | 67.18 | 68.30 | 68.25 | 67.88 |
| 30% 2000 times of Difenoconazole WP | 60.21 | 59.06 | 59.10 | 60.67 | 59.76 |
From above-described embodiment with contrast medicament contrast, after kresoxim-methyl and Difenoconazole are mixed, have significant synergies and expand the effect of fungicidal spectrum.
It is to be understood that: although above-described embodiment is to the mentality of designing of the present invention detailed text description of contrasting; but these text descriptions are just described the simple text of mentality of designing of the present invention; rather than the restriction to mentality of designing of the present invention; any combination, increase or modification that does not exceed mentality of designing of the present invention, all falls within the scope of protection of the present invention.
Claims (1)
1. a preparation method who contains 45% kresoxim-methyl difenoconazole suspending agent, is characterized in that kresoxim-methyl 30g, Difenoconazole 15g, alkylphenol polyoxyethylene formaldehyde condensation products sulfonate 3g, alkylnaphthalene sulfonate 2g, suspending agent aluminium-magnesium silicate 0.5g, antifreeze glycol 5g, defoamer organic silicone-8431 3g, thickener 0.15g, deionized water to add to 100g; Above-mentioned material is added in batching kettle and mixes in proportion, after clipper is just pulverized, enters sand mill sand milling and make suspending agent after particle diameter is less than 5 μ m, through after the assay was approved, carries out packing and gets product.
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| CN1951191A (en) * | 2001-11-30 | 2007-04-25 | 辛根塔参与股份公司 | Seed treatment compositions |
| CN102273443A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Superlow-capacity liquid reagent containing ethofenprox |
| CN102696624A (en) * | 2012-06-29 | 2012-10-03 | 青岛星牌作物科学有限公司 | Bactericidal composition containing difenoconazole and kresoxim-methyl |
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| CN1951191A (en) * | 2001-11-30 | 2007-04-25 | 辛根塔参与股份公司 | Seed treatment compositions |
| CN102273443A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Superlow-capacity liquid reagent containing ethofenprox |
| CN102696624A (en) * | 2012-06-29 | 2012-10-03 | 青岛星牌作物科学有限公司 | Bactericidal composition containing difenoconazole and kresoxim-methyl |
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