CN101664033B - Ethirimol-contained bactericide combination - Google Patents
Ethirimol-contained bactericide combination Download PDFInfo
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- CN101664033B CN101664033B CN 200910206555 CN200910206555A CN101664033B CN 101664033 B CN101664033 B CN 101664033B CN 200910206555 CN200910206555 CN 200910206555 CN 200910206555 A CN200910206555 A CN 200910206555A CN 101664033 B CN101664033 B CN 101664033B
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- ethirimol
- powdery mildew
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Abstract
The invention discloses an ethirimol-contained bactericide combination, which comprises A) a first active ingredient ethirimol and B) a second active ingredient quinoxyfen or brasilense cyclamine. The weight ratio of the first active ingredient and the second active ingredient is 1:100-100:1. The ingredient compounding is scientific and reasonable, the prevention and control effects can be obviously improved, the sterilization range can be enlarged, the occurrence of fastness can be stayed, and the safety to the crop is high. The ethirimol-contained bactericide combination has excellent prevention and control effects on various powdery mildew and rust disease.
Description
Technical field
What the present invention relates to contain the phonetic phenol of second has the bactericidal composition of synergistic effect to plant diseases such as powdery mildew, rust.
Background technology
Powdery mildew be a kind of host range wide, endanger very severe diseases, on some remunerative crops such as strawberry, grape, garden pea, mango, melon, flowers, generation is often arranged.The medicament of triazole type such as triazolone, nitrile bacterium azoles, Tebuconazole, Flusilazole all can be used for preventing and treating powdery mildew.Because long-term single use, the pathogen resistance obviously increases, and after working concentration and the number of times increase, causes phytotoxicity accident easily.
The phonetic phenol of second is a kind of to the active high miazines bactericide of crop powdery mildew, and its mechanism of action and sulphur, kresoxim-methyl (methoxy acrylic bactericide) are different fully with the triazole bactericidal agent action site.To the germ of methoxy acrylic bactericide and triazole bactericidal agent generation resistance, the phonetic phenol of second all shows excellent prevention and result of treatment for.And the safety to crop is very good, can not produce poisoning.But the phonetic phenol of second uses separately, and consumption is big, and also is easy to generate pesticide resistance.
Summary of the invention
The resistance that possibly bring for fear of the agent of the phonetic phenol list of long-term use second produces, degradation problem under the drug effect, and the present invention provides a kind of new high-activity composition.
The inventor finds through a large amount of tests are unexpected, and the phonetic phenol of second is mixed use with benzene oxygen quinoline or volution bacterium amine, can obviously improve control efficiency; The expanding prevention spectrum; And benzene oxygen quinoline, volution bacterium amine are different fully with the mechanism of action of the phonetic phenol of second, can delaying drug resistance produce, and improve safety.
Said benzene oxygen quinoline (quinoxyfen) is a kind of quinolines bactericide.To crop safety, no poisoning,, be desirable integrated control medicament to also safety of environment.Controlling object has powdery mildew etc.Benzene oxygen quinoline is an absorption property bactericide, and the control of cereals powdery mildew is had special efficacy, and behind the foliage application, medicament can penetrate in the plant tissue rapidly, and shifts to the top, and the lasting period reaches 70 days.Comprise no cross resistances such as triazole type, methoxy acrylic with existing bactericide in the market.
Said volution bacterium amine (spiroxamine) belongs to the substitutional amine-group bactericide, is a kind of blade face bactericide of novel, interior absorption, and is effective especially to powdery mildew.Speed of action is fast and the lasting period is long, has protection and therapeutic action concurrently.
Technical scheme of the present invention is following:
A kind of microbicide compositions that contains the phonetic phenol of second is characterized in that:
The phonetic phenol of the first active component second;
The second active component benzene oxygen quinoline or volution bacterium amine;
The mass ratio of first active component and second active component is 1: 100-100: 1, be preferably 1: 50-50: and 1, most preferably be 1: 20-20: 1.The weight percentage of the active component in the composition is 5%-95%.
The present composition can be mixed with suspending agent, wetting powder, water dispersible granules, aqueous emulsion or microemulsion.At least contain two kinds of auxiliary elements in the composition of the present invention, carrier can be solid or liquid, and any carrier that is generally used for preparing microbicide compositions all can use.
At least a auxiliary element is a surfactant in the composition of the present invention, for example dispersant, emulsifier or wetting agent etc.Selected surfactant all is well known to those skilled in the art, and is to be prone on the market buy, like neopelex, lignosulfonates, farming breast 2201,700#, 500# etc.
The present composition has following four advantages: the one, and composition shows fabulous synergistic effect in certain ratio range; Mixed composition obviously improves bactericidal effect than its single agent; Reduced the agricultural chemicals using dosage; Not only practice thrift peasant's use cost, reduced influence simultaneously environment.The 2nd, enlarged bactericidal range, the medicament characteristic has also obtained extremely strong mutual supplement with each other's advantages.A kind of medicament can be prevented and treated multiple diseases simultaneously, and sick means of controlling are provided more.To cereal class white powder, rust, cucurbits powdery mildew, fruit tree powdery mildew, smut, scab all have good prevention, result of treatment.The 3rd, this kind combination is owing to architectural difference between active ingredient is bigger, and the mechanism of action is different, has reduced the single selection pressure to germ, the generation and the development of ability delaying drug resistance.The 4th, improved safety to crop.Owing to reduced active ingredient mu amount of application, to the poisoning risk decline of crop.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer; The present invention describes with following specific embodiment; But the present invention is limited to these examples absolutely not; The following stated is merely the present invention embodiment preferably, only is used to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of within spirit of the present invention and principle, being made, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.In the prescription of all preparations, percentage all is weight percentage, and the treatment dosage of biologically-active moiety is active constituent content.
Formulation examples
1, the preparation of suspending agent
By the prescription requirement, be matrix with water, former medicine, dispersant, auxiliary agent and antifreezing agent etc. are mixed the back add in the sand milling still, carry out porphyrize, process suspending agent.
The phonetic phenol benzene of embodiment 1 35% second oxygen quinoline suspending agent
The phonetic phenol 15% of second, benzene oxygen quinoline 20%, sodium lignin sulfonate 6%, white carbon 0.4%, ethylene glycol 5%, antifoaming agent 0.1%, water complements to 100%.
The phonetic phenol volution of embodiment 2 40% second bacterium amine suspending agent
The phonetic phenol 15% of second, volution bacterium amine 25%, calcium lignosulfonate 8%, white carbon 0.5%, ethylene glycol 4%, antifoaming agent 0.1%, water complements to 100%.
2, wetting powder preparation
According to the prescription requirement, with various former medicines, each auxiliary agent and filler all fully mix, and after airslide disintegrating mill is pulverized, are configured to wetting powder.
The phonetic phenol benzene of embodiment 3 25% second oxygen quinoline wetting powder
The phonetic phenol 15% of second, benzene oxygen quinoline 10%, lauryl sodium sulfate 2%, carboxymethyl cellulose 2%, sodium lignin sulfonate 9%, precipitated calcium carbonate complements to 100%.
The phonetic phenol volution of embodiment 4 50.5% second bacterium amine wetting powder
The phonetic phenol 0.5% of second, volution bacterium amine 50%, neopelex 1.5%, carboxymethyl cellulose 3.0%, white carbon 4%, precipitated calcium carbonate complements to 100%.
The phonetic phenol volution of embodiment 5 90% second bacterium amine wetting powder
The phonetic phenol 20% of second, volution bacterium amine 70%, lauryl sodium sulfate 1%, carboxymethyl cellulose 1%, sodium lignin sulfonate 5%, precipitated calcium carbonate complements to 100%.
3, the preparation of water dispersible granules
Former medicine and powder carrier, wetting agent and binding agent etc. are mixed pulverizing, add water and mediate, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then through dry, sieve, process water dispersible granules.
The phonetic phenol benzene of embodiment 6 40% second oxygen quinoline water dispersible granules
The phonetic phenol 15% of second, benzene oxygen quinoline 25%, methyl naphthalene sulfonate formaldehyde condensate 10%, epoxidized polyether 5%, soluble starch 18%, gypsum complements to 100%.
The phonetic phenol volution of embodiment 7 50% second bacterium amine water dispersible granules
The phonetic phenol 10% of second, volution bacterium amine 40%, alkylnaphthalene sulfonate formaldehyde condensation products 5%, nekal salt 3%, lauryl sodium sulfate 2%, white carbon 5%, thiamines 8%, diatomite adds to 100%.
4, the preparation of aqueous emulsion
By the prescription requirement; With former medicinal little solvent; Surfactant dissolves stirs and obtains even oil phase, and water, preservative, antifreeze evenly are mixed forms even water then; Under normal temperature and high-speed stirred, oil phase is added water (or water adding oil phase), form the high aqueous emulsion of dispersity.
The phonetic phenol benzene of embodiment 8 30.3% second oxygen quinoline aqueous emulsion
The phonetic phenol 30% of second, benzene oxygen quinoline 0.3%, soybean oil 12%, octyl phenol polyoxy ethylene, propylene ether block thing 12%, ethylene glycol 3%, xanthans 0.3%, benzoic acid 0.1 gram, water complements to 100%.
The phonetic phenol volution of embodiment 9 40% second bacterium amine aqueous emulsion
The phonetic phenol 10% of second, volution bacterium amine 30%, rape oil 15%, OPEO 15%, ethylene glycol 4%, CMC0.3%, benzoic acid 0.1%, water is supplemented to 100%.
5, the preparation of microemulsion
By the prescription requirement, former medicine, solvent, cosolvent, emulsifier, water are stirred.
The phonetic phenol benzene of embodiment 10 30% second oxygen quinoline microemulsion
The phonetic phenol 15% of second, benzene oxygen quinoline 15%, dimethyl formamide 4%, cyclohexanone 3%, n-butanol 2%, calcium dodecyl benzene sulfonate 4%, styryl phenol polyethenoxy ether 3%, APES 5%, water is supplemented to 100%.
The phonetic phenol volution of embodiment 115% second bacterium amine microemulsion
The phonetic phenol 1% of second, volution bacterium amine 4%, dimethyl formamide 4%, cyclohexanone 2%, ethylene glycol 5%, calcium dodecyl benzene sulfonate 4%, styryl phenol polyethenoxy ether 3%, APES 5%, water is supplemented to 100%.
The biologically active instance
Embodiment 12 greenhouse pot culture biologically actives
The potted plant determination method of cucumber seedling is adopted in test.Subjects is the powdery mildew of cucumber bacterium.Trial crops is cultured to 2 leaf periods in the greenhouse, every processing 5 basins are numbered subsequent use.On the crop sprayer, carrying out foliar spray by design dosage handles.Chemicals treatment after 24 hours inoculum density be 3 * 10
5The powdery mildew of cucumber bacterium conidial suspension of individual spore/mL.Postvaccinal test material is positioned over 12 hours alternation of light and darkness, and temperature is to cultivate in 22 ℃ the phytotron.When the blank of not dispenser is fully fallen ill, carry out result's investigation, disease classification, preventive effect computational methods are all with reference to State Standard of the People's Republic of China " pesticide field efficacy medicine test criterion ".
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, concentration EC in calculating the virulence equation and suppress with method of least squares
50, according to the toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC>=120, then the composition performance is synergistic effect.
Result of the test shows:
The composition of phonetic phenol of second and benzene oxygen quinoline, volution bacterium amine; Each proportioning all has obvious synergistic effect, and the back EC50 value that is mixed obviously reduces, and explains that composition has higher activity to the powdery mildew of cucumber bacterium; Can effectively reduce the active component consumption, reduce peasant's use cost.Result of the test sees table 1 for details.
The Toxicity Determination of table 1 pair powdery mildew of cucumber bacterium (Sphaerotheca fuliginea)
Embodiment 13 drug effect test of field zone
Test is undertaken by the Ministry of Agriculture " pesticide field efficacy medicine test criterion (two) ".The spraying of 15L workers and peasants' 16 type knapsack hand sprayers is adopted in test.Each chemicals treatment and clear water contrast, 4 sub-districts of every processing, 20 square metres of every sub-district areas are established in test.Each sub-district is natural occurrence, investigates in 7 days before medicine and behind the medicine, calculates disease index and control efficiency, and the result sees embodiment table 2-4 for details.
Table 2 powdery mildew of cucumber (Sphaerotheca fuliginea)
Table 3 powdery mildew of strawberry (Sphaerothesa mawlaris)
Table 4 wheat rust (Wheat stripe rust)
Claims (6)
1. bactericidal composition is characterized in that: contain the phonetic phenol of active component (A) second and (B) benzene oxygen quinoline or volution bacterium amine, the weight ratio of A and B is 1 in the composition: 100-100: 1.
2. bactericidal composition according to claim 1 is characterized in that: the weight ratio of A and B is 1 in the composition: 50-50: 1.
3. bactericidal composition according to claim 2 is characterized in that: the weight ratio of A and B is 1 in the composition: 20-20: 1.
4. according to any described bactericidal composition of claim 1-3, it is characterized in that: the weight percentage of the active component in the composition is 5-95%.
5. bactericidal composition according to claim 4 is characterized in that: the formulation of said composition is suspending agent, wetting powder, water dispersible granules, aqueous emulsion and microemulsion.
6. the purposes of claims 1 said composition in control crop powdery mildew, rust.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200910206555 CN101664033B (en) | 2009-10-14 | 2009-10-14 | Ethirimol-contained bactericide combination |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910206555 CN101664033B (en) | 2009-10-14 | 2009-10-14 | Ethirimol-contained bactericide combination |
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| CN101664033A CN101664033A (en) | 2010-03-10 |
| CN101664033B true CN101664033B (en) | 2012-12-19 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308801A (en) * | 2011-04-28 | 2012-01-11 | 陕西韦尔奇作物保护有限公司 | Germicide composition containing spiroxamine and antibiotics compound |
| CN102349514A (en) * | 2011-10-11 | 2012-02-15 | 海利尔药业集团股份有限公司 | Bupirimate-containing antibacterial composition |
| CN103651374A (en) * | 2013-12-10 | 2014-03-26 | 济南凯因生物科技有限公司 | Combination for prevention and treatment of rice powdery mildew disease |
| CN105028420A (en) * | 2015-08-17 | 2015-11-11 | 陕西上格之路生物科学有限公司 | Sterilization composition containing spiroxamine and bupirimate |
| CN106417303A (en) * | 2016-12-05 | 2017-02-22 | 湖南泽丰农化有限公司 | Proquinazid-containing high-efficiency bactericidal composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005044813A1 (en) * | 2003-11-11 | 2005-05-19 | Shenyang Research Institute Of Chemical Industry | Benzopyrone compounds, preparation method and use thereof |
| CN101548677A (en) * | 2009-05-12 | 2009-10-07 | 陕西标正作物科学有限公司 | Sterilizing compound of ethirimol and triazole |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005044813A1 (en) * | 2003-11-11 | 2005-05-19 | Shenyang Research Institute Of Chemical Industry | Benzopyrone compounds, preparation method and use thereof |
| CN101548677A (en) * | 2009-05-12 | 2009-10-07 | 陕西标正作物科学有限公司 | Sterilizing compound of ethirimol and triazole |
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| CN101664033A (en) | 2010-03-10 |
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Owner name: SHAANXI HUANGPAI CROP TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: CHENGDU HUANGPAI CROPSCIENCE SCIENCE CO., LTD. Effective date: 20130225 |
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Effective date of registration: 20130225 Address after: 714000 west section of Chaoyang Avenue, Weinan hi tech Zone, Shaanxi Patentee after: Chengdu Huangpai Crop Science Co., Ltd. Address before: 611130, room 388, hatch building 6-6, Strait Science Park, Wenjiang District, Chengdu, Sichuan Patentee before: Chengdu Huangpai Crop Science Co., Ltd. |
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